AutismKB 2.0

Annotation Detail for DLL1


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Basic Information Top
Gene Symbol:DLL1 ( DELTA1,DL1,Delta )
Gene Full Name: delta-like 1 (Drosophila)
Band: 6q27
Quick LinksEntrez ID:28514; OMIM: 606582; Uniprot ID:DLL1_HUMAN; ENSEMBL ID: ENSG00000198719; HGNC ID: 2908
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04330Notch signaling pathway
Pathway IDPathway Name
Signaling by Notch
Pathway IDPathway Name
200013Notch signaling pathway
200052Presenilin action in Notch and Wnt signaling
Pathway IDPathway Name
P00005Angiogenesis
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1818Systemic scleroderma
1860Brain tumor
2048Hepatoblastoma
2051Leukemia
2053Colon cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of DLL1 mRNAincreases expression 19933214
C014949 acetylhydrazine acetylhydrazine results in decreased expression of DLL1 mRNAdecreases expression 15282401
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DLL1 mRNAaffects expression 16483693
D001280 Atrazine Atrazine results in increased expression of DLL1 mRNAincreases expression 18585445
D004041 Dietary Fats Dietary Fats results in increased expression of DLL1 mRNAincreases expression 18042831
D005419 Flavonoids Flavonoids results in decreased expression of DLL1 mRNAdecreases expression 18035473
C029424 hydrazine hydrazine results in decreased expression of DLL1 mRNAdecreases expression 15282401
D008044 Linuron Linuron results in increased expression of DLL1 mRNAincreases expression 12730624
C007350 nitrofen nitrofen results in increased expression of DLL1 mRNAincreases expression 17618886
C041786 palm oil palm oil results in increased expression of DLL1 mRNAincreases expression 18042831
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DLL1 mRNAincreases expression 17517823
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DLL1 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0415322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.4211874814
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D001161 Arteriosclerosis Dietary Fats 4.0615238619
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9720435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 18670907 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1512621046 15340226 16354765 8697196 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities nitrofen 2.9711405365
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.9720055451 10048152 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1216714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Dietary Fats 3.3818296743 17967931 19551842 19004024
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Dietary Fats 9.2218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2220067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital nitrofen 7.2516080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.2511294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic nitrofen 3.9710898224 9476886 7520565 15707848 16490937 9575882 11409163 8863223 12759764 17270546 9859898 15793718 12505043 18280291 18958481 7760232 18280292 11685700 15136996 12194112 12904592 12746050 12021965 10541330 11584395 16863852 15578192 11057544 15756563 10370016 17245593 7576705 9698600 12547725 11076806 15764645 16720372 10370017 15088113 11329586 9473106 12407540 15185205 11588001 10693666 16473863 17618886 10359170 16292651 10898222 11051153 10646786 16080930
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616354765 8697196 15340226 16959395 18606429
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D007248 Infertility, Male Atrazine 3.8012948887
MESH:D007249 Inflammation Dietary Fats 8.7220412841
MESH:D007249 Inflammation Flavonoids 8.7217296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.7212878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 3.1918457598 11836018
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9518296743
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7616984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1912151625
MESH:D008171 Lung Diseases nitrofen 4.5017245593 9859898 16863852 9614859
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008654 Mesothelioma Atrazine 3.571916698
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009765 Obesity Dietary Fats 2.3117217161 20518802 18674790 20132043 16723640 11836018 18457598 21332399 19632207
MESH:D010300 Parkinson Disease Atrazine 3.3217218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811896295 11399792 11118676 11222880
MESH:D012135 Respiratory Sounds Atrazine 4.6911874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
Pathway ID Pathway Name
KEGG:04330 Notch signaling pathway
REACT:299 Signaling by Notch
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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