AutismKB 2.0

Annotation Detail for DEXI


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DEXI ( MYLE )
Gene Full Name: Dexi homolog (mouse)
Band: 16p13.13
Quick LinksEntrez ID:28955; OMIM: NA; Uniprot ID:DEXI_HUMAN; ENSEMBL ID: ENSG00000182108; HGNC ID: 13267
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of DEXI mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of DEXI mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone affects the expression of DEXI mRNAaffects expression 19483382
D001553 Benzbromarone Benzbromarone affects the expression of DEXI mRNAaffects expression 19483382
D002994 Clofibrate Clofibrate affects the expression of DEXI mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in decreased expression of DEXI mRNAdecreases expression 20106945
D005001 Ethionine Ethionine affects the expression of DEXI mRNAaffects expression 19483382
C013598 methoxyacetic acid methoxyacetic acid results in increased expression of DEXI mRNAincreases expression 18199887
D009853 Omeprazole Omeprazole affects the expression of DEXI mRNAaffects expression 19483382
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of DEXI mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of DEXI mRNAdecreases expression 19482888
C006253 pirinixic acid pirinixic acid results in decreased expression of DEXI mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid affects the expression of DEXI mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of DEXI mRNAaffects expression 19483382
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DEXI mRNAdecreases expression 19465110
D013853 Thioacetamide Thioacetamide affects the expression of DEXI mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced methoxyacetic acid 14.881761407 3652986 15959878 1761404 12805644
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 14.886195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 14.8815322242 11752688 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.783712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.7917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.7916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.7916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8518057881 20041841 18218290
MESH:D001281 Atrial Fibrillation Amiodarone 3.9419698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.121440618 11289319
MESH:D001778 Blood Coagulation Disorders Amiodarone 60.0119483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 60.0119483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 60.0119483382
MESH:D001778 Blood Coagulation Disorders Ethionine 60.0119483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 60.0119483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 60.0119483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 60.0119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 60.0112125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 60.0119483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7120435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.983581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.983084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 8.981701930
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.9817173139 20007298 20935162 1701930 6705139
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 8.9817997003
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.707296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3916120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9115710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.1718974383
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.467505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 11.461399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.4612371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.324080065
MESH:D002637 Chest Pain Omeprazole 5.2015447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.7116835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.7118291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.629022650 19486331
MESH:D002779 Cholestasis Cyclosporine 13.6219486331
MESH:D002779 Cholestasis pirinixic acid 13.6219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.128697196 12621046 15340226 15668235 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8718759878 11906362 12868966 14531868 11298694 2524372 8156756 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.552952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.1916192314 18289764 18648102 8291058 6482804 9022650 11289319 18692083 1440618 9653073 7440962 6679447 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.1916227642 11461765 12958197 16177239 15619225 17906064 12392966 17522070 11834606 11287661 14986274 14725611 19420014 10915739 10774834 19085960 12540782 16081117 11529661 19739265 16393943 11421492 2444490 16109766 10663392 18071297 19923254 15968718 17562736 12705907 12594235 19416960 19370779 16781746 16485898 18713872 14550746 11743745 12153990 19164858 11739529
MESH:D056486 Drug-Induced Liver Injury Amiodarone 12.1915265979 18218290
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.1920420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 12.1912963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.3916613094 21218061 17151854 15991576
MESH:D050171 Dyslipidemias Clofibrate 4.1016707586
MESH:D004421 Dystonia Phenobarbital 4.061851702
MESH:D004487 Edema pirinixic acid 6.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0018230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0710568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.183659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.973922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.596401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.327750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.103659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005218 Fat Necrosis Thioacetamide 5.8216456712
MESH:D005234 Fatty Liver Amiodarone 19.2714986274
MESH:D005234 Fatty Liver Clofibrate 19.2719224547
MESH:D005234 Fatty Liver Cyclosporine 19.2719224547
MESH:D005234 Fatty Liver pirinixic acid 19.2719236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.126705139
MESH:D005355 Fibrosis Cyclosporine 8.7212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7220067830
MESH:D005532 Foot Deformities, Congenital methoxyacetic acid 5.793652986
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.107505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3611294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.6315929193 18665440 17276928
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.676705139
MESH:D006505 Hepatitis Thioacetamide 9.6716456712
MESH:D006529 Hepatomegaly Amiodarone 21.3215265979
MESH:D006529 Hepatomegaly Phenobarbital 21.3216109766
MESH:D006529 Hepatomegaly pirinixic acid 21.3219772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 21.3212621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1415340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.938137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0115034207
MESH:D006973 Hypertension Cyclosporine 5.0110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0118670907 18850075
MESH:D007037 Hypothyroidism Amiodarone 11.8617991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 11.8618031379 8137927
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8812878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.128074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.898314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.426582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.4212371664
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.1419248655
MESH:D017880 Limb Deformities, Congenital methoxyacetic acid 4.7812805644 15959878
MESH:D008064 Lipidoses Amiodarone 3.5515342952 17567588
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9221047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5012878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 3.5018458672 17127702 16098781 18263696 15288473 18395095 12557150 11682029 14739098 16126171 15465738 15158331 12175628 17629604 17050028 17292413 15334695 15078482 18606216 11172339 12891558 15716488 12679928 15288472 16097051 15316131 15362042 16343077 18615449 15474484 12531686 17355460 16248980 18295389 18416461 15095483 11481614 18380797 12085344 18032466 18031379 10677585 16511523 16489207 15075984
MESH:D008107 Liver Diseases Acetaminophen 6.6416610002 11587558 16611625 19014921 12969438 12587719 19460945 19784758
MESH:D008107 Liver Diseases Phenobarbital 6.6419363144
MESH:D008107 Liver Diseases Thioacetamide 6.6418374380 16337175 15158337
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8116871587 17185352
MESH:D017114 Liver Failure, Acute Thioacetamide 9.8117276928 15633222 12479984 15313186
MESH:D008113 Liver Neoplasms Phenobarbital 7.4621047994 19812893 19482888 8742319 15975961 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 7.4620007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.4616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.996587162 3712494 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.9917172636 2563599 1399818 18308698 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.9912151625
MESH:D008133 Long QT Syndrome Amiodarone 3.6217391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.4112587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.5818516814
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009181 Mycoses Amiodarone 5.0017974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5617484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.493581430
MESH:D009369 Neoplasms pirinixic acid 1.9717405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3318481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.956679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 5.019802331
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.474026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.123988306
MESH:D010018 Osteomalacia Phenobarbital 4.4517016548
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5116965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.557296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.576228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.1312371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.132563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711118676 11222880 11896295 11399792
MESH:D019310 Pseudolymphoma Phenobarbital 4.5912752131
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8711597910 12490602 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.413692021
MESH:D012640 Seizures Phenobarbital 2.7311442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.906407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.1718724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0716192470
MESH:D013272 Stomach Diseases Omeprazole 4.6918545984
MESH:D013276 Stomach Ulcer Amiodarone 7.7618087811
MESH:D013276 Stomach Ulcer Omeprazole 7.7610750652 18237397 15991576 16755016 17977527 11906479
MESH:D013576 Syndactyly methoxyacetic acid 5.691761404 1761407
MESH:D013610 Tachycardia Amiodarone 4.3511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2519225199
MESH:D013733 Testicular Diseases methoxyacetic acid 5.416499806 18486176
MESH:D013959 Thyroid Diseases Amiodarone 12.3819731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.3812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.296582329 1399818 6587162 3712494 7505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 12.291399818
MESH:D013964 Thyroid Neoplasms Propylthiouracil 12.2915710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.9319584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.2711989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.298074119
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved