AutismKB 2.0

Annotation Detail for PIGW


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Basic Information Top
Gene Symbol:PIGW ( FLJ37433,Gwt1 )
Gene Full Name: phosphatidylinositol glycan anchor biosynthesis, class W
Band: 17q12
Quick LinksEntrez ID:284098; OMIM: 610275; Uniprot ID:PIGW_HUMAN; ENSEMBL ID: ENSG00000184886; HGNC ID: 23213
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00563Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of proteins
No data
No data
Pathway IDPathway Name
500546Synthesis of glycosylphosphatidylinositol (GPI)
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PIGW mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PIGW mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of PIGW mRNAaffects expression 18648102
C051890 irinotecan irinotecan analog results in decreased expression of PIGW mRNAdecreases expression 18927307
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.963712494
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.7411289319 1440618
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.8316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8316705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.833581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.837296757
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.546135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.547505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.4419486331 9022650
MESH:D003110 Colonic Neoplasms irinotecan 2.6417287894 17725105
MESH:D015179 Colorectal Neoplasms irinotecan 2.3617159606 17454858 18259882 18509181 15273666 16303861 16391804
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.8318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.8318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.358970840 11906362 11298694 8156756 18759878 14531868 2524372 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.953621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.7821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.7818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.786482804 16192314 18692083 7440962 11289319 8291058 18648102 9022650 9653073 6679447 18289764 1440618 9328219
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.183581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.746705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.507505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.026705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5015034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.749022650 8074119
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.4716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.4716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 14.476582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4215034207 9327722
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.277678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.666135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.66598648 6587162 1399818 3712494
MESH:D052016 Mucositis irinotecan 5.6417159606
MESH:D009336 Necrosis 2,4-dinitrotoluene 12.5418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 12.5418551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.363581430
MESH:D009362 Neoplasm Metastasis irinotecan 6.3618259882
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.156679447
MESH:D009447 Neuroblastoma irinotecan 3.658761367
MESH:D017599 Neuroectodermal Tumors irinotecan 5.368761367
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 17.4712819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 17.4716049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 17.474026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.743988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.047296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.196228378
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.673692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.7418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.7418551238
MESH:D013274 Stomach Neoplasms irinotecan 2.3615723263
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.196582329 1399818 6587162 7505956 3712494
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 9.0316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 9.0316049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 9.038074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 14.1910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 14.1910091137
Pathway ID Pathway Name
KEGG:00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
KEGG:01100 Metabolic pathways
REACT:17015 Metabolism of proteins
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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