AutismKB 2.0

Annotation Detail for GRIA3


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Basic Information Top
Gene Symbol:GRIA3 ( GLUR-C,GLUR-K3,GLUR3,GLURC,GluA3,MRX94 )
Gene Full Name: glutamate receptor, ionotrophic, AMPA 3
Band: Xq25
Quick LinksEntrez ID:2892; OMIM: 305915; Uniprot ID:GRIA3_HUMAN; ENSEMBL ID: ENSG00000125675; HGNC ID: 4573
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04730Long-term depression
Pathway IDPathway Name
Synaptic Transmission
No data
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00037Ionotropic glutamate receptor pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
Citalopram/adverse effects*
REPRODUCTION
No data
Desease Name
Mental retardation, X-linked 94
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C012277 1,2-diamino-4-nitrobenzene 1,2-diamino-4-nitrobenzene results in decreased expression of GRIA3 mRNAdecreases expression 17070881
C036260 1-hexanol 1-hexanol results in decreased activity of GRIA3 proteindecreases activity 11429388
C035314 1-nitropropane 1-nitropropane results in decreased expression of GRIA3 mRNAdecreases expression 17070881
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of GRIA3 mRNAincreases expression 17070881
C025235 2,6-diaminotoluene 2,6-diaminotoluene results in decreased expression of GRIA3 mRNAdecreases expression 17070881
C014706 2-nitro-4-phenylenediamine 2-nitro-4-phenylenediamine results in increased expression of GRIA3 mRNAincreases expression 17070881
C016617 2-nitropropane 2-nitropropane results in increased expression of GRIA3 mRNAincreases expression 17070881
C028676 4-acetylaminofluorene 4-acetylaminofluorene results in decreased expression of GRIA3 mRNAdecreases expression 17070881
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRIA3 mRNAaffects expression 16483693
D020185 Benzoic Acids Benzoic Acids analog binds to and results in decreased activity of GRIA3 proteinaffects binding|decreases activity 14667236
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of GRIA3 mRNAincreases expression 20106945
D020001 1-Butanol 1-Butanol results in decreased activity of GRIA3 proteindecreases activity 11429388
D004390 Chlorpyrifos Chlorpyrifos affects the expression of GRIA3 mRNAaffects expression 19440498
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of GRIA3 mRNAincreases expression 17452286
D003024 Clozapine Clozapine results in increased expression of GRIA3 mRNAincreases expression 17141476
D000431 Ethanol Ethanol results in decreased activity of GRIA3 proteindecreases activity 11429388
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of GRIA3 mRNAincreases expression 17070881
D000432 Methanol Methanol results in decreased activity of GRIA3 proteindecreases activity 11429388
D009020 Morphine Morphine results in decreased expression of GRIA3 mRNAdecreases expression 15183518
C024999 n-pentanol n-pentanol results in decreased activity of GRIA3 proteindecreases activity 11429388
C076029 olanzapine olanzapine results in increased expression of GRIA3 mRNAincreases expression 11526992
D010862 Pilocarpine Pilocarpine results in increased expression of GRIA3 proteinincreases expression 15857427
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GRIA3 mRNAaffects binding|decreases expression|increases activity 19710929
D000433 1-Propanol 1-Propanol results in decreased activity of GRIA3 proteindecreases activity 11429388
C025643 vinclozolin vinclozolin affects the expression of GRIA3 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 3.7518926900 17676605
MESH:D000138 Acidosis Ammonium Chloride 9.8918287403
MESH:D000138 Acidosis Ethanol 9.8911192467
MESH:D055371 Acute Lung Injury pirinixic acid 2.9618653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9420127859 20464547
MESH:D000236 Adenoma 2-Acetylaminofluorene 6.6310737359
MESH:D000236 Adenoma Benzo(a)pyrene 6.636695378
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.846705139
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.3116434500
MESH:D000380 Agranulocytosis Clozapine 4.8814617031 16160616 12649775
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 4.1711874814 16611668 17119214
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.1515451040 15451039
MESH:D000853 Anophthalmos Ethanol 4.6515513904
MESH:D001008 Anxiety Disorders Ethanol 8.5611141031
MESH:D001008 Anxiety Disorders vinclozolin 8.5619015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9019183758
MESH:D001259 Ataxia 1-Butanol 5.427820390
MESH:D001321 Autistic Disorder olanzapine 3.3818685284 17069543
MESH:D001778 Blood Coagulation Disorders pirinixic acid 2.9919483382
MESH:D002545 Brain Ischemia Morphine 4.9719211983
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.4611921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4617474063 20146248
MESH:D002056 Burns Ethanol 4.4816374292
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 3.473581430 3084413 10737359 17761372 6705139
MESH:D006528 Carcinoma, Hepatocellular Ethanol 3.4715289165 15763234 18788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0020419170
MESH:D006332 Cardiomegaly Ethanol 3.3419332462
MESH:D002389 Catatonia olanzapine 6.0818071103 16772815
MESH:D002779 Cholestasis pirinixic acid 2.7019176532
MESH:D002971 Cleft Lip Ethanol 3.5015513904
MESH:D002972 Cleft Palate Ethanol 6.7415513904
MESH:D002972 Cleft Palate Methanol 6.748946559
MESH:D003072 Cognition Disorders Clozapine 4.7917123785
MESH:D019465 Craniofacial Abnormalities Ethanol 3.6115451039 15513904 19302082 11873399 11198716 10194807 15451040
MESH:D019465 Craniofacial Abnormalities Methanol 3.6115108243
MESH:D003456 Cryptorchidism vinclozolin 4.1714966744
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3518249437
MESH:D002658 Developmental Disabilities olanzapine 4.5817069543
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.9316402076
MESH:D003967 Diarrhea Morphine 4.362540324
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.3815331141
MESH:D056486 Drug-Induced Liver Injury 2-nitropropane 4.5520517888 16445897 15804453
MESH:D056486 Drug-Induced Liver Injury Ethanol 4.5511566570
MESH:D050171 Dyslipidemias Clozapine 4.0616402076
MESH:D004487 Edema pirinixic acid 2.3312083418
MESH:D004827 Epilepsy Pilocarpine 4.5719439326 11162239 19700373
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4516530937
MESH:D004938 Esophageal Neoplasms Ethanol 4.4516704527
MESH:D005234 Fatty Liver Ethanol 7.3718620774 16409862 19236843
MESH:D005234 Fatty Liver pirinixic acid 7.3719236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.4917920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.1316946407 15513904 15451040 10194807
MESH:D005756 Gastritis Ethanol 4.5215046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7616973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1316417039
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.5720471113
MESH:D006333 Heart Failure pirinixic acid 2.4320558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.146705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.256705139
MESH:D006529 Hepatomegaly pirinixic acid 2.8316221962 19176532 18467677 19772884
MESH:D006930 Hyperalgesia Ethanol 3.5818783367
MESH:D006943 Hyperglycemia pirinixic acid 3.0320558911
MESH:D006948 Hyperkinesis Clozapine 4.7416046005
MESH:D006963 Hyperphagia olanzapine 6.0617933447
MESH:D007248 Infertility, Male vinclozolin 2.9316467254
MESH:D007333 Insulin Resistance pirinixic acid 2.5216306350
MESH:D007569 Jaw Abnormalities Ethanol 4.2515513904
MESH:D007859 Learning Disorders Ethanol 4.0415451040
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5616417039
MESH:D017880 Limb Deformities, Congenital Ethanol 3.6917676605
MESH:D008064 Lipidoses Clozapine 3.8417567588
MESH:D008103 Liver Cirrhosis Ethanol 3.2815289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.9218295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.4818166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4815474484
MESH:D008107 Liver Diseases Chlorpyrifos 3.0315991261
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.4817347304 17207112
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 7.1211376686 16273603 14678523 18001218 10737359 10672840
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.1221137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 7.1220007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 3.42534488 6150874 1399818
MESH:D008133 Long QT Syndrome olanzapine 4.5920210726
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 2.6511376686
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.6520464547 6695378 20869020 18569708 20064080 18520028 18816296 17053015 20135361
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 3.4711921183
MESH:D008569 Memory Disorders Ethanol 4.0218411066 15451040
MESH:D001523 Mental Disorders Clozapine 8.0216856516
MESH:D001523 Mental Disorders olanzapine 8.0216856516
MESH:D038901 Mental Retardation, X-Linked marker/mechanism
MESH:D008659 Metabolic Diseases olanzapine 5.2319142110
MESH:D024821 Metabolic Syndrome X Clozapine 4.2719142101
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0616381670
MESH:D009135 Muscular Diseases pirinixic acid 3.3416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8116411023
MESH:D009336 Necrosis 2-nitropropane 5.3912195237
MESH:D009369 Neoplasms Benzo(a)pyrene 4.5411141357
MESH:D009369 Neoplasms pirinixic acid 4.5417405874
MESH:D009421 Nervous System Malformations Pilocarpine 5.4115987249
OMIM:601634 NEURAL TUBE DEFECTS, FOLATE-SENSITIVE Methanol 6.348946559
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.0515081274
MESH:D009765 Obesity Clozapine 7.4119142110 18515891
MESH:D009765 Obesity olanzapine 7.4118515891
MESH:D009765 Obesity pirinixic acid 7.4120558911
MESH:D010146 Pain Morphine 4.0516273134 15275824 18699797 15215642 20225289 6776300
MESH:D010190 Pancreatic Neoplasms Ethanol 2.9112384795
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.7318042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.7618220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0217292933
MESH:D011472 Prostatitis vinclozolin 4.7618629315
MESH:D011595 Psychomotor Agitation olanzapine 5.4118685284
MESH:D011618 Psychotic Disorders Clozapine 4.0615331141
MESH:D015427 Reperfusion Injury Morphine 6.6119211983
MESH:D015427 Reperfusion Injury pirinixic acid 6.6119058328
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.4717119214 11874814 16611668
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.7216611668 17119214
MESH:D012559 Schizophrenia Clozapine 4.2418855531 17123785 20452607 19369910 20107430 20168265 20521326 11151749 20580759 17726453 11763009 16141801 20521320 17667964 18806925
MESH:D012559 Schizophrenia olanzapine 4.2417726453 20521326 20107430
MESH:D012640 Seizures Ethanol 6.439754883
MESH:D012640 Seizures Pilocarpine 6.4319660546 7750514
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.926418539
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.2919755658 10029692
MESH:D013226 Status Epilepticus Pilocarpine 6.0919951488 19570321 11259499 15857427 15987249 19430551 19055492
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.492093021 20155912
MESH:D013274 Stomach Neoplasms Ethanol 2.4918456281
MESH:D013276 Stomach Ulcer Ethanol 3.3816755016 9211565 11906479 9562338 17918041 17189318
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.109754883
MESH:D017180 Tachycardia, Ventricular olanzapine 5.1720210726
MESH:D014202 Tremor Pilocarpine 5.6317594079
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 5.1115289314 1399818 15867355
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1117053015
MESH:D015430 Weight Gain Clozapine 9.8617502770 16402076 16141801 20107430 20521320 20564506
MESH:D015430 Weight Gain olanzapine 9.8617933447 19434072 20107430
MESH:D015431 Weight Loss Clozapine 4.9017933447
Pathway ID Pathway Name
KEGG:04724 Glutamatergic synapse
KEGG:04730 Long-term depression
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28968
    • No data
    Releated disease ID Related disease Name
    PA447278Depression
    Releated drug ID Related drug Name
    PA452229antidepressants
    PA449015citalopram
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB01356 potentiator Lithium
    DB04599 - Aniracetam Nootropic Agents;Antidepressive Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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