AutismKB 2.0

Annotation Detail for GRIK4


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Basic Information Top
Gene Symbol:GRIK4 ( EAA1,GRIK,KA1 )
Gene Full Name: glutamate receptor, ionotropic, kainate 4
Band: 11q23.3
Quick LinksEntrez ID:2900; OMIM: 600282; Uniprot ID:GRIK4_HUMAN; ENSEMBL ID: ENSG00000149403; HGNC ID: 4582
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Synaptic Transmission
No data
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00037Ionotropic glutamate receptor pathway
P00029Huntington disease
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
NEUROLOGICAL
Cognitive performance
Desease Name
Cognitive test performance
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in increased expression of GRIK4 mRNAincreases expression 20458559
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of GRIK4 mRNAdecreases expression 17452286
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of GRIK4 mRNAincreases expression 19440498
D003976 Diazinon Diazinon affects the expression of GRIK4 mRNAaffects expression 19440498
D006220 Haloperidol Haloperidol results in increased expression of GRIK4 mRNAincreases expression 15860345
D007657 Ketone Bodies Ketone Bodies results in increased expression of GRIK4 mRNAincreases expression 16807920
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3511798837 19825857
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 11.0316611668 17119214 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 11.0316487989
MESH:D001321 Autistic Disorder Haloperidol 2.7219368416 18080171
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.0416206674
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7311589617
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 1.9815553829 16217749 15073043 11135700 14691202
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4712490120
MESH:D002375 Catalepsy Haloperidol 5.4515215559 1977408
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6312609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 12.3015213294
MESH:D016757 Death, Sudden, Cardiac Haloperidol 12.3020210726
MESH:D003704 Dementia Haloperidol 4.9511575062
MESH:D004417 Dyspnea Diazinon 5.4116487989
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3812903497
MESH:D005234 Fatty Liver arsenic trioxide 3.6615073043
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7016904648
MESH:D006505 Hepatitis Diazinon 5.0116487989
MESH:D007248 Infertility, Male Diazinon 4.0412948887 16466525
MESH:D007938 Leukemia arsenic trioxide 2.9815070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.8516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1816467208 16968895 20471514 19850784 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4311468182 12679006 16112521 15622746 19075265 15748426 17712046 16331271 16823087 19225113 17107899 12018890 19035177 17869043 19642359 16330433 17649720 15336539 9834237 11161223 15213294 12712474 16966277 17217047 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7916882451
MESH:D008107 Liver Diseases Chlorpyrifos 3.1415991261
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4514682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9320377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6215213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8719825857 11798837
MESH:D001523 Mental Disorders Haloperidol 4.5516856516
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3515949261 19417148 11468182 19549372 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.2818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3216105982 16882451
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4016624393
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3310525206
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.3915081274
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4919769630 12452020 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6215580305
MESH:D010235 Paraganglioma arsenic trioxide 4.5719927285
MESH:D011041 Poisoning Diazinon 4.7517603234
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2219131511
MESH:D011595 Psychomotor Agitation Haloperidol 5.4411575062
MESH:D011618 Psychotic Disorders Haloperidol 4.5011575062
MESH:D012135 Respiratory Sounds Chlorpyrifos 5.1216611668 17119214 11874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.5016611668 17119214
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4016646077
MESH:D012559 Schizophrenia Haloperidol 2.841830565 19369910 18513383 20107430
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.706418539
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D017180 Tachycardia, Ventricular Haloperidol 5.1520210726
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3619014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5920435036 11780464 12845720 12973940
MESH:D014570 Urologic Diseases Diazinon 5.8916487989
Pathway ID Pathway Name
KEGG:04724 Glutamatergic synapse
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28976
    • No data
    Releated disease ID Related disease Name
    PA447278Depression
    Releated drug ID Related drug Name
    PA452229antidepressants
    PA449015citalopram
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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