AutismKB 2.0

Annotation Detail for GRIK2


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Basic Information Top
Gene Symbol:GRIK2 ( EAA4,GLR6,GLUK6,GLUR6,MGC74427,MRT6 )
Gene Full Name: glutamate receptor, ionotropic, kainate 2
Band: 6q16.3
Quick LinksEntrez ID:2898; OMIM: 138244; Uniprot ID:GRIK2_HUMAN; ENSEMBL ID: ENSG00000164418; HGNC ID: 4580
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Synaptic Transmission
No data
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00037Ionotropic glutamate receptor pathway
P00029Huntington disease
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
Biochemical measures
Huntington's disease
PSYCH
NEUROLOGICAL
Citalopram/adverse effects*
REPRODUCTION
Autism
Desease Name
Biochemical measures
Desease Name
Mental retardation, autosomal recessive, 6
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C084273 5-nitro-6,7,8,9-tetrahydrobenzo(G)indole-2,3-dione-3-oxime 5-nitro-6,7,8,9-tetrahydrobenzo(G)indole-2,3-dione-3-oxime binds to and results in decreased activity of GRIK2 proteinaffects binding|decreases activity 19596362
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRIK2 mRNAaffects expression 16483693
D020185 Benzoic Acids Benzoic Acids analog binds to and results in decreased activity of GRIK2 proteinaffects binding|decreases activity 14667236
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of GRIK2 mRNAaffects cotreatment|increases expression 20360939
D002220 Carbamazepine Carbamazepine results in decreased expression of GRIK2 mRNAdecreases expression 19596362
D002220 Carbamazepine Carbamazepine results in decreased expression of GRIK2 proteindecreases expression 19596362
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of GRIK2 mRNAdecreases expression 19440498
D003024 Clozapine Clozapine results in increased expression of GRIK2 mRNAincreases expression 18923069
D003976 Diazinon Diazinon affects the expression of GRIK2 mRNAaffects expression 19440498
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of GRIK2 mRNAaffects cotreatment|increases expression 20360939
D000431 Ethanol Ethanol results in increased expression of GRIK2 proteinincreases expression 12045474
D006220 Haloperidol Haloperidol results in increased expression of GRIK2 mRNAincreases expression 18923069
D008094 Lithium Lithium results in decreased expression of GRIK2 mRNAdecreases expression 19596362
D008094 Lithium Lithium results in decreased expression of GRIK2 proteindecreases expression 19596362
D008767 Methylmercury Compounds Methylmercury Compounds results in increased expression of GRIK2 mRNAincreases expression 16966085
C476610 oxcarbamazepine oxcarbamazepine results in decreased expression of GRIK2 mRNAdecreases expression 19596362
C476610 oxcarbamazepine oxcarbamazepine results in decreased expression of GRIK2 proteindecreases expression 19596362
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GRIK2 mRNAincreases expression 11752688
D014635 Valproic Acid Valproic Acid results in decreased expression of GRIK2 mRNAdecreases expression 19596362
D014635 Valproic Acid Valproic Acid results in decreased expression of GRIK2 proteindecreases expression 19596362
C025643 vinclozolin vinclozolin affects the expression of GRIK2 mRNAaffects expression 19015723
D015032 Zinc Zinc results in increased expression of GRIK2 mRNAincreases expression 16870260
C016837 zinc chloride zinc chloride results in increased expression of GRIK2 mRNAincreases expression 16870260
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 19.918986270
MESH:D000014 Abnormalities, Drug-Induced Ethanol 19.9117676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 19.9111752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 19.918875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8619490988
MESH:D000138 Acidosis Ammonium Chloride 10.2718287403
MESH:D000138 Acidosis Ethanol 10.2711192467
MESH:D000169 Acrodermatitis Zinc 5.3417202136 17190629 16889938
MESH:D000236 Adenoma Diethylnitrosamine 2.816695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.8517620307 19061943 19052882 17162532 16434500 18056438
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.8516835633
MESH:D000380 Agranulocytosis Clozapine 4.9912649775 16160616 14617031
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 8.9711874814 16611668 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 8.9716487989
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.2615451039 15451040
MESH:D000544 Alzheimer Disease Lithium 4.7819621015
MESH:D000544 Alzheimer Disease Zinc 4.7816325427 16580781 17119284 16410023
MESH:D000550 Amblyopia Valproic Acid 5.1817688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.8416916123
MESH:D000853 Anophthalmos Ethanol 4.7615513904
MESH:D001008 Anxiety Disorders Ethanol 14.5411141031
MESH:D001008 Anxiety Disorders Valproic Acid 14.5417497229
MESH:D001008 Anxiety Disorders vinclozolin 14.5419015723
MESH:D001249 Asthma Zinc 2.9317085522
MESH:D001321 Autistic Disorder marker/mechanism 11920157 20442744
MESH:D001321 Autistic Disorder Haloperidol 2.3418080171 19368416
MESH:D001321 Autistic Disorder Valproic Acid 2.3420603192 19460635 17507914 17688650 18316065 18396377 18558336 19232924 18985861 16609825 17157402 18940202 15238991 18775368 18177632
MESH:D001714 Bipolar Disorder marker/mechanism 18332879
MESH:D001714 Bipolar Disorder Carbamazepine 11.9817594078 20046352
MESH:D001714 Bipolar Disorder Lithium 11.9819153942 20046352 20338123 17594078
MESH:D001714 Bipolar Disorder Valproic Acid 11.9817594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.8815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.888888407
MESH:D001930 Brain Injuries Zinc 4.6317109824
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9817474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9820435547
MESH:D002056 Burns Ethanol 4.5916374292
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1918506893 18785209 16328049 19519916 17138121 16540662 19171122 16698587 17761372 20524982 17978847 18691550 19539802 17428255 20727157 17162532 17173139 18210153 10672840 16807293 18788625 10737359 18393292 20512989 16502159 19822196 3084413 3581430 16878318 16830150 20514400 11831363 19701751 20935162 16288022 16779866 17055752 20084675 19208518 16681979 20214788 19383236 19919837 18971187 18978308 21159647 16569478 20432363 16935385 18056438 18494052 20007298 19052882 19107877 18665156 19335982 19394651 20101231 19418558
MESH:D006528 Carcinoma, Hepatocellular Ethanol 3.1918788625 15763234 15289165
MESH:D002294 Carcinoma, Squamous Cell Zinc 2.8816543248
MESH:D006332 Cardiomegaly Ethanol 6.7219332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.7218850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Zinc 3.6116936243
MESH:D002375 Catalepsy Haloperidol 4.851977408 15215559
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.8121159647 7505956 2727394 17174075
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6820734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.1319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.1316835633
MESH:D002971 Cleft Lip Ethanol 3.5515513904
MESH:D002972 Cleft Palate Ethanol 5.8615513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8615668235 15340226 12621046 8697196 16354765
MESH:D003072 Cognition Disorders Clozapine 4.9017123785
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0017141729 14669216
MESH:D019465 Craniofacial Abnormalities Carbamazepine 7.299014606
MESH:D019465 Craniofacial Abnormalities Ethanol 7.2915513904 15451039 11198716 19302082 11873399 15451040 10194807
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 7.2920055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 7.2917688650 16575769 8888407
MESH:D019465 Craniofacial Abnormalities Zinc 7.2919302082
MESH:D003456 Cryptorchidism vinclozolin 4.2814966744
MESH:D007644 Darier Disease Lithium 5.8520338123
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.7820210726
MESH:D003704 Dementia Haloperidol 10.2311575062
MESH:D003704 Dementia Methylmercury Compounds 10.2316140633
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.6819244398
MESH:D003920 Diabetes Mellitus Zinc 4.1516479319
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 7.0816402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.0820387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.0817107852
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.5015331141
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.3811748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.3716538176 16538175 20216337 15057820
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 11.8417465707
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.8419107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 11.8411566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.8420420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.841733752 19641884
MESH:D004362 Drug Toxicity Carbamazepine 8.2320216337
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.2311462148
MESH:D050171 Dyslipidemias Clozapine 4.1316402076
MESH:D004417 Dyspnea Diazinon 4.7416487989
MESH:D004421 Dystonia Valproic Acid 3.991851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8515322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 4.6717654737
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9610568697 9294722
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.1916415921 16538176 20485159 19915237 18855540
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 10.9917275665
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 10.993659116 17275665
MESH:D004828 Epilepsies, Partial Carbamazepine 10.1916628512 15008574 17116037
MESH:D004828 Epilepsies, Partial Valproic Acid 10.1916628512 3922381
MESH:D004827 Epilepsy Carbamazepine 6.9618234410 19700373 7988514 9014606 17178248 19620853 821787 17465707 20417680 19439326
MESH:D004827 Epilepsy Valproic Acid 6.9618234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.537562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 11.507750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 11.507750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 10.6815276670 3659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 10.683659116
MESH:D004916 Erythromelalgia Carbamazepine 5.6619549232
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0616302075
MESH:D004938 Esophageal Neoplasms Ethanol 4.8616704527
MESH:D004938 Esophageal Neoplasms Zinc 4.8616543248
MESH:D005076 Exanthema Carbamazepine 5.4120485159
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver Diethylnitrosamine 12.8821071580 20387270
MESH:D005234 Fatty Liver Ethanol 12.8818620774 19236843 16409862
MESH:D005234 Fatty Liver Valproic Acid 12.8814986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.6117920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.2416946407 15451040 15513904 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.078888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8920067830
MESH:D005756 Gastritis Ethanol 11.3615046732
MESH:D005756 Gastritis Zinc 11.3617241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2416417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006130 Growth Disorders Zinc 3.9217217573
MESH:D006330 Heart Defects, Congenital Lithium 6.9119638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9110048152 11294989
MESH:D006333 Heart Failure Zinc 3.5717162251
MESH:D006335 Heart Injuries Zinc 5.7117074742
MESH:D016481 Helicobacter Infections Zinc 4.4717241300
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006505 Hepatitis Diazinon 4.5116487989
MESH:D006527 Hepatolenticular Degeneration Zinc 4.6317276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8316120746 15340226 12621046
MESH:D006849 Hydrocephalus Valproic Acid 4.8117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9915340226 16354765 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Ethanol 3.6618783367
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.6710459572
MESH:D006948 Hyperkinesis Clozapine 4.8516046005
MESH:D006965 Hyperplasia Carbamazepine 5.1518773962
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8818670907 18850075
MESH:D007248 Infertility, Male Diazinon 7.0016466525 12948887
MESH:D007248 Infertility, Male vinclozolin 7.0016467254
MESH:D007249 Inflammation Diethylnitrosamine 4.7818785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.7812878042 12200463
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.5310783313
MESH:D007511 Ischemia Zinc 4.5716584753
MESH:D007569 Jaw Abnormalities Ethanol 9.9115513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.9116580747
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 6.5315369732
MESH:D007674 Kidney Diseases Zinc 6.5316960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.3616518626
MESH:D007859 Learning Disorders Ethanol 4.1515451040
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1416294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 3.9516766008
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6716417039
MESH:D017880 Limb Deformities, Congenital Ethanol 3.7617676605
MESH:D008064 Lipidoses Clozapine 3.9117567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.7018665156 19638242 20032147 18407596 18522880
MESH:D008103 Liver Cirrhosis Ethanol 6.7015289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.0418295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.4718166357
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4712878042
MESH:D008107 Liver Diseases Chlorpyrifos 4.3815991261
MESH:D008107 Liver Diseases Diethylnitrosamine 4.3817034775
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.5917207112 17347304
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.3219426721 20405173 21278145 21047994 19690152 19551842 12112319 15885732 12771043 20501860 20137499 19427195 20452335 19642983 18644402 19256749 19499222 19255062 19294768 9163691 19812893 20434301 19638242 2422723 18977376 20118626 2862719 21071580 19254457 19833225 15175105 19996281 20101389 21167192 18648771 18978307 18754104 19850985 16942905 19090486 20583210 20492335 19073162 10737359
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.3216984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.6319519916 18775883 18253720 18079962 18282651 16267830 19126423 18544905 2563599 19539802 18093689 19009564 18164116 16842330 17174075 9362446 17942915 21159647 19004024 3124819 17854601 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.6312151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2117228818
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.2420970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2411884234 19555203
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.5516628512
MESH:D008325 Mammary Neoplasms, Experimental Zinc 3.2512773700
MESH:D008569 Memory Disorders Ethanol 9.8218411066 15451040
MESH:D008569 Memory Disorders Methylmercury Compounds 9.8218436314
MESH:D001523 Mental Disorders Clozapine 8.1616856516
MESH:D001523 Mental Disorders Haloperidol 8.1616856516
MESH:D008607 Mental Retardation Carbamazepine 3.709014606
OMIM:611092 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 6 marker/mechanism
MESH:D024821 Metabolic Syndrome X Clozapine 4.3519142101
MESH:D008881 Migraine Disorders Valproic Acid 3.1418803445 18765137
MESH:D009069 Movement Disorders Methylmercury Compounds 5.2618436314
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.968888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1217596541
MESH:D009203 Myocardial Infarction Lithium 3.9016288908
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D009224 Myotonia Congenita Carbamazepine 5.4120399394
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.543581430 9029167
MESH:D009421 Nervous System Malformations Carbamazepine 9.7116990009
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7114600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.0816359493 8888407
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.2820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0620387270
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.1215081274
MESH:D009765 Obesity Clozapine 3.0018515891 19142110
MESH:D010018 Osteomalacia Carbamazepine 5.4117016548
MESH:D010146 Pain Carbamazepine 3.9815215642
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3616540662
MESH:D010190 Pancreatic Neoplasms Ethanol 5.3612384795
MESH:D010267 Parapsoriasis Carbamazepine 5.6416538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.8617145499 17679678
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D011041 Poisoning Diazinon 4.2917603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.492563599
MESH:D011225 Pre-Eclampsia Zinc 4.1217114810
MESH:D011248 Pregnancy Complications Carbamazepine 5.099014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 29.879014606
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 29.8718436314
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 29.8711896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 29.8720603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 29.8718220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.8718220299
MESH:D011471 Prostatic Neoplasms Zinc 3.8412429649 16700911 16517595 16606632
MESH:D011472 Prostatitis vinclozolin 4.8718629315
MESH:D019310 Pseudolymphoma Carbamazepine 12.4112752131 9591791
MESH:D019310 Pseudolymphoma Valproic Acid 12.4111422049 12752131
MESH:D011595 Psychomotor Agitation Haloperidol 4.8911575062
MESH:D011618 Psychotic Disorders Clozapine 9.0015331141
MESH:D011618 Psychotic Disorders Haloperidol 9.0011575062
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.5716611668 17119214 11874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.8416611668 17119214
MESH:D012162 Retinal Degeneration Zinc 4.0716584753
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.1119155313
MESH:D012559 Schizophrenia marker/mechanism 18923069
MESH:D012559 Schizophrenia Clozapine 5.6620580759 16141801 20107430 17123785 18855531 18806925 20452607 19369910 17726453 20168265 20521326 11151749 11763009 20521320 17667964
MESH:D012559 Schizophrenia Haloperidol 5.6619369910 1830565 20107430 18513383
MESH:D012559 Schizophrenia Valproic Acid 5.6615737665 19110320
MESH:D012640 Seizures Carbamazepine 13.869046859 19414003 16876388 16938433 9844417 16180713 15946322
MESH:D012640 Seizures Ethanol 13.869754883
MESH:D012640 Seizures Lithium 13.8619660546
MESH:D012640 Seizures Valproic Acid 13.8616876388 14763951 15475178 11044598 17978042 3137016 11738929 1511512
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.036418539
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0116192470
MESH:D012893 Sleep Disorders Carbamazepine 5.0619414003
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7319490988
MESH:D013226 Status Epilepticus Lithium 12.4819951488 19430551 19570321
MESH:D013226 Status Epilepticus Valproic Acid 12.4812833885
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.1519915237 20485159 16538176 18855540 19694795 16415921 15057820
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.5918456281
MESH:D013274 Stomach Neoplasms Ethanol 2.5918456281
MESH:D013276 Stomach Ulcer Ethanol 3.4717189318 9562338 9211565 17918041 11906479 16755016
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.199754883
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.6420210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.937505956
MESH:D014062 Tongue Neoplasms Zinc 4.3416543248
MESH:D014178 Translocation, Genetic Valproic Acid 5.1817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.463119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.588888407
MESH:D014570 Urologic Diseases Diazinon 5.2216487989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D015430 Weight Gain Clozapine 4.4120521320 20107430 20564506 17502770 16141801 16402076
MESH:D015431 Weight Loss Clozapine 5.0217933447
Pathway ID Pathway Name
KEGG:04724 Glutamatergic synapse
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA164741600
    • No data
    Releated disease ID Related disease Name
    PA447278Depression
    Releated drug ID Related drug Name
    PA449015citalopram
    PA450626nicotine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00237 antagonist Butabarbital Anti-anxiety Agents;Hypnotics and Sedatives;Barbiturates
    DB00241 antagonist Trianal-C 1/2 Capsule Analgesics
    DB00306 antagonist Talbutal Analgesics
    DB00312 antagonist Cafergot PB Tab Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Barbiturates
    DB00418 antagonist Secobarbital Hypnotics and Sedatives;Adjuvants, Anesthesia;GABA Modulators;Barbiturates;Adjuvants
    DB00463 antagonist Metharbital Anticonvulsants
    DB00599 antagonist Thiotal 5g Hypnotics and Sedatives;Anticonvulsants;GABA Modulators;Anesthetics, Intravenous
    DB00794 antagonist Primidone Anticonvulsants;Barbiturates
    DB00849 antagonist Methylphenobarbital Hypnotics and Sedatives;Anticonvulsants;GABA Modulators
    DB01174 antagonist Phenobarbital Hypnotics and Sedatives;Anticonvulsants;GABA Modulators;Excitatory Amino Acid Antagonists
    DB01351 antagonist Amobarbital Hypnotics and Sedatives;GABA Modulators
    DB01352 antagonist Aprobarbital
    DB01353 antagonist Butethal Anti-anxiety Agents;Hypnotics and Sedatives;Barbiturates
    DB01354 antagonist Heptabarbital Hypnotics and Sedatives;Barbiturates
    DB01355 antagonist Hexobarbital Hypnotics and Sedatives;GABA Modulators;Barbiturates;Adjuvants
    DB01483 antagonist Barbital Hypnotics and Sedatives;GABA Modulators
    DB01496 antagonist Barbituric acid derivative
    DB02852 - Domoic Acid Neuromuscular Depolarizing Agents
    DB02999 - Quisqualate Excitatory Amino Acid Agonists
    DB03425 - 2s,4r-4-Methylglutamate
    DB03965 - Fucose
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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