AutismKB 2.0

Annotation Detail for METRNL


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Basic Information Top
Gene Symbol:METRNL ( MGC99788 )
Gene Full Name: meteorin, glial cell differentiation regulator-like
Band: 17q25.3
Quick LinksEntrez ID:284207; OMIM: NA; Uniprot ID:METRL_HUMAN; ENSEMBL ID: ENSG00000176845; HGNC ID: 27584
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of METRNL mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of METRNL proteinaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of METRNL mRNAincreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of METRNL mRNAincreases expression 16002434
D004958 Estradiol Estradiol results in increased expression of METRNL mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D001943 Breast Neoplasms Calcitriol 2.2311237771
MESH:D001943 Breast Neoplasms Estradiol 2.2312948864 17261762 18497071 19861407 17018787 14630087 17289903 16675129
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0016111702
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.8316705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.8321507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.8316924424
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.7011237771
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.3612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.3618566989
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5018551238
MESH:D003928 Diabetic Nephropathies Estradiol 3.7419279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 2.0421346803 18551238
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.3715138306
MESH:D016889 Endometrial Neoplasms Estradiol 3.2011473722 19148513 18566989
MESH:D005234 Fatty Liver Cyclosporine 3.2319224547
MESH:D005355 Fibrosis Cyclosporine 3.6212639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006558 Herpes Genitalis Estradiol 5.6415709030
MESH:D019584 Hot Flashes Estradiol 4.3617088409
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D007333 Insulin Resistance Estradiol 3.1816393666 16627594
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 6.558314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.5515618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.2016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 14.2012371664
MESH:D007680 Kidney Neoplasms Estradiol 14.2015610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814659978 14716833
MESH:D008113 Liver Neoplasms Aflatoxin B1 2.459163691 15890375 2125692 18177683
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.948603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8814755239
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7717203775 11807958 16891317 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.0919453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5516810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4018551238
MESH:D009389 Neovascularization, Pathologic Estradiol 4.2717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 4.0916427766 11399458
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7812819281 16049721
MESH:D010051 Ovarian Neoplasms Estradiol 2.3019401270
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.3215572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2620887781
MESH:D011471 Prostatic Neoplasms Calcitriol 3.2412479363 18247401 16289102 15754350 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 3.2416740699
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7618551238
MESH:D013978 Tibial Fractures Estradiol 5.3019048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3916049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.8610091137
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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