AutismKB 2.0

Annotation Detail for GPR35


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Basic Information Top
Gene Symbol:GPR35 ( - )
Gene Full Name: G protein-coupled receptor 35
Band: 2q37.3
Quick LinksEntrez ID:2859; OMIM: 602646; Uniprot ID:GPR35_HUMAN; ENSEMBL ID: ENSG00000178623; HGNC ID: 4492
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of GPR35 mRNAincreases expression 20064835
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GPR35 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GPR35 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GPR35 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil results in increased expression of GPR35 mRNAincreases expression 15331170
D005472 Fluorouracil GPR35 protein affects the susceptibility to Fluorouracilaffects response to substance 15331170
D017239 Paclitaxel GPR35 protein results in decreased susceptibility to Paclitaxeldecreases response to substance 16734730
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GPR35 mRNAaffects binding|decreases expression|increases activity 19710929
D013629 Tamoxifen Tamoxifen affects the expression of GPR35 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GPR35 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GPR35 mRNAdecreases expression 15652763
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.3920127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.3914692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.3917638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.2616835633
MESH:D000740 Anemia Fluorouracil 9.5817963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 9.5811748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.7319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.8715867366
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4017474063 20146248
MESH:D001943 Breast Neoplasms Fluorouracil 2.4018357371 19217205 18608205 16110121 16557594 15136595 16595493
MESH:D001943 Breast Neoplasms Paclitaxel 2.4011325840 16244791 18234424 16273361 16115903 18323546 18223236 15136595
MESH:D001943 Breast Neoplasms Tamoxifen 2.4019487384 17893378 19410462 18815881 17242785 20135344 21152245 19189210 19200415 19189212 19115204 15668708 20005174 19142967 17049068 20544844 18997820 19084267 19103187 19155303 18425577 16202921 19059307 15565566 17440819 19011961 16273361 11161223 21138602 18351453 20859285 19221464 17261762 18855134 19066611 16818667 18821012 19244106 19288272 18629630 20065188 19289846 18984771 20390343 16873071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.4020435547
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1116051944
MESH:D002277 Carcinoma Fluorouracil 8.9417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.9416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.9217045692 18930000 16332177 16799960 17088986 17971768
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 4.9216313753
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.9216924424
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1318695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8620419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8616757204 18986760 17066447 16280240
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018850075 18670907 16120746
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4215861022 17681005 11677210 16919318 17333356 16105132 17110522
MESH:D002779 Cholestasis pirinixic acid 8.4219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2012621046 15668235 16354765 8697196 15340226
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2717287894 16510598 17018589 17725105 17169374 15001691 17172411 16340194 18772588 17016597
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.8117401013 15148649 17016601 17695437 17255274 16282729 17594712 17454858 17094418 16303861 18448328 20501625 16391804 18802399 15289873 18383874 18288408 16331619 18949393 18509181 14970324 16524972
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.8118802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D007644 Darier Disease Fluorouracil 5.1916733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema pirinixic acid 7.4812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2119155303 17893378 16202921 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.6916530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.6916337965 16481741 15173087 17638652 16785472
MESH:D004938 Esophageal Neoplasms Paclitaxel 7.6916481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.7415345470
MESH:D005234 Fatty Liver pirinixic acid 14.7420131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 14.7419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005910 Glioma Fluorouracil 2.9616145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5615102660 15162350 18337622
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly pirinixic acid 9.4816221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.4815340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.498697196 18606429 15340226 16959395 16354765
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Tamoxifen 5.3219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3212878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007680 Kidney Neoplasms Fluorouracil 8.3016985049
MESH:D007680 Kidney Neoplasms Tamoxifen 8.3018625569
MESH:D008064 Lipidoses Tamoxifen 3.3515342952 17567588
MESH:D008080 Liposarcoma Paclitaxel 5.1317353645
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 15.2021137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 15.2017045692 16603448 18383874 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 15.2020007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 15.2016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.2016984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0418569708 20869020 18816296 17053015 20464547 20064080 18520028 6695378 20135361
MESH:D008175 Lung Neoplasms Fluorouracil 5.0415246190
MESH:D008175 Lung Neoplasms Tamoxifen 5.0418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0419555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.1915086387
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.3214749477
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7911731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma Paclitaxel 3.6512025231 16342250 12040289
MESH:D008545 Melanoma Tamoxifen 3.6519393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.2416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.2416757204 18986760
MESH:D009101 Multiple Myeloma Paclitaxel 3.8814749477
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.3015867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.3019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 8.9411141357
MESH:D009369 Neoplasms Fluorouracil 8.9418600527 18239605 16928823
MESH:D009369 Neoplasms pirinixic acid 8.9417405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6116436463
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010014 Osteolysis Paclitaxel 5.3815867366
MESH:D010051 Ovarian Neoplasms Paclitaxel 3.0611161223
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7416500647 16929163 15113037 19003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5911222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0617292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.0619082440 18626508
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.0617172428 16729912 16356831 17136230
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0615067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D012004 Rectal Neoplasms Fluorouracil 4.2615538739 18286688 16160472 18722050
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.8510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0916709447
MESH:D013088 Spermatocele Tamoxifen 13.0916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.5620155912 2093021
MESH:D013274 Stomach Neoplasms Fluorouracil 3.5617172411 17522103 19015929 16424979 16951190 18396642 19084572 18567086 17498489 15786421
MESH:D013274 Stomach Neoplasms Paclitaxel 3.5618506536 18396642
MESH:D024801 Tauopathies Paclitaxel 5.2116930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2516280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3017053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.3016712894 17572228 8653321
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1416803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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