AutismKB 2.0

Annotation Detail for DBNL


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Basic Information Top
Gene Symbol:DBNL ( ABP1,HIP-55,SH3P7 )
Gene Full Name: drebrin-like
Band: 7p13
Quick LinksEntrez ID:28988; OMIM: 610106; Uniprot ID:DBNL_HUMAN; ENSEMBL ID: ENSG00000136279; HGNC ID: 2696
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Apoptosis
Pathway IDPathway Name
200129JNK signaling in the CD4+ TCR pathway
200022TCR signaling in naive CD4+ T cells
No data
Pathway IDPathway Name
500271Caspase-mediated cleavage of cytoskeletal proteins
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DBNL mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DBNL mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of DBNL mRNAaffects expression 17331233
D003687 Dehydroepiandrosterone Dehydroepiandrosterone results in decreased expression of DBNL mRNAdecreases expression 16940010
D004041 Dietary Fats Dietary Fats results in decreased expression of DBNL mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of DBNL mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of DBNL mRNAdecreases expression 17426115
D011374 Progesterone Progesterone affects the expression of DBNL mRNAaffects expression 17251523
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000309 Adrenal Insufficiency Dehydroepiandrosterone 6.0717302879
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7117868700
MESH:D001930 Brain Injuries Progesterone 4.5615845082 15380490 15665606
MESH:D001943 Breast Neoplasms Dietary Fats 2.2420435547
MESH:D001943 Breast Neoplasms Progesterone 2.2416175315 17614352 15562024
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.393084413
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003922 Diabetes Mellitus, Type 1 Dehydroepiandrosterone 3.7516616286
MESH:D003929 Diabetic Neuropathies Progesterone 4.8017187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6415968718 15619225 16485898 12540782 19085960 19923254 17562736 2444490 19370779 19420014 12594235 18713872 16109766 11739529 16393943 14550746 16177239 12392966 19164858 11743745 12153990 10774834 11461765 12958197 17522070 10915739 16081117 16781746 11834606 10663392 11529661 11421492 18071297 12705907 14986274 14725611 11287661 17906064 19416960 16227642 19739265
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.0617692515
MESH:D004715 Endometriosis Progesterone 3.9916134523
MESH:D005234 Fatty Liver Dietary Fats 8.5217967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver pirinixic acid 8.5219236843 20131406
MESH:D005355 Fibrosis Dietary Fats 3.8318296743
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3019176532 16221962 18467677 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7115869954
MESH:D007249 Inflammation Dietary Fats 5.5620412841
MESH:D007249 Inflammation Progesterone 5.5615869954
MESH:D007333 Insulin Resistance Dietary Fats 7.7418457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.7416306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9918296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6716611625 19014921 12587719 19460945 11587558 19784758 16610002 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms Dehydroepiandrosterone 5.1518709148
MESH:D008113 Liver Neoplasms pirinixic acid 5.1515890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Dehydroepiandrosterone 4.008603461
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.3317365036
MESH:D008325 Mammary Neoplasms, Experimental Dehydroepiandrosterone 7.0316457693
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 7.0311408345 17203775
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2616966607 18303189 16166281
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity Dietary Fats 4.6017217161 19632207 21332399 18674790 16723640 18457598 20518802 20132043 11836018
MESH:D009765 Obesity pirinixic acid 4.6020558911
MESH:D015663 Osteoporosis, Postmenopausal Dehydroepiandrosterone 5.2916397352
MESH:D010051 Ovarian Neoplasms Progesterone 2.5816525653 17393432
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.2010923243
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1017365031 15814490 17975199 17322281
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9218045962
MESH:D013119 Spinal Cord Injuries Progesterone 4.6216503802 15862959
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
Pathway ID Pathway Name
REACT:578 Apoptosis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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