AutismKB 2.0

Annotation Detail for SLC39A5


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Basic Information Top
Gene Symbol:SLC39A5 ( LZT-Hs7,MGC34778,ZIP5 )
Gene Full Name: solute carrier family 39 (metal ion transporter), member 5
Band: 12q13.3
Quick LinksEntrez ID:283375; OMIM: 608730; Uniprot ID:S39A5_HUMAN; ENSEMBL ID: ENSG00000139540; HGNC ID: 20502
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Transmembrane transport of small molecules
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Pathway IDPathway Name
500356Zinc influx into cells by the SLC39 gene family
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC39A5 proteinaffects expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SLC39A5 mRNAaffects expression 17555576
C006253 pirinixic acid pirinixic acid results in increased expression of SLC39A5 mRNAincreases expression 18301758
D013629 Tamoxifen Tamoxifen affects the expression of SLC39A5 mRNAaffects expression 17555576
D015032 Zinc SLC39A5 protein results in increased transport of Zincincreases transport 18326752
D015032 Zinc SLC39A5 protein results in increased uptake of Zincincreases uptake 17126599
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.1614745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.5517505938
MESH:D000169 Acrodermatitis Zinc 5.9417202136 16889938 17190629
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8814692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D000544 Alzheimer Disease Zinc 2.8117119284 16580781 16325427 16410023
MESH:D000755 Anemia, Sickle Cell Zinc 5.3416916123
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8615885639
MESH:D001249 Asthma Zinc 3.0417085522
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001930 Brain Injuries Zinc 5.1717109824
MESH:D001943 Breast Neoplasms Tamoxifen 2.1719142967 17242785 19189212 19155303 21152245 18821012 16873071 18425577 19084267 17261762 15668708 18629630 18855134 19487384 19189210 20135344 15565566 19059307 17893378 17049068 19011961 19289846 19115204 16818667 19200415 18351453 16202921 19244106 17440819 21138602 20544844 20390343 19221464 19288272 18815881 19066611 19103187 18984771 18997820 20005174 20065188 20859285 11161223 16273361 19410462
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9919066611
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1921507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1916924424
MESH:D002294 Carcinoma, Squamous Cell Zinc 2.9816543248
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9617572228
MESH:D002318 Cardiovascular Diseases Zinc 3.8916936243
MESH:D002779 Cholestasis Ethinyl Estradiol 8.6216105132 17333356 17681005 17110522 16919318 11677210 15861022
MESH:D002779 Cholestasis pirinixic acid 8.6219176532
MESH:D019465 Craniofacial Abnormalities Zinc 2.4419302082
MESH:D003711 Demyelinating Diseases Tamoxifen 4.8519031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003920 Diabetes Mellitus Zinc 4.5316479319
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8019279558
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.4512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.4519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2619155303 16202921 20544844 17893378
MESH:D004938 Esophageal Neoplasms Zinc 2.9216543248
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.3115345470
MESH:D005234 Fatty Liver pirinixic acid 15.3119236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 15.3119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.0714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.7219069698
MESH:D005756 Gastritis Zinc 5.4117241300
MESH:D006130 Growth Disorders Zinc 4.1717217573
MESH:D006333 Heart Failure pirinixic acid 7.8220558911
MESH:D006333 Heart Failure Zinc 7.8217162251
MESH:D006335 Heart Injuries Zinc 6.3817074742
MESH:D016481 Helicobacter Infections Zinc 4.9417241300
MESH:D006527 Hepatolenticular Degeneration Zinc 5.1717276780
MESH:D006529 Hepatomegaly pirinixic acid 3.4816221962 19176532 19772884 18467677
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.7117937319
MESH:D007249 Inflammation Tamoxifen 2.5119457130
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007511 Ischemia Zinc 5.1116584753
MESH:D007674 Kidney Diseases Zinc 3.5016960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.7916518626
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3518625569
MESH:D008064 Lipidoses Tamoxifen 3.4015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.4018564211
MESH:D008113 Liver Neoplasms Aflatoxin B1 8.079163691 15890375 18177683 2125692
MESH:D008113 Liver Neoplasms pirinixic acid 8.0720007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 8.0716684651
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.948603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.5614755239
MESH:D008175 Lung Neoplasms Tamoxifen 2.5618625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.9611731420 19196723 14580682 19196722 16827153
MESH:D008325 Mammary Neoplasms, Experimental Zinc 6.9612773700
MESH:D020149 Manganese Poisoning Tamoxifen 5.1619453300
MESH:D008545 Melanoma Tamoxifen 1.9212393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.7215990972
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.6119189210 19200415 19196722
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0911578682
MESH:D011225 Pre-Eclampsia Zinc 4.4517114810
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3715067354
MESH:D011471 Prostatic Neoplasms Zinc 3.3716700911 12429649 16606632 16517595
MESH:D011537 Pruritus Ethinyl Estradiol 3.8516919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012162 Retinal Degeneration Zinc 4.3916584753
MESH:D013088 Spermatocele Ethinyl Estradiol 13.6916709447
MESH:D013088 Spermatocele Tamoxifen 13.6916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5819457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 4.0211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4815669648
MESH:D014062 Tongue Neoplasms Zinc 4.7516543248
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4616712894 17572228 8653321
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.7414692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.9114671159 15869587
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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