AutismKB 2.0

Annotation Detail for MCHR1


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Basic Information Top
Gene Symbol:MCHR1 ( GPR24,MCH1R,MGC32129,SLC1 )
Gene Full Name: melanin-concentrating hormone receptor 1
Band: 22q13.2
Quick LinksEntrez ID:2847; OMIM: 601751; Uniprot ID:MCHR1_HUMAN; ENSEMBL ID: ENSG00000128285; HGNC ID: 4479
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C018855 2-tert-butylhydroquinone 2-tert-butylhydroquinone results in increased expression of MCHR1 mRNAincreases expression 16014739
D000082 Acetaminophen Acetaminophen affects the expression of MCHR1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MCHR1 mRNAaffects expression 16483693
C018021 cobaltous chloride cobaltous chloride results in increased expression of MCHR1 mRNAincreases expression 20105288
D004041 Dietary Fats Dietary Fats results in decreased expression of MCHR1 mRNAdecreases expression 18721800
D006220 Haloperidol Haloperidol binds to MCHR1 proteinaffects binding 16983399
D008345 Manganese Manganese results in increased expression of MCHR1 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of MCHR1 mRNAincreases expression 17175027
D010100 Oxygen Oxygen deficiency results in increased expression of MCHR1 mRNAincreases expression 17175027
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MCHR1 mRNAaffects binding|decreases expression|increases activity 19710929
C025299 polyphenols polyphenols results in decreased expression of MCHR1 mRNAdecreases expression 16293270
C034028 vanadyl sulfate vanadyl sulfate results in increased expression of MCHR1 mRNAincreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D055371 Acute Lung Injury Oxygen 9.6216759491
MESH:D055371 Acute Lung Injury pirinixic acid 9.6218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D000756 Anemia, Sideroblastic Manganese 11.4016910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 11.4016910769
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D000860 Anoxia Oxygen 5.2120872349
MESH:D001161 Arteriosclerosis Dietary Fats 4.0315238619
MESH:D050197 Atherosclerosis Oxygen 3.8616391483
MESH:D001321 Autistic Disorder Acetaminophen 2.1318445737
MESH:D001321 Autistic Disorder Haloperidol 2.1318080171 19368416
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.5420435547
MESH:D001943 Breast Neoplasms Oxygen 2.5417263869
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.383084413
MESH:D002375 Catalepsy Haloperidol 5.061977408 15215559
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
MESH:D003110 Colonic Neoplasms polyphenols 2.6916293270
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.9620210726
MESH:D003704 Dementia Haloperidol 4.6911575062
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 4.1611298694 16823706 15059100
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.4616684804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.1016393943 14986274 11739529 11287661 14725611 11421492 12392966 16227642 19420014 11834606 11529661 16081117 16781746 2444490 16485898 12958197 17562736 16109766 11743745 19085960 19370779 17906064 10774834 19739265 10663392 10915739 14550746 18071297 15619225 19416960 18713872 17522070 12540782 19923254 12705907 15968718 12153990 12594235 16177239 19164858 11461765
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.1019370779
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D050171 Dyslipidemias Dietary Fats 3.5318367378
MESH:D004417 Dyspnea Oxygen 5.0120016425
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D005234 Fatty Liver Dietary Fats 8.0717967931 18296743 19551842 19004024
MESH:D005234 Fatty Liver pirinixic acid 8.0719236843 20131406
MESH:D005355 Fibrosis Dietary Fats 3.6618296743
MESH:D005739 Gas Poisoning Oxygen 5.3920016425
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005909 Glioblastoma Manganese 3.9817043766
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006529 Hepatomegaly pirinixic acid 3.1319772884 16221962 18467677 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7321332399
MESH:D007249 Inflammation Dietary Fats 5.5420412841
MESH:D007249 Inflammation polyphenols 5.5416366677
MESH:D007333 Insulin Resistance Dietary Fats 7.4818457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.4816306350
MESH:D007674 Kidney Diseases Acetaminophen 2.2612587719 15629191
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9318296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 4.2411587558 19014921 12587719 19460945 16610002 16611625 19784758 12969438
MESH:D008107 Liver Diseases polyphenols 4.2416698588
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.8515890375 20007298 16377806
MESH:D055370 Lung Injury Oxygen 4.6518339021
MESH:D020149 Manganese Poisoning Manganese 5.6916551646 16568477 19453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D001523 Mental Disorders Haloperidol 4.1616856516
MESH:D009069 Movement Disorders Manganese 5.1316551646
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009410 Nerve Degeneration Manganese 4.3616551646
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity Dietary Fats 4.5217217161 11836018 21332399 18457598 20132043 18674790 19632207 20518802 16723640
MESH:D009765 Obesity pirinixic acid 4.5220558911
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010300 Parkinson Disease Manganese 3.4111181820
MESH:D020734 Parkinsonian Disorders Manganese 4.5716140633
MESH:D011595 Psychomotor Agitation Haloperidol 5.0911575062
MESH:D011618 Psychotic Disorders Haloperidol 4.3311575062
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.6217627322 18339021
MESH:D012559 Schizophrenia Haloperidol 2.811830565 19369910 18513383 20107430
MESH:D013398 Sudden Infant Death Oxygen 5.7012563064
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.8320210726
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.4317997062
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D015430 Weight Gain Dietary Fats 3.8316723640
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28867
    • No data
    No data
    Releated drug ID Related drug Name
    PA452233antipsychotics
    PA449061clozapine
    PA449841haloperidol
    PA450688olanzapine
    Drug Bank Top

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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