AutismKB 2.0

Annotation Detail for GRIN2A


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Basic Information Top
Gene Symbol:GRIN2A ( NMDAR2A,NR2A )
Gene Full Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Band: 16p13.2
Quick LinksEntrez ID:2903; OMIM: 138253; Uniprot ID:NMDE1_HUMAN; ENSEMBL ID: ENSG00000183454; HGNC ID: 4585
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04720Long-term potentiation
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
hsa05322Systemic lupus erythematosus
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05010Alzheimer's disease
Pathway IDPathway Name
Synaptic Transmission
Pathway IDPathway Name
200051Reelin signaling pathway
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00037Ionotropic glutamate receptor pathway
P00029Huntington disease
P00041Metabotropic glutamate receptor group I pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
PSYCH
smoking cessation
schizophrenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C024566 1,1,1-trichloroethane 1,1,1-trichloroethane results in decreased activity of [GRIN1 protein binds to GRIN2A protein]affects binding|decreases activity 11090101
C076996 27-hydroxycholesterol 27-hydroxycholesterol results in decreased phosphorylation of GRIN2A proteindecreases phosphorylation 18503570
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of GRIN2A mRNAincreases expression 18648102
C498554 5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione 5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione results in decreased activity of GRIN2A proteindecreases activity 16822975
D000493 Allopurinol Allopurinol inhibits the reaction [ammonium acetate results in decreased expression of GRIN2A protein]decreases expression|decreases reaction 20084674
C018824 ammonium acetate Allopurinol inhibits the reaction [ammonium acetate results in decreased expression of GRIN2A protein]decreases expression|decreases reaction 20084674
C018824 ammonium acetate ammonium acetate results in decreased expression of GRIN2A proteindecreases expression 20084674
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRIN2A mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride affects the localization of GRIN2A proteinaffects localization 16678351
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of GRIN2A proteindecreases expression 16483693
D001554 Benzene Benzene results in decreased activity of [GRIN1 protein binds to GRIN2A protein]affects binding|decreases activity 11090101
D004390 Chlorpyrifos Chlorpyrifos affects the expression of GRIN2A mRNAaffects expression 19440498
17452286
D003024 Clozapine Clozapine results in decreased expression of GRIN2A mRNAdecreases expression 12608697
18923069
D003975 Diazepam GRIN2A protein affects the susceptibility to Diazepamaffects response to substance 15731593
D003976 Diazinon Diazinon affects the expression of GRIN2A mRNAaffects expression 19440498
D003976 Diazinon Diazinon results in increased expression of GRIN2A mRNAincreases expression 17452286
D004041 Dietary Fats Dietary Fats results in decreased phosphorylation of GRIN2A proteindecreases phosphorylation 18503570
D016291 Dizocilpine Maleate Dizocilpine Maleate results in increased phosphorylation of GRIN2A proteinincreases phosphorylation 11249956
D004958 Estradiol Estradiol results in decreased expression of GRIN2A mRNAdecreases expression 20068009
C004912 ethylbenzene ethylbenzene results in decreased activity of [GRIN1 protein binds to GRIN2A protein]affects binding|decreases activity 11090101
D018690 Excitatory Amino Acid Agonists Excitatory Amino Acid Agonists binds to and results in increased activity of [GRIN1 protein binds to GRIN2A protein]affects binding|increases activity 11812690
D018690 Excitatory Amino Acid Agonists Urethane inhibits the reaction [Excitatory Amino Acid Agonists binds to and results in increased activity of [GRIN1 protein binds to GRIN2A protein]]affects binding|decreases reaction|increases activity 11812690
D006220 Haloperidol Haloperidol results in decreased expression of GRIN2A mRNAdecreases expression 15860345
12608697
D007649 Ketamine GRIN2A protein affects the susceptibility to Ketamineaffects response to substance 15731593
D008874 Midazolam GRIN2A protein affects the susceptibility to Midazolamaffects response to substance 15731593
D008911 Minocycline Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2A mRNA]decreases reaction|increases expression 19660546
D009609 Nitrous Oxide GRIN2A protein affects the susceptibility to [Nitrous Oxide co-treated with sevoflurane]affects cotreatment|affects response to substance 15731593
C024268 n-propylbenzene n-propylbenzene results in decreased activity of [GRIN1 protein binds to GRIN2A protein]affects binding|decreases activity 11090101
D010424 Pentobarbital GRIN2A protein affects the susceptibility to Pentobarbitalaffects response to substance 15731593
D010424 Pentobarbital Pentobarbital affects the expression of GRIN2A mRNAaffects expression 9814547
D010862 Pilocarpine Pilocarpine results in decreased expression of GRIN2A proteindecreases expression 15857427
D011066 Poly C Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2A mRNA]decreases reaction|increases expression 19660546
D011066 Poly C Poly C results in increased expression of GRIN2A mRNAincreases expression 19660546
D015742 Propofol GRIN2A protein affects the susceptibility to Propofolaffects response to substance 15731593
C009250 sevoflurane GRIN2A protein affects the susceptibility to [Nitrous Oxide co-treated with sevoflurane]affects cotreatment|affects response to substance 15731593
C017947 sodium arsenite sodium arsenite results in decreased expression of GRIN2A mRNAdecreases expression 19041379
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GRIN2A mRNAincreases expression 16839606
11742229
D014050 Toluene Toluene results in increased expression of GRIN2A mRNAincreases expression 17870172
D014050 Toluene Toluene results in increased expression of GRIN2A proteinincreases expression 15695158
D014050 Toluene Toluene results in decreased activity of [GRIN1 protein binds to GRIN2A protein]affects binding|decreases activity 9655877
D014520 Urethane Urethane inhibits the reaction [Excitatory Amino Acid Agonists binds to and results in increased activity of [GRIN1 protein binds to GRIN2A protein]]affects binding|decreases reaction|increases activity 11812690
D014635 Valproic Acid Valproic Acid results in increased expression of GRIN2A proteinincreases expression 17675408
D014992 Xylenes Xylenes results in decreased activity of [GRIN1 protein binds to GRIN2A protein]affects binding|decreases activity 11090101
D015032 Zinc Zinc results in decreased activity of GRIN2A proteindecreases activity 16822975
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.1414514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.148875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6119490988
MESH:D000138 Acidosis Ammonium Chloride 3.2118287403
MESH:D000169 Acrodermatitis Zinc 5.0516889938 17190629 17202136
MESH:D000230 Adenocarcinoma Estradiol 4.4511473722
MESH:D000230 Adenocarcinoma Urethane 4.4518316556
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 5.3515814487
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.403712494
MESH:D000236 Adenoma Urethane 6.4017093202 10822126 17195641 16926031 10530776 6695378 11497255
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5416712894 17306315
MESH:D000380 Agranulocytosis Clozapine 4.7114617031 16160616 12649775
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 8.0011874814 16611668 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 8.0016487989
MESH:D000544 Alzheimer Disease 27-hydroxycholesterol 4.6320157255 14523054
MESH:D000544 Alzheimer Disease Zinc 4.6316325427 16410023 17119284 16580781
MESH:D000550 Amblyopia Valproic Acid 4.8717688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6411748828
MESH:D000741 Anemia, Aplastic Benzene 4.1017661222 14761424 11369114
MESH:D000755 Anemia, Sickle Cell Zinc 4.5616916123
MESH:D001008 Anxiety Disorders Diazepam 13.5516284244 18313124
MESH:D001008 Anxiety Disorders Pentobarbital 13.5518313124 11141031
MESH:D001008 Anxiety Disorders Valproic Acid 13.5517497229
MESH:D001145 Arrhythmias, Cardiac Xylenes 5.23513065
MESH:D001161 Arteriosclerosis Dietary Fats 3.5415238619
MESH:D001172 Arthritis, Rheumatoid Minocycline 4.1414528503
MESH:D001249 Asthma Zinc 2.8417085522
MESH:D050197 Atherosclerosis 27-hydroxycholesterol 4.229059518 11166758
MESH:D001321 Autistic Disorder marker/mechanism 15830322
MESH:D001321 Autistic Disorder Haloperidol 2.3419368416 18080171
MESH:D001321 Autistic Disorder Valproic Acid 2.3418396377 15238991 18940202 18985861 19460635 20603192 16609825 18316065 19232924 18558336 17157402 17507914 18177632 18775368 17688650
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.661440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 2.8920046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.7312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.2615746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.268888407
MESH:D001855 Bone Marrow Diseases Benzene 4.8716183116
MESH:D001930 Brain Injuries Zinc 4.3417109824
MESH:D001943 Breast Neoplasms Benzene 1.9111921183 17162533
MESH:D001943 Breast Neoplasms Dietary Fats 1.9120435547
MESH:D001943 Breast Neoplasms Estradiol 1.9119861407 12948864 17018787 17289903 16675129 17261762 14630087 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9120435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1116111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5216835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.237296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.2316924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.2316507464 17306315 15276417
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.517296757
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.5418572023
MESH:D002294 Carcinoma, Squamous Cell Zinc 4.5416543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1718850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Zinc 3.4216936243
MESH:D002375 Catalepsy Haloperidol 4.561977408 15215559
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 9.797505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.7918566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 9.7920056578 19524636
MESH:D002547 Cerebral Palsy Toluene 5.499294310
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8716835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 2.8919486331 9022650
MESH:D002972 Cleft Palate Diazepam 9.253629520
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.258697196 12621046 15340226 15668235 16354765
MESH:D002972 Cleft Palate Urethane 9.2512810352
MESH:D003072 Cognition Disorders Clozapine 4.6217123785
MESH:D015179 Colorectal Neoplasms marker/mechanism 17922030
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7617141729 14669216
MESH:D019465 Craniofacial Abnormalities Benzene 6.8815643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.8810048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Toluene 6.889294310
MESH:D019465 Craniofacial Abnormalities Valproic Acid 6.888888407 17688650 16575769
MESH:D019465 Craniofacial Abnormalities Zinc 6.8819302082
MESH:D003643 Death Toluene 5.316431079
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.5220210726
MESH:D003704 Dementia Haloperidol 4.2611575062
MESH:D003715 Dengue 27-hydroxycholesterol 5.3319427377
MESH:D003872 Dermatitis Benzene 4.4215902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.4812868966 11298694 18759878 2524372 8156756 14531868 8970840 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.172952479 3621924
MESH:D017453 Dermatitis, Irritant Xylenes 6.4817574719
MESH:D003920 Diabetes Mellitus Zinc 3.9116479319
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.1916402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1219279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.1915331141
MESH:D004283 Dog Diseases Allopurinol 5.9010449224
MESH:D056486 Drug-Induced Liver Injury 1,1,1-trichloroethane 8.156623471 2862719 4356632
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.151440618 9022650 9328219 18289764 7440962 18692083 9653073 6679447 8291058 16192314 18648102 11289319 6482804
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.1520420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 8.151733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5011462148
MESH:D050171 Dyslipidemias Clozapine 8.0216402076
MESH:D050171 Dyslipidemias Dietary Fats 8.0218367378
MESH:D004417 Dyspnea Diazinon 4.4416487989
MESH:D004421 Dystonia Diazepam 9.961851702
MESH:D004421 Dystonia Valproic Acid 9.961851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.0812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5415322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 27-hydroxycholesterol 9.3117410599
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Minocycline 9.3111835378
MESH:D016889 Endometrial Neoplasms Estradiol 2.7518566989 11473722 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.729294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.8117275665 3659116
MESH:D004828 Epilepsies, Partial Diazepam 9.393922381
MESH:D004828 Epilepsies, Partial Valproic Acid 9.393922381 16628512
MESH:D004827 Epilepsy marker/mechanism 20890276
MESH:D004827 Epilepsy Diazepam 10.40821787
MESH:D004827 Epilepsy Pilocarpine 10.4011162239 19700373 19439326
MESH:D004827 Epilepsy Valproic Acid 10.4018234410 20417680
MESH:D004832 Epilepsy, Absence Diazepam 8.496401628 6426943
MESH:D004832 Epilepsy, Absence Valproic Acid 8.496426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.957750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.713659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.343581430
MESH:D004938 Esophageal Neoplasms Zinc 4.3416543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7511564622
MESH:D005234 Fatty Liver Dietary Fats 6.8619551842 17967931 19004024 18296743
MESH:D005234 Fatty Liver Valproic Acid 6.8614986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1111858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.798888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.666705139
MESH:D005355 Fibrosis Dietary Fats 7.4818296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.4820067830
MESH:D005600 Fragile X Syndrome Minocycline 6.4018835858
MESH:D005756 Gastritis Zinc 4.4417241300
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3216452187
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.717505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2310696789
MESH:D006130 Growth Disorders Zinc 3.7317217573
MESH:D006261 Headache Ketamine 5.6511554966
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1410048152 11294989
MESH:D006331 Heart Diseases Urethane 4.0016046796
MESH:D006333 Heart Failure Zinc 3.3917162251
MESH:D006335 Heart Injuries Zinc 5.4117074742
MESH:D016481 Helicobacter Infections Zinc 4.2117241300
MESH:D006402 Hematologic Diseases Benzene 4.3316183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 8.476705139
MESH:D006505 Hepatitis Diazinon 8.4716487989
MESH:D006521 Hepatitis, Chronic 1,1,1-trichloroethane 11.6212594376
MESH:D006521 Hepatitis, Chronic Minocycline 11.6214986274
MESH:D006527 Hepatolenticular Degeneration Zinc 4.3417276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5512621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.6715709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.8712676792
MESH:D019584 Hot Flashes Estradiol 3.3917088409
MESH:D006849 Hydrocephalus Valproic Acid 4.5117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.688697196 16354765 15340226 18606429 16959395
MESH:D006937 Hypercholesterolemia 27-hydroxycholesterol 8.5917873880
MESH:D006937 Hypercholesterolemia Dietary Fats 8.5921332399
MESH:D006948 Hyperkinesis Clozapine 4.5616046005
MESH:D006949 Hyperlipidemias Dietary Fats 3.2921332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.5915034207
MESH:D006973 Hypertension Benzene 4.8417940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8418670907 18850075
MESH:D007248 Infertility, Male Diazinon 6.3516466525 12948887
MESH:D007248 Infertility, Male sodium arsenite 6.3512646999 15346721
MESH:D007249 Inflammation Dietary Fats 4.3020412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.3012200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 6.6018457598 11836018
MESH:D007333 Insulin Resistance Estradiol 6.6016393666 16627594
MESH:D007511 Ischemia Zinc 4.2916584753
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.668074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0216580747
MESH:D007674 Kidney Diseases Estradiol 8.9915618244
MESH:D007674 Kidney Diseases sodium arsenite 8.9920008137
MESH:D007674 Kidney Diseases Zinc 8.9916960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.1016518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 6.426582329
MESH:D007680 Kidney Neoplasms Estradiol 6.4215610895
MESH:D007859 Learning Disorders sevoflurane 4.4319212262
MESH:D016773 Leishmaniasis, Cutaneous Allopurinol 4.9812207774 9314461
MESH:D007898 Leishmaniasis, Visceral Allopurinol 4.857498017 10449224 11332679
MESH:D007938 Leukemia Benzene 3.2115935818 18335105 17119257 14694614
MESH:D007951 Leukemia, Myeloid Benzene 4.0017506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 3.8719478238
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.8716294345 17596541
MESH:D008064 Lipidoses Clozapine 3.7117567588
MESH:D008103 Liver Cirrhosis Dietary Fats 2.6818296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.9715034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.1414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1412878042
MESH:D008107 Liver Diseases Chlorpyrifos 2.9915991261
MESH:D008113 Liver Neoplasms sodium arsenite 6.7416712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 6.7416984957
MESH:D008113 Liver Neoplasms Urethane 6.7416391232 17093202 17559639
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 8.58598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Benzene 8.5812562636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.5812151625
MESH:D008171 Lung Diseases sodium arsenite 2.9419095001
MESH:D017563 Lung Diseases, Interstitial Benzene 10.1814698565
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 10.1817228818
MESH:D008175 Lung Neoplasms Benzene 4.5312562636
MESH:D008175 Lung Neoplasms sodium arsenite 4.5315276417 16712894 17077188 17306315 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.5319555203 11884234
MESH:D008175 Lung Neoplasms Urethane 4.5311893704 17093202 12765245 12117781 17255336 17195641 11544531 16007126 6695378 11497255 15166089 16391232 12466968 14587096 15902970 11552296 16926031 15136453 10997738 10530776 11807781 16788158 11992545 11074608 11323394 11062179 12957351 11307925 16289808 11246140 10822126 16337739 16204055 10779650 7750092
MESH:D008223 Lymphoma Benzene 3.4917584886 17119257
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.0912562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 8.8011921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.8011807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Zinc 8.8012773700
MESH:D020149 Manganese Poisoning Estradiol 4.1219453300
MESH:D008545 Melanoma marker/mechanism 21499247
MESH:D008545 Melanoma sodium arsenite 1.9816487513 19082730
MESH:D008569 Memory Disorders sevoflurane 4.4119212262
MESH:D001523 Mental Disorders Clozapine 7.2016856516
MESH:D001523 Mental Disorders Haloperidol 7.2016856516
MESH:D008607 Mental Retardation Toluene 3.539294310
MESH:D024821 Metabolic Syndrome X Clozapine 4.1219142101
MESH:D008881 Migraine Disorders Valproic Acid 2.9418765137 18803445
MESH:D019957 Motor Skills Disorders Toluene 4.919294310
MESH:D009101 Multiple Myeloma Benzene 3.4217119195
MESH:D020529 Multiple Sclerosis, Relapsing-Remitting Minocycline 6.4111835378
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.718888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.9517596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0116810080
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.323581430
MESH:D009369 Neoplasms sodium arsenite 4.9211559025
MESH:D009369 Neoplasms Urethane 4.9215625555
MESH:D009374 Neoplasms, Experimental sodium arsenite 8.3320056578
MESH:D009374 Neoplasms, Experimental Urethane 8.3315582191
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3817289903
MESH:D009395 Nephritis, Interstitial Minocycline 5.56435818 444868
MESH:D009421 Nervous System Malformations Estradiol 14.6211399458 16427766
MESH:D009421 Nervous System Malformations Pilocarpine 14.6215987249
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.6214600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 15.456679447
MESH:D009436 Neural Tube Defects Benzene 15.4515643154
MESH:D009436 Neural Tube Defects sodium arsenite 15.4512854658
MESH:D009436 Neural Tube Defects Valproic Acid 15.458888407 16359493
MESH:D020078 Neurogenic Inflammation Xylenes 5.6719159661
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.9315081274
MESH:D009765 Obesity Clozapine 4.5518515891 19142110
MESH:D009765 Obesity Dietary Fats 4.5518674790 20518802 19632207 11836018 16723640 20132043 18457598 17217161 21332399
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.144026338 6482804
MESH:D009784 Occupational Diseases Benzene 8.1417119257 15612468 17479406 15935809 17178637 16737584 15576619 15727169 15913788
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.663988306
MESH:D010051 Ovarian Neoplasms Benzene 10.3712562636
MESH:D010051 Ovarian Neoplasms Estradiol 10.3719401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.3717306315 15276417
MESH:D010051 Ovarian Neoplasms Urethane 10.3716391232
MESH:D010146 Pain Xylenes 4.6519159661 3412491
MESH:D010149 Pain, Postoperative Ketamine 5.7611554966
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.147296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8912520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.116228378
MESH:D010911 Pituitary Neoplasms Urethane 5.0716391232
MESH:D011041 Poisoning Diazinon 4.0317603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2218163543
MESH:D011225 Pre-Eclampsia Zinc 3.9017114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.2911896295 11222880 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.2920603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5720887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.7516740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.7516039940
MESH:D011471 Prostatic Neoplasms Zinc 2.7516700911 12429649 16606632 16517595
MESH:D019310 Pseudolymphoma Valproic Acid 4.1811422049 12752131
MESH:D011595 Psychomotor Agitation Haloperidol 4.6111575062
MESH:D011618 Psychotic Disorders Clozapine 8.3115331141
MESH:D011618 Psychotic Disorders Haloperidol 8.3111575062
MESH:D011649 Pulmonary Alveolar Proteinosis 27-hydroxycholesterol 6.0315466366
MESH:D012021 Reflex, Abnormal Pentobarbital 5.6710930210
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.2916611668 17119214 11874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5018990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.5316611668 17119214
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.143692021
MESH:D012162 Retinal Degeneration Zinc 8.1416584753
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.8519155313
MESH:D012559 Schizophrenia Clozapine 7.5320580759 17123785 18855531 16141801 20107430 18806925 20521326 19369910 11763009 20521320 17726453 20168265 20452607 11151749 17667964
MESH:D012559 Schizophrenia Haloperidol 7.5319369910 18513383 20107430 1830565
MESH:D012559 Schizophrenia Ketamine 7.5320000043
MESH:D012559 Schizophrenia Valproic Acid 7.5319110320 15737665
MESH:D012640 Seizures Diazepam 28.9715946322 10087439 9754883
MESH:D012640 Seizures Dizocilpine Maleate 28.9711218047 17157343 12660363
MESH:D012640 Seizures Midazolam 28.9710087439
MESH:D012640 Seizures Nitrous Oxide 28.979754883
MESH:D012640 Seizures Pentobarbital 28.9710087439 9754883
MESH:D012640 Seizures Pilocarpine 28.9719660546 7750514
MESH:D012640 Seizures Toluene 28.979294310 6431079
MESH:D012640 Seizures Valproic Acid 28.9715475178 1511512 16876388 3137016 11738929 11044598 17978042 14763951
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.736418539
MESH:D012878 Skin Neoplasms sodium arsenite 8.5718572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.5716192470
MESH:D012878 Skin Neoplasms Urethane 8.5711807781
MESH:D012893 Sleep Disorders Midazolam 5.666138072
MESH:D007319 Sleep Initiation and Maintenance Disorders Midazolam 5.446138071
MESH:D019082 Smith-Lemli-Opitz Syndrome 27-hydroxycholesterol 5.6711254748
OMIM:270800 SPASTIC PARAPLEGIA 5A, AUTOSOMAL RECESSIVE 27-hydroxycholesterol 6.0219812052
MESH:D016135 Spinal Dysraphism sodium arsenite 8.6412854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.6419490988
MESH:D013226 Status Epilepticus Pilocarpine 11.6415857427 11259499 19055492 19951488 19430551 15987249 19570321
MESH:D013226 Status Epilepticus Valproic Acid 11.6412833885
MESH:D013274 Stomach Neoplasms Benzene 2.4112562636
MESH:D013375 Substance Withdrawal Syndrome Diazepam 15.219754883
MESH:D013375 Substance Withdrawal Syndrome Nitrous Oxide 15.219754883
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 15.219754883 11529278
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.3720210726
MESH:D013733 Testicular Diseases Toluene 10.0910048760 10514026
MESH:D013733 Testicular Diseases Xylenes 10.0910048760 10514026
MESH:D013742 Tetanus Midazolam 12.932903605
MESH:D013742 Tetanus Propofol 12.932903605
MESH:D013953 Thymus Neoplasms Benzene 4.6010850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.626587162 6582329 7505956 1399818 3712494
MESH:D013978 Tibial Fractures Estradiol 4.3219048282
MESH:D014062 Tongue Neoplasms Zinc 4.0916543248
MESH:D014178 Translocation, Genetic Valproic Acid 4.8717262798
MESH:D014202 Tremor Pilocarpine 5.4417594079
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.173119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 4.618074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 4.6111723127 17306315 16452187 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.308888407
MESH:D014570 Urologic Diseases Diazinon 4.9216487989
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.4611813266
MESH:D014594 Uterine Neoplasms Benzene 4.0012562636
MESH:D014652 Vascular Diseases sodium arsenite 4.0717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2312125929
MESH:D019043 Vascular Neoplasms Urethane 5.5510620525
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8915886252
MESH:D015430 Weight Gain Clozapine 8.8416141801 20107430 20564506 17502770 20521320 16402076
MESH:D015430 Weight Gain Dietary Fats 8.8416723640
MESH:D015431 Weight Loss Clozapine 4.7217933447
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
KEGG:04020 Calcium signaling pathway
KEGG:04724 Glutamatergic synapse
KEGG:04720 Long-term potentiation
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
KEGG:05322 Systemic lupus erythematosus
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28979
    • No data
    Releated disease ID Related disease Name
    PA443309Alcoholism
    Releated drug ID Related drug Name
    PA152241909PP2
    PA450626nicotine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00145 antagonist Glycine Dietary supplement;Micronutrient;Non-Essential Amino Acids;Glycine Agents
    DB00454 blocker Meperidine Narcotics;Analgesics;Adjuvants, Anesthesia;Opiate Agonists;Analgesics, Opioid;Adjuvants
    DB00949 antagonist Felbamate Anticonvulsants;Neuroprotective Agents;Antiepileptic Agents
    DB01043 antagonist Memantine Dopamine Agents;Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Excitatory Amino Acid Antagonists
    DB01159 inhibitor Halothane Anesthetics, Inhalation;General Anesthetics;Anesthetics
    DB01520 antagonist Tenocyclidine Neuroprotective Agents;Anesthetics, Dissociative
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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