AutismKB 2.0

Annotation Detail for GRK4


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Basic Information Top
Gene Symbol:GRK4 ( GPRK2L,GPRK4,GRK4a,IT11 )
Gene Full Name: G protein-coupled receptor kinase 4
Band: 4p16.3
Quick LinksEntrez ID:2868; OMIM: 137026; Uniprot ID:GRK4_HUMAN; ENSEMBL ID: ENSG00000125388; HGNC ID: 4543
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
hsa04062Chemokine signaling pathway
No data
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
blood pressure, arterial
CARDIOVASCULAR
hypertension
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRK4 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of GRK4 mRNAincreases expression 15761015
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRK4 mRNAaffects cotreatment|increases expression 17942748
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of GRK4 mRNAaffects cotreatment|increases expression 17183730
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRK4 mRNAaffects cotreatment|increases expression 17942748
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of GRK4 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.9015322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.908875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2519490988
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5019825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5014692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000550 Amblyopia Valproic Acid 5.7517688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.8317497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001321 Autistic Disorder Valproic Acid 1.9917688650 17507914 18396377 15238991 18940202 18558336 18775368 18316065 16609825 18177632 19232924 20603192 19460635 18985861 17157402
MESH:D001714 Bipolar Disorder Valproic Acid 3.2117594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.0716206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.6515746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.658888407
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6811589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 1.9714691202 15553829 16217749 11135700 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4212490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218670907 18850075 16120746
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8020734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1017110522 16919318 15861022 17681005 11677210 16105132 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115340226 16354765 8697196 12621046 15668235
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.9210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9210048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.9217688650 8888407 16575769
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4515213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0220420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.021733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004421 Dystonia Valproic Acid 4.401851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.573659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.4416628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0718234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.876426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.533659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3712903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver arsenic trioxide 15.1015073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.1015345470
MESH:D005234 Fatty Liver Valproic Acid 15.1014986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005315 Fetal Diseases Valproic Acid 5.4116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.5118558336 8888407
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.6416904648
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 12621046 16120746
MESH:D006849 Hydrocephalus Valproic Acid 5.3317688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5715340226 16354765 8697196 16959395 18606429
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 5.0416612254
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007938 Leukemia arsenic trioxide 2.9615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0620471514 19850784 16467208 17050201 16968895
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0617596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4112712474 16330433 17712046 12018890 16112521 17869043 17649720 11161223 19035177 15622746 19642359 12679006 16823087 19225113 19075265 16966277 16891316 15336539 9834237 17217047 11468182 16331271 17107899 15748426 15213294
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7316882451
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008113 Liver Neoplasms arsenic trioxide 4.7714682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7716984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.4120377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5915213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7817228818
MESH:D008175 Lung Neoplasms arsenic trioxide 2.3719825857 11798837
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3711884234 19555203
MESH:D008881 Migraine Disorders Valproic Acid 3.4118765137 18803445
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3219549372 19417148 11468182 14977855 15949261
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.358888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.9616882451 16105982
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.9617596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.3416624393
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.9710525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.9716359493 8888407
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4812452020 16624393 19769630
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6115580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010235 Paraganglioma arsenic trioxide 4.5119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.0511222880 11896295 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 11.0520603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2219131511
MESH:D011537 Pruritus Ethinyl Estradiol 3.7716919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 5.0611422049 12752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5319155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.3416646077
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Valproic Acid 2.943137016 15475178 1511512 11738929 14763951 16876388 11044598 17978042
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0219490988
MESH:D013226 Status Epilepticus Valproic Acid 5.0612833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3219014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.4215213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.7517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.983119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5811780464 20435036 12845720 12973940
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.068888407
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
KEGG:04144 Endocytosis
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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