AutismKB 2.0

Annotation Detail for FRYL


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Basic Information Top
Gene Symbol:FRYL ( DKFZp686E205,FLJ16177,KIAA0826 )
Gene Full Name: FRY-like
Band: 4p11
Quick LinksEntrez ID:285527; OMIM: NA; Uniprot ID:FRYL_HUMAN; ENSEMBL ID: ENSG00000075539; HGNC ID: 29127
Relate to Another Database: SFARIGene; denovo-db
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Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of FRYL mRNAincreases expression 19933214
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of FRYL mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FRYL mRNAdecreases expression 19150397
20382639
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of FRYL mRNAincreases expression 20713471
C006253 pirinixic acid pirinixic acid results in decreased expression of FRYL mRNAdecreases expression 17426115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0520127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 7.496695378
MESH:D000236 Adenoma Methylcholanthrene 7.496695378 10545420
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D050197 Atherosclerosis Methylcholanthrene 3.6411922910
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2920146248 17474063
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.2917474063
MESH:D002277 Carcinoma Methylcholanthrene 4.2510545420
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.7120889678
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 7.7116192471
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5916530937
MESH:D005234 Fatty Liver pirinixic acid 3.1420131406 19236843
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.4810962813 14633661
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4818467677 16221962 19772884 19176532
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7320195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 4.7316377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 3.48598648 1399818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.6920464547 20135361 18569708 18520028 18816296 6695378 20064080 17053015 20869020
MESH:D008175 Lung Neoplasms Methylcholanthrene 2.691399818 17909032 16271038 11893704 9230183 20512841 16337739 21163286 7750092 6695378 20970405 10545420 15390079
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009190 Myelodysplastic Syndromes marker/mechanism 18575777
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3311141357
MESH:D009369 Neoplasms pirinixic acid 5.3317405874
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9117292933
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5110029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2917053015
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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