AutismKB 2.0

Annotation Detail for TMEM176B


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Basic Information Top
Gene Symbol:TMEM176B ( FLJ26014,LR8,MGC110857 )
Gene Full Name: transmembrane protein 176B
Band: 7q36.1
Quick LinksEntrez ID:28959; OMIM: 610385; Uniprot ID:T176B_HUMAN; ENSEMBL ID: ENSG00000106565; HGNC ID: 29596
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TMEM176B mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of TMEM176B proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TMEM176B mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in decreased expression of TMEM176B mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of TMEM176B mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TMEM176B mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of TMEM176B mRNAdecreases expression 17108234
C056933 fumonisin B1 fumonisin B1 results in increased expression of TMEM176B mRNAincreases expression 16221962
C041786 palm oil palm oil results in decreased expression of TMEM176B mRNAdecreases expression 18042831
D010656 Phenylephrine Phenylephrine results in decreased expression of TMEM176B mRNAdecreases expression 18158353
D010795 Phthalic Acids Phthalic Acids results in decreased expression of TMEM176B mRNAdecreases expression 15728792
C006253 pirinixic acid pirinixic acid results in decreased expression of TMEM176B mRNAdecreases expression 16221962
D013629 Tamoxifen Tamoxifen affects the expression of TMEM176B mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TMEM176B mRNAincreases expression 15644576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.3016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3016835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1917460149
MESH:D001161 Arteriosclerosis Dietary Fats 10.2615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.4120106747
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001919 Bradycardia Phenylephrine 4.6615306635
MESH:D001943 Breast Neoplasms Dietary Fats 1.8320435547
MESH:D001943 Breast Neoplasms Tamoxifen 1.8316873071 18425577 19200415 18997820 16202921 19103187 19084267 20005174 19189210 19066611 19487384 20065188 20390343 20135344 19410462 16818667 17261762 19244106 17049068 16273361 17440819 18984771 20544844 11161223 21152245 18821012 20859285 18351453 15565566 19059307 19115204 19289846 19189212 19155303 21138602 17242785 19142967 19288272 19221464 15668708 18855134 18815881 17893378 18629630 19011961
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8320435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6119066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.613084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.6112907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6116924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6917572228
MESH:D006332 Cardiomegaly Phenylephrine 7.0211179087 15728586 16170337 11754973 17287366 17124262
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0218670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5812371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Cyclosporine 13.7019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.7017110522 17681005 15861022 16919318 17333356 11677210 16105132
MESH:D002779 Cholestasis pirinixic acid 13.7019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1312621046 15340226 15668235 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4719031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5519279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3719370779 19739265 12392966 11287661 10774834 14725611 16485898 10915739 12153990 14550746 16227642 12705907 2444490 10663392 16081117 12540782 12594235 11743745 16177239 16781746 19923254 19416960 17562736 18713872 19420014 11461765 19085960 15968718 15619225 11529661 19164858 17906064 12958197 17522070 11834606 11421492 14986274 11739529 16393943 18071297 16109766
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 6.3716221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5118367378
MESH:D004487 Edema pirinixic acid 6.8112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.2612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.2619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1017893378 16202921 20544844 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 25.5719224547
MESH:D005234 Fatty Liver Dietary Fats 25.5717967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.5715345470
MESH:D005234 Fatty Liver pirinixic acid 25.5719236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 25.5719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3019069698
MESH:D005355 Fibrosis Cyclosporine 15.3512639820 12168785
MESH:D005355 Fibrosis Dietary Fats 15.3518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.3520067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly fumonisin B1 15.1216221962
MESH:D006529 Hepatomegaly pirinixic acid 15.1216221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.1212621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1818606429 16959395 15340226 16354765 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7021332399
MESH:D006973 Hypertension Cyclosporine 8.7810903974
MESH:D006973 Hypertension Phenylephrine 8.7812717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.7818670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.6318502941 12791704
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Dietary Fats 8.5120412841
MESH:D007249 Inflammation Tamoxifen 8.5119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5112200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.4218457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.4216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.948314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5312371664
MESH:D007680 Kidney Neoplasms Tamoxifen 7.5318625569
MESH:D008064 Lipidoses Tamoxifen 3.2115342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9218296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4312878042
MESH:D008107 Liver Diseases Acetaminophen 1.6519014921 16611625 19460945 12969438 12587719 16610002 11587558 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.9215890375 18177683 2125692 9163691
MESH:D008113 Liver Neoplasms pirinixic acid 10.9215890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 10.9216684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.9216984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.978603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9712151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4314755239
MESH:D008175 Lung Neoplasms Tamoxifen 3.4318625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4311884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8819428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6714580682 19196723 11731420 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.6819453300
MESH:D008545 Melanoma Tamoxifen 1.8912393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5419410462
MESH:D009369 Neoplasms pirinixic acid 1.9817405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1319200415 19189210 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3618481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009765 Obesity Dietary Fats 4.4918457598 21332399 16723640 18674790 20518802 11836018 20132043 19632207 17217161
MESH:D009765 Obesity pirinixic acid 4.4920558911
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111118676 11896295 11399792 11222880
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1415067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012852 Sinusitis Phenylephrine 4.827327846
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.0116709447
MESH:D013088 Spermatocele Tamoxifen 12.0116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1519457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.388653321 16712894 17572228
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6215869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D015430 Weight Gain Dietary Fats 3.8116723640
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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