AutismKB 2.0

Annotation Detail for LAMA1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LAMA1 ( LAMA )
Gene Full Name: laminin, alpha 1
Band: 18p11.31
Quick LinksEntrez ID:284217; OMIM: 150320; Uniprot ID:LAMA1_HUMAN; ENSEMBL ID: ENSG00000101680; HGNC ID: 6481
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05146Amoebiasis
hsa05145Toxoplasmosis
hsa05222Small cell lung cancer
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
hsa05200Pathways in cancer
Pathway IDPathway Name
Axon guidance
Integrin cell surface interactions
Pathway IDPathway Name
200164Syndecan-2-mediated signaling events
200115Syndecan-4-mediated signaling events
200021Glypican 1 network
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1901Endometriosis
2120Rabies
Desease Name
CHEMDEPENDENCY
smoking cessation
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001374 Azacitidine Azacitidine affects the localization of LAMA1 proteinaffects localization 18033690
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LAMA1 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of LAMA1 mRNAincreases expression 20106945
D009151 Mustard Gas Mustard Gas results in increased alkylation of LAMA1 proteinincreases alkylation 18342354
D014212 Tretinoin Tretinoin results in increased expression of LAMA1 mRNAincreases expression 17138961
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Mustard Gas 5.2710378619
MESH:D001249 Asthma Tretinoin 5.2716456186
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001768 Blister Mustard Gas 5.7019167455
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9816206674 16197459
MESH:D001943 Breast Neoplasms Tretinoin 2.2316443354 16873071 16166294
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.7015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.5917687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2616227642 16124888 15700767 10355542 15721981 16192424 15673190 16050911 18705752 3786805 16097048 16011737
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1618788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.161917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716051514 16096774
MESH:D002386 Cataract Tretinoin 3.2817460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tretinoin 2.799407595
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D015179 Colorectal Neoplasms marker/mechanism 21278247
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7219934284
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.839142499 16925845 9211117 17551590 14991402 10589399 9125849 9664655 8800419 9224671
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.113786805 19085960 7179309 11566570 6884620 17522070 3732212 15968718 15998439 4309450 15027814 2869522 19336974 7440962 10092053 16177239 7120509 9327722 6623471 21278145 10915739 16227642
MESH:D004487 Edema Mustard Gas 3.6711428631 9260866 11428647 11402378
MESH:D004489 Edema, Cardiac Tretinoin 5.0818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3216569247
MESH:D004890 Erythema Mustard Gas 5.709357497
MESH:D005124 Eye Abnormalities Tretinoin 3.849664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.9761145 15959796 16239168 12631006 17595544 12795759 19224547 16045604
MESH:D005234 Fatty Liver Cyclosporine 8.9719224547
MESH:D005355 Fibrosis Carbon Tetrachloride 17.8118705752
MESH:D005355 Fibrosis Cyclosporine 17.8112639820 12168785
MESH:D005355 Fibrosis Tretinoin 17.8117994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D005909 Glioblastoma Tretinoin 3.2217312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.059664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319900420 19110552
MESH:D006930 Hyperalgesia Tretinoin 3.5016870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D007249 Inflammation Mustard Gas 2.9416001271 11428620 11428647 11428631 11402378 8975870 9357497 9260866 17524151
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2717551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5218776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0412371664
MESH:D007938 Leukemia Azacitidine 7.1719148494
MESH:D007938 Leukemia Tretinoin 7.1717143497
MESH:D007951 Leukemia, Myeloid Azacitidine 11.0619077051
MESH:D007951 Leukemia, Myeloid Tretinoin 11.0619285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 4.3718720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.3719850784 16294345 17596541
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.6019299654
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3716331271 19035177 16766008 16891316 17506722 19225113 17217047 17712046 12679006 17107899 16935935 16788101 16140955 17649720 17301526 16823087 15748426 17339181 19029980 17294898 9834237 19642359 17368321 17361223 19075265
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9811408273 21278145 17157831 11903743 16239168 16221502 17174718 16943688 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5715996030 16033810 12958196 14620537 15052691 15925388 18418968 17805973 12741479 15931870 15959796 16015684 18429990 12649538 14724832 18395914 17721639 16136751 18263696 18054572 12586293 18472332 18156304 17823541 17525996 15370692 18279442 18251166 10355542 17698563 20821823 18277467 16011737 15338365 11481614 12546737 17766677 17922224 17976157 15730626 15123356 14512876 16116963 18006644 17557913 18210741 18339082 17869086 18317297 17481882 18187930 16097048 12445421 18376398 15362042 12898905 15876570 17708605 17565644 12389079 12632512 15673190 16192424 12445418 17631135 16638106 17640975 18472094 13678700 17714472 15893842 12666154 18205269 12632514 12667390 14716496 15650968 16248980 16027843 18412020 15057751 14748882 18166357 17761835 18481824 15818738 18395095 17900296 12609069 14716833 18705752 18420326 17944888
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5716248980 18397230
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1515720792 16246199 15830285 17285989 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0416899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.3219294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.8112014681 15583823
MESH:D008171 Lung Diseases Mustard Gas 3.6718702808 18161513
MESH:D008175 Lung Neoplasms Azacitidine 3.0321224363
MESH:D008175 Lung Neoplasms Mustard Gas 3.033148597 8781369
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009006 Monosomy Azacitidine 6.6919299654
MESH:D009101 Multiple Myeloma Azacitidine 4.2119549372 18443271
MESH:D009190 Myelodysplastic Syndromes Azacitidine 8.3117611569 18720364 17596541 19805378
MESH:D009190 Myelodysplastic Syndromes Tretinoin 8.3117596541
MESH:D009369 Neoplasms Tretinoin 2.5516594593 16946489
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D009421 Nervous System Malformations Tretinoin 4.229125849
MESH:D009436 Neural Tube Defects Tretinoin 3.279142499
MESH:D009503 Neutropenia Mustard Gas 4.377688884 16761898
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4316936753
MESH:D010146 Pain Tretinoin 3.2016870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5615976015
MESH:D011041 Poisoning Mustard Gas 4.2015727166
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011471 Prostatic Neoplasms Azacitidine 4.0818324645
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011537 Pruritus Mustard Gas 4.6318058305
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0310334151 17266442 17894541 17720292 17620002
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016116481 16283617
MESH:D012871 Skin Diseases Mustard Gas 2.7812880345 15451306 16961503
MESH:D012878 Skin Neoplasms Tretinoin 2.7516467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
REACT:18266 Axon guidance
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
REACT:13552 Integrin cell surface interactions
KEGG:05200 Pathways in cancer
KEGG:05222 Small cell lung cancer
KEGG:05145 Toxoplasmosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30270
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    Releated drug ID Related drug Name
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved