AutismKB 2.0

Annotation Detail for TMEM14A


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Basic Information Top
Gene Symbol:TMEM14A ( C6orf73 )
Gene Full Name: transmembrane protein 14A
Band: 6p12.2
Quick LinksEntrez ID:28978; OMIM: NA; Uniprot ID:TM14A_HUMAN; ENSEMBL ID: ENSG00000096092; HGNC ID: 21076
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TMEM14A mRNAaffects expression 17562736
C068073 Am 580 Am 580 results in decreased expression of TMEM14A mRNAdecreases expression 16982809
D016572 Cyclosporine Cyclosporine results in decreased expression of TMEM14A mRNAdecreases expression 20106945
D004317 Doxorubicin TMEM14A protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D010634 Phenobarbital Phenobarbital results in increased expression of TMEM14A mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TMEM14A mRNAaffects binding|decreases expression|increases activity 19710929
C089730 rosiglitazone rosiglitazone results in decreased expression of TMEM14A mRNAdecreases expression 16982809
D014747 Vinblastine TMEM14A protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.786195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Doxorubicin 2.6117418594
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.2717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2716434500
MESH:D000419 Albuminuria Doxorubicin 4.8321441931
MESH:D000544 Alzheimer Disease rosiglitazone 2.8919621015
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.0814601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.0417150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.5918234424 16115903 17983394 16264153 15668708 16935488 18628466 16322301 19526202 15567936 15939500 17426702 18695136 18382427 15136595 15994142 11325840 15634643 16096432 16826403 17369602 15692762 15993339 16595493
MESH:D002276 Carcinoid Tumor Doxorubicin 5.1916051944
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.773084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.7716234567 18059187 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7720007298 17173139 6705139 1701930 20935162
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 7.281485588 16201981
MESH:D002292 Carcinoma, Renal Cell Vinblastine 7.281485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.696189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.6817131338 16269455 17329180 17974986 16364871 16109756 16612575 16651473 17519947 16455267 15476868 16242529 17308081 15505089 17007740 17351982 17928571 17924179 17382496 15811867 16278810 16731534 16952015 15792986 18627295
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0116243910 17334414
MESH:D002386 Cataract Acetaminophen 8.1210977129
MESH:D002386 Cataract Am 580 8.1217460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6812371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D002779 Cholestasis Cyclosporine 8.3519486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D003092 Colitis Am 580 5.2717035595
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.9818259882 18802399
MESH:D015179 Colorectal Neoplasms Vinblastine 2.9818802399
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.5117446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 2.9812642470
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0917522070 10915739 12958197 12153990 11834606 16485898 12594235 16781746 19923254 19739265 16177239 10663392 19085960 11529661 14986274 14725611 2444490 12392966 16109766 19420014 19164858 19416960 11421492 12705907 16227642 10774834 16081117 19370779 15968718 17906064 17562736 15619225 18071297 11743745 11739529 14550746 11287661 12540782 16393943 11461765 18713872
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.0917416283
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Doxorubicin 3.8418602426
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004487 Edema pirinixic acid 7.8212083418
MESH:D004487 Edema rosiglitazone 7.8212083418
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6017359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.5318037988
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.2511558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D005234 Fatty Liver Cyclosporine 14.6119224547
MESH:D005234 Fatty Liver pirinixic acid 14.6119236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 14.6119196556
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.9319069698
MESH:D005355 Fibrosis Cyclosporine 3.4512639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005909 Glioblastoma Doxorubicin 3.4917150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.6815692506
MESH:D006331 Heart Diseases Doxorubicin 3.6414766674 18674790 16330681 16144979 12587719 17888722 16879835 18006777 16707910 17875725 16244372 16244371 16495754
MESH:D006333 Heart Failure Doxorubicin 7.5117481944
MESH:D006333 Heart Failure pirinixic acid 7.5120558911
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1415692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006529 Hepatomegaly Phenobarbital 9.5216109766
MESH:D006529 Hepatomegaly pirinixic acid 9.5218467677 19772884 16221962 19176532
MESH:D006689 Hodgkin Disease Doxorubicin 8.5217606976 18501091 15147373
MESH:D006689 Hodgkin Disease Vinblastine 8.5218501091 18180244
MESH:D006930 Hyperalgesia Acetaminophen 8.5316870215
MESH:D006930 Hyperalgesia rosiglitazone 8.5312083418
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007249 Inflammation rosiglitazone 3.2312083418
MESH:D007333 Insulin Resistance pirinixic acid 8.0016306350
MESH:D007333 Insulin Resistance rosiglitazone 8.0016306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 10.7912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.798314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 10.7915699352 15369732 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4016707910
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.5316085563
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0121047994
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.7416595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.7415474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 3.7415980055 17347453
MESH:D008107 Liver Diseases Acetaminophen 4.1012969438 19460945 16611625 19784758 16610002 12587719 11587558 19014921
MESH:D008107 Liver Diseases Phenobarbital 4.1019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 4.728742319 19073162 19812893 19482888 15975961 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 4.7220007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.5916842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.591399818 17172636 2563599 18308698 6150874
MESH:D008175 Lung Neoplasms Doxorubicin 2.1517418594 6189445
MESH:D008223 Lymphoma Doxorubicin 3.6316098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.9917654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.8715621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.9115458769
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 6.9116827153
MESH:D008545 Melanoma Doxorubicin 3.9016827129
MESH:D008545 Melanoma Vinblastine 3.9017761969 15577320 16248763 18332650 12374674 15577323 16432458 18176117 16809738 18505091
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008654 Mesothelioma Doxorubicin 3.1417638057
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.5817261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7415792986
MESH:D052016 Mucositis Doxorubicin 5.1317415656
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction Doxorubicin 6.0019429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 6.0019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0318259882
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009401 Nephrosis Doxorubicin 5.0816899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 10.0219348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 10.0216889571 15640375
MESH:D009447 Neuroblastoma Doxorubicin 3.3715555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009503 Neutropenia Vinblastine 4.8317378895
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D012516 Osteosarcoma Doxorubicin 4.3115930896
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5616965848
MESH:D003557 Phyllodes Tumor Doxorubicin 5.5317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.5317638057
MESH:D011230 Precancerous Conditions Cyclosporine 9.6912371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.692563599
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5118437689 15897917 16888761 16729912 15749863 16868541
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D051437 Renal Insufficiency Doxorubicin 4.5317922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012509 Sarcoma Doxorubicin 4.2217203757 18313854 17710206 15675481 16767912 15625365
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.5216326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.1317846226
MESH:D012640 Seizures Phenobarbital 2.8416876388 3137016 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D012878 Skin Neoplasms Doxorubicin 3.0515692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.8717203757 15625365 16767912
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.9417909728 16010429
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.941399818
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8417653716
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014625 Vaginal Neoplasms Vinblastine 5.3515577323
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.5317678736 17334414 17638931 16364871
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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