AutismKB 2.0

Annotation Detail for ANK2


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Basic Information Top
Gene Symbol:ANK2 ( DKFZp686M09125,DKFZp686P0948,FLJ38277,LQT4 )
Gene Full Name: ankyrin 2, neuronal
Band: 4q25-q26
Quick LinksEntrez ID:287; OMIM: 106410; Uniprot ID:ANK2_HUMAN; ENSEMBL ID: ENSG00000145362; HGNC ID: 493
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1999Thalassemia
2092Long QT syndrome
No data
No data
Desease Name
Long QT syndrome-4
Cardiac arrhythmia, ankyrin-B-related
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of ANK2 mRNAaffects expression 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of ANK2 mRNA]affects expression|affects reaction 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of ANK2 mRNA]affects expression|affects reaction 19414516
D000242 Cyclic AMP 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of ANK2 mRNA]affects expression|affects reaction 19414516
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ANK2 mRNAaffects expression 16483693
C004984 apocarotenal apocarotenal results in increased expression of ANK2 mRNAincreases expression 17034753
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ANK2 mRNAdecreases expression 20106945
D019207 beta Carotene beta Carotene results in increased expression of ANK2 mRNAincreases expression 17034753
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ANK2 mRNA]decreases expression|decreases reaction 11007951
D016572 Cyclosporine Cyclosporine results in increased expression of ANK2 mRNAincreases expression 20106945
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of ANK2 mRNAdecreases expression 20713471
C008493 methylselenic acid methylselenic acid results in increased expression of ANK2 mRNAincreases expression 18548127
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ANK2 mRNA]decreases expression|decreases reaction 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ANK2 mRNAdecreases expression 11007951
D014415 Tunicamycin Tunicamycin results in increased expression of ANK2 mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0011752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 7.076695378
MESH:D000236 Adenoma Methylcholanthrene 7.0710545420 6695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5111922910
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D002545 Brain Ischemia beta Carotene 5.2416157235
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8917474063 20146248
MESH:D001943 Breast Neoplasms Methylcholanthrene 1.8917474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8920435547
MESH:D002277 Carcinoma Methylcholanthrene 8.6310545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.6316835633
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
OMIM:600919 CARDIAC ARRHYTHMIA, ANKYRIN-B-RELATED marker/mechanism
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0912371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 7.0916192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 3.0019486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415340226 15668235 12621046 16354765 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0816714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 2.9619224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.0910962813 14633661
MESH:D005355 Fibrosis Cyclosporine 8.9512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6311294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0315340226 12621046 16120746
MESH:D015658 HIV Infections beta Carotene 4.1016960176
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2216354765 15340226 8697196 18606429 16959395
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.408314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8212371664
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.4521137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4516984957
MESH:D008114 Liver Neoplasms, Experimental beta Carotene 10.4517113696
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 10.451399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4512151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0118816296 18520028 18569708 20064080 20464547 20135361 20869020 17053015 6695378
MESH:D008175 Lung Neoplasms beta Carotene 5.0116401635
MESH:D008175 Lung Neoplasms Methylcholanthrene 5.016695378 16271038 17909032 20970405 20512841 9230183 10545420 7750092 21163286 11893704 1399818 15390079 16337739
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0119555203 11884234
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D020326 Migraine without Aura Cyclic AMP 5.2811304026
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009369 Neoplasms Benzo(a)pyrene 5.6111141357
MESH:D009369 Neoplasms beta Carotene 5.6117051425
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411399792 11896295 11222880 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3817292933
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.3816205645
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6310029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6316192470
MESH:D013272 Stomach Diseases beta Carotene 5.2417638125
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013276 Stomach Ulcer beta Carotene 4.3612500499
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2117053015
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24799
    • No data
    Releated disease ID Related disease Name
    PA446379Death, Sudden, Cardiac
    PA446294Torsades de Pointes
    PA444807Long QT Syndrome
    PA447228congenital long QT syndrome
    Releated drug ID Related drug Name
    PA448383amiodarone
    PA452233antipsychotics
    PA448486arsenic trioxide
    PA448498astemizole
    PA164754755bepridil
    PA448948chloroquine
    PA448964chlorpromazine
    PA449011cisapride
    PA449028clarithromycin
    PA449373disopyramide
    PA449389dofetilide
    PA134711056domperidone
    PA449422droperidol
    PA449493erythromycin
    PA449839halofantrine
    PA449841haloperidol
    PA449958ibutilide
    PA450215levomethadyl acetate
    PA450386mesoridazine
    PA450401methadone
    PA450850pentamidine
    PA450965pimozide
    PA451108procainamide
    PA451209quinidine
    PA451457sotalol
    PA451472sparfloxacin
    PA451619terfenadine
    PA451666thioridazine
    PA452249antiarrhythmics, class i and iii
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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