AutismKB 2.0

Annotation Detail for GRK5


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Basic Information Top
Gene Symbol:GRK5 ( FLJ39780,GPRK5 )
Gene Full Name: G protein-coupled receptor kinase 5
Band: 10q26.11
Quick LinksEntrez ID:2869; OMIM: 600870; Uniprot ID:GRK5_HUMAN; ENSEMBL ID: ENSG00000198873; HGNC ID: 4544
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
hsa04062Chemokine signaling pathway
Pathway IDPathway Name
Signaling by GPCR
Pathway IDPathway Name
200187Alpha-synuclein signaling
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway IDPathway Name
500436G alpha (q) signalling events
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063609 1,2-dimethyl-4-nitrobenzene 1,2-dimethyl-4-nitrobenzene results in decreased expression of GRK5 mRNAdecreases expression 19784758
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of GRK5 mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of GRK5 mRNAaffects expression 19784758
D000082 Acetaminophen Acetaminophen results in decreased expression of GRK5 mRNAdecreases expression 19784758
D000082 Acetaminophen Acetaminophen results in increased expression of GRK5 mRNAincreases expression 19784758
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GRK5 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRK5 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GRK5 mRNAdecreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GRK5 mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of GRK5 mRNAdecreases expression 19784758
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of GRK5 mRNAincreases expression 16644059
D003345 Corticosterone Corticosterone results in increased expression of GRK5 mRNAincreases expression 15755911
D016572 Cyclosporine Cyclosporine results in decreased expression of GRK5 mRNAdecreases expression 20106945
D003561 Cytarabine Cytarabine results in increased expression of GRK5 mRNAincreases expression 19194470
D002117 Calcitriol Calcitriol results in increased expression of GRK5 mRNAincreases expression 16002434
D004837 Epinephrine Epinephrine promotes the reaction [GRK5 protein results in increased phosphorylation of ADRB2 protein]increases phosphorylation|increases reaction 14722251
C008493 methylselenic acid methylselenic acid results in increased expression of GRK5 mRNAincreases expression 18548127
D009020 Morphine Morphine results in increased expression of GRK5 mRNAincreases expression 15183518
D009578 Nitrobenzenes Nitrobenzenes analog results in decreased expression of GRK5 mRNAdecreases expression 19784758
D010126 Ozone Ozone results in decreased expression of GRK5 mRNAdecreases expression 16330353
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of GRK5 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of GRK5 mRNAdecreases expression 19482888
19270015
D010634 Phenobarbital Phenobarbital results in increased expression of GRK5 mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GRK5 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of GRK5 mRNAdecreases expression 16985257
D020849 Raloxifene Raloxifene affects the expression of GRK5 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in increased expression of GRK5 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen Tamoxifen affects the expression of GRK5 mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in increased expression of GRK5 mRNAaffects cotreatment|increases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GRK5 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GRK5 mRNAdecreases expression 19933214
D013853 Thioacetamide Thioacetamide results in decreased expression of GRK5 mRNAdecreases expression 19784758
D014635 Valproic Acid Valproic Acid results in decreased expression of GRK5 mRNAdecreases expression 19101580
D002762 Cholecalciferol Cholecalciferol results in increased expression of GRK5 mRNAincreases expression 16508948
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3514745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.086195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.0815322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 13.088875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7519490988
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.9418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.546695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.1717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.1716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.1716835633
MESH:D000419 Albuminuria Raloxifene 4.4117308373 17451421
MESH:D000544 Alzheimer Disease Ozone 4.2215513908
MESH:D000544 Alzheimer Disease Raloxifene 4.2215800139
MESH:D000550 Amblyopia Valproic Acid 5.0417688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.4217497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8819183758
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5115570426
MESH:D001249 Asthma Ozone 2.5817854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518558336 17157402 17507914 19460635 15238991 18177632 18316065 19232924 20603192 18396377 18985861 16609825 18775368 17688650 18940202
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.8416142846
MESH:D001714 Bipolar Disorder Valproic Acid 2.9820046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.3419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.3412125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 14.3419483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.6215746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.628888407
MESH:D001930 Brain Injuries Raloxifene 4.2916580743
MESH:D002545 Brain Ischemia Morphine 4.9519211983
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2720146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 2.2711237771
MESH:D001943 Breast Neoplasms Raloxifene 2.2715572757 17242785 16912660 17952589 15758505 17261762 17893378 16837676 17440819 17595753 17049068 15775269
MESH:D001943 Breast Neoplasms Tamoxifen 2.2719200415 20544844 20390343 19084267 18821012 16202921 20859285 19115204 19410462 15668708 19103187 19189210 19288272 18855134 17261762 19189212 19487384 19142967 18997820 18629630 19244106 19221464 20005174 18815881 16273361 17893378 18425577 15565566 21152245 19011961 17440819 19155303 16818667 20135344 18984771 11161223 17049068 20065188 17242785 18351453 19066611 16873071 19289846 19059307 21138602
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2720435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5318417511 19059883 18315731 14754758 17626835 16777450 15516495
MESH:D002100 Cachexia Ozone 4.5516183385
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5915721981 16050911 15700767 16011737 16227642 3786805 15673190 16192424 10355542 18705752 16124888 16097048
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3219066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.983084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 10.9821507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 10.9818788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 10.981701930 17173139 6705139 20007298 20935162
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.9816924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 10.9817997003
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5020419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.5011237771
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.9417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.9417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2618850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.3115775269
MESH:D002386 Cataract Acetaminophen 2.4710977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.5820889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.5812371664
MESH:D002471 Cell Transformation, Neoplastic Cytarabine 10.588243401
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.064080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6420734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.0116835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.0118291259
MESH:D002779 Cholestasis Cyclosporine 7.2919486331
MESH:D002779 Cholestasis pirinixic acid 7.2919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0315668235 8697196 16354765 15340226 12621046
MESH:D003072 Cognition Disorders Raloxifene 4.4315800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9014669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.4216575769 17688650 8888407
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1719031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0017474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D003928 Diabetic Nephropathies Raloxifene 8.5017451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.5019279558
MESH:D003967 Diarrhea Morphine 4.342540324
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.4018071297 11529661 19739265 2444490 11287661 11743745 10915739 11739529 16109766 19420014 11461765 18713872 19416960 17562736 17522070 10774834 16781746 15619225 11421492 12594235 17906064 12705907 14725611 14550746 15968718 10663392 16081117 12540782 14986274 12153990 19085960 19923254 11834606 12392966 19164858 16485898 16177239 19370779 16227642 16393943 12958197
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.403732212 10915739 10092053 16177239 7179309 16227642 3786805 2869522 15998439 9327722 7120509 21278145 11566570 19085960 15027814 4309450 6623471 15968718 6884620 7440962 19336974 17522070
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.4020420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 11.4012963478
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.4019641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D004421 Dystonia Phenobarbital 9.841851702
MESH:D004421 Dystonia Valproic Acid 9.841851702
MESH:D004487 Edema pirinixic acid 10.4312083418
MESH:D004487 Edema Raloxifene 10.4315860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7115322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 14.3815138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 14.3815845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.3819031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.9219155303 16202921 20544844 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.869294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 10.163659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 10.163659116 17275665
MESH:D004828 Epilepsies, Partial Phenobarbital 9.3311558140 3922381
MESH:D004828 Epilepsies, Partial Valproic Acid 9.3316628512 3922381
MESH:D004827 Epilepsy Epinephrine 10.69821787
MESH:D004827 Epilepsy Phenobarbital 10.6920417680
MESH:D004827 Epilepsy Valproic Acid 10.6920417680 18234410
MESH:D004832 Epilepsy, Absence Phenobarbital 8.336401628
MESH:D004832 Epilepsy, Absence Valproic Acid 8.337562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.677750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 10.677750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 9.843659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 9.843659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.1820426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1816530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D005218 Fat Necrosis Thioacetamide 5.5316456712
MESH:D005234 Fatty Liver Carbon Tetrachloride 28.4712795759 61145 15959796 16239168 12631006 16045604 17595544 19224547
MESH:D005234 Fatty Liver Cyclosporine 28.4719224547
MESH:D005234 Fatty Liver pirinixic acid 28.4719236843 20131406
MESH:D005234 Fatty Liver Raloxifene 28.4717473493
MESH:D005234 Fatty Liver Tamoxifen 28.4714986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 28.4714986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6916575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.958888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9919069698
MESH:D005355 Fibrosis Carbon Tetrachloride 13.6118705752
MESH:D005355 Fibrosis Cyclosporine 13.6112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.6120067830
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.038708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1210048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.4011110106
MESH:D006333 Heart Failure pirinixic acid 2.4220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.4018665440 15929193 17276928
MESH:D006505 Hepatitis Carbon Tetrachloride 8.8719900420 19110552
MESH:D006505 Hepatitis Thioacetamide 8.8716456712
MESH:D006529 Hepatomegaly Phenobarbital 13.2916109766
MESH:D006529 Hepatomegaly pirinixic acid 13.2919176532 16221962 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.2915340226 12621046 16120746
MESH:D006689 Hodgkin Disease Cytarabine 4.2716200630
MESH:D006849 Hydrocephalus Valproic Acid 4.6717688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8515340226 16354765 8697196 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.5516870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3416899240
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D006973 Hypertension Cyclosporine 8.1610903974
MESH:D006973 Hypertension Raloxifene 8.1617577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1618850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9015338365
MESH:D007022 Hypotension Epinephrine 5.146740701
MESH:D007249 Inflammation Tamoxifen 4.5619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.5612200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.5116306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2515604871
MESH:D007674 Kidney Diseases Acetaminophen 5.4315629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.438314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 6.7812371664
MESH:D007680 Kidney Neoplasms Tamoxifen 6.7818625569
MESH:D007889 Leiomyoma Raloxifene 4.3216973256
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1217596541 16294345
MESH:D008064 Lipidoses Tamoxifen 3.0217567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.2911408273 16239168 16943688 17334410 11903743 21278145 16221502 17174718 17157831
MESH:D008103 Liver Cirrhosis Phenobarbital 6.2921047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.4712632514 15052691 17761835 13678700 18277467 12632512 12546737 16192424 12898905 18429990 17714472 17631135 17698563 15959796 18472094 17565644 18376398 15876570 15925388 12667390 12389079 15123356 18210741 18481824 18251166 18166357 10355542 18205269 15370692 15362042 17922224 18339082 15673190 18187930 18395914 18418968 17557913 17976157 18054572 18156304 17708605 12586293 16248980 12445421 12445418 15650968 17721639 15893842 15931870 17640975 12666154 12741479 17823541 16011737 16015684 12958196 15730626 15996030 14512876 18317297 18412020 16027843 18279442 18263696 14620537 17766677 16638106 16116963 15818738 15057751 14716496 18705752 15338365 17525996 12649538 17869086 18006644 12609069 17805973 17944888 17481882 14748882 16097048 18472332 20821823 18420326 11481614 16033810 16136751 18395095 14724832 14716833 17900296
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4715474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.4718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4712878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 6.4714739098 15158331 16511523 15316131 12175628 18031379 12891558 17292413 16097051 15095483 15362042 18295389 18615449 18380797 12557150 17629604 16098781 16343077 12679928 11172339 15334695 15288472 15465738 15716488 18606216 10677585 18263696 15078482 12085344 18032466 15288473 18458672 16489207 16126171 17127702 16248980 11682029 17355460 17050028 15075984 11481614 18395095 15474484 18416461 12531686
MESH:D008107 Liver Diseases marker/mechanism 19784758
MESH:D008107 Liver Diseases Acetaminophen 8.9812969438 19014921 11587558 19784758 16611625 19460945 12587719 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.9817285989 16964402 15830285 16246199 15720792
MESH:D008107 Liver Diseases Phenobarbital 8.9819363144
MESH:D008107 Liver Diseases Thioacetamide 8.9816337175 15158337 18374380
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 15.2816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 15.2814706259 16899240
MESH:D017114 Liver Failure, Acute Thioacetamide 15.2815313186 17276928 12479984 15633222
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.799163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.7921137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.7919294768
MESH:D008113 Liver Neoplasms Phenobarbital 20.7919482888 19812893 8742319 21047994 15975961 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 20.7916377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 20.7916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.7916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 13.148603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.1412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 13.1418308698 2563599 1399818 6150874 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.1412151625
MESH:D008171 Lung Diseases Ozone 3.2519066396 8266340
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.0717228818
MESH:D055370 Lung Injury Ozone 3.6620417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.3314755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.3318816296 20135361 18569708 18520028 20464547 17053015 20869020 6695378 20064080
MESH:D008175 Lung Neoplasms Ozone 6.338597069 7614698
MESH:D008175 Lung Neoplasms Tamoxifen 6.3318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.3311884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5719428831
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 5.9612807724
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.9614580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.3519453300
MESH:D008545 Melanoma Tamoxifen 1.8619393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5916801185
MESH:D008679 Metaplasia Ozone 4.9110496685
MESH:D008881 Migraine Disorders Valproic Acid 3.0618803445 18765137
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3615863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0416381670
MESH:D009101 Multiple Myeloma Raloxifene 3.3016497877
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.858888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.0517596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2817484760
MESH:D009232 Myxoma Raloxifene 5.3616343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 4.5111141357
MESH:D009369 Neoplasms pirinixic acid 4.5117405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8119189210 19200415 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1219348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0314600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.018888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7218514411
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D010018 Osteomalacia Phenobarbital 4.1717016548
MESH:D010024 Osteoporosis Raloxifene 3.2819059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.0517823083 17893378 15758505 15579764
MESH:D010146 Pain Acetaminophen 6.5516870215
MESH:D010146 Pain Morphine 6.5518699797 20225289 6776300 15215642 16273134 15275824
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.4316965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010538 Peritonitis Ozone 3.9416369182
MESH:D011014 Pneumonia Ozone 4.2018381685 18929643 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.4312371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.432563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cytarabine 4.3421297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.8211896295 11118676 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.8220603192
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5915572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Calcitriol 1.8916289102 16644109 12479363 15754350 18247401
MESH:D011471 Prostatic Neoplasms Cholecalciferol 1.8917024972
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.8916205645
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8915731164 16220300 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D019310 Pseudolymphoma Phenobarbital 11.5512752131
MESH:D019310 Pseudolymphoma Valproic Acid 11.5512752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011693 Purpura Raloxifene 5.3615770314
MESH:D015427 Reperfusion Injury Morphine 6.5819211983
MESH:D015427 Reperfusion Injury pirinixic acid 6.5819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.0019155313
MESH:D012559 Schizophrenia Valproic Acid 2.0415737665 19110320
MESH:D012640 Seizures Phenobarbital 5.573137016 4039156 11442880 16876388
MESH:D012640 Seizures Valproic Acid 5.5716876388 11738929 14763951 15475178 11044598 17978042 3137016 1511512
MESH:D003294 Seizures, Febrile Phenobarbital 4.636407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.1819755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.1816192470
MESH:D013088 Spermatocele Tamoxifen 4.1016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8519457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6319490988
MESH:D013226 Status Epilepticus Valproic Acid 4.3512833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.552093021 20155912
MESH:D020521 Stroke Raloxifene 3.6716837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 2.911399818
MESH:D013978 Tibial Fractures Raloxifene 5.0219048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.0417262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.333119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.9117053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 7.9117572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 7.9116712894 17572228 8653321
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.458888407
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D014605 Uveitis Cyclosporine 3.791336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.0216837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3616343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2517120751
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
KEGG:04144 Endocytosis
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA180
    • No data
    Releated disease ID Related disease Name
    PA443632Cardiomyopathy, Dilated
    PA443633Cardiomyopathy, Hypertrophic
    PA444370Heart Failure
    Releated drug ID Related drug Name
    PA164712535Beta Blocking Agents
    PA450121isoproterenol
    PA449092colchicine
    PA449396dopamine
    PA451578tacrolimus
    PA448499atenolol
    PA448817carvedilol
    PA450480metoprolol
    PA450966pindolol
    PA451145propranolol
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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