AutismKB 2.0

Annotation Detail for GRIA2


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Basic Information Top
Gene Symbol:GRIA2 ( GLUR2,GLURB,GluA2,GluR-K2,HBGR2 )
Gene Full Name: glutamate receptor, ionotropic, AMPA 2
Band: 4q32.1
Quick LinksEntrez ID:2891; OMIM: 138247; Uniprot ID:GRIA2_HUMAN; ENSEMBL ID: ENSG00000120251; HGNC ID: 4572
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04720Long-term potentiation
hsa04080Neuroactive ligand-receptor interaction
hsa04730Long-term depression
hsa05014Amyotrophic lateral sclerosis (ALS)
Pathway IDPathway Name
Synaptic Transmission
Pathway IDPathway Name
200180N-cadherin signaling events
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00037Ionotropic glutamate receptor pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRIA2 mRNAaffects expression 16483693
D000661 Amphetamine Amphetamine affects the expression of GRIA2 mRNA alternative formaffects expression 15784965
C025657 arsenic acid arsenic acid analog results in decreased expression of GRIA2 mRNAdecreases expression 19761793
D020185 Benzoic Acids Benzoic Acids analog binds to and results in decreased activity of GRIA2 proteinaffects binding|decreases activity 14667236
D001761 Bleomycin Bleomycin results in decreased expression of GRIA2 mRNAdecreases expression 15808516
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of GRIA2 mRNAdecreases expression 19440498
D003024 Clozapine Clozapine results in increased expression of GRIA2 mRNAincreases expression 17141476
D003976 Diazinon Diazinon results in decreased expression of GRIA2 mRNAdecreases expression 19440498
17452286
D004026 Dieldrin Dieldrin results in decreased expression of GRIA2 mRNAdecreases expression 19440498
D006220 Haloperidol Haloperidol results in increased expression of GRIA2 mRNAincreases expression 17141476
D016627 Oxidopamine Oxidopamine results in decreased expression of GRIA2 mRNAdecreases expression 11290405
D007608 Kainic Acid GRIA2 protein affects the susceptibility to Kainic Acidaffects response to substance 10551584
D007608 Kainic Acid Kainic Acid binds to and results in increased activity of GRIA2 proteinaffects binding|increases activity 11812690
D007608 Kainic Acid Urethane inhibits the reaction [Kainic Acid binds to and results in increased activity of GRIA2 protein]affects binding|decreases reaction|increases activity 11812690
D007657 Ketone Bodies Ketone Bodies results in increased expression of GRIA2 mRNAincreases expression 16807920
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GRIA2 mRNAincreases expression 19285098
C076029 olanzapine olanzapine results in increased expression of GRIA2 mRNAincreases expression 11526992
D010424 Pentobarbital GRIA2 protein affects the susceptibility to Pentobarbitalaffects response to substance 10551584
D010634 Phenobarbital GRIA2 protein affects the susceptibility to Phenobarbitalaffects response to substance 10551584
D010862 Pilocarpine Pilocarpine results in increased expression of GRIA2 proteinincreases expression 15857427
D012643 Selenium Selenium results in decreased expression of GRIA2 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GRIA2 mRNAincreases expression 16922920
D013874 Thiopental GRIA2 protein affects the susceptibility to Thiopentalaffects response to substance 10551584
D024505 Tocopherols Tocopherols results in increased expression of GRIA2 mRNAincreases expression 17654050
D014212 Tretinoin Tretinoin results in decreased expression of GRIA2 mRNAdecreases expression 16604517
D014520 Urethane Urethane inhibits the reaction [Kainic Acid binds to and results in increased activity of GRIA2 protein]affects binding|decreases reaction|increases activity 11812690
C025643 vinclozolin vinclozolin affects the expression of GRIA2 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in decreased expression of GRIA2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.596195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5915322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D055371 Acute Lung Injury Bleomycin 4.6917118201
MESH:D000230 Adenocarcinoma Urethane 3.2718316556
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 5.5015814487
MESH:D000236 Adenoma Urethane 3.8710530776 10822126 17195641 6695378 17093202 16926031 11497255
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.3817620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3816835633
MESH:D000380 Agranulocytosis Clozapine 4.8516160616 12649775 14617031
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 8.4711874814 16611668 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 8.4716487989
MESH:D000505 Alopecia Tretinoin 3.4515955085
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.8516916582 18475255 15010207 16459022
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D000855 Anorexia Amphetamine 10.0516101753 12005258 12183048 16084549
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 10.0515146954
MESH:D000860 Anoxia Bleomycin 5.2015782499
MESH:D001008 Anxiety Disorders Pentobarbital 8.7318313124 11141031
MESH:D001008 Anxiety Disorders vinclozolin 8.7319015723
MESH:D001169 Arthritis, Experimental Tretinoin 2.9516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2216292516
MESH:D001249 Asthma Tretinoin 2.2816456186
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 4.5114699433
MESH:D001321 Autistic Disorder Haloperidol 2.8419368416 18080171
MESH:D001321 Autistic Disorder olanzapine 2.8417069543 18685284
MESH:D001471 Barrett Esophagus Tretinoin 4.2016935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.3116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D001943 Breast Neoplasms Dieldrin 1.9915770527 11859874
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9920435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9916873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3816813970
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.7216050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9516168501
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 2.9620007298 17173139 1701930 6705139 20935162
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 2.961917145
MESH:D002294 Carcinoma, Squamous Cell Bleomycin 4.936189445
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.9316096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2518850075 18670907 16120746
MESH:D002375 Catalepsy Haloperidol 4.701977408 15215559
MESH:D002386 Cataract Tretinoin 2.9717460283
MESH:D002389 Catatonia olanzapine 6.0418071103 16772815
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.044080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002822 Choriocarcinoma Tretinoin 4.9516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.4112621046 15668235 16354765 15340226 8697196
MESH:D002972 Cleft Palate Tretinoin 9.419407595
MESH:D002972 Cleft Palate Urethane 9.4112810352
MESH:D003072 Cognition Disorders Clozapine 4.7617123785
MESH:D003092 Colitis Selenium 8.8117936198
MESH:D003092 Colitis Tretinoin 8.8117035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6315322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.6310589399 14991402 17551590 9664655 9125849 8800419 9211117 9224671 9142499 16925845
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.6319769572
MESH:D003456 Cryptorchidism vinclozolin 4.1414966744
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.6520210726
MESH:D003704 Dementia Haloperidol 4.3911575062
MESH:D002658 Developmental Disabilities olanzapine 4.5517069543
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.3316402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3317107852
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.3415331141
MESH:D056486 Drug-Induced Liver Injury Selenium 3.5715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5720420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6111462148
MESH:D050171 Dyslipidemias Clozapine 4.0316402076
MESH:D004417 Dyspnea Diazinon 4.5916487989
MESH:D004421 Dystonia Phenobarbital 3.811851702
MESH:C538011 Eales disease Vitamin E 4.499068938
MESH:D004487 Edema Bleomycin 6.5717118201
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.2318230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.2318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8410568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.903659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.663922381 11558140
MESH:D004827 Epilepsy Phenobarbital 6.9420417680
MESH:D004827 Epilepsy Pilocarpine 6.9419439326 19700373 11162239
MESH:D004832 Epilepsy, Absence Phenobarbital 3.376401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.047750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.813659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.3216938888 9664655
MESH:D005221 Fatigue Amphetamine 5.3919890266
MESH:D005234 Fatty Liver arsenic acid 4.8918296743
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005355 Fibrosis arsenic acid 13.8218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.8220067830
MESH:D005355 Fibrosis Tretinoin 13.8217994277
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7216973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0916417039
MESH:D005909 Glioblastoma Tretinoin 2.8717312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9516084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.5011294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.5014991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 10.5016080930
MESH:D006331 Heart Diseases Urethane 4.1016046796
MESH:D006333 Heart Failure Selenium 2.9517162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006505 Hepatitis Diazinon 4.3716487989
MESH:D006529 Hepatomegaly Phenobarbital 7.7516109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7512621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6316490937 16863852
MESH:D006689 Hodgkin Disease Bleomycin 4.2015147373 18501091 17606976
MESH:D019584 Hot Flashes Vitamin E 3.7614716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8316959395 15340226 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.0516870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3616778211
MESH:D006948 Hyperkinesis Amphetamine 11.101977408 14960337
MESH:D006948 Hyperkinesis Clozapine 11.1016046005
MESH:D006963 Hyperphagia olanzapine 6.0217933447
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8318850075 18670907
MESH:D007247 Infertility, Female Dieldrin 4.7410630421
MESH:D007248 Infertility, Male Diazinon 6.6912948887 16466525
MESH:D007248 Infertility, Male vinclozolin 6.6916467254
MESH:D007249 Inflammation Bleomycin 5.0317118201
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.0312878042 12200463
MESH:D007251 Influenza, Human Selenium 10.2516624496
MESH:D007251 Influenza, Human Vitamin E 10.2516624496
MESH:D007410 Intestinal Diseases Tretinoin 3.5617994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3015992940 17551590
MESH:D007674 Kidney Diseases Vitamin E 2.6912488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.7016518626
MESH:D007938 Leukemia Tretinoin 2.6717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5116932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0419850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0219225113 16766008 16891316 16788101 19029980 17649720 12679006 19075265 16935935 17294898 16140955 16331271 15748426 17712046 17301526 17361223 17217047 17107899 17368321 19642359 17506722 17339181 9834237 19035177 16823087
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5216417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.169224671
MESH:D008064 Lipidoses Clozapine 3.8117567588
MESH:D008103 Liver Cirrhosis arsenic acid 6.9618296743
MESH:D008103 Liver Cirrhosis Phenobarbital 6.9621047994
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.3316248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.3316169303
MESH:D008107 Liver Diseases Chlorpyrifos 4.2815991261
MESH:D008107 Liver Diseases Phenobarbital 4.2819363144
MESH:D008113 Liver Neoplasms Dieldrin 10.149539021 8742319
MESH:D008113 Liver Neoplasms Phenobarbital 10.1419812893 19073162 8742319 15975961 19482888 21047994
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.1416984957
MESH:D008113 Liver Neoplasms Urethane 10.1417093202 17559639 16391232
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 5.366150874 17172636 18308698 1399818 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.3612151625
MESH:D008133 Long QT Syndrome olanzapine 4.5720210726
MESH:D008171 Lung Diseases Vitamin E 3.0416863852
MESH:D008175 Lung Neoplasms Bleomycin 4.756189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7519555203 11884234
MESH:D008175 Lung Neoplasms Urethane 4.7512957351 16007126 16204055 17093202 11807781 11552296 12765245 11062179 10997738 16926031 15902970 14587096 12466968 15136453 10822126 16788158 6695378 11497255 17255336 16337739 11544531 17195641 11992545 7750092 16289808 11246140 15166089 11074608 10779650 16391232 11893704 11323394 12117781 10530776 11307925
MESH:D008175 Lung Neoplasms Vitamin E 4.7511062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.1415318939
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 6.1417927505
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Bleomycin 3.6715577320
MESH:D008545 Melanoma Tretinoin 3.6716752155
MESH:D008591 Meningomyelocele Tretinoin 4.2216940565
MESH:D001523 Mental Disorders Clozapine 12.2316856516
MESH:D001523 Mental Disorders Haloperidol 12.2316856516
MESH:D001523 Mental Disorders olanzapine 12.2316856516
MESH:D008654 Mesothelioma Selenium 6.4015107826
MESH:D008654 Mesothelioma Tocopherols 6.4015878867
MESH:D008659 Metabolic Diseases olanzapine 5.2019142110
MESH:D024821 Metabolic Syndrome X Clozapine 4.2419142101
MESH:D009175 Mycoplasma Infections Thiopental 6.4210773494
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9617596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2617484760
MESH:D009369 Neoplasms Dieldrin 7.988820588
MESH:D009369 Neoplasms Tretinoin 7.9816594593 16946489
MESH:D009369 Neoplasms Urethane 7.9815625555
MESH:D009374 Neoplasms, Experimental Urethane 4.4715582191
MESH:D009421 Nervous System Malformations Pilocarpine 15.4215987249
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.4214600291
MESH:D009421 Nervous System Malformations Tretinoin 15.429125849
MESH:D009436 Neural Tube Defects Tretinoin 2.929142499
MESH:D019636 Neurodegenerative Diseases Amphetamine 8.7915183010
MESH:D019636 Neurodegenerative Diseases Oxidopamine 8.7918514411
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.0315081274
MESH:D009765 Obesity Clozapine 5.2218515891 19142110
MESH:D009765 Obesity olanzapine 5.2218515891
MESH:D010018 Osteomalacia Phenobarbital 4.1517016548
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0316936753
MESH:D010051 Ovarian Neoplasms Urethane 5.0316391232
MESH:D010146 Pain Tretinoin 2.7416870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.0216965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.0215976015
MESH:D010300 Parkinson Disease Dieldrin 3.4516809432 11181820 11445065 16112328 17291500
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 5.2515893579 11771942
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010911 Pituitary Neoplasms Urethane 5.2116391232
MESH:D010954 Plasmacytoma Selenium 4.6815087411
MESH:D011014 Pneumonia Bleomycin 5.2018024389 17071938 16317386
MESH:D011041 Poisoning Diazinon 4.1617603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.452563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.7911896295 11118676 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.7918042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.7218220299
MESH:D011471 Prostatic Neoplasms Tocopherols 3.8612504091
MESH:D011471 Prostatic Neoplasms Vitamin E 3.8615084515
MESH:D011472 Prostatitis vinclozolin 4.7218629315
MESH:D011507 Proteinuria Tretinoin 3.4116636307
MESH:D019310 Pseudolymphoma Phenobarbital 4.2812752131
MESH:D011595 Psychomotor Agitation Haloperidol 11.1211575062
MESH:D011595 Psychomotor Agitation olanzapine 11.1218685284
MESH:D011618 Psychotic Disorders Clozapine 8.6615331141
MESH:D011618 Psychotic Disorders Haloperidol 8.6611575062
MESH:D011625 Pterygium Tretinoin 4.5816723453
MESH:D011654 Pulmonary Edema Bleomycin 5.1015808516
MESH:D011658 Pulmonary Fibrosis Bleomycin 3.7915322207 11554783 17177178 15541506 21435439 14609568 17434272 16115399 18162602 18008008 16314464 17241526 12624602 12574379
MESH:D012021 Reflex, Abnormal Pentobarbital 5.8110930210
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.4316611668 17119214 11874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.6816611668 17119214
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9016116481 16283617
MESH:D012559 Schizophrenia Clozapine 5.7017123785 11763009 19369910 20107430 17667964 20521326 20168265 20452607 16141801 17726453 20521320 20580759 11151749 18855531 18806925
MESH:D012559 Schizophrenia Haloperidol 5.7018513383 19369910 20107430 1830565
MESH:D012559 Schizophrenia olanzapine 5.7020521326 20107430 17726453
MESH:D012640 Seizures Kainic Acid 13.1618657176 1641125 10686065 16336964 14637104 17827730 15686955 19414003 19186208
MESH:D012640 Seizures Pentobarbital 13.169754883 10087439
MESH:D012640 Seizures Phenobarbital 13.163137016 16876388 4039156 11442880
MESH:D012640 Seizures Pilocarpine 13.1619660546 7750514
MESH:D003294 Seizures, Febrile Phenobarbital 4.616407741
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.886418539
MESH:D012871 Skin Diseases Vitamin E 2.3918709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.9916192470
MESH:D012878 Skin Neoplasms Tretinoin 8.9916467112
MESH:D012878 Skin Neoplasms Urethane 8.9911807781
MESH:D012893 Sleep Disorders Kainic Acid 5.4919414003
MESH:D013226 Status Epilepticus Pilocarpine 6.0519430551 19951488 15857427 11259499 19570321 15987249 19055492
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.211977408
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D020521 Stroke Vitamin E 3.3616517955
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 4.799754883 11529278
MESH:D017180 Tachycardia, Ventricular Haloperidol 10.2820210726
MESH:D017180 Tachycardia, Ventricular olanzapine 10.2820210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.671399818
MESH:D013964 Thyroid Neoplasms Tretinoin 6.6717045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.6016051514
MESH:D014202 Tremor Pilocarpine 5.5917594079
MESH:D014376 Tuberculosis Tretinoin 3.1016040207
MESH:D014570 Urologic Diseases Diazinon 5.0616487989
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4916129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.4016752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D019043 Vascular Neoplasms Urethane 5.7010620525
MESH:D014820 Vitiligo Tretinoin 3.8516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D015430 Weight Gain Clozapine 9.7616402076 20107430 20564506 17502770 20521320 16141801
MESH:D015430 Weight Gain olanzapine 9.7619434072 17933447 20107430
MESH:D015431 Weight Loss Bleomycin 11.7212624602
MESH:D015431 Weight Loss Clozapine 11.7217933447
MESH:D009396 Wilms Tumor Tretinoin 3.7916287080
Pathway ID Pathway Name
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
KEGG:04724 Glutamatergic synapse
KEGG:04730 Long-term depression
KEGG:04720 Long-term potentiation
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28967
    • No data
    Releated disease ID Related disease Name
    PA447199Bipolar Disorder
    PA447216Schizophrenia
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00237 antagonist Butabarbital Anti-anxiety Agents;Hypnotics and Sedatives;Barbiturates
    DB00241 antagonist Trianal-C 1/2 Capsule Analgesics
    DB00306 antagonist Talbutal Analgesics
    DB00312 antagonist Cafergot PB Tab Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Barbiturates
    DB00418 antagonist Secobarbital Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Barbiturates;Adjuvants
    DB00463 antagonist Metharbital Anticonvulsants
    DB00599 antagonist Thiotal 5g Hypnotics and Sedatives;Anticonvulsants;GABA Modulators;Anesthetics, Intravenous
    DB00794 antagonist Primidone Anticonvulsants;Barbiturates
    DB00849 antagonist Methylphenobarbital Hypnotics and Sedatives;Anticonvulsants;GABA Modulators
    DB01174 antagonist Phenobarbital Hypnotics and Sedatives;Anticonvulsants;GABA Modulators;Excitatory Amino Acid Antagonists
    DB01346 antagonist Quinidine barbiturate
    DB01351 antagonist Amobarbital Hypnotics and Sedatives;GABA Modulators
    DB01352 antagonist Aprobarbital
    DB01353 antagonist Butethal Anti-anxiety Agents;Hypnotics and Sedatives;Barbiturates
    DB01354 antagonist Heptabarbital Hypnotics and Sedatives;Barbiturates
    DB01355 antagonist Hexobarbital Hypnotics and Sedatives;GABA Modulators;Barbiturates;Adjuvants
    DB01483 antagonist Barbital Hypnotics and Sedatives;GABA Modulators
    DB01496 antagonist Barbituric acid derivative
    DB01664 - (S)-Des-Me-Ampa
    DB02057 - AMPA
    DB02347 - 2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic Acid
    DB02818 - Iodo-Willardiine
    DB02966 - Fluoro-Willardiine
    DB02999 - Quisqualate Excitatory Amino Acid Agonists
    DB03240 - (S)-2-Amino-3-(1,3,5,7-Pentahydro-2,4-Dioxo-Cyclopenta[E]Pyrimidin-1-Yl) Proionic Acid
    DB03319 - (S)-ATPA
    DB03759 - Dnqx Excitatory Amino Acid Antagonists
    DB04000 - Bromo-Willardiine
    DB04129 - Willardiine
    DB04152 - 2-Amino-3-(3-Hydroxy-7,8-Dihydro-6h-Cyclohepta[D]-4-Isoxazolyl)Propionic Acid
    DB04184 - Acetate Ion Indicators and Reagents
    DB04599 - Aniracetam Nootropic Agents;Antidepressive Agents
    DB04798 - THIO-ATPA
    DB07455 - N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dimethanesulfonamide
    DB07598 - 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE
    DB08303 - (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
    DB08304 - (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide
    DB08305 - (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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