AutismKB 2.0

Annotation Detail for C11orf67


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Basic Information Top
Gene Symbol:C11orf67 ( CK067,FLJ21035,MGC3367 )
Gene Full Name: chromosome 11 open reading frame 67
Band: 11q14.1
Quick LinksEntrez ID:28971; OMIM: NA; Uniprot ID:CK067_HUMAN; ENSEMBL ID: ENSG00000087884; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of C11ORF67 mRNAincreases expression 19150397
D016572 Cyclosporine Cyclosporine results in decreased expression of C11ORF67 mRNAdecreases expression 20106945
D004317 Doxorubicin C11ORF67 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Doxorubicin 2.6517418594
MESH:D000419 Albuminuria Doxorubicin 5.1321441931
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.5714601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.2617150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.5715993339 18695136 16826403 19526202 15692762 17426702 15668708 16322301 15994142 16264153 18382427 16935488 18234424 15567936 17369602 15634643 11325840 16595493 16115903 15939500 17983394 15136595 18628466 16096432
MESH:D002276 Carcinoid Tumor Doxorubicin 5.6816051944
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 2.2617876044 16234567 18059187 16023760
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.331485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.736189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.8017329180 17519947 17131338 17924179 16109756 16612575 15505089 16455267 16364871 15476868 16651473 16242529 17351982 17308081 18627295 17007740 16278810 17382496 16731534 15811867 17974986 15792986 17928571 16269455 16952015
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0616243910 17334414
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.5412371664
MESH:D002779 Cholestasis Cyclosporine 3.2419486331
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1518259882 18802399
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 2.5317416283
MESH:D004362 Drug Toxicity Doxorubicin 3.9918602426
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.7217359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 6.0218037988
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1520426865
MESH:D005234 Fatty Liver Cyclosporine 3.3419224547
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 5.3319069698
MESH:D005355 Fibrosis Cyclosporine 3.7912639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.968708960
MESH:D005909 Glioblastoma Doxorubicin 3.6117150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.8115692506
MESH:D006331 Heart Diseases Doxorubicin 3.7816879835 18006777 14766674 17875725 16495754 16244371 16244372 18674790 16707910 12587719 16144979 17888722 16330681
MESH:D006333 Heart Failure Doxorubicin 3.5917481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.3815692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.1615720958
MESH:D006689 Hodgkin Disease Doxorubicin 3.8215147373 18501091 17606976
MESH:D006973 Hypertension Cyclosporine 2.2310903974
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.3115604871
MESH:D007674 Kidney Diseases Cyclosporine 6.8718776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 6.8716775033 15699352 15369732
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.6416707910
MESH:D007680 Kidney Neoplasms Cyclosporine 3.1212371664
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 6.0216085563
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.1616439617 16595196
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.2616842330 17085340
MESH:D008175 Lung Neoplasms Doxorubicin 2.1517418594 6189445
MESH:D008223 Lymphoma Doxorubicin 3.7716098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.1817654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 5.2215621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.2915458769
MESH:D008545 Melanoma Doxorubicin 2.3316827129
MESH:D008654 Mesothelioma Doxorubicin 3.2017638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.6516801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.9815792986
MESH:D052016 Mucositis Doxorubicin 5.5317415656
MESH:D009203 Myocardial Infarction Doxorubicin 3.0915857846 19429709
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0918259882
MESH:D009401 Nephrosis Doxorubicin 5.4216899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 10.7118481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 10.7115640375 16889571
MESH:D009447 Neuroblastoma Doxorubicin 3.4515555623
MESH:D012516 Osteosarcoma Doxorubicin 4.4815930896
MESH:D003557 Phyllodes Tumor Doxorubicin 6.0217983394
MESH:D010997 Pleural Neoplasms Doxorubicin 6.0217638057
MESH:D011230 Precancerous Conditions Cyclosporine 3.6412371664
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.4915897917 16888761 18437689 16729912 16868541 15749863
MESH:D011565 Psoriasis Cyclosporine 2.3416882103
MESH:D051437 Renal Insufficiency Doxorubicin 4.8717922066
MESH:D012509 Sarcoma Doxorubicin 4.4415625365 17203757 17710206 18313854 16767912 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.8314601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.5317846226
MESH:D012878 Skin Neoplasms Doxorubicin 3.1215692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 5.2217203757 16767912 15625365
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.7116010429 17909728
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8917653716
MESH:D014605 Uveitis Cyclosporine 4.851336536
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.8717334414 17678736 16364871 17638931
MESH:D014985 Xerophthalmia Cyclosporine 5.3117120751
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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