AutismKB 2.0

Annotation Detail for GAS2L3


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Basic Information Top
Gene Symbol:GAS2L3 ( - )
Gene Full Name: growth arrest-specific 2 like 3
Band: 12q23.1
Quick LinksEntrez ID:283431; OMIM: NA; Uniprot ID:GA2L3_HUMAN; ENSEMBL ID: ENSG00000139354; HGNC ID: 27475
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of GAS2L3 mRNAincreases expression 20713471
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GAS2L3 mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of GAS2L3 mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GAS2L3 mRNAdecreases expression 19150397
20382639
20018196
D016572 Cyclosporine Cyclosporine results in decreased expression of GAS2L3 mRNAdecreases expression 20106945
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in decreased expression of GAS2L3 mRNAdecreases expression 20713471
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of GAS2L3 mRNAincreases expression 20713471
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GAS2L3 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of GAS2L3 mRNAincreases expression 18301758
C017947 sodium arsenite sodium arsenite results in decreased expression of GAS2L3 mRNAdecreases expression 17998272
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GAS2L3 mRNAincreases expression 20159946
D014415 Tunicamycin Tunicamycin results in increased expression of GAS2L3 mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0811752688 14514962 15322242
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma 2-Acetylaminofluorene 11.9010737359
MESH:D000236 Adenoma Benzo(a)pyrene 11.906695378
MESH:D000236 Adenoma Methylcholanthrene 11.906695378 10545420
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 6.276705139
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1717306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5511922910
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.3519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.0211921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0217474063 20146248
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.0217474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0220435547
MESH:D002277 Carcinoma Methylcholanthrene 8.8010545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.8016835633
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 3.473084413 10737359 6705139 3581430 17761372
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.4715276417 17306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7420419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.7418572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 16120746 18850075
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.0220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.0212371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 17.0216192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 17.0220056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615668235 15340226 12621046 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema pirinixic acid 7.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4820426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4816530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Cyclosporine 8.1419224547
MESH:D005234 Fatty Liver pirinixic acid 8.1419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.1814633661 10962813
MESH:D005355 Fibrosis Cyclosporine 9.2112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.9216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7210048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.586705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.586705139
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly pirinixic acid 8.9916221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.9912621046 16120746 15340226
MESH:D006689 Hodgkin Disease sodium arsenite 3.3012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3118606429 8697196 16354765 15340226 16959395
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D007248 Infertility, Male sodium arsenite 3.1012646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Cyclosporine 6.328314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 6.3220008137
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8812371664
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1812878042
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 14.8811376686 18001218 14678523 10737359 10672840 16273603
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.8821137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 14.8820007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 14.8816712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.8816984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 10.616150874 1399818 534488
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 10.61598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.6112151625
MESH:D008171 Lung Diseases sodium arsenite 3.2819095001
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 6.8011376686
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.8018816296 18520028 20464547 20064080 17053015 20869020 18569708 6695378 20135361
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.8016271038 20512841 16337739 6695378 1399818 21163286 20970405 17909032 15390079 11893704 9230183 10545420 7750092
MESH:D008175 Lung Neoplasms sodium arsenite 6.8019931552 17306315 15276417 16712894 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.8019555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 3.6811921183
MESH:D008545 Melanoma sodium arsenite 2.0516487513 19082730
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009369 Neoplasms Benzo(a)pyrene 8.6611141357
MESH:D009369 Neoplasms pirinixic acid 8.6617405874
MESH:D009369 Neoplasms sodium arsenite 8.6611559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8820056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.2512854658
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4815276417 17306315
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311118676 11896295 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1517292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.1516039940
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8319755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 9.8319524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.8316192470
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9312854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 8.7815289314 1399818 15867355
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7817053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.7816712894 16452187 17306315 11723127
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.9311813266
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014652 Vascular Diseases sodium arsenite 4.6617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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