AutismKB 2.0

Annotation Detail for SLC9A9


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Basic Information Top
Gene Symbol:SLC9A9 ( AUTS16,FLJ35613,NHE9 )
Gene Full Name: solute carrier family 9 (sodium/hydrogen exchanger), member 9
Band: 3q24
Quick LinksEntrez ID:285195; OMIM: 608396; Uniprot ID:SL9A9_HUMAN; ENSEMBL ID: ENSG00000181804; HGNC ID: 20653
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
No data
No data
Pathway IDPathway Name
500336Sodium/Proton exchangers
Related Diseases/Disorders Top
No data
No data
Desease Name
tonometry
Desease Name
Non-alcoholic fatty liver disease histology (other)
Tonometry
Attention deficit hyperactivity disorder
Desease Name
Autism, susceptibility to, 16
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene affects the expression of SLC9A9 mRNAaffects expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SLC9A9 mRNAincreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of SLC9A9 mRNAdecreases expression 20713471
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SLC9A9 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of SLC9A9 mRNAincreases expression 20106945
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of SLC9A9 mRNAdecreases expression 20713471
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SLC9A9 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3814514962 11752688 15322242
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 7.496695378
MESH:D000236 Adenoma Methylcholanthrene 7.4910545420 6695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.9216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D050197 Atherosclerosis Methylcholanthrene 3.6411922910
MESH:D001321 Autistic Disorder marker/mechanism 18621663
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8917474063 20146248
MESH:D001943 Breast Neoplasms Methylcholanthrene 1.8917474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8920435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2616124888 15673190 16050911 16227642 3786805 18705752 15721981 16011737 15700767 10355542 16192424 16097048
MESH:D002277 Carcinoma Methylcholanthrene 9.3110545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 9.3116835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 1.8618788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5418850075 18670907 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.6312371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 7.6316192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2212621046 16354765 15668235 8697196 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2715322242 10048152 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.007179309 7120509 6884620 15998439 4309450 9327722 7440962 3732212 16227642 15968718 2869522 19336974 10092053 6623471 10915739 11566570 16177239 3786805 21278145 17522070 15027814 19085960
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.5116714409 18230668 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3710568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2711564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.9716239168 61145 17595544 12795759 16045604 12631006 15959796 19224547
MESH:D005234 Fatty Liver Cyclosporine 8.9719224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.4814633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 17.7318705752
MESH:D005355 Fibrosis Cyclosporine 17.7312639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.7320067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9910048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3716120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.668697196 18606429 16354765 16959395 15340226
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006973 Hypertension Cyclosporine 5.3110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3118850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 2.528314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0412371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9816221502 17157831 16239168 11903743 17334410 16943688 21278145 11408273 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3716116963 12546737 15057751 12667390 18705752 17714472 20821823 17640975 18054572 12445421 14724832 15818738 18429990 17823541 18263696 17557913 12958196 18251166 16011737 18412020 16136751 15673190 18395095 15876570 15996030 18210741 14748882 12389079 16638106 14512876 10355542 12666154 16015684 18376398 15650968 17631135 12609069 15338365 18205269 17525996 15362042 12632512 15893842 18156304 16027843 18418968 11481614 17805973 12649538 15370692 18277467 16192424 18279442 14620537 16033810 18395914 18420326 12632514 18339082 18006644 17721639 15730626 12586293 18187930 17976157 15925388 12741479 12898905 17481882 14716496 15931870 17761835 15123356 16248980 17869086 17766677 15052691 17708605 18481824 13678700 18166357 17698563 17922224 17900296 16097048 18472332 14716833 18472094 15959796 17565644 12445418 17944888 18317297
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3712878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1516246199 17285989 15830285 16964402 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0416899240 14706259
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.0220195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.0219294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.0216984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 11.1012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 11.101399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 11.1012151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6018569708 6695378 20464547 20135361 17053015 20869020 18520028 20064080 18816296
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.607750092 15390079 9230183 20512841 20970405 21163286 16271038 1399818 16337739 17909032 10545420 11893704 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6019555203 11884234
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3111141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.6514600291
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9516192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2917053015
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134889062
    • No data
    Releated disease ID Related disease Name
    PA447198Autistic Disorder
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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