AutismKB 2.0

Annotation Detail for ATP11C


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Basic Information Top
Gene Symbol:ATP11C ( ATPIG,ATPIQ )
Gene Full Name: ATPase, class VI, type 11C
Band: Xq27.1
Quick LinksEntrez ID:286410; OMIM: 300516; Uniprot ID:AT11C_HUMAN; ENSEMBL ID: ENSG00000101974; HGNC ID: 13554
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ATP11C mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ATP11C mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ATP11C mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of ATP11C mRNAincreases expression 19774075
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ATP11C mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ATP11C mRNA]decreases reaction|increases expression 17942915
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ATP11C mRNAaffects expression 17555576
C006253 pirinixic acid pirinixic acid results in decreased expression of ATP11C mRNAdecreases expression 18445702
D013629 Tamoxifen Tamoxifen affects the expression of ATP11C mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ATP11C mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma Diethylnitrosamine 2.966695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 19.0316434500 17620307 18056438 19052882 17162532 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 19.0316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.0316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9918057881 18218290 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001281 Atrial Fibrillation Amiodarone 4.0519698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 16.5519483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.5519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.5512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8217474063
MESH:D001943 Breast Neoplasms Tamoxifen 1.8217440819 19189210 19200415 18815881 19288272 17893378 19289846 18855134 19487384 19221464 16873071 18629630 20859285 16202921 15565566 19011961 17049068 19115204 20544844 19142967 21152245 19084267 19410462 19189212 21138602 18351453 17261762 16273361 20005174 17242785 15668708 18997820 20390343 19103187 18984771 16818667 18425577 20135344 19155303 20065188 19244106 18821012 19059307 19066611 11161223
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8220435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7619066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.1616705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.1616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.163084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.1617138121 19383236 16288022 18210153 17978847 16502159 18506893 18494052 19701751 18971187 3581430 17055752 19171122 18788625 18393292 18665156 19539802 20214788 21159647 16681979 20007298 20514400 17173139 18691550 19335982 20512989 19822196 19107877 16779866 16935385 20935162 16569478 16830150 20101231 16540662 10672840 17428255 20727157 16698587 10737359 19394651 19919837 20084675 20432363 19519916 18056438 11831363 19052882 18978308 19418558 16807293 16328049 18785209 16878318 20524982 17162532 19208518 17761372 3084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 9.1616924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8117572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718850075 16120746 18670907
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9519225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.3718974383
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.156135515
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.152727394 21159647 7505956 17174075
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.9419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.9416835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.2511677210 15861022 17110522 17333356 17681005 16105132 16919318
MESH:D002779 Cholestasis pirinixic acid 8.2519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1812621046 15340226 16354765 8697196 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.7718551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.7718551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3617107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.9818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.9818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.9814725611 17906064 12153990 15968718 12392966 19085960 12540782 17522070 10774834 16177239 12705907 11421492 11529661 10915739 18071297 19739265 11743745 11287661 11739529 19370779 11461765 16485898 18713872 15619225 10663392 19923254 14550746 16393943 16781746 14986274 19416960 16227642 16109766 16081117 12594235 11834606 12958197 19164858 2444490 17562736 19420014
MESH:D056486 Drug-Induced Liver Injury Amiodarone 15.9818218290 15265979
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.9819107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.9820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema pirinixic acid 7.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.7519031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1720544844 16202921 17893378 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Amiodarone 27.0214986274
MESH:D005234 Fatty Liver Diethylnitrosamine 27.0221071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.0215345470
MESH:D005234 Fatty Liver pirinixic acid 27.0220131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 27.0214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8114745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4719069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Amiodarone 15.9915265979
MESH:D006529 Hepatomegaly pirinixic acid 15.9918467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.9915340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.089751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 4.7718020914 17991464
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Diethylnitrosamine 8.8418785209
MESH:D007249 Inflammation Tamoxifen 8.8419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.8412200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3012587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.4316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.4316705839
MESH:D007680 Kidney Neoplasms Tamoxifen 13.4318625569
MESH:D008064 Lipidoses Amiodarone 8.4015342952 17567588
MESH:D008064 Lipidoses Tamoxifen 8.4017567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9318407596 19638242 18665156 18522880 20032147
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5012878042
MESH:D008107 Liver Diseases Acetaminophen 4.0519784758 12969438 19460945 16611625 11587558 16610002 19014921 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.977678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.9719254457 20452335 18648771 19427195 19850985 19073162 19551842 19426721 19294768 19499222 18977376 16942905 20434301 19638242 20118626 19690152 19812893 21047994 15885732 12771043 20501860 12112319 19090486 20137499 2422723 21278145 18644402 19642983 18754104 19255062 18978307 19996281 20101389 19833225 15175105 9163691 20583210 20492335 10737359 20405173 2862719 19256749 21071580 21167192
MESH:D008113 Liver Neoplasms pirinixic acid 14.9720007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 14.9716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.9716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.506135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.5016267830 18308698 19004024 18164116 21159647 19519916 18775883 18253720 2563599 18282651 19539802 17942915 17854601 18093689 19009564 9362446 17174075 16842330 18544905 18079962 3124819 19126423
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.5012151625
MESH:D008133 Long QT Syndrome Amiodarone 3.7317391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 3.5012587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.8018516814
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4820970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 3.4818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4811884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0419428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7411731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.8719453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009181 Mycoses Amiodarone 5.2217974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.3218551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.979029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.9719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5719410462
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3219200415 19196722 19189210
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.7620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5412819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.5416049721
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4816540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.732563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811118676 11399792 11222880 11896295
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9212490602 11597910 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.3718724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.6516709447
MESH:D013088 Spermatocele Tamoxifen 12.6516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3219457130
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013276 Stomach Ulcer Amiodarone 3.5218087811
MESH:D013610 Tachycardia Amiodarone 4.5311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4319225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Amiodarone 13.1419731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 13.1412697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.147505956
MESH:D013971 Thyrotoxicosis Amiodarone 5.1219584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.4711989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.7016049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7016049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.7017572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.9610091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
Pathway ID Pathway Name
REACT:15518 Transmembrane transport of small molecules
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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