AutismKB 2.0

Annotation Detail for HIPK2


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Basic Information Top
Gene Symbol:HIPK2 ( DKFZp686K02111,FLJ23711,PRO0593 )
Gene Full Name: homeodomain interacting protein kinase 2
Band: 7q34
Quick LinksEntrez ID:28996; OMIM: 606868; Uniprot ID:HIPK2_HUMAN; ENSEMBL ID: ENSG00000064393; HGNC ID: 14402
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200130C-MYB transcription factor network
200175p53 pathway
No data
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
1712Yersinia infection
1860Brain tumor
2011Leukoencephalopathy
2051Leukemia
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of HIPK2 mRNAincreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HIPK2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of HIPK2 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of HIPK2 mRNAaffects expression 17562736
C068073 Am 580 Am 580 results in increased expression of HIPK2 mRNAincreases expression 16982809
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HIPK2 mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HIPK2 mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of HIPK2 mRNAaffects expression 17484886
D004041 Dietary Fats Dietary Fats results in decreased expression of HIPK2 mRNAdecreases expression 18042831
D004137 Dinitrochlorobenzene Dinitrochlorobenzene results in increased expression of HIPK2 mRNAincreases expression 16314067
C533894 LG 100815 LG 100815 results in increased expression of HIPK2 mRNAincreases expression 16951191
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of HIPK2 mRNAdecreases expression 20713471
C029938 nickel sulfate nickel sulfate results in increased expression of HIPK2 mRNAincreases expression 16314067
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in increased expression of HIPK2 mRNAincreases expression 16951191
C041786 palm oil palm oil results in decreased expression of HIPK2 mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of HIPK2 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of HIPK2 mRNAincreases expression 18301758
D011374 Progesterone Progesterone results in decreased expression of HIPK2 mRNAdecreases expression 18070364
C089730 rosiglitazone rosiglitazone results in increased expression of HIPK2 mRNAincreases expression 16982809
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of HIPK2 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of HIPK2 mRNAdecreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in decreased expression of HIPK2 mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HIPK2 mRNAincreases expression 17035482
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of HIPK2 mRNAdecreases expression 18087596
C025643 vinclozolin vinclozolin affects the expression of HIPK2 mRNAaffects expression 19015723
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of HIPK2 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of HIPK2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7014514962 15322242 11752688
MESH:D055371 Acute Lung Injury nickel sulfate 8.6719131640 12718980 11954676 16100012
MESH:D055371 Acute Lung Injury pirinixic acid 8.6718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9520127859 20464547
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.3815814487
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.713712494
MESH:D000236 Adenoma Benzo(a)pyrene 10.716695378
MESH:D000236 Adenoma Methylcholanthrene 10.7110545420 6695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3916835633
MESH:D000544 Alzheimer Disease rosiglitazone 2.8219621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D001008 Anxiety Disorders vinclozolin 3.5219015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9219183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.7415238619
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.1519898480
MESH:D050197 Atherosclerosis Methylcholanthrene 3.3611922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.871440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1917868700
MESH:D001930 Brain Injuries Progesterone 4.1115665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2920146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 2.2920435547
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.2917474063
MESH:D001943 Breast Neoplasms Progesterone 2.2916175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2920435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.4316011737 15673190 16192424 15700767 16124888 15721981 10355542 16227642 3786805 16097048 16050911 18705752
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.4316050911
MESH:D002277 Carcinoma Methylcholanthrene 7.9310545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.9316835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.3416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.343581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.343084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.3418788625
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.3711212258
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.617296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7620419170
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 4.7611212258
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 7.3910977129
MESH:D002386 Cataract Am 580 7.3917460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.196135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.197505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.1920889678
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 15.1916192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0316835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 7.479022650 19486331
MESH:D002779 Cholestasis pirinixic acid 7.4719176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6015894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0416354765 15340226 12621046 8697196 15668235
MESH:D003092 Colitis Am 580 9.4617035595
MESH:D003092 Colitis Selenium 9.4617936198
MESH:D003093 Colitis, Ulcerative Dinitrochlorobenzene 3.8017373747 19159591
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9317141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4315322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.4319769572
MESH:D003456 Cryptorchidism vinclozolin 4.1914966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8718551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 10.9214531868 12868966 11906362 18759878 2524372 8156756 11298694 8970840
MESH:D017449 Dermatitis, Allergic Contact Dinitrochlorobenzene 10.9215491423
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 10.9216823706 11298694 16780908
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.352952479 3621924
MESH:D003920 Diabetes Mellitus rosiglitazone 8.9917446233
MESH:D003920 Diabetes Mellitus Sodium Selenite 8.9916285004
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.3712642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3717107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.3417187935
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 17.9918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 17.9918289764 18648102 18692083 16192314 11289319 7440962 9328219 6679447 6482804 1440618 9653073 8291058 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.9911743745 12705907 11739529 19416960 19420014 11834606 12153990 17522070 12540782 19739265 14550746 15968718 10774834 11421492 15619225 19085960 10663392 16227642 12392966 14725611 11529661 14986274 19923254 16177239 16485898 12958197 12594235 18713872 19164858 16109766 16393943 16781746 17562736 16081117 2444490 18071297 19370779 17906064 11287661 10915739 11461765
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 17.996884620 16227642 7179309 9327722 3786805 7440962 11566570 4309450 15998439 2869522 15027814 10915739 7120509 21278145 19336974 17522070 6623471 19085960 10092053 15968718 3732212 16177239
MESH:D056486 Drug-Induced Liver Injury Selenium 17.9915131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 17.9915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.9920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3418367378
MESH:C538011 Eales disease Vitamin E 4.559068938
MESH:D004487 Edema pirinixic acid 10.6712083418
MESH:D004487 Edema rosiglitazone 10.6712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.6712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7515322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.6317692515
MESH:D004715 Endometriosis Progesterone 8.4816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.489294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.953581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9520426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.9516530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 17.6712631006 19224547 12795759 16239168 15959796 17595544 16045604 61145
MESH:D005234 Fatty Liver Dietary Fats 17.6718296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver pirinixic acid 17.6719236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 17.6719196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.876705139
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.7914633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 13.8918705752
MESH:D005355 Fibrosis Dietary Fats 13.8918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.8920067830
MESH:D005756 Gastritis Acetaminophen 3.5216983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1516417039
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.897505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.6520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.6511294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 10.6516080930
MESH:D006333 Heart Failure pirinixic acid 6.6420558911
MESH:D006333 Heart Failure Selenium 6.6417162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.736705139
MESH:D006505 Hepatitis Carbon Tetrachloride 8.7319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.7619176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7615340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6516490937 16863852
MESH:D019584 Hot Flashes Vitamin E 3.8214716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8918606429 8697196 16959395 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.4816870215
MESH:D006930 Hyperalgesia rosiglitazone 7.4812083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3816899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4521332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.4721332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7915034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8518850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9415338365
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2515869954
MESH:D007248 Infertility, Male vinclozolin 2.9416467254
MESH:D007249 Inflammation Dietary Fats 15.0620412841
MESH:D007249 Inflammation Progesterone 15.0615869954
MESH:D007249 Inflammation rosiglitazone 15.0612083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.0612878042 12200463
MESH:D007249 Inflammation Tobacco Smoke Pollution 15.0618590791
MESH:D007251 Influenza, Human Selenium 10.4516624496
MESH:D007251 Influenza, Human Vitamin E 10.4516624496
MESH:D007333 Insulin Resistance Dietary Fats 16.8718457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 16.8716306350
MESH:D007333 Insulin Resistance rosiglitazone 16.8716306350
MESH:D007333 Insulin Resistance Sodium Selenite 16.8714714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.878074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007674 Kidney Diseases Acetaminophen 5.6812587719 15629191
MESH:D007674 Kidney Diseases Vitamin E 5.6812488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.7516518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 6.9516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 6.956582329
MESH:D007984 Leydig Cell Tumor vinclozolin 4.5816417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.3511903743 16221502 16943688 17157831 11408273 17334410 21278145 17174718 16239168
MESH:D008103 Liver Cirrhosis Dietary Fats 6.3518296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.109327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.5314748882 16027843 14716496 14724832 18472332 12609069 16097048 17766677 12666154 16033810 17823541 12632512 17900296 12586293 18277467 16192424 12649538 10355542 16015684 18279442 17714472 13678700 18210741 15996030 18472094 17565644 18412020 11481614 18251166 18395095 18376398 18339082 12445418 12958196 18054572 20821823 15338365 18166357 15925388 15650968 14620537 18705752 18006644 18187930 16136751 12445421 12389079 12667390 18395914 17525996 17698563 12741479 15673190 18481824 17481882 17944888 15370692 15052691 14512876 16011737 16638106 17640975 12898905 16116963 16248980 18420326 17869086 15057751 15818738 15123356 17922224 18205269 15931870 15893842 17761835 15959796 17557913 17631135 12632514 14716833 17708605 17976157 17805973 15876570 18317297 17721639 15362042 12546737 18418968 18429990 18156304 18263696 15730626
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5315474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 6.5315980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5312878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.5316169303
MESH:D008107 Liver Diseases Acetaminophen 3.7711587558 16611625 12587719 19460945 16610002 19014921 12969438 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.7716246199 15830285 15720792 17285989 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.9616871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.9614706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.617678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.6120195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.6119294768
MESH:D008113 Liver Neoplasms pirinixic acid 13.6115890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.6116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 17.652876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.65598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.6512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 17.651399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.6512151625
MESH:D008171 Lung Diseases Vitamin E 3.0816863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.4120135361 18816296 6695378 18569708 20869020 20464547 20064080 17053015 18520028
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.4110545420 16271038 21163286 7750092 20512841 9230183 6695378 20970405 17909032 1399818 11893704 15390079 16337739
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.4119555203 11884234
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 6.4116288123 12111688 11091918 3440675
MESH:D008175 Lung Neoplasms Vitamin E 6.4111062179
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.9214737004
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.5411408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 9.5416827153
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.5415318939
MESH:D008545 Melanoma Dinitrochlorobenzene 3.1812202904 17334785
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D008654 Mesothelioma Selenium 2.7315107826
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.2517261469
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.4116381670
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 8.4115006635
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.7118551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.413581430
MESH:D009369 Neoplasms Benzo(a)pyrene 4.5711141357
MESH:D009369 Neoplasms pirinixic acid 4.5717405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0714600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.826679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7518514411
MESH:D009765 Obesity Dietary Fats 4.3119632207 17217161 20132043 21332399 18674790 20518802 16723640 11836018 18457598
MESH:D009765 Obesity pirinixic acid 4.3120558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.4416049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.444026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.873988306
MESH:D010051 Ovarian Neoplasms Progesterone 2.4817393432 16525653
MESH:D010146 Pain Acetaminophen 2.2716870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.337296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.326228378
MESH:D010954 Plasmacytoma Selenium 4.7415087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9811118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.9819015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.7818220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6117292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6118760546
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6115084515
MESH:D011472 Prostatitis vinclozolin 4.7818629315
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.4718410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.263692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8018045962
MESH:D012640 Seizures 2,6-dinitrotoluene 2.4418551238
MESH:D012871 Skin Diseases Vitamin E 2.4018709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.1019755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.1016192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 9.1018590791
MESH:D013119 Spinal Cord Injuries Progesterone 4.1315862959 16503802
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.552093021 20155912
MESH:D020521 Stroke Vitamin E 3.4016517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.776587162 6582329 1399818 3712494 7505956
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.4716049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.478074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.4717053015
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 11.4712846360
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1710091137
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D015430 Weight Gain Dietary Fats 3.6116723640
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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