AutismKB 2.0

Annotation Detail for GRID2


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Basic Information Top
Gene Symbol:GRID2 ( MGC117022,MGC117023,MGC117024 )
Gene Full Name: glutamate receptor, ionotropic, delta 2
Band: 4q22.1-q22.2
Quick LinksEntrez ID:2895; OMIM: 602368; Uniprot ID:GRID2_HUMAN; ENSEMBL ID: ENSG00000152208; HGNC ID: 4576
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04730Long-term depression
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004390 Chlorpyrifos Chlorpyrifos affects the expression of GRID2 mRNAaffects expression 19440498
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of GRID2 geneincreases mutagenesis 16724327
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma Ethylnitrosourea 3.976695378
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 5.2216611668 11874814 17119214
MESH:D001927 Brain Diseases Ethylnitrosourea 5.3914991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.8015144691 18412241 16651633 16357521 16436596
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 4.0416003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 7.0517160924
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 7.0518357618
MESH:D005909 Glioblastoma Ethylnitrosourea 4.1216436596
MESH:D005910 Glioma Ethylnitrosourea 3.6416357521 18412241 16651633
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.3617379185
MESH:D008107 Liver Diseases Chlorpyrifos 3.1615991261
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.636695378 16019985 17703301 16271038
MESH:D008223 Lymphoma Ethylnitrosourea 4.2815790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.8115375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.8010838139 10767621 18041768
MESH:D008579 Meningioma Ethylnitrosourea 7.0517943659
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 5.1616707424
MESH:D009442 Neurilemmoma Ethylnitrosourea 6.3016003739 16651423 17160924
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.4815081274
MESH:D009837 Oligodendroglioma Ethylnitrosourea 7.0517160924
MESH:D012135 Respiratory Sounds Chlorpyrifos 5.4011874814 16611668 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.9617119214 16611668
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 7.166418539
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 6.0515790496
Pathway ID Pathway Name
KEGG:04730 Long-term depression
KEGG:04080 Neuroactive ligand-receptor interaction
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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