AutismKB 2.0

Annotation Detail for GRIK5


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Basic Information Top
Gene Symbol:GRIK5 ( EAA2,GRIK2,KA2 )
Gene Full Name: glutamate receptor, ionotropic, kainate 5
Band: 19q13.2
Quick LinksEntrez ID:2901; OMIM: 600283; Uniprot ID:GRIK5_HUMAN; ENSEMBL ID: ENSG00000105737; HGNC ID: 4583
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Synaptic Transmission
No data
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00037Ionotropic glutamate receptor pathway
P00029Huntington disease
P00041Metabotropic glutamate receptor group I pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of GRIK5 mRNAdecreases expression 16788091
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRIK5 mRNAaffects expression 16483693
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GRIK5 mRNAaffects cotreatment|decreases expression 20360939
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of GRIK5 mRNAincreases expression 19440498
D003024 Clozapine Clozapine affects the expression of GRIK5 mRNAaffects expression 14647396
D003024 Clozapine Clozapine results in decreased expression of GRIK5 mRNAdecreases expression 18923069
D003976 Diazinon Diazinon affects the expression of GRIK5 mRNAaffects expression 19440498
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GRIK5 mRNAaffects cotreatment|decreases expression 20360939
D006220 Haloperidol Haloperidol results in increased expression of GRIK5 mRNAincreases expression 14647396
D006220 Haloperidol Haloperidol results in increased expression of GRIK5 mRNAincreases expression 15860345
C025299 polyphenols polyphenols results in decreased expression of GRIK5 mRNAdecreases expression 16293270
D013849 Thimerosal Thimerosal affects the expression of GRIK5 proteinaffects expression 15184908
D014212 Tretinoin Tretinoin results in decreased expression of GRIK5 mRNAdecreases expression 16788091
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000236 Adenoma Diethylnitrosamine 2.936695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.0919052882 17620307 18056438 19061943 17162532 16434500
MESH:D000380 Agranulocytosis Clozapine 5.2316160616 12649775 14617031
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 9.8316611668 17119214 11874814
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.8316487989
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.1616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3816456186
MESH:D001321 Autistic Disorder Haloperidol 2.7318080171 19368416
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.7516197459 16206674
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1617474063
MESH:D001943 Breast Neoplasms Tretinoin 2.1616873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1018494052 19919837 18978308 16935385 19519916 16878318 3581430 18506893 19394651 16288022 19335982 20727157 21159647 19539802 20084675 20214788 18785209 17055752 16807293 16328049 17162532 17138121 16830150 17978847 20101231 19052882 19822196 10672840 17428255 19208518 16540662 19701751 20512989 18210153 20524982 18788625 16698587 17173139 20935162 16569478 19383236 18393292 19107877 16502159 11831363 20514400 16779866 19171122 20007298 17761372 18056438 3084413 16681979 18971187 10737359 20432363 18665156 18691550 19418558
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.101917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3216096774 16051514
MESH:D002375 Catalepsy Haloperidol 5.101977408 15215559
MESH:D002386 Cataract Tretinoin 3.1717460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.9517174075 21159647 2727394 7505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8119052882
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D002972 Cleft Palate Tretinoin 2.729407595
MESH:D003072 Cognition Disorders Clozapine 5.1417123785
MESH:D003092 Colitis Tretinoin 3.8817035595
MESH:D003110 Colonic Neoplasms polyphenols 2.6916293270
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8214991402 9125849 9211117 16925845 9142499 10589399 9664655 17551590 9224671 8800419
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.9920210726
MESH:D003704 Dementia Haloperidol 4.7211575062
MESH:D017449 Dermatitis, Allergic Contact Thimerosal 4.7015932584 16958921
MESH:D002658 Developmental Disabilities Thimerosal 4.9315764492
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.8016402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.8020387270
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.7715331141
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.2919107877
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.2919370779
MESH:D050171 Dyslipidemias Clozapine 4.2816402076
MESH:D004417 Dyspnea Diazinon 5.0216487989
MESH:D004489 Edema, Cardiac Tretinoin 4.6818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1916569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D005124 Eye Abnormalities Tretinoin 3.689664655 16938888
MESH:D005234 Fatty Liver Diethylnitrosamine 3.3221071580 20387270
MESH:D005355 Fibrosis Tretinoin 3.6917994277
MESH:D005909 Glioblastoma Tretinoin 3.0917312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.9614991402 9664655
MESH:D006505 Hepatitis Diazinon 4.7316487989
MESH:D006930 Hyperalgesia Tretinoin 3.3216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D006948 Hyperkinesis Clozapine 5.1016046005
MESH:D007248 Infertility, Male Diazinon 3.9112948887 16466525
MESH:D007249 Inflammation Diethylnitrosamine 5.5618785209
MESH:D007249 Inflammation polyphenols 5.5616366677
MESH:D007410 Intestinal Diseases Tretinoin 3.9417994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.7210783313
MESH:D007569 Jaw Abnormalities Tretinoin 4.0415992940 17551590
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 3.6215369732
MESH:D007938 Leukemia Tretinoin 2.8317143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8416482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1017596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 8.2116766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.2117649720 17301526 17294898 15748426 19075265 16140955 17339181 16935935 16788101 12679006 9834237 17506722 16823087 17217047 17712046 19029980 19642359 16766008 19035177 17368321 17107899 16331271 16891316 17361223 19225113
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008064 Lipidoses Clozapine 4.0617567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8918522880 18665156 20032147 19638242 18407596
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008107 Liver Diseases Chlorpyrifos 6.9515991261
MESH:D008107 Liver Diseases Diethylnitrosamine 6.9517034775
MESH:D008107 Liver Diseases polyphenols 6.9516698588
MESH:D008113 Liver Neoplasms Diethylnitrosamine 2.282862719 19427195 10737359 19254457 20492335 18648771 20405173 12112319 15885732 12771043 21167192 19690152 21047994 15175105 21071580 19638242 19073162 18977376 19642983 19294768 20434301 19499222 19255062 21278145 19996281 18754104 19833225 19812893 9163691 18644402 16942905 20137499 20583210 19426721 19256749 20452335 19850985 20101389 20118626 18978307 2422723 19551842 19090486 20501860
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7119539802 19519916 18164116 19004024 19009564 17174075 18079962 2563599 18253720 18093689 16267830 17942915 18544905 9362446 18775883 16842330 3124819 18308698 19126423 17854601 18282651 21159647
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7621163286 20970405 6695378 20512841
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D001523 Mental Disorders Clozapine 9.0216856516
MESH:D001523 Mental Disorders Haloperidol 9.0216856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.5319142101
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1517596541
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.613581430 9029167
MESH:D009369 Neoplasms Tretinoin 2.4716946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 3.949125849
MESH:D009436 Neural Tube Defects Tretinoin 3.149142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.2615081274
MESH:D009765 Obesity Clozapine 3.0419142110 18515891
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3816936753
MESH:D010146 Pain Tretinoin 3.0216870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4016540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4015976015
MESH:D011041 Poisoning Diazinon 4.5017603234
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D011507 Proteinuria Tretinoin 3.7516636307
MESH:D011595 Psychomotor Agitation Haloperidol 5.1311575062
MESH:D011618 Psychotic Disorders Clozapine 9.4915331141
MESH:D011618 Psychotic Disorders Haloperidol 9.4911575062
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.8111874814 16611668 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.1117119214 16611668
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2516283617 16116481
MESH:D012559 Schizophrenia marker/mechanism 18923069
MESH:D012559 Schizophrenia Clozapine 4.1617123785 11763009 17667964 20521326 20168265 20107430 20521320 20452607 18806925 18855531 11151749 17726453 16141801 20580759 19369910
MESH:D012559 Schizophrenia Haloperidol 4.161830565 19369910 20107430 18513383
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.316418539
MESH:D012878 Skin Neoplasms Tretinoin 2.6716467112
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4518456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.4517261132
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.8720210726
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.4717997062
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.537505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.5316026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9216051514
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D014570 Urologic Diseases Diazinon 5.4916487989
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8116129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8316752155
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D015430 Weight Gain Clozapine 4.5920521320 17502770 20564506 20107430 16141801 16402076
MESH:D015431 Weight Loss Clozapine 5.2717933447
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
Pathway ID Pathway Name
KEGG:04724 Glutamatergic synapse
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28977
    • No data
    Releated disease ID Related disease Name
    PA447278Depression
    PA161615744Mental Retardation, Autosomal Recessive
    PA444929Mental Retardation
    Releated drug ID Related drug Name
    PA452229antidepressants
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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