AutismKB 2.0

Annotation Detail for GRIN1


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Basic Information Top
Gene Symbol:GRIN1 ( NMDA1,NMDAR1,NR1 )
Gene Full Name: glutamate receptor, ionotropic, N-methyl D-aspartate 1
Band: 9q34.3
Quick LinksEntrez ID:2902; OMIM: 138249; Uniprot ID:NMDZ1_HUMAN; ENSEMBL ID: ENSG00000176884; HGNC ID: 4584
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04720Long-term potentiation
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05016Huntington's disease
hsa05010Alzheimer's disease
Pathway IDPathway Name
Synaptic Transmission
No data
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00037Ionotropic glutamate receptor pathway
P00029Huntington disease
P00041Metabotropic glutamate receptor group I pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
alcoholism-related traits
PSYCH
alcoholism
NEUROLOGICAL
seizures
schizophrenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C024566 1,1,1-trichloroethane 1,1,1-trichloroethane results in decreased activity of [GRIN1 protein binds to GRIN2A protein]affects binding|decreases activity 11090101
C024566 1,1,1-trichloroethane 1,1,1-trichloroethane results in decreased activity of [GRIN1 protein binds to GRIN2B protein]affects binding|decreases activity 11090101
C025603 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid affects the activity of GRIN1 proteinaffects activity 16139540
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of GRIN1 mRNAaffects expression 21346803
C076996 27-hydroxycholesterol 27-hydroxycholesterol results in decreased expression of GRIN1 proteindecreases expression 18503570
C079215 3,5-dihydroxyphenylglycine 3,5-dihydroxyphenylglycine results in increased phosphorylation of GRIN1 proteinincreases phosphorylation 16600209
C079215 3,5-dihydroxyphenylglycine 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of GRIN1 protein]]decreases reaction|increases phosphorylation|increases reaction 16600209
C079215 3,5-dihydroxyphenylglycine N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of GRIN1 protein]increases phosphorylation|increases reaction 16600209
C121465 6-methyl-2-(phenylethynyl)pyridine 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of GRIN1 protein]]decreases reaction|increases phosphorylation|increases reaction 16600209
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRIN1 mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride affects the localization of GRIN1 proteinaffects localization 16678351
D000643 Ammonium Chloride Ammonium Chloride results in increased phosphorylation of GRIN1 proteinincreases phosphorylation 16678351
D000661 Amphetamine Amphetamine results in increased phosphorylation of GRIN1 proteinincreases phosphorylation 14622123
D001554 Benzene Benzene results in decreased activity of [GRIN1 protein binds to GRIN2A protein]affects binding|decreases activity 11090101
D001554 Benzene Benzene results in decreased activity of [GRIN1 protein binds to GRIN2B protein]affects binding|decreases activity 11090101
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [CARTPT protein results in increased phosphorylation of GRIN1 protein]decreases reaction|increases phosphorylation 19632277
C006780 bisphenol A bisphenol A results in increased expression of GRIN1 proteinincreases expression 12411739
C031938 calmidazolium calmidazolium affects the activity of GRIN1 proteinaffects activity 16139540
C059041 calyculin A calyculin A results in increased activity of GRIN1 proteinincreases activity 16139540
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of GRIN1 mRNAincreases expression 19440498
D003024 Clozapine Clozapine results in decreased expression of GRIN1 mRNAdecreases expression 17266109
D003024 Clozapine Clozapine results in decreased expression of GRIN1 mRNAdecreases expression 12608697
D003024 Clozapine Clozapine results in increased expression of GRIN1 mRNAincreases expression 12020038
18923069
C017160 cypermethrin cypermethrin affects the activity of GRIN1 proteinaffects activity 16139540
D004026 Dieldrin Dieldrin results in increased expression of GRIN1 mRNAincreases expression 19440498
D004041 Dietary Fats Dietary Fats results in decreased expression of GRIN1 proteindecreases expression 18503570
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of GRIN1 mRNAdecreases expression 15518916
D016291 Dizocilpine Maleate Dizocilpine Maleate promotes the reaction [GRIN1 protein binds to SRC protein]affects binding|increases reaction 11249956
D004298 Dopamine [Dopamine results in increased activity of DRD1A protein] which results in increased phosphorylation of GRIN1 proteinincreases activity|increases phosphorylation 14622123
D004298 Dopamine N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dopamine results in increased activity of DRD1A protein] which results in increased phosphorylation of GRIN1 protein]decreases reaction|increases activity|increases phosphorylation 14622123
D004958 Estradiol [Lithium Chloride co-treated with Estradiol] results in decreased expression of GRIN1 mRNAaffects cotreatment|decreases expression 19285052
D004958 Estradiol [[Lithium Chloride co-treated with Estradiol] results in decreased expression of GRIN1 mRNA] which affects the susceptibility to Excitatory Amino Acid Agonistsaffects cotreatment|affects response to substance|decreases expression 19285052
D004958 Estradiol Estradiol results in increased expression of GRIN1 proteinincreases expression 12411739
D000431 Ethanol Ethanol results in decreased expression of GRIN1 mRNAdecreases expression 18713641
D000431 Ethanol Ethanol results in increased expression of GRIN1 proteinincreases expression 12045474
C004912 ethylbenzene ethylbenzene results in decreased activity of [GRIN1 protein binds to GRIN2A protein]affects binding|decreases activity 11090101
C004912 ethylbenzene ethylbenzene results in decreased activity of [GRIN1 protein binds to GRIN2B protein]affects binding|decreases activity 11090101
D018690 Excitatory Amino Acid Agonists Excitatory Amino Acid Agonists binds to and results in increased activity of [GRIN1 protein binds to GRIN2A protein]affects binding|increases activity 11812690
D018690 Excitatory Amino Acid Agonists Urethane inhibits the reaction [Excitatory Amino Acid Agonists binds to and results in increased activity of [GRIN1 protein binds to GRIN2A protein]]affects binding|decreases reaction|increases activity 11812690
D018690 Excitatory Amino Acid Agonists [[Lithium Chloride co-treated with Estradiol] results in decreased expression of GRIN1 mRNA] which affects the susceptibility to Excitatory Amino Acid Agonistsaffects cotreatment|affects response to substance|decreases expression 19285052
D018690 Excitatory Amino Acid Agonists Excitatory Amino Acid Agonists results in decreased expression of GRIN1 proteindecreases expression 17550430
D005576 Forskolin Forskolin results in increased phosphorylation of GRIN1 proteinincreases phosphorylation 14622123
D005576 Forskolin N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Forskolin results in increased phosphorylation of GRIN1 protein]decreases reaction|increases phosphorylation 14622123
D005839 Gentamicins Gentamicins results in increased expression of GRIN1 mRNAincreases expression 15200423
D005839 Gentamicins Gentamicins results in increased expression of GRIN1 proteinincreases expression 15200423
D006220 Haloperidol Haloperidol results in decreased expression of GRIN1 mRNAdecreases expression 12020038
D006220 Haloperidol Haloperidol results in increased expression of GRIN1 mRNAincreases expression 12020038
D016627 Oxidopamine Oxidopamine results in decreased expression of GRIN1 mRNAdecreases expression 15518916
C057416 KT 5720 KT 5720 inhibits the reaction [CARTPT protein results in increased phosphorylation of GRIN1 protein]decreases reaction|increases phosphorylation 19632277
D018021 Lithium Chloride [Lithium Chloride co-treated with Estradiol] results in decreased expression of GRIN1 mRNAaffects cotreatment|decreases expression 19285052
D018021 Lithium Chloride [[Lithium Chloride co-treated with Estradiol] results in decreased expression of GRIN1 mRNA] which affects the susceptibility to Excitatory Amino Acid Agonistsaffects cotreatment|affects response to substance|decreases expression 19285052
D018021 Lithium Chloride Lithium Chloride results in decreased expression of GRIN1 mRNAdecreases expression 19285052
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of DRD1A protein] which results in increased phosphorylation of GRIN1 protein]decreases reaction|increases activity|increases phosphorylation 14622123
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dopamine results in increased activity of DRD1A protein] which results in increased phosphorylation of GRIN1 protein]decreases reaction|increases activity|increases phosphorylation 14622123
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Forskolin results in increased phosphorylation of GRIN1 protein]decreases reaction|increases phosphorylation 14622123
C481448 N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of GRIN1 protein]]decreases reaction|increases phosphorylation|increases reaction 16600209
C481448 N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide promotes the reaction [3,5-dihydroxyphenylglycine results in increased phosphorylation of GRIN1 protein]increases phosphorylation|increases reaction 16600209
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in decreased expression of GRIN1 mRNAdecreases expression 12832660
C025256 nonylphenol nonylphenol results in decreased expression of GRIN1 mRNAdecreases expression 15518916
C024268 n-propylbenzene n-propylbenzene results in decreased activity of [GRIN1 protein binds to GRIN2A protein]affects binding|decreases activity 11090101
C024268 n-propylbenzene n-propylbenzene results in decreased activity of [GRIN1 protein binds to GRIN2B protein]affects binding|decreases activity 11090101
D019319 Okadaic Acid Okadaic Acid results in increased activity of GRIN1 proteinincreases activity 16139540
D010269 Paraquat Paraquat results in decreased expression of GRIN1 mRNAdecreases expression 19146868
D010278 Parathion Parathion results in decreased expression of GRIN1 mRNAdecreases expression 19146868
D010424 Pentobarbital Pentobarbital affects the expression of GRIN1 mRNAaffects expression 10717408
D010622 Phencyclidine Phencyclidine results in decreased expression of GRIN1 mRNAdecreases expression 17266109
D010795 Phthalic Acids Phthalic Acids results in decreased expression of GRIN1 mRNAdecreases expression 15518916
D013467 Sulindac Sulindac affects the expression of GRIN1 proteinaffects expression 15123337
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GRIN1 mRNAdecreases expression 14984010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GRIN1 proteindecreases expression 14984010
D015647 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of DRD1A protein] which results in increased phosphorylation of GRIN1 proteinincreases activity|increases phosphorylation 14622123
D015647 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of DRD1A protein] which results in increased phosphorylation of GRIN1 protein]decreases reaction|increases activity|increases phosphorylation 14622123
D013849 Thimerosal Thimerosal results in decreased expression of GRIN1 proteindecreases expression 15184908
D024505 Tocopherols Tocopherols results in increased expression of GRIN1 mRNAincreases expression 17654050
D014050 Toluene Toluene results in decreased activity of [GRIN1 protein binds to GRIN2A protein]affects binding|decreases activity 9655877
D014050 Toluene Toluene results in decreased activity of [GRIN1 protein binds to GRIN2B protein]affects binding|decreases activity 9655877
D014520 Urethane Urethane inhibits the reaction [Excitatory Amino Acid Agonists binds to and results in increased activity of [GRIN1 protein binds to GRIN2A protein]]affects binding|decreases reaction|increases activity 11812690
D014992 Xylenes Xylenes results in decreased activity of [GRIN1 protein binds to GRIN2A protein]affects binding|decreases activity 11090101
D014992 Xylenes Xylenes results in decreased activity of [GRIN1 protein binds to GRIN2B protein]affects binding|decreases activity 11090101
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 4.9614745880
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 11.376734493
MESH:D000014 Abnormalities, Drug-Induced Ethanol 11.3718926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.3711752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 8.7218287403
MESH:D000138 Acidosis Ethanol 8.7211192467
MESH:D058186 Acute Kidney Injury Gentamicins 7.7111274264
MESH:D058186 Acute Kidney Injury Sulindac 7.717897758
MESH:D000230 Adenocarcinoma Estradiol 6.4011473722
MESH:D000230 Adenocarcinoma Sulindac 6.4011910360
MESH:D000230 Adenocarcinoma Urethane 6.4018316556
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 5.1715814487
MESH:D000236 Adenoma Sulindac 6.3810223192
MESH:D000236 Adenoma Urethane 6.3810822126 10530776 16926031 17093202 6695378 17195641 11497255
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.8516835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.1411874996 11535846 16460482 19003578 15623613 12394442 17611924
MESH:D000380 Agranulocytosis Clozapine 4.5414617031 16160616 12649775
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 16.2511874814 16611668 17119214
MESH:D000382 Agricultural Workers' Diseases cypermethrin 16.2516487989
MESH:D000382 Agricultural Workers' Diseases Paraquat 16.2511874814
MESH:D000382 Agricultural Workers' Diseases Parathion 16.2517119214 11874814
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.7815451039 15451040
MESH:D000544 Alzheimer Disease 27-hydroxycholesterol 3.6014523054 20157255
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.5315010207 16916582 18475255 16459022
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.4911748828
MESH:D000741 Anemia, Aplastic Benzene 3.9614761424 11369114 17661222
MESH:D000853 Anophthalmos Ethanol 4.3015513904
MESH:D000855 Anorexia 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine 9.3512183048
MESH:D000855 Anorexia Amphetamine 9.3512183048 16084549 16101753 12005258
MESH:D001008 Anxiety Disorders Ethanol 8.0111141031
MESH:D001008 Anxiety Disorders Pentobarbital 8.0111141031 18313124
MESH:D001145 Arrhythmias, Cardiac Xylenes 5.08513065
MESH:D001161 Arteriosclerosis Dietary Fats 3.3815238619
MESH:D050197 Atherosclerosis 27-hydroxycholesterol 4.1111166758 9059518
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 7.7014699433
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 7.7020106747
MESH:D001321 Autistic Disorder Haloperidol 2.8118080171 19368416
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.5712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4115746008
MESH:D001855 Bone Marrow Diseases Benzene 4.6916183116
MESH:D001862 Bone Resorption bisphenol A 3.3911985600
MESH:D001913 Bowen's Disease Sulindac 4.8211207687
MESH:D001943 Breast Neoplasms Benzene 4.1711921183 17162533
MESH:D001943 Breast Neoplasms bisphenol A 4.1717123778
MESH:D001943 Breast Neoplasms Dieldrin 4.1711859874 15770527
MESH:D001943 Breast Neoplasms Dietary Fats 4.1720435547
MESH:D001943 Breast Neoplasms Estradiol 4.1714630087 17289903 17018787 12948864 18497071 16675129 17261762 19861407
MESH:D001943 Breast Neoplasms Parathion 4.1712762645
MESH:D001943 Breast Neoplasms Sulindac 4.1716642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.1720435547
MESH:D002056 Burns Ethanol 4.1416374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9316111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.3816835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.0416705839
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.0416924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 4.0415763234 15289165 18788625
MESH:D002278 Carcinoma in Situ bisphenol A 4.4617123778
MESH:D006332 Cardiomegaly Ethanol 5.8019332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.8016120746 18670907 18850075
MESH:D002375 Catalepsy Haloperidol 4.381977408 15215559
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 5.436135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.4318566989
MESH:D002547 Cerebral Palsy Toluene 5.329294310
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7216835633
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.6612912871
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 3.9315500046 18590720 18164287 12927374 19486331 7624871 15913567 16629650
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.3210220858 19407337
MESH:D002971 Cleft Lip Ethanol 3.2915513904
MESH:D002972 Cleft Palate Ethanol 8.5415513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.5415668235 8697196 12621046 15340226 16354765
MESH:D002972 Cleft Palate Urethane 8.5412810352
MESH:D003072 Cognition Disorders Clozapine 4.4517123785
MESH:D003110 Colonic Neoplasms Sulindac 2.8212902858 12458338
MESH:D015179 Colorectal Neoplasms Sulindac 2.6811076880 10666051 18059344 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6117141729 14669216
MESH:D019465 Craniofacial Abnormalities 6-methyl-2-(phenylethynyl)pyridine 6.5617065172
MESH:D019465 Craniofacial Abnormalities Benzene 6.5615643154
MESH:D019465 Craniofacial Abnormalities Ethanol 6.5611198716 19302082 15451040 11873399 15513904 15451039 10194807
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.5615322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Toluene 6.569294310
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.5018551238
MESH:D003643 Death Toluene 5.136431079
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.3620210726
MESH:D003704 Dementia Haloperidol 4.1111575062
MESH:D003715 Dengue 27-hydroxycholesterol 5.1519427377
MESH:D003872 Dermatitis Benzene 4.2515902427
MESH:D017449 Dermatitis, Allergic Contact Thimerosal 4.0515932584 16958921
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 3.7816882537
MESH:D017453 Dermatitis, Irritant Xylenes 6.3017574719
MESH:D002658 Developmental Disabilities Thimerosal 4.4815764492
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 3.9816402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9817107852
MESH:D003928 Diabetic Nephropathies Estradiol 2.9719279558
MESH:D003930 Diabetic Retinopathy Sulindac 4.6812861449 17621415
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.0215331141
MESH:D056486 Drug-Induced Liver Injury 1,1,1-trichloroethane 10.076623471 2862719 4356632
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 10.0717522070 7624871 18289764 20133375
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 10.0721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Ethanol 10.0711566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.0720420201
MESH:D004362 Drug Toxicity Gentamicins 7.0715033597 11033412
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.0711462148
MESH:D050171 Dyslipidemias Clozapine 7.5716402076
MESH:D050171 Dyslipidemias Dietary Fats 7.5718367378
MESH:D004417 Dyspnea cypermethrin 4.8516487989
MESH:D004487 Edema bisindolylmaleimide I 5.728273558
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.7211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3616714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 27-hydroxycholesterol 4.6817410599
MESH:D016889 Endometrial Neoplasms Estradiol 2.6318566989 11473722 19148513
MESH:D004715 Endometriosis Sulindac 7.6715652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.6710568697 9294722
MESH:D004938 Esophageal Neoplasms Ethanol 4.4716704527
MESH:D004938 Esophageal Neoplasms Sulindac 4.4712235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6111564622
MESH:D005221 Fatigue Amphetamine 5.0719890266
MESH:D005234 Fatty Liver Dietary Fats 6.5018296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Ethanol 6.5019236843 18620774 16409862
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1317920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.7716946407 15451040 10194807 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9411858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 4.9514745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 4.6019069698
MESH:D005355 Fibrosis Dietary Fats 6.9218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 6.9220067830
MESH:D005756 Gastritis Ethanol 4.1615046732
MESH:D005764 Gastroesophageal Reflux Sulindac 4.5111910360
MESH:D005909 Glioblastoma Okadaic Acid 4.2817312396
MESH:D005911 Gliosis Paraquat 4.6211124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0510696789
MESH:D034381 Hearing Loss Gentamicins 4.4419130971 17868369 18024279 15968427
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.0410048152 11294989
MESH:D006331 Heart Diseases Urethane 3.8716046796
MESH:D006402 Hematologic Diseases Benzene 4.1716183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8611000095
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 8.5818590720
MESH:D006505 Hepatitis cypermethrin 8.5816487989
MESH:D006521 Hepatitis, Chronic 1,1,1-trichloroethane 6.2912594376
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.3916120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.4915709030
MESH:D019584 Hot Flashes Estradiol 3.2217088409
MESH:D006869 Hydronephrosis Lithium Chloride 11.2419797860
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 11.2416354765 8697196 18606429 15340226 16959395
MESH:D006930 Hyperalgesia Ethanol 3.3018783367
MESH:D053565 Hypercalciuria Gentamicins 5.1817652376
MESH:D006937 Hypercholesterolemia 27-hydroxycholesterol 8.0717873880
MESH:D006937 Hypercholesterolemia Dietary Fats 8.0721332399
MESH:D006948 Hyperkinesis Amphetamine 10.051977408 14960337
MESH:D006948 Hyperkinesis Clozapine 10.0516046005
MESH:D006949 Hyperlipidemias Dietary Fats 3.1321332399
MESH:D006973 Hypertension Benzene 4.5517940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.5518670907 18850075
MESH:D007022 Hypotension Dopamine 4.536740701
MESH:D007247 Infertility, Female Dieldrin 4.4510630421
MESH:D007248 Infertility, Male Paraquat 6.274850670
MESH:D007248 Infertility, Male Parathion 6.2716029889
MESH:D007249 Inflammation bisindolylmaleimide I 9.618273558
MESH:D007249 Inflammation Dietary Fats 9.6120412841
MESH:D007249 Inflammation Sulindac 9.613291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.6112878042 12200463
MESH:D007299 Insect Bites and Stings cypermethrin 5.4415189238
MESH:D007333 Insulin Resistance bisphenol A 10.3016393666
MESH:D007333 Insulin Resistance Dietary Fats 10.3011836018 18457598
MESH:D007333 Insulin Resistance Estradiol 10.3016393666 16627594
MESH:D007414 Intestinal Neoplasms Sulindac 4.1810213222 12584176 12663524 12351151 12628509 10223192
MESH:D007417 Intestinal Polyps Sulindac 4.5011245490 12394442
MESH:D007569 Jaw Abnormalities Ethanol 8.5415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.5416580747
MESH:D007673 Kidney Cortex Necrosis Gentamicins 5.1918842672
MESH:D007674 Kidney Diseases Estradiol 5.4215618244
MESH:D007674 Kidney Diseases Gentamicins 5.4217934191 18289764 19349640
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 5.9416705839
MESH:D007680 Kidney Neoplasms Estradiol 5.9415610895
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 4.8411231351
MESH:D007859 Learning Disorders Ethanol 3.7015451040
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.0310219319
MESH:D007938 Leukemia Benzene 3.1117119257 14694614 15935818 18335105
MESH:D007951 Leukemia, Myeloid Benzene 3.8517506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.6019478238
MESH:D017880 Limb Deformities, Congenital Ethanol 3.4317676605
MESH:D008064 Lipidoses Clozapine 3.5817567588
MESH:D008103 Liver Cirrhosis Dietary Fats 5.8018296743
MESH:D008103 Liver Cirrhosis Ethanol 5.8015289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.5718295389
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 3.8812468960
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.0714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.0718166357
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.0712878042
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 8.2117184895
MESH:D008107 Liver Diseases Chlorpyrifos 8.2115991261
MESH:D008107 Liver Diseases cypermethrin 8.2115991261
MESH:D008107 Liver Diseases Sulindac 8.2114986274 16867024
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.1417347304 17207112
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.847678174
MESH:D008113 Liver Neoplasms Dieldrin 11.848742319 9539021
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 11.8411940454
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.8416984957
MESH:D008113 Liver Neoplasms Urethane 11.8416391232 17559639 17093202
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 7.886135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Benzene 7.8812562636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 7.8812151625
MESH:D017563 Lung Diseases, Interstitial Benzene 4.2714698565
MESH:D008175 Lung Neoplasms Benzene 4.3112562636
MESH:D008175 Lung Neoplasms Sulindac 4.3119359593 15713900
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.3111884234 19555203
MESH:D008175 Lung Neoplasms Urethane 4.3112957351 17195641 16926031 12117781 15166089 11062179 11807781 11497255 10822126 16337739 11893704 16788158 12466968 10530776 17255336 11246140 16204055 7750092 11323394 10779650 12765245 17093202 6695378 11552296 16289808 15136453 11544531 11074608 16391232 16007126 10997738 14587096 15902970 11307925 11992545
MESH:D008223 Lymphoma Benzene 3.3617584886 17119257
MESH:D015674 Mammary Neoplasms, Animal Benzene 3.9212562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 8.1811921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.1811807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 8.1817927505
MESH:D020149 Manganese Poisoning Estradiol 3.9419453300
MESH:D008545 Melanoma Sulindac 2.7516642371
MESH:D008569 Memory Disorders Ethanol 3.6918411066 15451040
MESH:D001523 Mental Disorders Clozapine 6.6416856516
MESH:D001523 Mental Disorders Haloperidol 6.6416856516
MESH:D008607 Mental Retardation Toluene 3.459294310
MESH:D008654 Mesothelioma Tocopherols 3.8715878867
MESH:D024821 Metabolic Syndrome X Clozapine 3.9819142101
MESH:D019957 Motor Skills Disorders Toluene 4.759294310
MESH:D009101 Multiple Myeloma Benzene 3.2917119195
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 5.7418694830
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.8716810080
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.347678174 18551238
MESH:D009369 Neoplasms Dieldrin 4.958820588
MESH:D009369 Neoplasms Urethane 4.9515625555
MESH:D009374 Neoplasms, Experimental Urethane 4.1715582191
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2117289903
MESH:D009410 Nerve Degeneration Paraquat 3.3116893418
MESH:D009421 Nervous System Malformations bisphenol A 13.4616427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 13.4616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.4614600291
MESH:D009436 Neural Tube Defects Benzene 3.3215643154
MESH:D019636 Neurodegenerative Diseases Amphetamine 12.0515183010
MESH:D019636 Neurodegenerative Diseases Oxidopamine 12.0518514411
MESH:D019636 Neurodegenerative Diseases Sulindac 12.0517266991 16850258
MESH:D020078 Neurogenic Inflammation Xylenes 5.5119159661
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.8015081274
MESH:D009765 Obesity Clozapine 4.3418515891 19142110
MESH:D009765 Obesity Dietary Fats 4.3421332399 11836018 18674790 18457598 17217161 16723640 19632207 20518802 20132043
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.6416049721
MESH:D009784 Occupational Diseases Benzene 7.6417479406 15727169 17119257 15612468 17178637 15935809 15576619 16737584 15913788
MESH:D010049 Ovarian Diseases bisphenol A 4.4611985600
MESH:D010051 Ovarian Neoplasms Benzene 6.9512562636
MESH:D010051 Ovarian Neoplasms Estradiol 6.9519401270
MESH:D010051 Ovarian Neoplasms Urethane 6.9516391232
MESH:D010146 Pain Sulindac 6.443291741
MESH:D010146 Pain Xylenes 6.443412491 19159661
MESH:D010190 Pancreatic Neoplasms Ethanol 5.0512384795
MESH:D010190 Pancreatic Neoplasms Sulindac 5.0511504793 16820089
MESH:D010300 Parkinson Disease Dieldrin 5.0311181820 17291500 16809432 16112328 11445065
MESH:D010300 Parkinson Disease Paraquat 5.0316510128 11445065 16140633 15451049 11124998 12911755 11181820 15824117
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 9.6815893579 11771942
MESH:D010302 Parkinson Disease, Secondary Paraquat 9.6816190885
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 12.0020133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 12.0012520081
MESH:D010911 Pituitary Neoplasms Urethane 4.9016391232
MESH:D011014 Pneumonia Paraquat 3.9312504350
MESH:D011141 Polyuria Lithium Chloride 5.4719692487
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0618163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 7.7610548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.7611896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 8.9820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 8.9820887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.9716740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.9716740699
MESH:D011471 Prostatic Neoplasms Tocopherols 2.9712504091
MESH:D011507 Proteinuria Gentamicins 4.2415033597
MESH:D011595 Psychomotor Agitation Haloperidol 4.4411575062
MESH:D011618 Psychotic Disorders marker/mechanism 14708030
MESH:D011618 Psychotic Disorders Clozapine 7.8615331141
MESH:D011618 Psychotic Disorders Haloperidol 7.8611575062
MESH:D011629 Puberty, Precocious bisphenol A 4.2610548101
MESH:D011649 Pulmonary Alveolar Proteinosis 27-hydroxycholesterol 5.8515466366
MESH:D011658 Pulmonary Fibrosis Paraquat 2.6917997886 16324872
MESH:D012021 Reflex, Abnormal Pentobarbital 5.4910930210
MESH:D051437 Renal Insufficiency Gentamicins 4.4815728788 17132701
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.4211700416
MESH:D012135 Respiratory Sounds Chlorpyrifos 13.3911874814 16611668 17119214
MESH:D012135 Respiratory Sounds Paraquat 13.3911874814
MESH:D012135 Respiratory Sounds Parathion 13.3917119214 11874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3318990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 9.4916611668 17119214
MESH:D012140 Respiratory Tract Diseases Parathion 9.4917119214
MESH:D012162 Retinal Degeneration Paraquat 3.4716458197
MESH:D012173 Retinitis Gentamicins 5.7418644591
MESH:D012559 Schizophrenia Clozapine 3.7618806925 20168265 11763009 17667964 11151749 19369910 18855531 20521320 20107430 16141801 17726453 17123785 20452607 20521326 20580759
MESH:D012559 Schizophrenia Haloperidol 3.7619369910 20107430 18513383 1830565
MESH:D012640 Seizures 2,6-dinitrotoluene 14.7418551238
MESH:D012640 Seizures Dizocilpine Maleate 14.7417157343 12660363 11218047
MESH:D012640 Seizures Ethanol 14.749754883
MESH:D012640 Seizures Pentobarbital 14.7410087439 9754883
MESH:D012640 Seizures Toluene 14.749294310 6431079
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.556418539
MESH:D012878 Skin Neoplasms Okadaic Acid 8.1912628509
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.1916192470
MESH:D012878 Skin Neoplasms Urethane 8.1911807781
MESH:D019082 Smith-Lemli-Opitz Syndrome 27-hydroxycholesterol 5.5011254748
OMIM:270800 SPASTIC PARAPLEGIA 5A, AUTOSOMAL RECESSIVE 27-hydroxycholesterol 5.8419812052
MESH:D019956 Stereotypic Movement Disorder Amphetamine 5.881977408
MESH:D013274 Stomach Neoplasms Benzene 2.6912562636
MESH:D013274 Stomach Neoplasms Ethanol 2.6918456281
MESH:D013276 Stomach Ulcer Ethanol 3.0816755016 11906479 9211565 17918041 17189318 9562338
MESH:D019966 Substance-Related Disorders bisphenol A 3.4616045194 16684133
MESH:D013375 Substance Withdrawal Syndrome Ethanol 8.739754883
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 8.7311529278 9754883
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.2120210726
MESH:D013733 Testicular Diseases Toluene 9.5110514026 10048760
MESH:D013733 Testicular Diseases Xylenes 9.5110514026 10048760
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.2920133375
MESH:D013953 Thymus Neoplasms Benzene 4.4310850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3612697716
MESH:D013978 Tibial Fractures Estradiol 4.1519048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.0716049721
MESH:D014570 Urologic Diseases cypermethrin 5.3316487989
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.7910091137
MESH:D014591 Uterine Diseases bisphenol A 4.4714652134
MESH:D014594 Uterine Neoplasms Benzene 8.3912562636
MESH:D014594 Uterine Neoplasms Sulindac 8.3918645019
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0512125929
MESH:D019043 Vascular Neoplasms Urethane 5.3710620525
MESH:D015837 Vestibular Diseases Gentamicins 5.0218776599
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7115886252
MESH:D015430 Weight Gain Clozapine 8.3416402076 20107430 20521320 17502770 16141801 20564506
MESH:D015430 Weight Gain Dietary Fats 8.3416723640
MESH:D015431 Weight Loss Clozapine 4.5517933447
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
KEGG:04020 Calcium signaling pathway
KEGG:04724 Glutamatergic synapse
KEGG:05016 Huntington's disease
KEGG:04720 Long-term potentiation
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28978
    • No data
    Releated disease ID Related disease Name
    PA443309Alcoholism
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00454 blocker Meperidine Narcotics;Analgesics;Adjuvants, Anesthesia;Opiate Agonists;Analgesics, Opioid;Adjuvants
    DB01173 antagonist Orphenadrine Skeletal Muscle Relaxants;Antiparkinson Agents;Antidyskinetics;Muscarinic Antagonists;Muscle Relaxants, Central;Parasympatholytics
    DB01931 - Dcka, 5,7-Dichlorokynurenic Acid Excitatory Amino Acid Antagonists
    DB03123 - (R)-4-Amino-Isoxazolidin-3-One Antimetabolites;Antibiotics, Antitubercular;Anti-Infective Agents, Urinary
    DB03929 - D-Serine
    DB04620 - Cycloleucine Antineoplastic Agents;Immunosuppressive Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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