AutismKB 2.0

Annotation Detail for ABR


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Basic Information Top
Gene Symbol:ABR ( FLJ45954,MDB )
Gene Full Name: active BCR-related gene
Band: 17p13.3
Quick LinksEntrez ID:29; OMIM: 600365; Uniprot ID:ABR_HUMAN; ENSEMBL ID: ENSG00000159842; HGNC ID: 81
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Signaling by Rho GTPases
Pathway IDPathway Name
200165Regulation of RAC1 activity
200050Regulation of RhoA activity
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ABR mRNAdecreases expression 20064835
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ABR mRNAincreases expression 15003993
D002945 Cisplatin ABR protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D012643 Selenium Selenium results in increased expression of ABR mRNAincreases expression 19244175
C017947 sodium arsenite sodium arsenite results in increased expression of ABR mRNAincreases expression 17879257
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 4.3312690470 17670903 15814532
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.7620464547 20127859
MESH:D000230 Adenocarcinoma Cisplatin 4.7611798837 17638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.846695378
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.3115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.5117306315 16712894
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.5619183758
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.5014601052
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2717474063 20146248
MESH:D001943 Breast Neoplasms Cisplatin 2.2719526202 18382427
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 3.4117982673
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.4116507464 15276417 17306315
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1316685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 8.0720419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 8.076189445 17066447 18337622
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 8.0718572023
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.2220056578 19524636
MESH:D003092 Colitis Selenium 4.2617936198
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2515131321
MESH:D004362 Drug Toxicity Cisplatin 4.1112649298 19839026 12231392 15033597
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.8516530937
MESH:D004938 Esophageal Neoplasms Cisplatin 4.8515464296 16481741 16785472 17638652 15173087
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.2216452187
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.9415102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.6219898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.7315464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8220471113
MESH:D006333 Heart Failure Selenium 3.2717162251
MESH:D006689 Hodgkin Disease Cisplatin 8.6416170182 16200630
MESH:D006689 Hodgkin Disease sodium arsenite 8.6412676792
MESH:D007248 Infertility, Male sodium arsenite 3.2115346721 12646999
MESH:D007251 Influenza, Human Selenium 4.8116624496
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.7515464296
MESH:D007674 Kidney Diseases Cisplatin 6.9615190930 18289764 19839026 12231392 12649298
MESH:D007674 Kidney Diseases sodium arsenite 6.9620008137
MESH:D007676 Kidney Failure, Chronic Selenium 4.2616518626
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.4111231351
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.9420195826 21137059
MESH:D008113 Liver Neoplasms sodium arsenite 4.9415276417 16712894
MESH:D008171 Lung Diseases sodium arsenite 3.4019095001
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6820869020 17053015 18816296 20464547 6695378 18520028 20064080 18569708 20135361
MESH:D008175 Lung Neoplasms Cisplatin 3.686189445 11798837 17225452
MESH:D008175 Lung Neoplasms sodium arsenite 3.6817077188 19931552 15276417 16712894 17306315
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9715318939
MESH:D008527 Medulloblastoma marker/mechanism
MESH:D008545 Melanoma Cisplatin 3.6912393984 16809738 18176117 16248763 16432458 15577323 18505091 11135225 12374674 12883367 17761969 17023156 18332650
MESH:D008545 Melanoma sodium arsenite 3.6919082730 16487513
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.3115990972
MESH:D008654 Mesothelioma Cisplatin 6.7417638057
MESH:D008654 Mesothelioma Selenium 6.7415107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4616381670
MESH:D009369 Neoplasms Benzo(a)pyrene 9.2411141357
MESH:D009369 Neoplasms Cisplatin 9.2416773208
MESH:D009369 Neoplasms sodium arsenite 9.2411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.1520056578
MESH:D009395 Nephritis, Interstitial Cisplatin 5.1015464296
MESH:D009436 Neural Tube Defects sodium arsenite 3.3612854658
MESH:D009447 Neuroblastoma Cisplatin 3.608761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 5.248761367
MESH:D010051 Ovarian Neoplasms Cisplatin 5.3819769630 6897625 15464296 17225452
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.3817306315 15276417
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0919003803
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.7515464296
MESH:D010954 Plasmacytoma Selenium 5.5015087411
MESH:D010997 Pleural Neoplasms Cisplatin 5.9517638057
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1117292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.1116039940
MESH:D051437 Renal Insufficiency Cisplatin 4.8915464296
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.8714601052
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 10.3310029692 19755658
MESH:D012878 Skin Neoplasms sodium arsenite 10.3318572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 10.338532709
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.9515464296
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0712854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.612093021 20155912
MESH:D013274 Stomach Neoplasms Cisplatin 2.6117522103 18396642 15958060
MESH:D013736 Testicular Neoplasms Cisplatin 5.0317225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 9.0617053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 9.0612973940 15464296 17225452
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 9.0616452187 11723127 17306315 16712894
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 10.7916803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 10.7911813266
MESH:D014625 Vaginal Neoplasms Cisplatin 5.0915577323
MESH:D014652 Vascular Diseases sodium arsenite 4.9617056641
MESH:D014839 Vomiting Cisplatin 5.3311897121
Pathway ID Pathway Name
KEGG:05220 Chronic myeloid leukemia
KEGG:05200 Pathways in cancer
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:11061 Signalling by NGF
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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