AutismKB 2.0

Annotation Detail for GRN


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Basic Information Top
Gene Symbol:GRN ( GEP,GP88,PCDGF,PEPI,PGRN )
Gene Full Name: granulin
Band: 17q21.31
Quick LinksEntrez ID:2896; OMIM: 138945; Uniprot ID:GRN_HUMAN; ENSEMBL ID: ENSG00000030582; HGNC ID: 4601
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Desease IDDesease Name
H00078Pick's disease
Nervous system diseases
Neurodegenerative diseases
No data
Desease Name
frontotemporal dementia
NEUROLOGICAL
frontotemporal lobar degeneration
No data
Desease Name
Frontotemporal lobar degeneration with ubiquitin-positive inclusions
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of GRN mRNA]affects expression|affects reaction 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of GRN mRNA]affects expression|affects reaction 19414516
D000082 Acetaminophen Acetaminophen affects the expression of GRN mRNAaffects expression 17562736
D000242 Cyclic AMP 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of GRN mRNA]affects expression|affects reaction 19414516
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRN mRNAaffects expression 16483693
C005948 astaxanthine astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of GRN mRNA]decreases reaction|increases expression 16964424
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GRN mRNAincreases expression 20382639
D002330 Carmustine Carmustine results in decreased expression of GRN mRNAdecreases expression 15980968
D002392 Catechin Catechin results in increased expression of GRN mRNAincreases expression 15465739
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in decreased expression of GRN mRNAaffects cotreatment|decreases expression 19684285
D003993 Dibutyl Phthalate Dibutyl Phthalate results in increased expression of GRN mRNAincreases expression 16493179
D004041 Dietary Fats Dietary Fats results in decreased expression of GRN mRNAdecreases expression 18042831
C012125 diisononyl phthalate diisononyl phthalate results in increased expression of GRN mRNAincreases expression 16493179
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide results in increased expression of GRN mRNAincreases expression 16873554
C013966 dioctyl adipate dioctyl adipate results in decreased expression of GRN mRNAdecreases expression 16493179
C074283 estradiol 3-benzoate estradiol 3-benzoate results in increased expression of GRN mRNAincreases expression 11137762
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GRN mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GRN mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GRN mRNAaffects cotreatment|decreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GRN mRNAincreases expression 11137762
D005419 Flavonoids Flavonoids results in increased expression of GRN mRNAincreases expression 15465739
C056933 fumonisin B1 fumonisin B1 results in increased expression of GRN mRNAincreases expression 16221962
D008727 Methotrexate GRN protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D005996 Nitroglycerin Nitroglycerin results in decreased expression of GRN mRNAdecreases expression 12102619
C041786 palm oil palm oil results in decreased expression of GRN mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of GRN mRNAincreases expression 18445702
18301758
D010936 Plant Extracts Plant Extracts results in increased expression of GRN mRNAincreases expression 15465739
C025299 polyphenols polyphenols results in increased expression of GRN mRNAincreases expression 15465739
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of GRN mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of GRN mRNAincreases expression 19244175
D013467 Sulindac Sulindac inhibits the reaction [CDKN1A protein results in increased expression of GRN mRNA]decreases reaction|increases expression 15190207
C025462 sulindac sulfide sulindac sulfide results in decreased expression of GRN mRNAdecreases expression 16184548
D013629 Tamoxifen Tamoxifen affects the expression of GRN mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in decreased expression of GRN mRNAaffects cotreatment|decreases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GRN mRNAdecreases expression 19684285
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GRN mRNAaffects cotreatment|decreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GRN mRNAdecreases expression 19684285
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of GRN mRNAincreases expression 16873554
D014212 Tretinoin Tretinoin affects the expression of GRN mRNAaffects expression 16873554
D014212 Tretinoin Tretinoin results in increased expression of GRN mRNAincreases expression 16054129
D014635 Valproic Acid Valproic Acid results in increased expression of GRN mRNAincreases expression 19101580
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of GRN mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of GRN mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 11.9114745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 11.9114745880
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 12.4212039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.4211752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 12.428875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6419490988
MESH:D000138 Acidosis Ammonium Chloride 3.2318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6117505938
MESH:D058186 Acute Kidney Injury Sulindac 4.037897758
MESH:D055371 Acute Lung Injury pirinixic acid 2.8218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3014692618
MESH:D000230 Adenocarcinoma Sulindac 4.3011910360
MESH:D000236 Adenoma Sulindac 3.5910223192
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.8216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.8216835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.3211535846 17611924 11874996 15623613 12394442 19003578 16460482
MESH:D000505 Alopecia Tretinoin 3.3615955085
MESH:D000544 Alzheimer Disease Plant Extracts 4.5116962711
MESH:D000544 Alzheimer Disease sulindac sulfide 4.5118759972
MESH:D000550 Amblyopia Valproic Acid 4.9017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6711748828
MESH:D000799 Angioedema Acetaminophen 3.5110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.3217497229
MESH:D001161 Arteriosclerosis Dietary Fats 8.8515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.8511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.1715885639
MESH:D001169 Arthritis, Experimental Plant Extracts 11.1714686799
MESH:D001169 Arthritis, Experimental Tretinoin 11.1716412693
MESH:D001172 Arthritis, Rheumatoid Methotrexate 4.5917286800
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.5916292516
MESH:D001249 Asthma Tretinoin 2.2416456186
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8515238991 18940202 17507914 17688650 18985861 18775368 20603192 16609825 18316065 18396377 18177632 19232924 18558336 19460635 17157402
MESH:D001471 Barrett Esophagus Tretinoin 4.0916935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.9120046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.5912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.5916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.3315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.338888407
MESH:D001913 Bowen's Disease Sulindac 5.0211207687
MESH:D002545 Brain Ischemia Plant Extracts 4.4016041641
MESH:D001932 Brain Neoplasms Carmustine 4.1116187019
MESH:D001943 Breast Neoplasms Dietary Fats 2.7920435547
MESH:D001943 Breast Neoplasms Methotrexate 2.7916978400
MESH:D001943 Breast Neoplasms Sulindac 2.7916642371
MESH:D001943 Breast Neoplasms Tamoxifen 2.7917440819 11161223 17261762 19011961 19059307 19221464 21152245 19142967 20005174 20135344 18984771 15668708 16873071 16202921 16273361 15565566 19200415 19155303 21138602 19189210 19410462 19084267 18997820 20390343 18821012 18815881 20065188 18629630 19289846 17893378 19066611 20544844 19288272 19189212 16818667 19115204 19487384 18855134 17242785 19244106 18425577 19103187 17049068 18351453 20859285
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.7920435547
MESH:D001943 Breast Neoplasms Tretinoin 2.7916166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2616813970
MESH:D002057 Burns, Chemical Plant Extracts 5.009625245
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.6116050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1919066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8316168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.123084413
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 6.1218834353
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.1216924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.121917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.3312391285
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 4.5618922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.5616096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3317572228
MESH:D006332 Cardiomegaly Plant Extracts 6.3717645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3718670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 6.5910977129
MESH:D002386 Cataract Tretinoin 6.5917460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.5120889678
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2616129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5920734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 6.9515861022 17333356 11677210 16105132 17110522 17681005 16919318
MESH:D002779 Cholestasis pirinixic acid 6.9519176532
MESH:D002822 Choriocarcinoma Tretinoin 4.8316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3012621046 8697196 16354765 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 5.309407595
MESH:D003092 Colitis Selenium 8.4417936198
MESH:D003092 Colitis Tretinoin 8.4417035595
MESH:D003110 Colonic Neoplasms polyphenols 4.0216293270
MESH:D003110 Colonic Neoplasms Sulindac 4.0212902858 12458338
MESH:D015179 Colorectal Neoplasms Sulindac 2.6811076880 18059344 11197048 10666051
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7917141729 14669216
MESH:D019465 Craniofacial Abnormalities Methotrexate 6.9012039119 9562676
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.9020055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.908800419 17551590 9664655 10589399 14991402 16925845 9224671 9142499 9125849 9211117
MESH:D019465 Craniofacial Abnormalities Valproic Acid 6.9016575769 8888407 17688650
MESH:D019465 Craniofacial Abnormalities Vitamin E 6.9019769572
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.1416037377
MESH:D003550 Cystic Fibrosis Methotrexate 3.9619747007
MESH:D003704 Dementia marker/mechanism 18543312 17436289
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0419031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003882 Dermatomyositis Methotrexate 4.8120191521
MESH:D003924 Diabetes Mellitus, Type 2 astaxanthine 4.5916964424
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5917107852
MESH:D003928 Diabetic Nephropathies Plant Extracts 8.3019706694
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.3019279558
MESH:D003930 Diabetic Retinopathy Sulindac 4.8712861449 17621415
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 13.9019923254 14725611 2444490 19416960 11743745 10915739 10663392 12958197 12392966 11287661 12153990 16781746 15619225 11421492 19420014 15968718 10774834 11529661 14550746 16177239 12540782 17522070 18713872 11834606 11739529 19085960 19370779 19739265 12594235 16081117 16485898 11461765 19164858 14986274 17562736 12705907 16393943 17906064 16109766 16227642 18071297
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 13.9016221962
MESH:D056486 Drug-Induced Liver Injury polyphenols 13.9019370779
MESH:D056486 Drug-Induced Liver Injury Selenium 13.9015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.9020420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 13.901733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5211462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2218367378
MESH:D004421 Dystonia Valproic Acid 3.751851702
MESH:C538011 Eales disease Vitamin E 4.379068938
MESH:D004487 Edema pirinixic acid 14.1112083418
MESH:D004487 Edema Plant Extracts 14.1112787963
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.1112711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 14.118273558 15177302 9599246 16716910 8113982 11698051 7812673
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.8415322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.8418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.9212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.9219031437
MESH:D018159 Endolymphatic Hydrops Dimethyl Sulfoxide 6.2320641076
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.7316202921 17893378 19155303 20544844
MESH:D016889 Endometrial Neoplasms Tretinoin 6.7316569247
MESH:D004715 Endometriosis Sulindac 8.2615652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.2610568697 9294722
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.3515268973
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.843659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.5916628512 3922381
MESH:D004827 Epilepsy Plant Extracts 6.4119700373 19439326
MESH:D004827 Epilepsy Valproic Acid 6.4118234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.327562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.987750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.743659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4620426865
MESH:D004938 Esophageal Neoplasms Sulindac 4.4612235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.0411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.049664655 16938888
MESH:D005234 Fatty Liver Dietary Fats 26.9417967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 26.9415345470
MESH:D005234 Fatty Liver pirinixic acid 26.9420131406 19236843
MESH:D005234 Fatty Liver Plant Extracts 26.9415975614
MESH:D005234 Fatty Liver Tamoxifen 26.9419224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 26.9414986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.8218558336 8888407
MESH:D018221 Fibromatosis, Abdominal Sulindac 11.8714745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 11.8714745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 10.5519069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.5519069698
MESH:D005355 Fibrosis Dietary Fats 12.9318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.9320067830
MESH:D005355 Fibrosis Tretinoin 12.9317994277
MESH:D057174 Frontotemporal Lobar Degeneration marker/mechanism 20154673
OMIM:607485 FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED marker/mechanism
MESH:D005756 Gastritis Acetaminophen 3.3416983495
MESH:D005764 Gastroesophageal Reflux Sulindac 4.7011910360
MESH:D005909 Glioblastoma Carmustine 6.7516187019
MESH:D005909 Glioblastoma Tretinoin 6.7517312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D006086 Graft vs Host Disease Methotrexate 4.8316518429
MESH:D006261 Headache Nitroglycerin 4.8611554966 11284996
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.9716096774
MESH:D034381 Hearing Loss Dimethyl Sulfoxide 4.9020641076
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.1310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.139664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 10.1316080930
MESH:D006333 Heart Failure pirinixic acid 10.7120558911
MESH:D006333 Heart Failure Plant Extracts 10.7118097624
MESH:D006333 Heart Failure Selenium 10.7117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0511000095
MESH:D006529 Hepatomegaly fumonisin B1 12.6416221962
MESH:D006529 Hepatomegaly pirinixic acid 12.6419772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.6415340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5916490937 16863852
MESH:D006561 Herpes Simplex Plant Extracts 4.3010715843
MESH:D015658 HIV Infections Plant Extracts 3.5112878215
MESH:D019584 Hot Flashes Plant Extracts 9.3117454163 16566672 14716179
MESH:D019584 Hot Flashes Vitamin E 9.3114716179
MESH:D006849 Hydrocephalus Valproic Acid 4.5417688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.718697196 16959395 18606429 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 6.7816870215
MESH:D006930 Hyperalgesia Tretinoin 6.7816870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3021332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2516778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9020558911
MESH:D020138 Hyperhomocysteinemia Catechin 9.0217292331
MESH:D020138 Hyperhomocysteinemia Plant Extracts 9.0216484555
MESH:D006949 Hyperlipidemias Dietary Fats 8.4621332399
MESH:D006949 Hyperlipidemias Plant Extracts 8.4615268973 15975614
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4916945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2717937319
MESH:D007249 Inflammation Dietary Fats 25.6420412841
MESH:D007249 Inflammation Flavonoids 25.6417296493
MESH:D007249 Inflammation Plant Extracts 25.6419332304 12787963 16366677 15997105
MESH:D007249 Inflammation polyphenols 25.6416366677
MESH:D007249 Inflammation Sulindac 25.643291741
MESH:D007249 Inflammation Tamoxifen 25.6419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 25.6412200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 25.647562506 7812673 11698051 8273558 15177302
MESH:D007251 Influenza, Human Selenium 9.8516624496
MESH:D007251 Influenza, Human Vitamin E 9.8516624496
MESH:D007333 Insulin Resistance Dietary Fats 6.5418457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 6.5416306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4517994277
MESH:D007414 Intestinal Neoplasms Plant Extracts 9.3312584176 12628509 12351151
MESH:D007414 Intestinal Neoplasms Sulindac 9.3312584176 12351151 12663524 10223192 10213222 12628509
MESH:D007417 Intestinal Polyps Sulindac 4.6911245490 12394442
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.9716580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.9715992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 5.3412587719 15629191
MESH:D007674 Kidney Diseases Vitamin E 5.3412488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.6016518626
MESH:D007680 Kidney Neoplasms Tamoxifen 2.7918625569
MESH:D007805 Language Development Disorders Methotrexate 4.809562676
MESH:D007938 Leukemia Tretinoin 2.6117143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4116932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.6717596541 19850784 16294345
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.6716294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9419029980 16891316 17301526 17712046 17506722 19642359 16140955 9834237 12679006 16788101 19225113 17339181 16935935 17361223 17368321 17107899 17217047 19035177 16331271 16823087 16766008 17294898 15748426 19075265 17649720
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.089224671
MESH:D008064 Lipidoses Tamoxifen 2.9317567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 10.2118296743
MESH:D008103 Liver Cirrhosis Methotrexate 10.2114986274
MESH:D008103 Liver Cirrhosis Plant Extracts 10.2117157831
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.0212468960
MESH:D008106 Liver Cirrhosis, Experimental Dimethyl Sulfoxide 10.2211682029
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.2215474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 10.2215479170
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 10.2218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.2212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.2218397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 10.2216169303
MESH:D008107 Liver Diseases Acetaminophen 8.7212587719 19460945 11587558 19014921 16611625 19784758 16610002 12969438
MESH:D008107 Liver Diseases Plant Extracts 8.7217034775
MESH:D008107 Liver Diseases polyphenols 8.7216698588
MESH:D008107 Liver Diseases Sulindac 8.7216867024 14986274
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9617185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 9.6416377806 20007298 15890375
MESH:D008113 Liver Neoplasms Plant Extracts 9.6419168119
MESH:D008113 Liver Neoplasms Tamoxifen 9.6416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.6416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 1.9112151625
MESH:D008171 Lung Diseases Vitamin E 2.9616863852
MESH:D017563 Lung Diseases, Interstitial Methotrexate 10.3618516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 10.3617228818
MESH:D008175 Lung Neoplasms Plant Extracts 7.9820869020
MESH:D008175 Lung Neoplasms Sulindac 7.9815713900 19359593
MESH:D008175 Lung Neoplasms Tamoxifen 7.9818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.9819555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 7.9811807781
MESH:D008175 Lung Neoplasms Vitamin E 7.9811062179
MESH:D008223 Lymphoma Methotrexate 3.7217352296
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4419428831
MESH:D008325 Mammary Neoplasms, Experimental estradiol 3-benzoate 12.6615375486
MESH:D008325 Mammary Neoplasms, Experimental Selenium 12.6615318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.6614580682 16827153 11731420 19196722 19196723
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 12.668985016
MESH:D020149 Manganese Poisoning Tamoxifen 4.2219453300
MESH:D008527 Medulloblastoma Tretinoin 2.6517453147
MESH:D008545 Melanoma Carmustine 6.8412393984
MESH:D008545 Melanoma Sulindac 6.8416642371
MESH:D008545 Melanoma Tamoxifen 6.8412393984 19393235
MESH:D008545 Melanoma Tretinoin 6.8416752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8615990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2519513568
MESH:D008591 Meningomyelocele Tretinoin 4.1116940565
MESH:D008654 Mesothelioma Selenium 2.6615107826
MESH:D008708 Methemoglobinemia Nitroglycerin 4.443537620
MESH:D008881 Migraine Disorders Valproic Acid 2.9618765137 18803445
MESH:D020326 Migraine without Aura Cyclic AMP 10.1411304026
MESH:D020326 Migraine without Aura Nitroglycerin 10.1414659530
MESH:D052016 Mucositis Methotrexate 4.9517488658
MESH:D009135 Muscular Diseases pirinixic acid 3.1916239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.748888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.7717596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 6.7717596541
MESH:D009203 Myocardial Infarction Nitroglycerin 5.5514729435
MESH:D009203 Myocardial Infarction pirinixic acid 5.5519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7016411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4119410462
MESH:D009369 Neoplasms pirinixic acid 4.3717405874
MESH:D009369 Neoplasms Tretinoin 4.3716594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6719200415 19189210 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.4814600291
MESH:D009421 Nervous System Malformations Tretinoin 8.489125849
MESH:D009436 Neural Tube Defects Tretinoin 6.609142499
MESH:D009436 Neural Tube Defects Valproic Acid 6.608888407 16359493
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.8617168769
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6518514411
MESH:D019636 Neurodegenerative Diseases Sulindac 7.6517266991 16850258
MESH:D009765 Obesity Dietary Fats 6.9718674790 16723640 21332399 11836018 17217161 20132043 18457598 20518802 19632207
MESH:D009765 Obesity pirinixic acid 6.9720558911
MESH:D009765 Obesity Plant Extracts 6.9719056576 20132043
MESH:D010051 Ovarian Neoplasms Tretinoin 2.2416936753
MESH:D010146 Pain Acetaminophen 9.8116870215
MESH:D010146 Pain Sulindac 9.813291741
MESH:D010146 Pain Tretinoin 9.8116870215
MESH:D010190 Pancreatic Neoplasms Sulindac 8.1011504793 16820089
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 8.1015976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.1015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3911578682
MESH:D010212 Papilloma Plant Extracts 8.7115173996 16517061
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 8.718330346 12065085 18404319 18922899
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9212520081
MESH:D010954 Plasmacytoma Selenium 4.5615087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.3811222880 11896295 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.3820603192
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.7917804756 14666653
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.7915067354
MESH:D011471 Prostatic Neoplasms Vitamin E 2.7915084515
MESH:D011507 Proteinuria Tretinoin 3.3116636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.9915861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.2112752131 11422049
MESH:D011565 Psoriasis Methotrexate 3.3217410198
MESH:D011625 Pterygium Tretinoin 4.4716723453
MESH:D051437 Renal Insufficiency Methotrexate 4.3917352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.8616283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 9.8619155313
MESH:D012559 Schizophrenia Valproic Acid 2.0315737665 19110320
MESH:D012640 Seizures Valproic Acid 2.531511512 11738929 11044598 17978042 3137016 16876388 14763951 15475178
MESH:D012871 Skin Diseases Vitamin E 2.3618709164
MESH:D012878 Skin Neoplasms Plant Extracts 12.3316517061 15173996
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.3316192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 12.3318404319 8985016 8330346 11807781 12065085
MESH:D012878 Skin Neoplasms Tretinoin 12.3316467112
MESH:D013088 Spermatocele Ethinyl Estradiol 10.4616709447
MESH:D013088 Spermatocele Tamoxifen 10.4616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7119457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5319490988
MESH:D013226 Status Epilepticus Valproic Acid 4.2112833885
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D013276 Stomach Ulcer Plant Extracts 3.6117135157 12787963 15255614 18237397 18193104
MESH:D020521 Stroke Vitamin E 3.2716517955
MESH:D013576 Syndactyly Methotrexate 4.729562676
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 12.1717997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 12.1717997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5712697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.7816026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.5116051514
MESH:D014178 Translocation, Genetic Valproic Acid 4.9017262798
MESH:D014376 Tuberculosis Tretinoin 3.0316040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.193119515
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.238653321 16712894 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.328888407
MESH:D014581 Urticaria Acetaminophen 2.6810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4016129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 14.4214692618
MESH:D014594 Uterine Neoplasms Sulindac 14.4218645019
MESH:D014594 Uterine Neoplasms sulindac sulfide 14.4218645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.2816752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2514671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 4.4318097624
MESH:D020257 Ventricular Remodeling Plant Extracts 4.9918097624
MESH:D014820 Vitiligo Tretinoin 3.7516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
MESH:D015430 Weight Gain Dietary Fats 3.4716723640
MESH:D009396 Wilms Tumor Tretinoin 3.6916287080
MESH:D014947 Wounds and Injuries Plant Extracts 3.9920213670 19894650
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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