AutismKB 2.0

Annotation Detail for ANGPT1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ANGPT1 ( AGP1,AGPT,ANG1 )
Gene Full Name: angiopoietin 1
Band: 8q23.1
Quick LinksEntrez ID:284; OMIM: 601667; Uniprot ID:ANGP1_HUMAN; ENSEMBL ID: ENSG00000154188; HGNC ID: 484
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Hemostasis
Pathway IDPathway Name
200066Angiopoietin receptor Tie2-mediated signaling
Pathway IDPathway Name
P00005Angiogenesis
Pathway IDPathway Name
500306Tie2 Signaling
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1878Ischemia
1901Endometriosis
1904Diabetes mellitus
1934Cancer
2074Asthma
2111Systemic infection
2236Cardiovascular disease
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT1 protein inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]]decreases reaction|increases expression 15763944
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT1 protein results in decreased susceptibility to Doxorubicin]decreases reaction|decreases response to substance 15763944
D000111 Acetylcysteine Acetylcysteine results in decreased secretion of ANGPT1 proteindecreases secretion 19622383
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ANGPT1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ANGPT1 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of ANGPT1 mRNAdecreases expression 19654921
C006632 arsenic trioxide arsenic trioxide results in decreased expression of ANGPT1 mRNAdecreases expression 20458559
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of ANGPT1 mRNAdecreases expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ANGPT1 mRNAincreases expression 15135347
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ANGPT1 proteinincreases expression 15135347
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of ANGPT1 mRNAincreases expression 17403535
D016572 Cyclosporine Cyclosporine results in decreased expression of ANGPT1 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ANGPT1 mRNAincreases expression 17034775
D004052 Diethylnitrosamine Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of ANGPT1 mRNA]decreases reaction|increases expression 17034775
D004317 Doxorubicin 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT1 protein inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]]decreases reaction|increases expression 15763944
D004317 Doxorubicin 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT1 protein results in decreased susceptibility to Doxorubicin]decreases reaction|decreases response to substance 15763944
D004317 Doxorubicin ANGPT1 protein inhibits the reaction [Doxorubicin results in increased expression of FASLG mRNA]decreases reaction|increases expression 15763944
D004317 Doxorubicin ANGPT1 protein inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]decreases reaction|increases expression 15763944
D004317 Doxorubicin ANGPT1 protein inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]decreases reaction|increases expression 15763944
D004317 Doxorubicin ANGPT1 protein results in decreased susceptibility to Doxorubicindecreases response to substance 15763944
D004958 Estradiol Estradiol results in decreased expression of ANGPT1 mRNAdecreases expression 16705744
D005472 Fluorouracil ANGPT1 protein promotes the reaction [Fluorouracil results in increased expression of IFNA1 protein]increases expression|increases reaction 17786339
D005472 Fluorouracil Fluorouracil results in increased expression of ANGPT1 proteinincreases expression 17786339
D019833 Genistein Genistein results in decreased expression of ANGPT1 mRNAdecreases expression 16705744
D016285 Iloprost Iloprost results in increased expression of ANGPT1 mRNAincreases expression 16373414
D016285 Iloprost tyrphostin AG 1478 inhibits the reaction [Iloprost results in increased expression of ANGPT1 mRNA]decreases reaction|increases expression 16373414
D008731 Methoxychlor Methoxychlor results in increased expression of ANGPT1 proteinincreases expression 15503810
C030589 methylmercury cysteine methylmercury cysteine results in increased expression of ANGPT1 mRNAincreases expression 19465457
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of ANGPT1 mRNAdecreases expression 17616710
D010126 Ozone Ozone results in decreased expression of ANGPT1 mRNAdecreases expression 17460151
C073402 PD 123319 PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]decreases reaction|increases expression 14638905
D010656 Phenylephrine ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]decreases reaction|increases expression 18502941
D010656 Phenylephrine ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]decreases reaction|increases expression 18502941
D010656 Phenylephrine ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]decreases reaction|increases expression 18502941
D010656 Phenylephrine ANGPT1 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]decreases reaction|increases expression 18502941
D010656 Phenylephrine Phenylephrine affects the reaction [ANGPT1 protein results in increased expression of ILK protein]affects reaction|increases expression 18502941
D010656 Phenylephrine Phenylephrine results in increased expression of ANGPT1 mRNAincreases expression 18502941
D010656 Phenylephrine Phenylephrine results in increased expression of ANGPT1 proteinincreases expression 18502941
D010936 Plant Extracts Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of ANGPT1 mRNA]decreases reaction|increases expression 17034775
D011143 Polyvinyl Chloride Polyvinyl Chloride results in decreased expression of ANGPT1 mRNAdecreases expression 12809767
C116926 rofecoxib rofecoxib results in decreased expression of ANGPT1 mRNAdecreases expression 17070997
D012406 Roxarsone Roxarsone results in decreased expression of ANGPT1 mRNAdecreases expression 18414637
D012643 Selenium Selenium results in decreased expression of ANGPT1 mRNAdecreases expression 19244175
C101426 sildenafil sildenafil results in increased expression of ANGPT1 mRNAincreases expression 18373738
C101426 sildenafil sildenafil results in increased expression of ANGPT1 proteinincreases expression 18373738
C017947 sodium arsenite sodium arsenite results in decreased secretion of ANGPT1 proteindecreases secretion 19622383
C017947 sodium arsenite sodium arsenite results in increased expression of ANGPT1 proteinincreases expression 19622383
D013311 Streptozocin Streptozocin results in increased expression of ANGPT1 mRNAincreases expression 15643138
D013311 Streptozocin Streptozocin results in increased expression of ANGPT1 proteinincreases expression 15643138
C004648 testosterone enanthate testosterone enanthate affects the expression of ANGPT1 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ANGPT1 mRNAdecreases expression 16120747
C101044 tyrphostin AG 1478 tyrphostin AG 1478 inhibits the reaction [Iloprost results in increased expression of ANGPT1 mRNA]decreases reaction|increases expression 16373414
C081489 valsartan valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]decreases reaction|increases expression 14638905
C081489 valsartan valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 protein]decreases reaction|increases expression 14638905
C025643 vinclozolin vinclozolin affects the expression of ANGPT1 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in decreased expression of ANGPT1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5011752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.2118287403
MESH:D000230 Adenocarcinoma arsenic trioxide 12.4911798837 19825857
MESH:D000230 Adenocarcinoma Doxorubicin 12.4917418594
MESH:D000230 Adenocarcinoma Estradiol 12.4911473722
MESH:D000230 Adenocarcinoma Fluorouracil 12.4917638652
MESH:D000230 Adenocarcinoma Genistein 12.4911473722
MESH:D000236 Adenoma Diethylnitrosamine 2.6510737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.8816434500 17620307 19052882 19061943 18056438 17162532
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.8816835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3415276417
MESH:D018246 Adrenocortical Adenoma Arsenic 12.5917306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 12.5917306315 16712894
MESH:D000419 Albuminuria Doxorubicin 4.2121441931
MESH:D000544 Alzheimer Disease Ozone 4.2515513908
MESH:D000544 Alzheimer Disease Plant Extracts 4.2516962711
MESH:D000740 Anemia Fluorouracil 7.6717963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.6711748828
MESH:D001008 Anxiety Disorders vinclozolin 3.3619015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.8117460149
MESH:D020261 Arsenic Poisoning Arsenic 2.7616251483 18414634 16835338 12569548
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.2515014928
MESH:D001169 Arthritis, Experimental Plant Extracts 7.4114686799
MESH:D001169 Arthritis, Experimental rofecoxib 7.4116690336
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4715570426
MESH:D001249 Asthma Ozone 2.5317854713 16373670
MESH:D050197 Atherosclerosis Arsenic 3.0419371607 12928151
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 7.9116206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.9112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5415746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.3414601052
MESH:D001919 Bradycardia Phenylephrine 4.1915306635
MESH:D002545 Brain Ischemia Plant Extracts 4.3816041641
MESH:D001932 Brain Neoplasms Doxorubicin 3.5117150277
MESH:D001943 Breast Neoplasms Cyclophosphamide 3.5111325840 18234424 15136595 18323546 16978400 17388661 15093573 17020986 12006526
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.5117474063
MESH:D001943 Breast Neoplasms Doxorubicin 3.5116096432 16322301 15939500 16115903 15136595 19526202 18628466 18234424 16264153 15567936 15994142 17369602 15692762 17983394 16935488 17426702 15634643 11325840 18695136 15668708 16595493 16826403 15993339 18382427
MESH:D001943 Breast Neoplasms Estradiol 3.5117018787 16675129 18497071 12948864 17261762 17289903 19861407 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 3.5115136595 18357371 19217205 16110121 18608205 16595493 16557594
MESH:D001943 Breast Neoplasms Genistein 3.5116541309 16873071 17200150
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.5120435547
MESH:D016535 Bronchial Hyperreactivity Ozone 8.1318417511 17626835 18315731 16777450 15516495 14754758 19059883
MESH:D016535 Bronchial Hyperreactivity tyrphostin AG 1478 8.1312794006
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0011589617
MESH:D002057 Burns, Chemical Plant Extracts 4.979625245
MESH:D002100 Cachexia Ozone 4.3916183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 8.7816011737 15721981 10355542 16050911 16124888 16192424 3786805 16227642 18705752 15700767 16097048 15673190
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 8.7816050911
MESH:D002276 Carcinoid Tumor Doxorubicin 19.1416051944
MESH:D002276 Carcinoid Tumor Fluorouracil 19.1416051944
MESH:D002276 Carcinoid Tumor Streptozocin 19.1416051944
MESH:D002277 Carcinoma Fluorouracil 7.2617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.2616835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.3917687452 15504454
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 31.0412907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Arsenic 31.0416507464 17306315
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 31.0416217749 15553829 14691202 11135700 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 31.0418788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 31.0419701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 31.0419208518 16698587 16935385 20935162 20214788 19919837 3084413 20512989 16288022 19107877 17173139 16830150 16569478 16681979 20727157 10737359 19052882 19383236 16878318 18056438 18210153 10672840 18506893 17428255 17978847 18971187 16328049 17162532 16502159 20101231 17761372 17055752 19171122 20432363 17138121 18788625 16779866 19418558 19394651 18494052 20084675 18978308 19335982 18691550 20007298 20514400 18393292 18665156 11831363 16540662 16807293 3581430 19822196 20524982 21159647 19539802 19519916 18785209 19701751
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 31.0417876044 16234567 16023760 18059187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 31.0416924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 31.0418930000 16799960 17088986 16332177 17971768 17045692
MESH:D006528 Carcinoma, Hepatocellular Genistein 31.0416924424
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 31.0418834353
MESH:D006528 Carcinoma, Hepatocellular Polyvinyl Chloride 31.0412040117
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 31.0415276417 17306315 16507464
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.5316152834
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5119014326
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 9.9016201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 9.901485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 9.9018695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8112490120
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 13.1617015178
MESH:D002294 Carcinoma, Squamous Cell Arsenic 13.1618922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 13.166189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 13.1617066447 18986760 16757204 16280240
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 13.1618572023
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.7718640142
MESH:D006332 Cardiomegaly Phenylephrine 14.7711754973 11179087 15728586 16170337 17287366 17124262
MESH:D006332 Cardiomegaly Plant Extracts 14.7717645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 14.7718670907 18850075 16120746
MESH:D006332 Cardiomegaly valsartan 14.7719597038
MESH:D009202 Cardiomyopathies Doxorubicin 12.0418627295 17519947 17974986 16612575 17351982 17329180 16651473 15476868 17382496 16364871 15505089 17308081 17924179 17131338 16269455 17928571 16731534 15792986 16109756 17007740 16278810 16952015 15811867 16242529 16455267
MESH:D009202 Cardiomyopathies sildenafil 12.0415811867
MESH:D009202 Cardiomyopathies valsartan 12.0416247790
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8217334414 16243910
MESH:D002318 Cardiovascular Diseases Arsenic 15.4915738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases Genistein 15.4916332659
MESH:D002318 Cardiovascular Diseases Polyvinyl Chloride 15.4914651027
MESH:D002318 Cardiovascular Diseases valsartan 15.4911230374
MESH:D002340 Carotid Artery Diseases Arsenic 4.0118022660 16973168
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 18.5218226522
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 18.5212371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 18.522727394 17174075 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 18.5218566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 18.5219524636 20056578
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.3419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.3416835633
MESH:D002779 Cholestasis Cyclosporine 2.6619486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.958697196 12621046 15340226 15668235 16354765
MESH:D003092 Colitis Selenium 3.4417936198
MESH:D003110 Colonic Neoplasms Fluorouracil 5.5717169374 16340194 18772588 15001691 17172411 17725105 17016597 16510598 17287894 17018589
MESH:D003110 Colonic Neoplasms Genistein 5.5717182828
MESH:D003110 Colonic Neoplasms rofecoxib 5.5712902858
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.2720501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.2718802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.2715148649 17255274 17401013 14970324 17695437 18288408 18802399 18949393 18383874 16331619 17454858 17094418 16303861 17016601 18509181 15289873 16524972 16282729 20501625 18448328 17594712 16391804
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7617141729 14669216
MESH:D003324 Coronary Artery Disease valsartan 3.7717719468
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8512609071
MESH:D003384 Coxsackievirus Infections valsartan 5.4920392896
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.5310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5320055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.5319769572
MESH:D003456 Cryptorchidism vinclozolin 4.0014966744
MESH:D003550 Cystic Fibrosis Acetylcysteine 8.5319747007
MESH:D003550 Cystic Fibrosis sildenafil 8.5319747007
MESH:D003556 Cystitis Cyclophosphamide 4.6317979934 12388444 18710439 10498854 18483878 11948286 10700343 12913760 18295254 16614059 16651033 18372110 15643279 15276878 17010015 18433785 12161096 18093676 16989017 16413132
MESH:D007644 Darier Disease Fluorouracil 4.4416733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7715213294
MESH:D003920 Diabetes Mellitus Streptozocin 4.4316285004
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 12.6115331540 11751995 10990075
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 12.6117442507 12644472 8740154 7637645 11055810 15298345 1374869 19298542 12093613 6379147 19586609 16684804 15862027 15831366 18715473 18603373 12446591 2177838 19960420 16286809 11260395 17874149 12083368 19496084
MESH:D003921 Diabetes Mellitus, Experimental valsartan 12.6111508273
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 5.6818772604
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 5.6818603373
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.4820387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 9.4816647724
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 9.4819586609 19647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.4817107852
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.3716025228
MESH:D003928 Diabetic Nephropathies Estradiol 19.1319279558
MESH:D003928 Diabetic Nephropathies Plant Extracts 19.1319706694
MESH:D003928 Diabetic Nephropathies Streptozocin 19.1319960420 19682444
MESH:D003928 Diabetic Nephropathies valsartan 19.1311427623 18630688
MESH:D003930 Diabetic Retinopathy Streptozocin 5.0917662242
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 13.7611287661
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 13.767440962 2869522 16227642 7179309 4309450 21278145 17522070 6884620 19336974 10915739 11566570 15998439 19085960 15027814 9327722 3786805 16177239 7120509 15968718 10092053 6623471 3732212
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 13.7619107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 13.7617416283
MESH:D056486 Drug-Induced Liver Injury Selenium 13.7615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.7620420201
MESH:D004362 Drug Toxicity Doxorubicin 7.2418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.2411462148
MESH:C538011 Eales disease Vitamin E 4.349068938
MESH:D004487 Edema Plant Extracts 6.0012787963
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5418230668 15322242 16714409
MESH:D004714 Endometrial Hyperplasia Genistein 4.2316402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 11.1717359293
MESH:D016889 Endometrial Neoplasms Estradiol 11.1719148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 11.1711473722
MESH:D004715 Endometriosis rofecoxib 8.3215652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.329294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 12.8618037988
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 12.8615268973
MESH:D004802 Eosinophilia Cyclophosphamide 3.8711006010
MESH:D004827 Epilepsy Plant Extracts 3.5519439326 19700373
MESH:D007172 Erectile Dysfunction sildenafil 5.4616368379
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7616302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.7712903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.7716481741 15173087 16785472 16337965 17638652
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 6.7716805852 15878914 15150132 16510608 15547733 15264214 15547721 15623463 16704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7511564622
MESH:D005234 Fatty Liver arsenic trioxide 21.3215073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 21.3219224547 15959796 17595544 12631006 61145 16239168 12795759 16045604
MESH:D005234 Fatty Liver Cyclosporine 21.3219224547
MESH:D005234 Fatty Liver Diethylnitrosamine 21.3220387270 21071580
MESH:D005234 Fatty Liver Plant Extracts 21.3215975614
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1111858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.2319069698
MESH:D005355 Fibrosis Carbon Tetrachloride 18.3518705752
MESH:D005355 Fibrosis Cyclosporine 18.3512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.3520067830
MESH:D005355 Fibrosis valsartan 18.3516893502
MESH:D005534 Foot Diseases Arsenic 5.206392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9316904648
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5816973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9416417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.868708960
MESH:D005909 Glioblastoma Doxorubicin 6.5717150277
MESH:D005909 Glioblastoma Genistein 6.5716598420
MESH:D005910 Glioma Fluorouracil 2.7316145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.1611389073
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.2116928621
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2310696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.6916376943 11014644 15172196
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.1215692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.1215162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9410048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 5.9416080930
MESH:D006331 Heart Diseases Doxorubicin 7.3017875725 16330681 18006777 16707910 16495754 16879835 16244372 14766674 12587719 17888722 16244371 18674790 16144979
MESH:D006331 Heart Diseases Streptozocin 7.3012093613
MESH:D006333 Heart Failure Doxorubicin 15.1817481944
MESH:D006333 Heart Failure Plant Extracts 15.1818097624
MESH:D006333 Heart Failure Selenium 15.1817162251
MESH:D006333 Heart Failure valsartan 15.1819027736
MESH:D006394 Hemangiosarcoma Doxorubicin 3.5915692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0715720958
MESH:D006467 Hemophilia A Cyclophosphamide 4.9411918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0211000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.1714986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2619110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5516120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5716490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.6715709030
MESH:D006561 Herpes Simplex Plant Extracts 4.2710715843
MESH:D015658 HIV Infections Plant Extracts 3.4912878215
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.3917440010
MESH:D006689 Hodgkin Disease Cyclophosphamide 10.6616135485 17606976
MESH:D006689 Hodgkin Disease Doxorubicin 10.6618501091 17606976 15147373
MESH:D006689 Hodgkin Disease sodium arsenite 10.6612676792
MESH:D019584 Hot Flashes Estradiol 15.0517088409
MESH:D019584 Hot Flashes Plant Extracts 15.0514716179 16566672 17454163
MESH:D019584 Hot Flashes Vitamin E 15.0514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6816959395 15340226 18606429 8697196 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1816899240
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.1716484555
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.1517050553
MESH:D006949 Hyperlipidemias Plant Extracts 4.1515975614 15268973
MESH:D006973 Hypertension Arsenic 14.8911953799 16076760 9931084
MESH:D006973 Hypertension Cyclosporine 14.8910903974
MESH:D006973 Hypertension Phenylephrine 14.8912717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 14.8918670907 18850075
MESH:D006973 Hypertension valsartan 14.8911427623 16475468 10903974 12850387 12692753 18344623 18390891 20102058
MESH:D006974 Hypertension, Malignant valsartan 6.0511560862
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7415338365
MESH:D006984 Hypertrophy therapeutic 18502941
MESH:D006984 Hypertrophy Phenylephrine 4.2418502941 12791704
MESH:D006987 Hypesthesia Arsenic 5.2016093927
MESH:D007154 Immune System Diseases Cyclophosphamide 4.9716076520
MESH:D007248 Infertility, Male Cyclophosphamide 14.217193160 16517039
MESH:D007248 Infertility, Male Methoxychlor 14.2111955947 16467254
MESH:D007248 Infertility, Male sodium arsenite 14.2115346721 12646999
MESH:D007248 Infertility, Male vinclozolin 14.2116467254
MESH:D007249 Inflammation Diethylnitrosamine 7.3018785209
MESH:D007249 Inflammation Plant Extracts 7.3012787963 15997105 19332304 16366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.3012878042 12200463
MESH:D007251 Influenza, Human Selenium 9.7616624496
MESH:D007251 Influenza, Human Vitamin E 9.7616624496
MESH:D007333 Insulin Resistance Estradiol 2.7416627594 16393666
MESH:D007410 Intestinal Diseases rofecoxib 4.6915831440
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.3112628509 12584176 12351151
MESH:D007417 Intestinal Polyps rofecoxib 5.0411245490
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0815604871
MESH:D007642 Keratosis Arsenic 4.6416930632 12749816
MESH:D007674 Kidney Diseases Cyclosporine 25.688314463 18776723 10903974
MESH:D007674 Kidney Diseases Doxorubicin 25.6815369732 16775033 15699352
MESH:D007674 Kidney Diseases Estradiol 25.6815618244
MESH:D007674 Kidney Diseases sodium arsenite 25.6820008137
MESH:D007674 Kidney Diseases Streptozocin 25.6812093613
MESH:D007674 Kidney Diseases valsartan 25.6812164870 16893502 10903974
MESH:D007674 Kidney Diseases Vitamin E 25.6812488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.9316707910
MESH:D007676 Kidney Failure, Chronic Selenium 8.9316518626
MESH:D007680 Kidney Neoplasms Cyclosporine 10.7612371664
MESH:D007680 Kidney Neoplasms Estradiol 10.7615610895
MESH:D007680 Kidney Neoplasms Fluorouracil 10.7616985049
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 17.8312970779
MESH:D007938 Leukemia arsenic trioxide 17.8315070760
MESH:D007938 Leukemia Cyclophosphamide 17.8310602166
MESH:D007938 Leukemia Genistein 17.8318980019 17468513
MESH:D007938 Leukemia Polyvinyl Chloride 17.8314651027
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8016085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.3417008537 18172266 17296974 18587576 17802794 17658394
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 7.7514633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 7.7510373061
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.4519077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.0817050201 16968895 19850784 20471514 16467208
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.0117339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.019834237 19225113 11468182 16966277 17217047 16331271 12018890 15748426 19642359 11161223 17712046 16330433 17107899 15622746 15336539 16823087 19035177 15213294 12712474 19075265 16112521 12679006 16891316 17869043 17649720
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0216882451
MESH:D007970 Leukopenia Cyclophosphamide 4.6110052129 11830472
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3816417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 14.2721278145 16221502 11408273 17157831 17174718 16239168 17334410 16943688 11903743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.2720032147 18665156 18522880 19638242 18407596
MESH:D008103 Liver Cirrhosis Plant Extracts 14.2717157831
MESH:D008103 Liver Cirrhosis Polyvinyl Chloride 14.2714651027
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 14.7017976157 17714472 18472332 12445418 18166357 18251166 16097048 18376398 17900296 16015684 12666154 18472094 14748882 18054572 18317297 14620537 17944888 18006644 18263696 15925388 15959796 15931870 16033810 17698563 14716833 17922224 15052691 12389079 18481824 16136751 12609069 14512876 15057751 15370692 14716496 17869086 18277467 15818738 18395095 17761835 16011737 17481882 18705752 17708605 18420326 16638106 17823541 12649538 17565644 18279442 16116963 17766677 12445421 15362042 15650968 20821823 15730626 17805973 17557913 15996030 18205269 15338365 15893842 15123356 11481614 15673190 15876570 18187930 12741479 12632514 18395914 13678700 12546737 12898905 16027843 14724832 17640975 12667390 18412020 12586293 18339082 12632512 16192424 12958196 18418968 18156304 16248980 17631135 17525996 18210741 18429990 17721639 10355542
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 14.7016439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 14.7014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 14.7017823541
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 14.7015479170
MESH:D008106 Liver Cirrhosis, Experimental rofecoxib 14.7017565644
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 14.7012878042
MESH:D008106 Liver Cirrhosis, Experimental valsartan 14.7015619341 16872305 15504291
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 14.7016169303
MESH:D008107 Liver Diseases Arsenic 8.6111134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.6117285989 16964402 15830285 16246199 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 8.6117034775
MESH:D008107 Liver Diseases Plant Extracts 8.6117034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.3814706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 31.3515890375 9163691 18177683 2125692
MESH:D008113 Liver Neoplasms Arsenic 31.3516368122
MESH:D008113 Liver Neoplasms arsenic trioxide 31.3514682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 31.3519294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 31.3520501860 18644402 21071580 19294768 19850985 20137499 20118626 12771043 9163691 18977376 19642983 18754104 2862719 19638242 20583210 12112319 2422723 20452335 19996281 20101389 18978307 19812893 19833225 21278145 19256749 18648771 19551842 19499222 21167192 15175105 19255062 19254457 19090486 10737359 20434301 16942905 15885732 19426721 20492335 19073162 19427195 21047994 19690152 20405173
MESH:D008113 Liver Neoplasms Fluorouracil 31.3515113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms Plant Extracts 31.3519168119
MESH:D008113 Liver Neoplasms Polyvinyl Chloride 31.3514651027
MESH:D008113 Liver Neoplasms sodium arsenite 31.3516712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 31.3516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 20.478603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 20.4720377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 20.4715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 20.4718079962 17174075 18544905 18282651 18775883 19004024 17942915 18093689 3124819 19009564 18164116 19539802 18253720 16267830 19126423 2563599 19519916 18308698 21159647 16842330 17854601 9362446
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 20.4717085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 20.4712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0815213294
MESH:D008171 Lung Diseases Acetylcysteine 15.6812815614
MESH:D008171 Lung Diseases Ozone 15.6819066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 15.6819095001
MESH:D008171 Lung Diseases Vitamin E 15.6816863852
MESH:D055370 Lung Injury Ozone 3.5120417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 22.0114755239
MESH:D008175 Lung Neoplasms Arsenic 22.0117976673 19168569 17306315
MESH:D008175 Lung Neoplasms arsenic trioxide 22.0111798837 19825857
MESH:D008175 Lung Neoplasms Diethylnitrosamine 22.0121163286 20970405 20512841 6695378
MESH:D008175 Lung Neoplasms Doxorubicin 22.016189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 22.0115246190
MESH:D008175 Lung Neoplasms Ozone 22.017614698 8597069
MESH:D008175 Lung Neoplasms Plant Extracts 22.0120869020
MESH:D008175 Lung Neoplasms Polyvinyl Chloride 22.0114651027 12771394
MESH:D008175 Lung Neoplasms sodium arsenite 22.0115276417 17306315 19931552 17077188 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 22.0119555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 22.0111062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.4415086387
MESH:D008223 Lymphoma Cyclophosphamide 11.5012854902
MESH:D008223 Lymphoma Doxorubicin 11.5016098063
MESH:D008223 Lymphoma Polyvinyl Chloride 11.5014651027
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.2716675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 8.0411911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 8.0417654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.2215621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 12.4115458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.4111807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.4112929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Selenium 12.4115318939
MESH:D020149 Manganese Poisoning Estradiol 4.1219453300
MESH:D008545 Melanoma Doxorubicin 3.2516827129
MESH:D008545 Melanoma sodium arsenite 3.2516487513 19082730
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.4516388313
MESH:D008654 Mesothelioma Doxorubicin 5.8017638057
MESH:D008654 Mesothelioma Selenium 5.8015107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4316801185
MESH:D008679 Metaplasia Ozone 4.7510496685
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1815792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.3618986760 16757204
MESH:D052016 Mucositis Doxorubicin 4.4417415656
MESH:D009101 Multiple Myeloma arsenic trioxide 2.8614977855 15949261 11468182 19417148 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 2.9416882451 16105982
MESH:D009203 Myocardial Infarction Doxorubicin 5.4619429709 15857846
MESH:D009203 Myocardial Infarction Genistein 5.4617141266
MESH:D017202 Myocardial Ischemia Arsenic 8.0815371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.6216810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.6217141266
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6216624393
MESH:D009362 Neoplasm Metastasis Acetylcysteine 8.8014720322
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.809029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 8.8018259882
MESH:D009369 Neoplasms Cyclophosphamide 10.5418854779
MESH:D009369 Neoplasms Fluorouracil 10.5416928823 18600527 18239605
MESH:D009369 Neoplasms Polyvinyl Chloride 10.5414651027
MESH:D009369 Neoplasms sodium arsenite 10.5411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3220056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3817289903
MESH:D009401 Nephrosis Doxorubicin 4.4216899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.3119348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.3116889571 15640375
MESH:D009421 Nervous System Malformations Estradiol 14.4211399458 16427766
MESH:D009421 Nervous System Malformations Genistein 14.4216427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.4214600291
MESH:D009436 Neural Tube Defects Acetylcysteine 15.4919446573
MESH:D009436 Neural Tube Defects Arsenic 15.4916620997
MESH:D009436 Neural Tube Defects arsenic trioxide 15.4910525206
MESH:D009436 Neural Tube Defects sodium arsenite 15.4912854658
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.8417168769
MESH:D009447 Neuroblastoma Cyclophosphamide 6.598761367 16115947 15176712
MESH:D009447 Neuroblastoma Doxorubicin 6.5915555623
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.0620387270
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.5312837982 8761367
MESH:D020078 Neurogenic Inflammation Arsenic 4.0517056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7620387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.2016436463
MESH:D009503 Neutropenia Cyclophosphamide 4.008291058
MESH:D009765 Obesity Plant Extracts 3.0520132043 19056576
MESH:D009784 Occupational Diseases Polyvinyl Chloride 5.5714651027
MESH:D009845 Oligospermia Cyclophosphamide 4.3616517039
MESH:D010003 Osteoarthritis rofecoxib 4.1616690336
MESH:D010024 Osteoporosis Genistein 3.0419401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.7616169203
MESH:D012516 Osteosarcoma Doxorubicin 3.8315930896
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 17.3016211241
MESH:D010051 Ovarian Neoplasms Arsenic 17.3017306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 17.3016624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms Estradiol 17.3019401270
MESH:D010051 Ovarian Neoplasms Genistein 17.3019005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 17.3017306315 15276417
MESH:D010146 Pain Cyclophosphamide 3.3512161096 18093676
MESH:D010149 Pain, Postoperative rofecoxib 5.0316678543 18165598
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.2515580305
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 11.2511332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.2516540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.2519003803 16500647 16929163 15113037
MESH:D010212 Papilloma Plant Extracts 4.1515173996 16517061
MESH:D010235 Paraganglioma arsenic trioxide 3.8419927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8912520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.8416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.6416905509 6392382 15371236
MESH:D010538 Peritonitis Ozone 3.7916369182
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8017983394
MESH:D010954 Plasmacytoma Selenium 4.5315087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8017638057
MESH:D011014 Pneumonia Ozone 4.0418929643 18007984 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2218163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.9612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.962563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.6021297632
MESH:D011225 Pre-Eclampsia Iloprost 5.4610329876
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.3111118676 11222880 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.3118042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.5818220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5720887781
MESH:D011471 Prostatic Neoplasms Arsenic 3.3816140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3819131511
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 3.3817136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.3815897917 15749863 16868541 16888761 18437689 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 3.3816740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.3818626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 3.3815256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Plant Extracts 3.3814666653 17804756
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3816039940
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3815084515
MESH:D011472 Prostatitis vinclozolin 4.5818629315
MESH:D011507 Proteinuria Arsenic 8.6621343184
MESH:D011507 Proteinuria valsartan 8.6612164870 18344623 17664856
MESH:D011565 Psoriasis Cyclosporine 2.1016882103
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 5.8516636934
MESH:D011658 Pulmonary Fibrosis valsartan 5.8517241526
MESH:D011928 Raynaud Disease Iloprost 6.2416363279
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7118286688 18722050 15538739 16160472
MESH:D051437 Renal Insufficiency Doxorubicin 3.8817922066
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.2012210543
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5018990726
MESH:D012509 Sarcoma Doxorubicin 3.6815625365 17203757 15675481 16767912 17710206 18313854
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.1616646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.1616326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.4417846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.4916636934
MESH:D012852 Sinusitis Phenylephrine 4.357327846
MESH:D012871 Skin Diseases Arsenic 4.7018709164 17938729 16759981 15952646 16353154 17548696 17453740 17050553 6392382 19834688 16702368
MESH:D012871 Skin Diseases Vitamin E 4.7018709164
MESH:D012878 Skin Neoplasms Arsenic 16.1117050553 17976673 16251483 17029826 15504454 19538983
MESH:D012878 Skin Neoplasms Doxorubicin 16.1115692506
MESH:D012878 Skin Neoplasms Plant Extracts 16.1116517061 15173996
MESH:D012878 Skin Neoplasms sodium arsenite 16.1119524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 16.1116192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.2217203757 15625365 16767912
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.1616517039
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5312854658
MESH:D013272 Stomach Diseases sildenafil 5.4916113693
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.4217007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.4218456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.4217498489 16424979 17172411 17522103 19084572 15786421 18396642 19015929 16951190 18567086
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.4212958204 17575124
MESH:D013276 Stomach Ulcer Acetylcysteine 6.8417918041
MESH:D013276 Stomach Ulcer Plant Extracts 6.8415255614 18237397 12787963 17135157 18193104
MESH:D020521 Stroke Vitamin E 3.2416517955
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.7012837982
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 5.1217997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 10.4819014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.487505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 10.4816010429 17909728
MESH:D013978 Tibial Fractures Estradiol 4.3219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.6816280240
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6115213294
MESH:D001749 Urinary Bladder Neoplasms Arsenic 14.2717976673 17306315 19322015 18640142 11144890 19429237 15987713
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 14.2712845720 20435036 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 14.2714692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 14.2717653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 14.2716712894 16452187 17306315 11723127
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.4716803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.4711813266
MESH:D014605 Uveitis Cyclosporine 3.621336536
MESH:D014652 Vascular Diseases Arsenic 10.6717056641
MESH:D014652 Vascular Diseases sodium arsenite 10.6717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2312125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 9.3517334414 16364871 17638931 17678736
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 9.3518097624
MESH:D020257 Ventricular Remodeling Plant Extracts 11.6818097624
MESH:D020257 Ventricular Remodeling valsartan 11.6819027736
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8915886252
MESH:D014947 Wounds and Injuries Plant Extracts 3.9720213670 19894650
MESH:D014985 Xerophthalmia Cyclosporine 4.0817120751
Pathway ID Pathway Name
REACT:604 Hemostasis
KEGG:05323 Rheumatoid arthritis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24791
    • No data
    No data
    Releated drug ID Related drug Name
    PA448976choline
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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