AutismKB 2.0

Annotation Detail for GRB10


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Basic Information Top
Gene Symbol:GRB10 ( GRB-IR,Grb-10,IRBP,KIAA0207,MEG1,RSS )
Gene Full Name: growth factor receptor-bound protein 10
Band: 7p12.1
Quick LinksEntrez ID:2887; OMIM: 601523; Uniprot ID:GRB10_HUMAN; ENSEMBL ID: ENSG00000106070; HGNC ID: 4564
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by Insulin receptor
Pathway IDPathway Name
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
200012Insulin Pathway
200127PDGFR-beta signaling pathway
200084IGF1 pathway
200161Signaling events mediated by VEGFR1 and VEGFR2
200058Signaling events regulated by Ret tyrosine kinase
No data
Pathway IDPathway Name
500505Signal attenuation
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in increased expression of GRB10 mRNAincreases expression 17547211
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of GRB10 mRNAincreases expression 18648102
C075773 4-phenylbutyric acid 4-phenylbutyric acid results in increased expression of GRB10 mRNAincreases expression 14583596
C006632 arsenic trioxide arsenic trioxide results in increased expression of GRB10 mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GRB10 mRNAdecreases expression 20106945
20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GRB10 mRNAdecreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GRB10 mRNAaffects expression 17484886
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GRB10 mRNA]decreases reaction|increases expression 18200517
D016572 Cyclosporine Cyclosporine results in increased expression of GRB10 mRNAincreases expression 20106945
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of GRB10 mRNAincreases expression 17547211
C479799 (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide results in decreased expression of GRB10 mRNAdecreases expression 15528975
D004958 Estradiol Estradiol affects the expression of GRB10 mRNAaffects expression 14699072
D020849 Raloxifene Raloxifene affects the expression of GRB10 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in increased expression of GRB10 mRNAaffects cotreatment|increases expression 19059307
C017947 sodium arsenite sodium arsenite results in decreased expression of GRB10 mRNAdecreases expression 19072884
D018038 Sodium Selenite Sodium Selenite results in decreased expression of GRB10 mRNAdecreases expression 16705456
D013467 Sulindac Sulindac results in increased expression of GRB10 mRNAincreases expression 11906190
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in increased expression of GRB10 mRNAaffects cotreatment|increases expression 19059307
D013876 Thiophenes Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of GRB10 mRNA]decreases expression|increases reaction 16140955
D014212 Tretinoin Thiophenes analog promotes the reaction [Tretinoin results in decreased expression of GRB10 mRNA]decreases expression|increases reaction 16140955
D014212 Tretinoin Tretinoin results in decreased expression of GRB10 mRNAdecreases expression 16140955
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GRB10 mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of GRB10 mRNAincreases expression 18200517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 12.7514745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 12.7514745880
MESH:D058186 Acute Kidney Injury Sulindac 4.237897758
MESH:D000230 Adenocarcinoma arsenic trioxide 13.3411798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 13.3420127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 13.3416033868
MESH:D000230 Adenocarcinoma Estradiol 13.3411473722
MESH:D000230 Adenocarcinoma Sulindac 13.3411910360
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 15.623712494
MESH:D000236 Adenoma Benzo(a)pyrene 15.626695378
MESH:D000236 Adenoma Dimethylnitrosamine 15.6219555203
MESH:D000236 Adenoma Sulindac 15.6210223192
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.5219003578 11874996 15623613 11535846 16460482 12394442 17611924
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8217306315 16712894
MESH:D000419 Albuminuria Raloxifene 4.5117308373 17451421
MESH:D019973 Alcohol-Related Disorders Curcumin 5.0017887948
MESH:D000505 Alopecia Tretinoin 3.5415955085
MESH:D000544 Alzheimer Disease Curcumin 4.3715590663
MESH:D000544 Alzheimer Disease Raloxifene 4.3715800139
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.0216412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.6616807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.6616292516
MESH:D001249 Asthma Tretinoin 2.3216456186
MESH:D050197 Atherosclerosis Curcumin 3.2718704882
MESH:D001327 Autoimmune Diseases Curcumin 4.4019761891
MESH:D001471 Barrett Esophagus Tretinoin 4.3216935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.941440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.8916206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.8916197459 16206674
MESH:D001913 Bowen's Disease Sulindac 5.2711207687
MESH:D001930 Brain Injuries Raloxifene 4.3916580743
MESH:D002545 Brain Ischemia Curcumin 4.2516770732
MESH:D001932 Brain Neoplasms Curcumin 3.8617596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.6717474063 20146248
MESH:D001943 Breast Neoplasms Curcumin 4.6719250217 16243823 18593918 18462866
MESH:D001943 Breast Neoplasms (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide 4.6715528975
MESH:D001943 Breast Neoplasms Estradiol 4.6712948864 17261762 17289903 17018787 16675129 18497071 19861407 14630087
MESH:D001943 Breast Neoplasms Raloxifene 4.6716837676 15775269 17595753 17242785 15572757 17261762 16912660 17440819 17893378 17049068 17952589 15758505
MESH:D001943 Breast Neoplasms Sulindac 4.6716642371
MESH:D001943 Breast Neoplasms Tamoxifen 4.6717440819 16202921 19103187 18855134 18425577 19289846 19066611 18629630 17242785 19142967 17049068 18815881 19059307 11161223 20390343 19221464 18984771 19115204 19244106 19189212 18821012 20135344 16818667 19155303 21138602 19189210 19410462 15668708 19084267 15565566 21152245 18351453 17261762 19011961 19487384 20544844 20859285 17893378 19288272 19200415 16873071 18997820 20005174 20065188 16273361
MESH:D001943 Breast Neoplasms Tretinoin 4.6716443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5016813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2411589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6916192424 16227642 10355542 15700767 16097048 15673190 18705752 15721981 16124888 16011737 16050911 3786805
MESH:D002277 Carcinoma Curcumin 8.5018593918
MESH:D002277 Carcinoma Dimethylnitrosamine 8.5019555203
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4219066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0816168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.883581430 7296757
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.8811135700 14691202 15553829 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.8818788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.8816924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.8816507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.8816924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.881917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9518414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7919014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.637296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0412490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 14.0820419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 14.0818462866
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 14.0816033868
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 14.0818572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 14.0816096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.2317572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.2317572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.3815775269
MESH:D002386 Cataract Tretinoin 3.0417460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 20.447505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 20.4420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 20.4412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 20.4418566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 20.4420056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5016129372
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.6619486331 9022650
MESH:D002779 Cholestasis Cyclosporine 7.6619486331
MESH:D002822 Choriocarcinoma Tretinoin 5.0816461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6615894690
MESH:D002972 Cleft Palate Tretinoin 2.639407595
MESH:D003072 Cognition Disorders Raloxifene 4.5315800139
MESH:D003092 Colitis Curcumin 15.6516782535 16804969 18200517
MESH:D003092 Colitis Tretinoin 15.6517035595
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 15.6517936198 16804969 17991707 16474422 16867261 11698051 18023891 16782535 18200517
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.4117276891
MESH:D003103 Coloboma Curcumin 4.4718809619
MESH:D003110 Colonic Neoplasms Curcumin 4.1316340194 19359593
MESH:D003110 Colonic Neoplasms Sulindac 4.1312458338 12902858
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7820501625
MESH:D015179 Colorectal Neoplasms Sulindac 2.7811197048 18059344 10666051 11076880
MESH:D016510 Corneal Neovascularization Curcumin 4.8118497527
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.6510525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.659664655 10589399 9142499 16925845 9125849 17551590 14991402 8800419 9211117 9224671
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0115213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2819031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0817474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.728156756 11298694 18759878 2524372 12868966 8970840 14531868 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.412952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7016285004
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.6818403477
MESH:D003928 Diabetic Nephropathies Curcumin 20.8118204486
MESH:D003928 Diabetic Nephropathies Estradiol 20.8119279558
MESH:D003928 Diabetic Nephropathies Raloxifene 20.8117308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 20.8119279558
MESH:D003930 Diabetic Retinopathy Sulindac 5.0917621415 12861449
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.8218692083 1440618 18289764 9328219 8291058 16192314 9653073 9022650 18648102 7440962 6679447 6482804 11289319
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.8221278145 19085960 2869522 10915739 16227642 16177239 11566570 17522070 15998439 7440962 7120509 15968718 3732212 9327722 10092053 4309450 3786805 15027814 6623471 6884620 7179309 19336974
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 8.828172417
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 8.8215131321
MESH:D004381 Duodenal Ulcer Curcumin 3.9617351913
MESH:D004487 Edema Raloxifene 3.2615860553
MESH:D004489 Edema, Cardiac Tretinoin 4.3918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 8.9615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.9619031437
MESH:D016889 Endometrial Neoplasms Estradiol 12.0919148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.0916202921 19155303 20544844 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 12.0916569247
MESH:D004715 Endometriosis Sulindac 4.3915652904
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 17.193581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.1920426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 17.1912903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 17.1916530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 17.1917016578
MESH:D004938 Esophageal Neoplasms Sulindac 17.1912235107
MESH:D005124 Eye Abnormalities Tretinoin 3.519664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 29.6715073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 29.6715959796 17595544 12795759 16045604 12631006 16239168 61145 19224547
MESH:D005234 Fatty Liver Curcumin 29.6719297423
MESH:D005234 Fatty Liver Cyclosporine 29.6719224547
MESH:D005234 Fatty Liver Raloxifene 29.6717473493
MESH:D005234 Fatty Liver Tamoxifen 29.6714986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1816709447
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.946705139
MESH:D018221 Fibromatosis, Abdominal Sulindac 12.6714745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 12.6714745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 11.3519069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 11.3519069698
MESH:D005355 Fibrosis Carbon Tetrachloride 26.8518705752
MESH:D005355 Fibrosis Curcumin 26.8518705752
MESH:D005355 Fibrosis Cyclosporine 26.8512168785 12639820
MESH:D005355 Fibrosis Tretinoin 26.8517994277
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 26.8517994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1816904648
MESH:D005764 Gastroesophageal Reflux Sulindac 4.9211910360
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.6118462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5916452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D005909 Glioblastoma Curcumin 7.1017596214
MESH:D005909 Glioblastoma Tretinoin 7.1017312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.957505956
MESH:D006258 Head and Neck Neoplasms Curcumin 7.6918829502 18462866
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.6916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5020471113
MESH:D006330 Heart Defects, Congenital Tretinoin 6.5014991402 9664655
MESH:D006331 Heart Diseases Raloxifene 3.4711110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.946705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.9419900420 19110552
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.9517701891
MESH:D006558 Herpes Genitalis Estradiol 4.9515709030
MESH:D006689 Hodgkin Disease sodium arsenite 3.0812676792
MESH:D019584 Hot Flashes Estradiol 3.6717088409
MESH:D006930 Hyperalgesia Tretinoin 3.1416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4516899240
MESH:D006937 Hypercholesterolemia Curcumin 3.9718704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4816778211
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.8515034207
MESH:D006973 Hypertension Cyclosporine 5.1910903974
MESH:D006973 Hypertension Raloxifene 5.1915787275 17577099
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0015338365
MESH:D007248 Infertility, Male sodium arsenite 2.9315346721 12646999
MESH:D007249 Inflammation Curcumin 8.2718403477 16956363 17151092
MESH:D007249 Inflammation Sulindac 8.273291741
MESH:D007249 Inflammation Tamoxifen 8.2719457130
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.5718596194 18200517
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 6.5718200517
MESH:D007333 Insulin Resistance Estradiol 7.2416627594 16393666
MESH:D007333 Insulin Resistance Sodium Selenite 7.2414714311
MESH:D007410 Intestinal Diseases Tretinoin 9.7017994277
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 9.7017994277
MESH:D007414 Intestinal Neoplasms Curcumin 9.8510783313
MESH:D007414 Intestinal Neoplasms Sulindac 9.8512663524 12584176 10223192 10213222 12628509 12351151
MESH:D007417 Intestinal Polyps Sulindac 4.9011245490 12394442
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.949022650 8074119
MESH:D007569 Jaw Abnormalities Tretinoin 3.8217551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007674 Kidney Diseases Cyclosporine 9.7618776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 9.7615618244
MESH:D007674 Kidney Diseases sodium arsenite 9.7620008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 17.136582329
MESH:D007680 Kidney Neoplasms Cyclosporine 17.1312371664
MESH:D007680 Kidney Neoplasms Estradiol 17.1315610895
MESH:D007680 Kidney Neoplasms Tamoxifen 17.1318625569
MESH:D007889 Leiomyoma Curcumin 10.8718555241
MESH:D007889 Leiomyoma Raloxifene 10.8716973256
MESH:D007938 Leukemia arsenic trioxide 10.2815070760
MESH:D007938 Leukemia Curcumin 10.2818462866
MESH:D007938 Leukemia Tretinoin 10.2817143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.4912560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 9.4916106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.2019077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.2016482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.8316467208 17050201 19850784 20471514 16968895
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8319850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 12.6217649720 12679006 9834237 12018890 17107899 16891316 11468182 17217047 19075265 16330433 19035177 11161223 16112521 16966277 16823087 17869043 17712046 15336539 16331271 15213294 15748426 19225113 19642359 15622746 12712474
MESH:D015473 Leukemia, Promyelocytic, Acute Thiophenes 12.6216140954 16140955
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 12.6217339181 16140955 19642359 15748426 17107899 17368321 17217047 16935935 16788101 16331271 19035177 12679006 17649720 19075265 17712046 16766008 9834237 17506722 17361223 17301526 16891316 19225113 16823087 19029980 17294898
MESH:D015458 Leukemia, T-Cell arsenic trioxide 11.4316882451
MESH:D015458 Leukemia, T-Cell Curcumin 11.4316106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.249224671
MESH:D008064 Lipidoses Tamoxifen 3.0917567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7616943688 11408273 17157831 21278145 16239168 11903743 16221502 17334410 17174718
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 8.3215034207 9327722
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 8.3212468960
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.6112898905 16027843 12632514 15052691 16192424 18279442 15370692 17721639 18251166 10355542 12546737 17944888 18006644 15362042 17481882 17766677 14620537 12609069 17761835 12741479 14512876 15057751 14716496 18705752 18472332 18420326 18472094 16033810 18395914 18205269 17805973 15123356 15931870 18395095 15925388 13678700 17714472 16097048 14748882 18187930 18277467 18339082 15730626 11481614 17708605 17900296 18376398 15876570 16248980 14716833 17631135 12445421 12389079 17640975 12445418 18166357 15338365 12667390 17869086 14724832 17557913 17525996 16638106 18481824 17922224 12586293 15673190 15996030 18210741 18418968 18412020 20821823 16136751 18156304 17698563 12958196 12649538 18429990 15818738 15650968 16015684 18054572 17823541 18263696 12632512 15959796 12666154 18317297 17976157 16116963 17565644 15893842 16011737
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 8.6117355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 8.6116169303 18364076 16009107 15086199 17534399 18672772 14568256 14709902 16627068 15864749 15591649 14659978 16570917 17036385 17724770 15733078 18239293 15942678 15383259 18237412 16603200 12918455 15161499 16544323 15571005 18210741 15577212 17640959 15723089 17348192 15798949 17465448 14726149 17666798 17201889 15138612 17203207 15369754 17198567 15298665 18629640 15842777 15793283 17719030 18567088 18095165 18637143 15339415 15504291 15067225 15744066 15492853 17196135 17432682 18371158 14643895 15479170 16042886 17881167 15099470 16270385 12925901 15366600 15763062 15081153
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.6114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.6118564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.6116248980 18397230
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.6015830285 16246199 15720792 17285989 16964402
MESH:D008107 Liver Diseases Curcumin 6.6016956363
MESH:D008107 Liver Diseases Sulindac 6.6014986274 16867024
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.5714706259 16899240
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 9.5717457977
MESH:D008113 Liver Neoplasms arsenic trioxide 17.5614682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.5620195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.5619294768
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 17.563113478 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 17.5615276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 17.5616684651
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.716587162 598648 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 13.7120377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.7112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 13.711848544 15603536 6150874
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2815213294
MESH:D008171 Lung Diseases sodium arsenite 3.1119095001
MESH:D008175 Lung Neoplasms arsenic trioxide 12.8319825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 12.8320064080 20464547 17053015 18816296 20869020 18569708 20135361 18520028 6695378
MESH:D008175 Lung Neoplasms Curcumin 12.8318462866 19359593 16243823
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 12.8311884234 16061637 19555203
MESH:D008175 Lung Neoplasms (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide 12.8315528975
MESH:D008175 Lung Neoplasms sodium arsenite 12.8319931552 16712894 15276417 17306315 17077188
MESH:D008175 Lung Neoplasms Sulindac 12.8315713900 19359593
MESH:D008175 Lung Neoplasms Tamoxifen 12.8318625569
MESH:D008223 Lymphoma Curcumin 3.5218462866
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.9714737004
MESH:D016399 Lymphoma, T-Cell Curcumin 4.6116173963
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6719428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.7816891317 11807958 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.7819196722 11731420 19196723 16827153 14580682
MESH:D020149 Manganese Poisoning Estradiol 12.3819453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.3819453300
MESH:D008527 Medulloblastoma Tretinoin 2.7517453147
MESH:D008545 Melanoma Curcumin 9.6517885582 18462866
MESH:D008545 Melanoma sodium arsenite 9.6519082730 16487513
MESH:D008545 Melanoma Sulindac 9.6516642371
MESH:D008545 Melanoma Tamoxifen 9.6512393984 19393235
MESH:D008545 Melanoma Tretinoin 9.6516752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1015990972
MESH:D008569 Memory Disorders Curcumin 4.0717263510
MESH:D008591 Meningomyelocele Tretinoin 4.3416940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.4715863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1216381670
MESH:D009101 Multiple Myeloma arsenic trioxide 11.8319417148 14977855 15949261 19549372 11468182
MESH:D009101 Multiple Myeloma Curcumin 11.8319372569
MESH:D009101 Multiple Myeloma Raloxifene 11.8316497877
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.8317962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.2216105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.2217596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2116810080
MESH:D009232 Myxoma Raloxifene 5.4716343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 10.0416624393
MESH:D009361 Neoplasm Invasiveness Curcumin 10.0418495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.583581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.5819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009369 Neoplasms 4-phenylbutyric acid 11.5719116145
MESH:D009369 Neoplasms Benzo(a)pyrene 11.5711141357
MESH:D009369 Neoplasms sodium arsenite 11.5711559025
MESH:D009369 Neoplasms Tretinoin 11.5716946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5820056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 10.5712497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.5719189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2118481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 9.3911399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 9.399125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.5518462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 16.856679447
MESH:D009436 Neural Tube Defects arsenic trioxide 16.8510525206
MESH:D009436 Neural Tube Defects sodium arsenite 16.8512854658
MESH:D009436 Neural Tube Defects Tretinoin 16.859142499
MESH:D019636 Neurodegenerative Diseases Sulindac 4.2017266991 16850258
MESH:D009765 Obesity Curcumin 2.7319297423
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.344026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.943988306
MESH:D010024 Osteoporosis Curcumin 7.2318719352
MESH:D010024 Osteoporosis Raloxifene 7.2317882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.1417823083 15579764 17893378 15758505
MESH:D010051 Ovarian Neoplasms arsenic trioxide 18.5316624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Curcumin 18.5319020741 18462866
MESH:D010051 Ovarian Neoplasms (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide 18.5315528975
MESH:D010051 Ovarian Neoplasms Estradiol 18.5319401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 18.5317306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 18.5316936753
MESH:D010146 Pain Sulindac 6.863291741
MESH:D010146 Pain Tretinoin 6.8616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 12.1415580305
MESH:D010190 Pancreatic Neoplasms Curcumin 12.1419401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Sulindac 12.1411504793 16820089
MESH:D010190 Pancreatic Neoplasms Tretinoin 12.1415976015
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.1217698068
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.407296757
MESH:D010235 Paraganglioma arsenic trioxide 4.0819927285
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.396228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.1412371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8020887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.4519131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4517292933
MESH:D011471 Prostatic Neoplasms Curcumin 2.4511398177 18769126 15129424 10851300 18156803 18226269 12497104
MESH:D011471 Prostatic Neoplasms Estradiol 2.4516740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.4516220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.4516039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.4518760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4515067354
MESH:D011507 Proteinuria Tretinoin 3.5216636307
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D011625 Pterygium Tretinoin 4.7116723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.4519168576
MESH:D011693 Purpura Raloxifene 5.4715770314
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.9418379247 10666014
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.313692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0216283617 16116481
MESH:D012509 Sarcoma Curcumin 4.0418462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8716646077
MESH:D018805 Sepsis Curcumin 4.0018389075
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.2310029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 9.2319524636 18572023
MESH:D012878 Skin Neoplasms Tretinoin 9.2316467112
MESH:D013088 Spermatocele Tamoxifen 4.2116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9519457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7312854658
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.1912587719
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.6717007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.6720155912 2093021
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 4.6716033868
MESH:D013274 Stomach Neoplasms Tretinoin 4.6717261132
MESH:D013276 Stomach Ulcer Curcumin 3.4219188055 16631530
MESH:D020521 Stroke Raloxifene 3.7516837676
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.571399818 6582329 3712494 7505956 6587162
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.5719014326
MESH:D013964 Thyroid Neoplasms Tretinoin 11.5717045167 16026305
MESH:D013978 Tibial Fractures Estradiol 13.4419048282
MESH:D013978 Tibial Fractures Raloxifene 13.4419048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.7116051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8815213294
MESH:D014376 Tuberculosis Tretinoin 3.1716040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 23.638074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 23.6311780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 23.6317053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 23.6318593936
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 23.6317572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 23.6316712894 16452187 17306315 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 23.6316712894 8653321 17572228
MESH:D014565 Urogenital Neoplasms Curcumin 5.1818462866
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.1511813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.1516129372
MESH:D014594 Uterine Neoplasms Sulindac 4.5118645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.5316752155
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D014652 Vascular Diseases sodium arsenite 4.3417056641
MESH:D054556 Venous Thromboembolism Raloxifene 5.1316837676
MESH:D014820 Vitiligo Tretinoin 3.9716761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.4716343187
MESH:D009396 Wilms Tumor Tretinoin 3.8916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
Pathway ID Pathway Name
REACT:498 Signaling by Insulin receptor
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28960
    • No data
    No data
    Releated drug ID Related drug Name
    PA10804imatinib
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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