AutismKB 2.0

Annotation Detail for PPIL6


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Basic Information Top
Gene Symbol:PPIL6 ( MGC27054,MGC27056,MGC41939,RSPH12,bA425D10.6,dJ919F19.1 )
Gene Full Name: peptidylprolyl isomerase (cyclophilin)-like 6
Band: 6q21
Quick LinksEntrez ID:285755; OMIM: NA; Uniprot ID:PPIL6_HUMAN; ENSEMBL ID: ENSG00000185250; HGNC ID: 21557
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
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DEVELOPMENTAL
Desease Name
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PPIL6 mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of PPIL6 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of PPIL6 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PPIL6 mRNAincreases expression 20106945
D014212 Tretinoin Tretinoin results in decreased expression of PPIL6 mRNAdecreases expression 17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3814514962 15322242 11752688
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5220127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.5211473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.9216835633
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2911748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.2112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 10.2116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.4015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9620146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 1.9616675129 17261762 12948864 18497071 19861407 17289903 17018787 14630087
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9616166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1416924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.141917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8420419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8416051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5416120746 18670907 18850075
MESH:D002386 Cataract Tretinoin 3.2817460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.3612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.3618566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4916835633
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.1812621046 8697196 16354765 15668235 15340226
MESH:D002972 Cleft Palate Tretinoin 6.189407595
MESH:D003092 Colitis Tretinoin 4.1917035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5310048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.539211117 9664655 9224671 9142499 16925845 17551590 8800419 9125849 14991402 10589399
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7317107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.7419279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 14.0718230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 14.0718230668
MESH:D016889 Endometrial Neoplasms Estradiol 8.1419148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Tretinoin 8.1416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3710568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.7111564622
MESH:D005124 Eye Abnormalities Tretinoin 9.7116938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 3.2319224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.9411858732
MESH:D005355 Fibrosis Cyclosporine 17.7412168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.7420067830
MESH:D005355 Fibrosis Tretinoin 17.7417994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D005909 Glioblastoma Tretinoin 3.2217312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.2110696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 12.0520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 12.0511294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 12.0514991402 9664655
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3715340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.6415709030
MESH:D019584 Hot Flashes Estradiol 4.3617088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.6616959395 15340226 16354765 8697196 18606429
MESH:D006930 Hyperalgesia Tretinoin 3.5016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D006973 Hypertension Cyclosporine 5.3110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3118670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0112878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.1816627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 11.2016580747
MESH:D007569 Jaw Abnormalities Tretinoin 11.2017551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Cyclosporine 6.5518776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 6.5515618244
MESH:D007680 Kidney Neoplasms Cyclosporine 8.3012371664
MESH:D007680 Kidney Neoplasms Estradiol 8.3015610895
MESH:D007938 Leukemia Tretinoin 2.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0716482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1219850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3717217047 16788101 16331271 17712046 17301526 19035177 19029980 17649720 17107899 19075265 17339181 16891316 17368321 9834237 16140955 17361223 16766008 17294898 19225113 16823087 15748426 12679006 16935935 17506722 19642359
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.6218397230 16248980
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7021137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7016984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3112151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2618520028 20464547 17053015 20064080 20135361 20869020 6695378 18569708 18816296
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2611884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7716891317 17203775 11807958 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.0919453300
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2617596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5516810080
MESH:D009369 Neoplasms Benzo(a)pyrene 5.5011141357
MESH:D009369 Neoplasms Tretinoin 5.5016946489 16594593
MESH:D009389 Neovascularization, Pathologic Estradiol 4.2717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 19.0516427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 19.0514600291
MESH:D009421 Nervous System Malformations Tretinoin 19.059125849
MESH:D009436 Neural Tube Defects Tretinoin 3.279142499
MESH:D010051 Ovarian Neoplasms Estradiol 5.1019401270
MESH:D010051 Ovarian Neoplasms Tretinoin 5.1016936753
MESH:D010146 Pain Tretinoin 3.2016870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5615976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.8612520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.7311118676 11896295 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2620887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0317292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.0316740699
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2818990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016116481 16283617
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 10.2319755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.2316192470
MESH:D012878 Skin Neoplasms Tretinoin 10.2316467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4120155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.4117261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.5112697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2917045167 16026305
MESH:D013978 Tibial Fractures Estradiol 5.3019048282
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2917053015
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.2112125929
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.8615886252
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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