AutismKB 2.0

Annotation Detail for NEK8


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Basic Information Top
Gene Symbol:NEK8 ( JCK,MGC138445,NEK12A,NPHP9 )
Gene Full Name: NIMA (never in mitosis gene a)- related kinase 8
Band: 17q11.1
Quick LinksEntrez ID:284086; OMIM: 609799; Uniprot ID:NEK8_HUMAN; ENSEMBL ID: ENSG00000160602; HGNC ID: 13387
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
No data
No data
Desease Name
Nephronophthisis 9
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NEK8 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of NEK8 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of NEK8 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of NEK8 mRNAincreases expression 19774075
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NEK8 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEK8 mRNAaffects cotreatment|increases expression 17942748
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of NEK8 mRNAaffects binding|decreases expression|increases activity 19710929
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEK8 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.837525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.8315322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0718057881 20041841 18218290
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001281 Atrial Fibrillation Amiodarone 4.1119698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 17.0219483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 17.0219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 17.0212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.9216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.923084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 16120746 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9715710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4818974383
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.9114694615
MESH:D002386 Cataract Acetaminophen 7.9110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.956135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4211677210 16919318 17110522 16105132 15861022 17681005 17333356
MESH:D002779 Cholestasis pirinixic acid 8.4219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.208697196 15668235 15340226 12621046 16354765
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 10.0315095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 10.0314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.7821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 12.7821346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.7815968718 10915739 18713872 16781746 12392966 19739265 11743745 11287661 12594235 16081117 16393943 14725611 2444490 18071297 19164858 16109766 14550746 11461765 19923254 17906064 12153990 12705907 16485898 19085960 19370779 16227642 19420014 14986274 17562736 16177239 10663392 19416960 17522070 12958197 15619225 11834606 11529661 11421492 10774834 12540782 11739529
MESH:D056486 Drug-Induced Liver Injury Amiodarone 12.7815265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.7820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema pirinixic acid 7.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2910568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Amiodarone 14.7914986274
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.7915345470
MESH:D005234 Fatty Liver pirinixic acid 14.7920131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4610048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Amiodarone 16.6215265979
MESH:D006529 Hepatomegaly pirinixic acid 16.6219176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.6215340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.498697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.159751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 4.8718020914 17991464
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2116705839
MESH:D008064 Lipidoses Amiodarone 3.7017567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.2015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2012878042
MESH:D008107 Liver Diseases Acetaminophen 1.6812587719 16610002 19784758 16611625 11587558 19460945 19014921 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.857678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.8516377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.8516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.276135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2712151625
MESH:D008133 Long QT Syndrome Amiodarone 3.7917391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.5512587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.9218516814
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009181 Mycoses Amiodarone 5.3417974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2618551238 7678174
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
OMIM:609799 NEVER IN MITOSIS GENE A-RELATED KINASE 8 marker/mechanism
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 10.0316049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 10.0314694615
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911118676 11896295 11222880 11399792
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9411597910 12490602 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7118551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4818724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D013276 Stomach Ulcer Amiodarone 3.5918087811
MESH:D013610 Tachycardia Amiodarone 4.6211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.5219225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Amiodarone 13.5819731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 13.5812697716
MESH:D013971 Thyrotoxicosis Amiodarone 5.2218020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.5917467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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