AutismKB 2.0

Annotation Detail for PGP


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Basic Information Top
Gene Symbol:PGP ( MGC4692 )
Gene Full Name: phosphoglycolate phosphatase
Band: 16p13.3
Quick LinksEntrez ID:283871; OMIM: 172280; Uniprot ID:PGP_HUMAN; ENSEMBL ID: ENSG00000184207; HGNC ID: 8909
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00630Glyoxylate and dicarboxylate metabolism
hsa01100Metabolic pathways
No data
No data
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No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of PGP mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of PGP mRNAaffects expression 17562736
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 3.003712494
MESH:D000799 Angioedema Acetaminophen 4.9110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 6.091440618 11289319
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.987296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.983084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.867296757
MESH:D002386 Cataract Acetaminophen 2.8310977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.087505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.519022650 19486331
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.5511906362 12868966 14531868 11298694 2524372 18759878 8156756 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.102952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.0818692083 1440618 9022650 9328219 18289764 18648102 16192314 11289319 6482804 7440962 9653073 8291058 6679447
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0819923254 16081117 19164858 10915739 15619225 11461765 16227642 11287661 12153990 19739265 16393943 14725611 11834606 18071297 11529661 11739529 2444490 17522070 16177239 16109766 10663392 15968718 19370779 11421492 12540782 11743745 12594235 17906064 12958197 18713872 14550746 16781746 19420014 19416960 17562736 12705907 12392966 10774834 19085960 16485898 14986274
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 5.1719426721
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.193581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 6.096705139
MESH:D005756 Gastritis Acetaminophen 4.7416983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.647505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.196705139
MESH:D006930 Hyperalgesia Acetaminophen 3.1116870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.7015034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 6.098074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.4412587719 15629191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.406582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4715034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 1.7119014921 16611625 12587719 12969438 11587558 19784758 16610002 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.7416871587 17185352
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.801399818 598648 6587162 3712494
MESH:D008546 Melanoma, Experimental Acetaminophen 4.3319513568
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.623581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.216679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.3118514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.924026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 6.093988306
MESH:D010146 Pain Acetaminophen 2.8216870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.247296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.546228378
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.743692021
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.266587162 6582329 3712494 7505956 1399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.428074119
MESH:D014581 Urticaria Acetaminophen 3.5810982225
Pathway ID Pathway Name
KEGG:00630 Glyoxylate and dicarboxylate metabolism
KEGG:01100 Metabolic pathways
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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