AutismKB 2.0

Annotation Detail for ANGPT2


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Basic Information Top
Gene Symbol:ANGPT2 ( AGPT2,ANG2 )
Gene Full Name: angiopoietin 2
Band: 8p23.1
Quick LinksEntrez ID:285; OMIM: 601922; Uniprot ID:ANGP2_HUMAN; ENSEMBL ID: ENSG00000091879; HGNC ID: 485
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Hemostasis
Pathway IDPathway Name
200066Angiopoietin receptor Tie2-mediated signaling
Pathway IDPathway Name
P00005Angiogenesis
Pathway IDPathway Name
500306Tie2 Signaling
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1898Placenta disease
1901Endometriosis
1904Diabetes mellitus
1918Atherosclerosis
1934Cancer
1997Dental plaque
2091Hypertension
2099Hepatitis B
2111Systemic infection
Desease Name
uterine leiomyomas
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ANGPT2 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ANGPT2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ANGPT2 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of ANGPT2 mRNAincreases expression 20458559
D016589 Astemizole Astemizole results in increased expression of ANGPT2 mRNAincreases expression 20221588
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ANGPT2 mRNAincreases expression 15135347
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ANGPT2 proteinincreases expression 15135347
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ANGPT2 mRNAincreases expression 17034775
D004052 Diethylnitrosamine Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of ANGPT2 mRNA]decreases reaction|increases expression 17034775
C007517 diphenyleneiodonium diphenyleneiodonium promotes the reaction [Oxygen deficiency results in increased expression of ANGPT2 mRNA]increases expression|increases reaction 10854229
C007517 diphenyleneiodonium diphenyleneiodonium results in increased expression of ANGPT2 mRNAincreases expression 10854229
C031291 diphenyliodonium diphenyliodonium results in increased expression of ANGPT2 mRNAincreases expression 10854229
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of ANGPT2 mRNAaffects cotreatment|decreases expression 17404688
D004958 Estradiol Estradiol affects the expression of ANGPT2 mRNAaffects expression 15598610
D005472 Fluorouracil ANGPT2 protein promotes the reaction [Fluorouracil results in decreased expression of IFNA1 protein]decreases expression|increases reaction 17786339
D005472 Fluorouracil Fluorouracil results in decreased expression of ANGPT2 proteindecreases expression 17786339
D005665 Furosemide Furosemide affects the expression of ANGPT2 mRNAaffects expression 16526316
D016285 Iloprost Iloprost results in increased expression of ANGPT2 mRNAincreases expression 16373414
D016285 Iloprost tyrphostin AG 1478 inhibits the reaction [Iloprost results in increased expression of ANGPT2 mRNA]decreases reaction|increases expression 16373414
C069741 norcantharidin norcantharidin results in decreased expression of ANGPT2 mRNAdecreases expression 16681930
C069741 norcantharidin norcantharidin results in decreased expression of ANGPT2 proteindecreases expression 16681930
D010100 Oxygen diphenyleneiodonium promotes the reaction [Oxygen deficiency results in increased expression of ANGPT2 mRNA]increases expression|increases reaction 10854229
D010100 Oxygen Oxygen deficiency results in increased expression of ANGPT2 mRNAincreases expression 10854229
D010100 Oxygen Oxygen deficiency results in increased expression of ANGPT2 mRNAincreases expression 10854229
D010100 Oxygen Oxygen deficiency results in increased expression of ANGPT2 mRNAincreases expression 10854229
C073402 PD 123319 PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA]decreases reaction|increases expression 14638905
C060836 pioglitazone [ANGPT2 protein binds to and results in increased activity of AGTR2 protein] promotes the reaction [pioglitazone binds to and results in increased activity of PPARG protein]affects binding|increases activity|increases reaction 15992368
D010936 Plant Extracts Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of ANGPT2 mRNA]decreases reaction|increases expression 17034775
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of ANGPT2 mRNAaffects cotreatment|decreases expression 17404688
D013311 Streptozocin Streptozocin results in increased expression of ANGPT2 mRNAincreases expression 15643138
D013311 Streptozocin Streptozocin results in increased expression of ANGPT2 proteinincreases expression 15643138
D013792 Thalidomide Thalidomide affects the expression of ANGPT2 mRNAaffects expression 15939924
D014212 Tretinoin Tretinoin results in increased secretion of ANGPT2 proteinincreases secretion 17170094
D014303 Trinitrotoluene Trinitrotoluene affects the expression of ANGPT2 mRNAaffects expression 21346803
C101044 tyrphostin AG 1478 tyrphostin AG 1478 inhibits the reaction [Iloprost results in increased expression of ANGPT2 mRNA]decreases reaction|increases expression 16373414
C081489 valsartan valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA]decreases reaction|increases expression 14638905
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Thalidomide 8.568333272
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 8.567525203
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D055371 Acute Lung Injury Oxygen 4.3516759491
MESH:D000230 Adenocarcinoma arsenic trioxide 6.8411798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 6.8411473722
MESH:D000230 Adenocarcinoma Fluorouracil 6.8417638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.303712494
MESH:D000236 Adenoma Diethylnitrosamine 6.306695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.7118056438 19061943 17162532 19052882 16434500 17620307
MESH:D000505 Alopecia Tretinoin 3.4615955085
MESH:D000544 Alzheimer Disease Plant Extracts 2.9716962711
MESH:D000690 Amyotrophic Lateral Sclerosis Thalidomide 4.2416510725
MESH:D000740 Anemia Fluorouracil 3.5517963324 16511603 15504547
MESH:D000799 Angioedema Acetaminophen 11.3810982225
MESH:D000799 Angioedema Astemizole 11.382883202
MESH:D000860 Anoxia Oxygen 4.8620872349
MESH:D001169 Arthritis, Experimental Plant Extracts 11.8714686799
MESH:D001169 Arthritis, Experimental Thalidomide 11.879598899
MESH:D001169 Arthritis, Experimental Tretinoin 11.8716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2216292516
MESH:D001249 Asthma Tretinoin 2.2916456186
MESH:D050197 Atherosclerosis Oxygen 3.6916391483
MESH:D001321 Autistic Disorder Acetaminophen 2.3818445737
MESH:D001321 Autistic Disorder pioglitazone 2.3817207275
MESH:D001471 Barrett Esophagus Tretinoin 4.2216935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8311289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.5916206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.5916206674 16197459
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1417868700
MESH:D001930 Brain Injuries Progesterone 4.0715665606 15380490 15845082
MESH:D002545 Brain Ischemia Plant Extracts 4.5416041641
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.8717474063
MESH:D001943 Breast Neoplasms Estradiol 2.8719861407 12948864 17261762 16675129 17289903 18497071 17018787 14630087
MESH:D001943 Breast Neoplasms Fluorouracil 2.8719217205 18357371 16110121 15136595 16557594 18608205 16595493
MESH:D001943 Breast Neoplasms Oxygen 2.8717263869
MESH:D001943 Breast Neoplasms Progesterone 2.8716175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tretinoin 2.8716166294 16873071 16443354
MESH:D016535 Bronchial Hyperreactivity tyrphostin AG 1478 4.7412794006
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4016813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1511589617
MESH:D002057 Burns, Chemical Plant Extracts 5.149625245
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5918705752 15721981 16011737 15700767 10355542 15673190 16097048 16227642 16050911 16192424 16124888 3786805
MESH:D002276 Carcinoid Tumor Fluorouracil 12.0016051944
MESH:D002276 Carcinoid Tumor Streptozocin 12.0016051944
MESH:D002277 Carcinoma Fluorouracil 3.4117121937
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9716168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 22.347296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 22.343084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 22.3415553829 16217749 15073043 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 22.3418788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 22.3418978308 19539802 19519916 16288022 21159647 17978847 19822196 17138121 16807293 3084413 18785209 19701751 16779866 18506893 16830150 19394651 16540662 18210153 20007298 20935162 3581430 19052882 16698587 17173139 19335982 11831363 20084675 20524982 20727157 19171122 18494052 17428255 16935385 20512989 16328049 18665156 20214788 20101231 20432363 18971187 17162532 18691550 17055752 10672840 17761372 19919837 16878318 16681979 18056438 19418558 16502159 10737359 19208518 16569478 18393292 19107877 20514400 18788625 19383236
MESH:D006528 Carcinoma, Hepatocellular Estradiol 22.3416924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 22.3418930000 17088986 16332177 17971768 17045692 16799960
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 22.3418834353
MESH:D006528 Carcinoma, Hepatocellular Thalidomide 22.3416313753
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 22.341917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6819014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.207296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.2018695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9512490120
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.5417066447 18986760 16757204 16280240
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.5416051514 16096774
MESH:D006332 Cardiomegaly Plant Extracts 7.3017645561
MESH:D006332 Cardiomegaly valsartan 7.3019597038
MESH:D009202 Cardiomyopathies valsartan 4.3116247790
MESH:D002318 Cardiovascular Diseases valsartan 4.1711230374
MESH:D002386 Cataract Acetaminophen 11.7710977129
MESH:D002386 Cataract Tretinoin 11.7717460283
MESH:D002386 Cataract Trinitrotoluene 11.7715817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.437505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.432727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.4318566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4016129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.4219052882
MESH:D018281 Cholangiocarcinoma Thalidomide 9.4218291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.0119486331 9022650
MESH:D002822 Choriocarcinoma Tretinoin 4.9716461808
MESH:D002972 Cleft Palate Tretinoin 2.599407595
MESH:D003092 Colitis Thalidomide 9.2616680017
MESH:D003092 Colitis Tretinoin 9.2617035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2016340194 17725105 17016597 16510598 18772588 15001691 17287894 17018589 17169374 17172411
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5020501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5018802399 16331619 17695437 15148649 16282729 17255274 20501625 17594712 17454858 17094418 16303861 18383874 16524972 17016601 18509181 17401013 14970324 18288408 18448328 16391804 15289873 18949393
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.2415095906
MESH:D016510 Corneal Neovascularization Thalidomide 5.389301478
MESH:D003324 Coronary Artery Disease valsartan 3.8317719468
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0012609071
MESH:D003384 Coxsackievirus Infections valsartan 5.6520392896
MESH:D003389 Cranial Nerve Diseases Thalidomide 6.119200351
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8710525206
MESH:D019465 Craniofacial Abnormalities Thalidomide 3.879200351
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.878800419 17551590 9142499 14991402 9211117 10589399 16925845 9664655 9224671 9125849
MESH:D003424 Crohn Disease Thalidomide 4.0716078585
MESH:D003490 Cyanosis Trinitrotoluene 4.7318551238
MESH:D003550 Cystic Fibrosis pioglitazone 4.7619747007
MESH:D007644 Darier Disease Fluorouracil 4.6016733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9215213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6212868966 8970840 18759878 11906362 14531868 11298694 8156756 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.312952479 3621924
MESH:D003920 Diabetes Mellitus Streptozocin 4.5716285004
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 8.6218715473 18603373 12446591 19496084 15831366 16286809 11055810 7637645 1374869 19960420 11260395 15862027 12093613 17442507 12083368 19298542 19586609 16684804 2177838 12644472 17874149 8740154 15298345 6379147
MESH:D003921 Diabetes Mellitus, Experimental valsartan 8.6211508273
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.5818603373
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.2220387270
MESH:D003924 Diabetes Mellitus, Type 2 pioglitazone 7.2212642470 16023994
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 7.2219647726 19586609
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.5316025228
MESH:D003928 Diabetic Nephropathies Estradiol 20.2319279558
MESH:D003928 Diabetic Nephropathies Plant Extracts 20.2319706694
MESH:D003928 Diabetic Nephropathies Streptozocin 20.2319682444 19960420
MESH:D003928 Diabetic Nephropathies valsartan 20.2311427623 18630688
MESH:D003929 Diabetic Neuropathies Progesterone 4.3017187935
MESH:D003930 Diabetic Retinopathy Streptozocin 5.2417662242
MESH:D004244 Dizziness Astemizole 6.273105558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 11.419653073 1440618 18692083 7440962 18289764 16192314 8291058 9328219 18648102 11289319 6482804 9022650 6679447
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.4115619225 16081117 17522070 12958197 19923254 10915739 2444490 19739265 12594235 11287661 19420014 14986274 15968718 16109766 10774834 11834606 19164858 19085960 11421492 16227642 16393943 17906064 12540782 16177239 12153990 11461765 14725611 11739529 18071297 11529661 12705907 19416960 10663392 16781746 14550746 19370779 17562736 16485898 11743745 12392966 18713872
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.4116227642 6623471 9327722 15998439 2869522 19085960 4309450 19336974 10915739 3786805 17522070 15968718 7179309 11566570 6884620 3732212 10092053 16177239 15027814 7120509 21278145 7440962
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.4119107877
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 11.4121346803 18551238
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004417 Dyspnea Furosemide 10.1616935035
MESH:D004417 Dyspnea Oxygen 10.1620016425
MESH:D004487 Edema Furosemide 7.0611834646
MESH:D004487 Edema Plant Extracts 7.0612787963
MESH:D004489 Edema, Cardiac Tretinoin 4.2718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.6017692515
MESH:D016889 Endometrial Neoplasms Estradiol 7.0019148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tretinoin 7.0016569247
MESH:D004715 Endometriosis Progesterone 3.6016134523
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.4915268973
MESH:D004802 Eosinophilia Astemizole 4.611355641
MESH:D004827 Epilepsy Plant Extracts 3.6319700373 19439326
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9216302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.983581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.9812903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 6.9816481741 16337965 17638652 15173087 16785472
MESH:D005124 Eye Abnormalities Tretinoin 3.4416938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 17.4115073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 17.4112795759 17595544 12631006 15959796 19224547 16239168 61145 16045604
MESH:D005234 Fatty Liver Diethylnitrosamine 17.4120387270 21071580
MESH:D005234 Fatty Liver Plant Extracts 17.4115975614
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.836705139
MESH:D005355 Fibrosis Carbon Tetrachloride 13.9118705752
MESH:D005355 Fibrosis Tretinoin 13.9117994277
MESH:D005355 Fibrosis valsartan 13.9116893502
MESH:D005499 Folliculitis Astemizole 5.721671328
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 11.4016904648
MESH:D005706 Gallbladder Neoplasms norcantharidin 11.4016681930
MESH:D005739 Gas Poisoning Oxygen 5.0320016425
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D005871 Giant Lymph Node Hyperplasia Thalidomide 6.1112701121
MESH:D005909 Glioblastoma Tretinoin 2.8817312396
MESH:D005910 Glioma Fluorouracil 6.2116145905
MESH:D005910 Glioma Thalidomide 6.2116327979
MESH:D015432 Glomerulonephritis, Membranoproliferative valsartan 5.3616928621
MESH:D005923 Glomerulosclerosis, Focal Segmental pioglitazone 5.0916687628
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.867505956
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.3718337622 15162350 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.3716096774
MESH:D034381 Hearing Loss Furosemide 4.6717868369
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.809664655 14991402
MESH:D006331 Heart Diseases Streptozocin 4.1412093613
MESH:D006333 Heart Failure Furosemide 11.5712660669 16845234 16011733
MESH:D006333 Heart Failure Plant Extracts 11.5718097624
MESH:D006333 Heart Failure valsartan 11.5719027736
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.616705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.6119110552 19900420
MESH:D006529 Hepatomegaly Trinitrotoluene 4.0515817613
MESH:D006558 Herpes Genitalis Estradiol 4.8415709030
MESH:D006561 Herpes Simplex Plant Extracts 4.4310715843
MESH:D015658 HIV Infections Plant Extracts 3.5812878215
MESH:D019584 Hot Flashes Estradiol 9.6917088409
MESH:D019584 Hot Flashes Plant Extracts 9.6916566672 14716179 17454163
MESH:D006930 Hyperalgesia Acetaminophen 7.1316870215
MESH:D006930 Hyperalgesia Tretinoin 7.1316870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3416899240
MESH:D006934 Hypercalcemia Furosemide 4.9017652376
MESH:D053565 Hypercalciuria Furosemide 5.4617652376
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3816778211
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.3016484555
MESH:D006949 Hyperlipidemias Plant Extracts 4.2915268973 15975614
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 5.6815086907
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7515034207
MESH:D006973 Hypertension valsartan 3.6516475468 10903974 18390891 12692753 11427623 12850387 18344623 20102058
MESH:D006974 Hypertension, Malignant valsartan 6.2211560862
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9015338365
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.1016612254
MESH:C537153 Hypomagnesemia primary Furosemide 5.4611041285
MESH:D007019 Hypoproteinemia Furosemide 5.6816096441
MESH:D007022 Hypotension Furosemide 4.4411041285
MESH:D007024 Hypotension, Orthostatic Furosemide 5.2215811171
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2115869954
MESH:D007248 Infertility, Male Trinitrotoluene 3.5512150543
MESH:D007249 Inflammation Diethylnitrosamine 14.8818785209
MESH:D007249 Inflammation pioglitazone 14.8816908763
MESH:D007249 Inflammation Plant Extracts 14.8816366677 15997105 12787963 19332304
MESH:D007249 Inflammation Progesterone 14.8815869954
MESH:D007249 Inflammation Thalidomide 14.8816134734
MESH:D007333 Insulin Resistance Estradiol 2.8416393666 16627594
MESH:D007410 Intestinal Diseases Tretinoin 3.5817994277
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.4512351151 12584176 12628509
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.839022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 3.7317551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 17.9512587719 15629191
MESH:D007674 Kidney Diseases Estradiol 17.9515618244
MESH:D007674 Kidney Diseases Furosemide 17.9511041285
MESH:D007674 Kidney Diseases Streptozocin 17.9512093613
MESH:D007674 Kidney Diseases valsartan 17.9512164870 10903974 16893502
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.546582329
MESH:D007680 Kidney Neoplasms Estradiol 11.5415610895
MESH:D007680 Kidney Neoplasms Fluorouracil 11.5416985049
MESH:D007898 Leishmaniasis, Visceral Thalidomide 4.2016514283
MESH:D007938 Leukemia arsenic trioxide 6.0315070760
MESH:D007938 Leukemia Tretinoin 6.0317143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.9019077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.9016482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.0519850784 20471514 16467208 17050201 16968895
MESH:D015470 Leukemia, Myeloid, Acute Thalidomide 6.0518720364
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.0519850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.2219225113 16891316 15622746 17712046 16330433 15213294 19075265 12712474 17869043 17649720 12679006 19035177 16966277 11468182 15336539 16112521 11161223 16823087 17107899 9834237 16331271 15748426 19642359 12018890 17217047
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.2219075265 16140955 17107899 16766008 16788101 17217047 19035177 19642359 9834237 17712046 17339181 17368321 16891316 15748426 19225113 16331271 16935935 17649720 17506722 12679006 17294898 19029980 16823087 17301526 17361223
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1716882451
MESH:D017513 Lichen Nitidus Astemizole 6.272563723
MESH:D017880 Limb Deformities, Congenital Thalidomide 8.1010473037
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.109224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 15.0017157831 16221502 11903743 21278145 11408273 16239168 16943688 17334410 17174718
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 15.0020032147 19638242 18522880 18407596 18665156
MESH:D008103 Liver Cirrhosis Plant Extracts 15.0017157831
MESH:D008103 Liver Cirrhosis Thalidomide 15.0016943688 17174718
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.5617761835 12445418 12632514 15893842 15818738 17565644 15876570 15959796 17708605 15650968 17805973 15052691 12445421 17976157 14512876 18472332 17640975 12649538 18205269 18277467 14620537 17869086 12898905 16136751 18054572 16011737 15338365 17481882 17525996 16015684 18412020 18472094 12389079 15931870 18156304 16638106 15925388 14748882 18376398 17922224 18418968 18263696 18395914 12958196 13678700 15996030 15673190 16116963 16027843 18705752 17714472 15057751 18279442 12632512 12546737 16192424 17721639 17944888 18429990 17631135 14716496 18317297 18210741 15362042 17823541 18339082 10355542 18187930 18006644 20821823 12667390 17766677 12666154 15123356 18251166 11481614 17698563 14716833 15370692 16033810 16248980 18481824 17557913 18166357 15730626 12741479 17900296 14724832 12609069 18395095 12586293 16097048 18420326
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.5614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pioglitazone 10.5615052691 16484506
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 10.5615479170
MESH:D008106 Liver Cirrhosis, Experimental Thalidomide 10.5615465738
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.5616248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental valsartan 10.5615504291 15619341 16872305
MESH:D008107 Liver Diseases Acetaminophen 8.9919460945 16611625 12587719 12969438 11587558 19784758 19014921 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.9915720792 15830285 17285989 16246199 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 8.9917034775
MESH:D008107 Liver Diseases Plant Extracts 8.9917034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.8516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.8514706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 13.4914682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.4919294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.4920583210 15885732 2862719 20118626 10737359 19294768 20492335 18648771 20405173 18978307 19427195 20501860 21071580 15175105 21167192 19090486 19642983 18977376 19073162 19850985 21047994 19254457 19833225 2422723 19255062 20101389 19996281 19551842 16942905 20434301 9163691 19812893 20137499 20452335 21278145 19499222 19638242 12112319 19690152 18754104 19256749 19426721 18644402 12771043
MESH:D008113 Liver Neoplasms Fluorouracil 13.4918383874 15113037 17045692 16603448
MESH:D008113 Liver Neoplasms Plant Extracts 13.4919168119
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.161399818 3712494 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 13.1620377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.1612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.169362446 17854601 16842330 19004024 18308698 18544905 3124819 2563599 19126423 21159647 18093689 19539802 19519916 16267830 17942915 18079962 18282651 19009564 18775883 17174075 18253720 18164116
MESH:D008133 Long QT Syndrome arsenic trioxide 8.0915213294
MESH:D008133 Long QT Syndrome Astemizole 8.0918472280 11989578
MESH:D055370 Lung Injury Oxygen 4.3218339021
MESH:D008175 Lung Neoplasms arsenic trioxide 4.7311798837 19825857
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.7320970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Fluorouracil 4.7315246190
MESH:D008175 Lung Neoplasms Plant Extracts 4.7320869020
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6015086387
MESH:D008288 Malaria Astemizole 4.6116816845
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.6616891317 17203775 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.6611408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.2919453300
MESH:D008527 Medulloblastoma Tretinoin 2.7117453147
MESH:D008545 Melanoma Thalidomide 3.6216098027 12829675 17089043
MESH:D008545 Melanoma Tretinoin 3.6216752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D008591 Meningomyelocele Tretinoin 4.2416940565
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4916757204 18986760
MESH:D009101 Multiple Myeloma arsenic trioxide 7.2414977855 19549372 15949261 11468182 19417148
MESH:D009101 Multiple Myeloma Thalidomide 7.2415741222 16445831 19112817 15744524 15867202 19372569 15920492 15939924 19112201 17168659
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 11.8316882451 16105982
MESH:D009190 Myelodysplastic Syndromes Thalidomide 11.8318720364
MESH:D009190 Myelodysplastic Syndromes Tretinoin 11.8317596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1316810080
MESH:D009336 Necrosis Trinitrotoluene 4.5718551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7816624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.323581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.323581430 9029167
MESH:D009362 Neoplasm Metastasis norcantharidin 9.3215711181
MESH:D009369 Neoplasms Fluorouracil 4.8416928823 18600527 18239605
MESH:D009369 Neoplasms Tretinoin 4.8416946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5417289903
MESH:D009397 Nephrocalcinosis Furosemide 5.6815086907
MESH:D009421 Nervous System Malformations Estradiol 15.4916427766 11399458
MESH:D009421 Nervous System Malformations Thalidomide 15.4916859833
MESH:D009421 Nervous System Malformations Tretinoin 15.499125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.416679447
MESH:D009436 Neural Tube Defects arsenic trioxide 11.4110525206
MESH:D009436 Neural Tube Defects Tretinoin 11.419142499
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.9917168769
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9220387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3116436463
MESH:D053206 Nocturnal Enuresis Furosemide 5.6817945291
MESH:D009759 Nystagmus, Pathologic Astemizole 6.276135121
MESH:D009765 Obesity Plant Extracts 3.1020132043 19056576
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.664026338 6482804
MESH:D009784 Occupational Diseases Trinitrotoluene 8.6612819281 17852074 14694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.833988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 14.3519769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 14.3519401270
MESH:D010051 Ovarian Neoplasms Progesterone 14.3516525653 17393432
MESH:D010051 Ovarian Neoplasms Thalidomide 14.3516288038
MESH:D010051 Ovarian Neoplasms Tretinoin 14.3516936753
MESH:D010146 Pain Acetaminophen 6.0816870215
MESH:D010146 Pain Tretinoin 6.0816870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.7715580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.7716540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 11.7716500647 16929163 19003803 15113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.7715976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.847296757
MESH:D010212 Papilloma Plant Extracts 8.8415173996 16517061
MESH:D010235 Paraganglioma arsenic trioxide 3.9819927285
MESH:D010291 Paresis Thalidomide 6.119200351
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.286228378
MESH:D011141 Polyuria Furosemide 5.4617945291
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.392563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Thalidomide 4.1217031469
MESH:D011225 Pre-Eclampsia Iloprost 5.5810329876
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7120887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.9119131511
MESH:D011471 Prostatic Neoplasms Estradiol 1.9116740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.9118626508 19082440
MESH:D011471 Prostatic Neoplasms Plant Extracts 1.9117804756 14666653
MESH:D011471 Prostatic Neoplasms Thalidomide 1.9116729912
MESH:D011507 Proteinuria pioglitazone 14.7216687628
MESH:D011507 Proteinuria Tretinoin 14.7216636307
MESH:D011507 Proteinuria valsartan 14.7218344623 17664856 12164870
MESH:D011536 Prurigo Thalidomide 6.1112755975
MESH:D011625 Pterygium Tretinoin 4.6016723453
MESH:D011658 Pulmonary Fibrosis valsartan 3.7417241526
MESH:D011928 Raynaud Disease Iloprost 6.4016363279
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8518722050 18286688 15538739 16160472
MESH:D015427 Reperfusion Injury Furosemide 3.8216526316
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 9.1115912074 12394941 16096441
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 9.1117627322 18339021
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.233692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9216283617 16116481
MESH:D012221 Rhinitis, Allergic, Perennial Astemizole 5.2410822083
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7918045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.7816646077
MESH:D019873 Schnitzler Syndrome Thalidomide 5.7516096327
MESH:D012640 Seizures Trinitrotoluene 3.3218551238
MESH:D012878 Skin Neoplasms Plant Extracts 5.7916517061 15173996
MESH:D012878 Skin Neoplasms Tretinoin 5.7916467112
MESH:D013119 Spinal Cord Injuries Progesterone 4.0916503802 15862959
MESH:D013163 Splenomegaly Trinitrotoluene 5.0115817613
MESH:D013274 Stomach Neoplasms arsenic trioxide 6.2017007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.2018456281
MESH:D013274 Stomach Neoplasms Fluorouracil 6.2019015929 19084572 17172411 16424979 16951190 17498489 17522103 15786421 18567086 18396642
MESH:D013274 Stomach Neoplasms Furosemide 6.2017052386
MESH:D013274 Stomach Neoplasms Tretinoin 6.2017261132
MESH:D013276 Stomach Ulcer Plant Extracts 7.3715255614 12787963 18237397 18193104 17135157
MESH:D013276 Stomach Ulcer Thalidomide 7.3715138204
MESH:D013398 Sudden Infant Death Oxygen 5.3512563064
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 5.2917997062
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 15.911399818 6582329 3712494 6587162 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 15.9119014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 15.917505956
MESH:D013964 Thyroid Neoplasms Tretinoin 15.9116026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.4919048282
MESH:D014062 Tongue Neoplasms Fluorouracil 9.2716280240
MESH:D014062 Tongue Neoplasms Tretinoin 9.2716051514
MESH:D016171 Torsades de Pointes arsenic trioxide 9.9915213294
MESH:D016171 Torsades de Pointes Astemizole 9.999583453 8256756
MESH:D014376 Tuberculosis Tretinoin 3.1116040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.838074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 4.8312973940 20435036 11780464 12845720
MESH:D014581 Urticaria Acetaminophen 8.4410982225
MESH:D014581 Urticaria Astemizole 8.441683191 3097109 2859714 2885854 2568189 1976298 2147912 2565098 2883202 3134034 2568013 3080510
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.9016803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.9016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.4216752155
MESH:D014652 Vascular Diseases Thalidomide 5.2915741222
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 4.5618097624
MESH:D020257 Ventricular Remodeling Plant Extracts 12.2218097624
MESH:D020257 Ventricular Remodeling valsartan 12.2219027736
MESH:D014717 Vertigo Astemizole 6.273105558
MESH:D014820 Vitiligo Tretinoin 3.8716761959
MESH:D009396 Wilms Tumor Tretinoin 3.8116287080
MESH:D014947 Wounds and Injuries Plant Extracts 4.1020213670 19894650
Pathway ID Pathway Name
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24792
    • No data
    No data
    Releated drug ID Related drug Name
    PA448976choline
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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