AutismKB 2.0

Annotation Detail for GRID1


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Basic Information Top
Gene Symbol:GRID1 ( KIAA1220 )
Gene Full Name: glutamate receptor, ionotropic, delta 1
Band: 10q23.1-q23.2
Quick LinksEntrez ID:2894; OMIM: 610659; Uniprot ID:GRID1_HUMAN; ENSEMBL ID: ENSG00000182771; HGNC ID: 4575
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
No data
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Related Diseases/Disorders Top
No data
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Desease Name
CARDIOVASCULAR
Cardiac structure and function
Desease Name
Cardiac structure and function
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004390 Chlorpyrifos Chlorpyrifos affects the expression of GRID1 mRNAaffects expression 17452286
D004026 Dieldrin Dieldrin affects the expression of GRID1 mRNAaffects expression 19440498
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of GRID1 mRNAdecreases expression 12057914
D014212 Tretinoin Tretinoin results in decreased expression of GRID1 mRNAdecreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.4918653653 11850527
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 4.9716611668 11874814 17119214
MESH:D000505 Alopecia Tretinoin 3.9415955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.3016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001471 Barrett Esophagus Tretinoin 4.9116935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 4.0316197459 16206674
MESH:D001943 Breast Neoplasms Dieldrin 2.5511859874 15770527
MESH:D001943 Breast Neoplasms Tretinoin 2.5516166294 16873071 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.2216813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.8816168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.921917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3716051514 16096774
MESH:D002386 Cataract Tretinoin 3.3017460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.2216129372
MESH:D002822 Choriocarcinoma Tretinoin 5.8816461808
MESH:D002972 Cleft Palate Tretinoin 2.809407595
MESH:D003092 Colitis Tretinoin 4.2617035595
MESH:D015179 Colorectal Neoplasms marker/mechanism 21278247
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8314991402 9142499 9664655 8800419 10589399 9211117 17551590 9224671 16925845 9125849
MESH:D004489 Edema, Cardiac Tretinoin 5.1918230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3516569247
MESH:D019446 Endotoxemia Lipopolysaccharides 5.0315328337 15821434 17637181
MESH:D005124 Eye Abnormalities Tretinoin 3.8716938888 9664655
MESH:D005334 Fever Lipopolysaccharides 4.4111852909 9205823
MESH:D005355 Fibrosis Tretinoin 4.0717994277
MESH:D005909 Glioblastoma Tretinoin 3.2417312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.8816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0714991402 9664655
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.7816366002
MESH:D006930 Hyperalgesia Tretinoin 3.5316870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.1316778211
MESH:D007247 Infertility, Female Dieldrin 5.4010630421
MESH:D007249 Inflammation Lipopolysaccharides 3.0417255318 12878042 17963957 17237260 9205823
MESH:D007410 Intestinal Diseases Tretinoin 4.3317994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 5.0917255318
MESH:D007569 Jaw Abnormalities Tretinoin 4.3317551590 15992940
MESH:D007938 Leukemia Tretinoin 2.9317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.1216482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1216294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3917649720 17107899 16788101 17361223 17294898 17712046 16823087 19035177 16140955 19642359 16331271 9834237 19029980 19075265 17217047 17339181 17301526 16891316 16766008 17368321 16935935 19225113 17506722 12679006 15748426
MESH:D007970 Leukopenia Lipopolysaccharides 5.3315821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.589224671
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.7712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.7716248980 18397230
MESH:D008107 Liver Diseases Chlorpyrifos 3.1415991261
MESH:D008113 Liver Neoplasms Dieldrin 3.469539021 8742319
MESH:D055370 Lung Injury Lipopolysaccharides 4.5721114838
MESH:D008527 Medulloblastoma Tretinoin 2.9117453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008591 Meningomyelocele Tretinoin 4.9916940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2817596541
MESH:D009369 Neoplasms Dieldrin 6.038820588
MESH:D009369 Neoplasms Tretinoin 6.0316946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.289125849
MESH:D009436 Neural Tube Defects Tretinoin 3.299142499
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.4215081274
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4416936753
MESH:D010146 Pain Tretinoin 3.2416870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5715976015
MESH:D010300 Parkinson Disease Dieldrin 3.6416809432 11181820 11445065 17291500 16112328
MESH:D011014 Pneumonia Lipopolysaccharides 5.1812224865 11605937
MESH:D011507 Proteinuria Tretinoin 4.0716636307
MESH:D011625 Pterygium Tretinoin 5.4216723453
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.9710835634
MESH:D012135 Respiratory Sounds Chlorpyrifos 5.1916611668 17119214 11874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.6117119214 16611668
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5616116481 16283617
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.816418539
MESH:D012878 Skin Neoplasms Tretinoin 2.7616467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.5615821434
MESH:D013964 Thyroid Neoplasms Tretinoin 3.3317045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 4.1816051514
MESH:D014376 Tuberculosis Tretinoin 3.4516040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0716129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.3316752155
MESH:D014820 Vitiligo Tretinoin 4.5616761959
MESH:D009396 Wilms Tumor Tretinoin 4.3416287080
Pathway ID Pathway Name
KEGG:04080 Neuroactive ligand-receptor interaction
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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