Gene Symbol:	GPX3 ( GPx-P,GSHPx-3,GSHPx-P )
Gene Full Name:	glutathione peroxidase 3 (plasma)
Band:	5q33.1
Quick Links	Entrez ID:2878; OMIM: 138321; Uniprot ID:GPX3_HUMAN; ENSEMBL ID: ENSG00000211445; HGNC ID: 4555
Relate to Another Database:	SFARIGene; denovo-db

Pathway ID	Pathway Name
hsa00480	Glutathione metabolism
hsa00590	Arachidonic acid metabolism

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of GPX3 mRNA	affects cotreatment\|decreases expression	11509743
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in increased expression of GPX3 mRNA	affects cotreatment\|increases expression	11509743
C075773	4-phenylbutyric acid	4-phenylbutyric acid results in increased expression of GPX3 mRNA	increases expression	14583596
D000082	Acetaminophen	Acetaminophen affects the expression of GPX3 mRNA	affects expression	17562736
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GPX3 mRNA	affects expression	16483693
D000728	Androgens	Androgens affects the expression of GPX3	affects expression	10645275
C006632	arsenic trioxide	arsenic trioxide results in increased expression of GPX3 mRNA	increases expression	15073043
C015001	arsenite	arsenite results in increased expression of GPX3 mRNA	increases expression	19429247
C005948	astaxanthine	astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GPX3 mRNA]	decreases reaction\|increases expression	16964424
D019324	beta-Naphthoflavone	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPX3 mRNA	affects cotreatment\|increases expression	18164116
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GPX3 mRNA	increases expression	20382639
D002087	Butyrates	Butyrates results in increased expression of GPX3 mRNA	increases expression	14674679
D002104	Cadmium	Cadmium results in decreased expression of GPX3 protein	decreases expression	17120531
D002713	Chlorine	Chlorine results in increased expression of GPX3 mRNA	increases expression	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of GPX3 mRNA	affects cotreatment\|affects expression	18636392
D003345	Corticosterone	Corticosterone results in increased expression of GPX3 mRNA	increases expression	15755911
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of GPX3 mRNA	increases expression	17654400
D016572	Cyclosporine	Cyclosporine results in decreased expression of GPX3 mRNA	decreases expression	20106945
C014347	decitabine	[decitabine affects the methylation of GPX3 promoter] which affects the expression of GPX3 mRNA	affects expression\|affects methylation	18664505
C014347	decitabine	[decitabine affects the methylation of GPX3 promoter] which affects the expression of GPX3 protein	affects expression\|affects methylation	18664505
C014347	decitabine	decitabine results in increased expression of GPX3 mRNA	increases expression	19194470
C014347	decitabine	trichostatin A promotes the reaction [[decitabine affects the methylation of GPX3 promoter] which affects the expression of GPX3 protein]	affects expression\|affects methylation\|increases reaction	18664505
D003976	Diazinon	Diazinon results in increased expression of GPX3 mRNA	increases expression	19440498
D002945	Cisplatin	GPX3 protein affects the susceptibility to Cisplatin	affects response to substance	16217747
D004026	Dieldrin	Dieldrin results in increased expression of GPX3 mRNA	increases expression	19440498
D004041	Dietary Fats	Dietary Fats results in decreased expression of GPX3 mRNA	decreases expression	18042831
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPX3 mRNA	affects cotreatment\|increases expression	18164116
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of GPX3 mRNA	increases expression	19638242
D004317	Doxorubicin	Doxorubicin results in increased expression of GPX3 mRNA	increases expression	16243910
D004958	Estradiol	[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in decreased expression of GPX3 mRNA	affects cotreatment\|decreases expression	11509743
D004958	Estradiol	[Estradiol co-treated with 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane] results in increased expression of GPX3 mRNA	affects cotreatment\|increases expression	11509743
D004958	Estradiol	[Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of GPX3 mRNA	affects cotreatment\|decreases expression	11509743
D004958	Estradiol	[Estradiol co-treated with Methoxychlor metabolite] results in increased expression of GPX3 mRNA	affects cotreatment\|increases expression	11509743
D004958	Estradiol	Estradiol results in decreased expression of GPX3 mRNA	decreases expression	11509743
D004958	Estradiol	Estradiol results in increased expression of GPX3 mRNA	increases expression	11509743
D005480	Flurbiprofen	Flurbiprofen results in decreased expression of GPX3 mRNA	decreases expression	16949054
C071834	glycidamide	glycidamide results in increased expression of GPX3 mRNA	increases expression	17822822
C010176	halofuginone	halofuginone results in increased expression of GPX3 mRNA	increases expression	17180598
D006581	Hexachlorobenzene	Hexachlorobenzene affects the expression of GPX3 mRNA	affects expression	15159207
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the reaction [SHC1 protein affects the expression of GPX3 mRNA]	affects expression\|affects reaction	16972253
D007213	Indomethacin	Indomethacin results in increased expression of GPX3 mRNA	increases expression	18299717
D007213	Indomethacin	rebamipide inhibits the reaction [Indomethacin results in increased expression of GPX3 mRNA]	decreases reaction\|increases expression	18299717
C051890	irinotecan	irinotecan metabolite results in increased expression of GPX3 mRNA	increases expression	15956246
C051890	irinotecan	irinotecan results in increased expression of GPX3 mRNA	increases expression	15956246
D001556	Lindane	Lindane analog results in decreased expression of GPX3 mRNA	decreases expression	16509360
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of GPX3 mRNA	increases expression	19339665
D008070	Lipopolysaccharides	methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of GPX3 mRNA]	decreases reaction\|increases expression	19339665
D008727	Methotrexate	GPX3 protein affects the susceptibility to Methotrexate	affects response to substance	16217747
D008731	Methoxychlor	[Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of GPX3 mRNA	affects cotreatment\|decreases expression	11509743
D008731	Methoxychlor	[Estradiol co-treated with Methoxychlor metabolite] results in increased expression of GPX3 mRNA	affects cotreatment\|increases expression	11509743
C008435	methyldithiocarbamate	methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of GPX3 mRNA]	decreases reaction\|increases expression	19339665
D008942	Mitoxantrone	GPX3 protein affects the susceptibility to Mitoxantrone	affects response to substance	16217747
D009532	Nickel	Nickel affects the expression of GPX3 mRNA	affects expression	19440498
D009585	Nitrogen Dioxide	Nitrogen Dioxide results in increased expression of GPX3 mRNA	increases expression	15336314
D010100	Oxygen	Oxygen results in increased expression of and results in increased activity of GPX3 protein	increases activity\|increases expression	10590029
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of GPX3 mRNA	affects cotreatment\|affects expression	18636392
D010126	Ozone	Ozone results in increased expression of GPX3 mRNA	increases expression	16716893
C041786	palm oil	palm oil results in decreased expression of GPX3 mRNA	decreases expression	18042831
D010269	Paraquat	Paraquat results in increased expression of GPX3 mRNA	increases expression	12732627
D010269	Paraquat	Paraquat affects the expression of GPX3 mRNA	affects expression	15206577
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of GPX3 mRNA]	affects reaction\|increases expression	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of GPX3 mRNA	increases expression	19482888
C025299	polyphenols	polyphenols results in decreased expression of GPX3 mRNA	decreases expression	16293270
D011374	Progesterone	Progesterone affects the expression of GPX3 mRNA	affects expression	17251523
D011374	Progesterone	Progesterone results in decreased expression of GPX3	decreases expression	17510236
C052785	rebamipide	rebamipide inhibits the reaction [Indomethacin results in increased expression of GPX3 mRNA]	decreases reaction\|increases expression	18299717
C052785	rebamipide	rebamipide results in increased expression of GPX3 mRNA	increases expression	18299717
D012643	Selenium	Selenium deficiency results in decreased activity of GPX3 protein	decreases activity	19181766
D012643	Selenium	Selenium results in increased expression of GPX3 mRNA	increases expression	19244175
D012643	Selenium	Selenium results in increased expression of GPX3 mRNA	increases expression	15894816
D012643	Selenium	Selenium affects the activity of GPX3 protein	affects activity	19351701 19106321
D012643	Selenium	Selenium affects the expression of GPX3 mRNA	affects expression	19106321
D012643	Selenium	Selenium results in increased activity of GPX3 protein	increases activity	19022953
D012645	Selenomethionine	Selenomethionine results in increased activity of GPX3 protein	increases activity	19448000
D012645	Selenomethionine	Selenomethionine results in increased expression of GPX3 protein	increases expression	19448000
D018038	Sodium Selenite	GPX4 gene SNP inhibits the reaction [Sodium Selenite results in increased activity of GPX3 protein]	decreases reaction\|increases activity	18400727
D018038	Sodium Selenite	GPX4 gene SNP inhibits the reaction [Sodium Selenite results in increased expression of GPX3 protein]	decreases reaction\|increases expression	18400727
D018038	Sodium Selenite	Sodium Selenite results in increased expression of GPX3 protein	increases expression	17536041
D018038	Sodium Selenite	Sodium Selenite results in increased activity of GPX3 protein	increases activity	16952904
D013749	Tetrachlorodibenzodioxin	GPX3 protein results in increased susceptibility to Tetrachlorodibenzodioxin	increases response to substance	16682824
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased activity of GPX3 protein	increases activity	16682824
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GPX3 mRNA	increases expression	17035482 16682824
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GPX3 protein	increases expression	16682824
D013752	Tetracycline	Tetracycline results in decreased expression of GPX3 mRNA	decreases expression	16917069
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of GPX3 mRNA	increases expression	15289447
C012589	trichostatin A	trichostatin A promotes the reaction [[decitabine affects the methylation of GPX3 promoter] which affects the expression of GPX3 protein]	affects expression\|affects methylation\|increases reaction	18664505
D014415	Tunicamycin	Tunicamycin results in increased expression of GPX3 mRNA	increases expression	17127020
D014635	Valproic Acid	Valproic Acid results in increased expression of GPX3 mRNA	increases expression	19101580
C025643	vinclozolin	vinclozolin affects the expression of GPX3 mRNA	affects expression	19015723
D014810	Vitamin E	Vitamin E results in increased expression of GPX3 mRNA	increases expression	19244175

Pathway ID	Pathway Name
KEGG:00590	Arachidonic acid metabolism
KEGG:00480	Glutathione metabolism

Desease Name
CARDIOVASCULAR
stroke, ischemic

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D000014	Abnormalities, Drug-Induced	Methotrexate	15.47	12039119
MESH:D000014	Abnormalities, Drug-Induced	Phenobarbital	15.47	6195326
MESH:D000014	Abnormalities, Drug-Induced	Tetrachlorodibenzodioxin	15.47	15322242 14514962 11752688
MESH:D000014	Abnormalities, Drug-Induced	Valproic Acid	15.47	8875741
MESH:D000015	Abnormalities, Multiple	Valproic Acid	3.39	19490988
MESH:D000138	Acidosis	Ammonium Chloride	2.96	18287403
MESH:D058186	Acute Kidney Injury	Cisplatin	3.43	15814532 17670903 12690470
MESH:D055371	Acute Lung Injury	Chlorine	17.35	20601635
MESH:D055371	Acute Lung Injury	Lipopolysaccharides	17.35	11850527 18653653
MESH:D055371	Acute Lung Injury	Nickel	17.35	16166738
MESH:D055371	Acute Lung Injury	Oxygen	17.35	16759491
MESH:D000230	Adenocarcinoma	arsenic trioxide	11.46	19825857 11798837
MESH:D000230	Adenocarcinoma	Cisplatin	11.46	11798837 17638652
MESH:D000230	Adenocarcinoma	Doxorubicin	11.46	17418594
MESH:D000230	Adenocarcinoma	Estradiol	11.46	11473722
MESH:D000230	Adenocarcinoma	Indomethacin	11.46	16537180
MESH:D002282	Adenocarcinoma, Bronchiolo-Alveolar	Tobacco Smoke Pollution	4.92	15814487
MESH:D000236	Adenoma	beta-Naphthoflavone	9.12	19389873
MESH:D000236	Adenoma	Diethylnitrosamine	9.12	10737359 6695378
MESH:D000236	Adenoma	Indomethacin	9.12	11497255
MESH:D018248	Adenoma, Liver Cell	Diethylnitrosamine	13.88	19052882 17162532 19061943 18056438 17620307 16434500
MESH:D018248	Adenoma, Liver Cell	Phenobarbital	13.88	17620307
MESH:D018248	Adenoma, Liver Cell	Tetrachlorodibenzodioxin	13.88	16835633
MESH:D011125	Adenomatous Polyposis Coli	Flurbiprofen	4.54	10680582
MESH:D000382	Agricultural Workers' Diseases	Diazinon	11.11	16487989
MESH:D000382	Agricultural Workers' Diseases	Lindane	11.11	12661182
MESH:D000382	Agricultural Workers' Diseases	Paraquat	11.11	11874814
MESH:D000419	Albuminuria	Doxorubicin	3.97	21441931
MESH:D016301	Alveolar Bone Loss	Indomethacin	4.76	17225004
MESH:D000544	Alzheimer Disease	Androgens	5.82	17182789 17917157
MESH:D000544	Alzheimer Disease	Indomethacin	5.82	17627676 15579461
MESH:D000544	Alzheimer Disease	Ozone	5.82	15513908
MESH:D000550	Amblyopia	Valproic Acid	4.62	17688650
MESH:D000740	Anemia	Tetrachlorodibenzodioxin	2.43	11748828
MESH:D000799	Angioedema	Acetaminophen	3.23	10982225
MESH:D000860	Anoxia	Oxygen	4.46	20872349
MESH:D001008	Anxiety Disorders	Valproic Acid	7.25	17497229
MESH:D001008	Anxiety Disorders	vinclozolin	7.25	19015723
MESH:D001014	Aortic Aneurysm	Indomethacin	4.28	10231640
MESH:D017544	Aortic Aneurysm, Abdominal	Indomethacin	4.29	10388637

AutismKB 2.0

Annotation Detail for GPX3

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics