AutismKB 2.0

Annotation Detail for GRIN2B


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GRIN2B ( MGC142178,MGC142180,NMDAR2B,NR2B,hNR3 )
Gene Full Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Band: 12p13.1
Quick LinksEntrez ID:2904; OMIM: 138252; Uniprot ID:NMDE2_HUMAN; ENSEMBL ID: ENSG00000150086; HGNC ID: 4586
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04720Long-term potentiation
hsa04080Neuroactive ligand-receptor interaction
hsa05322Systemic lupus erythematosus
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05016Huntington's disease
hsa05010Alzheimer's disease
Pathway IDPathway Name
Synaptic Transmission
Pathway IDPathway Name
200009ErbB4 signaling events
200051Reelin signaling pathway
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00037Ionotropic glutamate receptor pathway
P00029Huntington disease
P00041Metabotropic glutamate receptor group I pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
alcoholism-related traits
PSYCH
NEUROLOGICAL
attention deficit hyperactivity disorder
schizophrenia
Cognitive performance
Desease Name
Cognitive performance
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C024566 1,1,1-trichloroethane 1,1,1-trichloroethane results in decreased activity of [GRIN1 protein binds to GRIN2B protein]affects binding|decreases activity 11090101
C018824 ammonium acetate ammonium acetate results in decreased expression of GRIN2B proteindecreases expression 20084674
D000661 Amphetamine Amphetamine results in increased expression of GRIN2B mRNAincreases expression 20422365
D000661 Amphetamine Amphetamine results in increased expression of GRIN2B proteinincreases expression 20422365
D000661 Amphetamine rhyncophylline inhibits the reaction [Amphetamine results in increased expression of GRIN2B mRNA]decreases reaction|increases expression 20422365
D000661 Amphetamine rhyncophylline inhibits the reaction [Amphetamine results in increased expression of GRIN2B protein]decreases reaction|increases expression 20422365
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in decreased expression of GRIN2B mRNAdecreases expression 18687144
D001374 Azacitidine Azacitidine results in decreased methylation of GRIN2B genedecreases methylation 18618247
D001554 Benzene Benzene results in decreased activity of [GRIN1 protein binds to GRIN2B protein]affects binding|decreases activity 11090101
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of GRIN2B mRNAincreases expression 19440498
17452286
D003024 Clozapine Clozapine results in decreased expression of GRIN2B mRNAdecreases expression 18923069
D003976 Diazinon Diazinon results in decreased expression of GRIN2B mRNAdecreases expression 19440498
D004026 Dieldrin Dieldrin results in decreased expression of GRIN2B mRNAdecreases expression 19440498
D016291 Dizocilpine Maleate Dizocilpine Maleate results in decreased expression of GRIN2B mRNAdecreases expression 11169168
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GRIN2B mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRIN2B mRNAaffects cotreatment|increases expression 17942748
C004912 ethylbenzene ethylbenzene results in decreased activity of [GRIN1 protein binds to GRIN2B protein]affects binding|decreases activity 11090101
C010739 ifenprodil ifenprodil results in decreased activity of GRIN2B proteindecreases activity 16822975
C010739 ifenprodil [Zinc co-treated with ifenprodil] results in decreased activity of GRIN2B proteinaffects cotreatment|decreases activity 16822975
D008694 Methamphetamine Methamphetamine results in increased expression of GRIN2B proteinincreases expression 17105907
D009532 Nickel Nickel results in decreased expression of GRIN2B mRNAdecreases expression 19440498
C024268 n-propylbenzene n-propylbenzene results in decreased activity of [GRIN1 protein binds to GRIN2B protein]affects binding|decreases activity 11090101
D010269 Paraquat Paraquat affects the expression of GRIN2B mRNAaffects expression 15206577
D010424 Pentobarbital Pentobarbital affects the expression of GRIN2B mRNAaffects expression 9814547
D010862 Pilocarpine Pilocarpine results in decreased expression of GRIN2B proteindecreases expression 15857427
C023666 pyridine pyridine analog binds to and results in decreased activity of GRIN2B proteinaffects binding|decreases activity 17768047
C052714 rhyncophylline rhyncophylline inhibits the reaction [Amphetamine results in increased expression of GRIN2B mRNA]decreases reaction|increases expression 20422365
C052714 rhyncophylline rhyncophylline inhibits the reaction [Amphetamine results in increased expression of GRIN2B protein]decreases reaction|increases expression 20422365
D013467 Sulindac Sulindac affects the expression of GRIN2B proteinaffects expression 15123337
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRIN2B mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GRIN2B mRNAdecreases expression 16839606
11742229
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GRIN2B proteindecreases expression 16839606
D013849 Thimerosal Thimerosal results in decreased expression of GRIN2B proteindecreases expression 15184908
D014050 Toluene Toluene results in increased expression of GRIN2B mRNAincreases expression 16737738
D014050 Toluene Toluene results in increased expression of GRIN2B proteinincreases expression 15695158
D014050 Toluene Toluene results in decreased activity of [GRIN1 protein binds to GRIN2B protein]affects binding|decreases activity 9655877
D014212 Tretinoin Tretinoin results in increased expression of GRIN2B proteinincreases expression 17460065
D014635 Valproic Acid Valproic Acid results in increased expression of GRIN2B proteinincreases expression 17675408
D014992 Xylenes Xylenes results in decreased activity of [GRIN1 protein binds to GRIN2B protein]affects binding|decreases activity 11090101
D015032 Zinc [Zinc co-treated with ifenprodil] results in decreased activity of GRIN2B proteinaffects cotreatment|decreases activity 16822975
D015032 Zinc Zinc results in decreased activity of GRIN2B proteindecreases activity 16822975
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.2114745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.3815322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.388875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6819490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6617505938
MESH:D000169 Acrodermatitis Zinc 5.1217202136 17190629 16889938
MESH:D058186 Acute Kidney Injury Sulindac 4.077897758
MESH:D055371 Acute Lung Injury Nickel 4.3316166738
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3414692618
MESH:D000230 Adenocarcinoma Sulindac 4.3411910360
MESH:D000236 Adenoma Sulindac 3.6210223192
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1016835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.3611535846 17611924 11874996 15623613 12394442 16460482 19003578
MESH:D000380 Agranulocytosis Clozapine 4.7816160616 12649775 14617031
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 12.9411874814 16611668 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 12.9416487989
MESH:D000382 Agricultural Workers' Diseases Paraquat 12.9411874814
MESH:D000505 Alopecia Tretinoin 3.4015955085
MESH:D000544 Alzheimer Disease Zinc 2.7017119284 16580781 16325427 16410023
MESH:D000550 Amblyopia Valproic Acid 4.9517688650
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.7818475255 15010207 16459022 16916582
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7111748828
MESH:D000741 Anemia, Aplastic Benzene 4.1611369114 17661222 14761424
MESH:D000755 Anemia, Sickle Cell Zinc 4.6316916123
MESH:D000855 Anorexia Amphetamine 4.7712183048 16084549 16101753 12005258
MESH:D001008 Anxiety Disorders Pentobarbital 8.5318313124 11141031
MESH:D001008 Anxiety Disorders Valproic Acid 8.5317497229
MESH:D001145 Arrhythmias, Cardiac ifenprodil 9.7717460149
MESH:D001145 Arrhythmias, Cardiac Xylenes 9.77513065
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.6415885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.6416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2016292516
MESH:D001249 Asthma Tretinoin 4.7716456186
MESH:D001249 Asthma Zinc 4.7717085522
MESH:D001321 Autistic Disorder Valproic Acid 2.0318940202 17507914 17688650 15238991 18396377 18177632 18775368 20603192 19232924 18558336 19460635 18985861 16609825 18316065 17157402
MESH:D001471 Barrett Esophagus Tretinoin 4.1416935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.9420046352 17594078
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.1112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.1116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.4315746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.438888407
MESH:D001855 Bone Marrow Diseases Benzene 4.9516183116
MESH:D001913 Bowen's Disease Sulindac 5.0711207687
MESH:D001930 Brain Injuries Zinc 4.4217109824
MESH:D001943 Breast Neoplasms Benzene 2.8417162533 11921183
MESH:D001943 Breast Neoplasms Dieldrin 2.8415770527 11859874
MESH:D001943 Breast Neoplasms Nickel 2.8415986119
MESH:D001943 Breast Neoplasms Sulindac 2.8416642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8420435547
MESH:D001943 Breast Neoplasms Tretinoin 2.8416873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3116813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5816835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8716168501
MESH:D006528 Carcinoma, Hepatocellular pyridine 3.6610696769
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.661917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.6016051514 16096774
MESH:D002294 Carcinoma, Squamous Cell Zinc 4.6016543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2118670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Zinc 3.4716936243
MESH:D002386 Cataract Tretinoin 2.9317460283
MESH:D002547 Cerebral Palsy Toluene 5.579294310
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3116129372
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 21572417
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6120734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6717110522 17333356 15861022 16105132 11677210 16919318 17681005
MESH:D002822 Choriocarcinoma Tretinoin 4.8716461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3716354765 15340226 12621046 8697196 15668235
MESH:D002972 Cleft Palate Tretinoin 5.379407595
MESH:D003072 Cognition Disorders Clozapine 4.6917123785
MESH:D003092 Colitis Tretinoin 3.4317035595
MESH:D003110 Colonic Neoplasms Sulindac 2.8712902858 12458338
MESH:D015179 Colorectal Neoplasms Azacitidine 3.0419934284
MESH:D015179 Colorectal Neoplasms Sulindac 3.0411197048 10666051 18059344 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8317141729 14669216
MESH:D019465 Craniofacial Abnormalities Benzene 9.0415643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 9.0410048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Toluene 9.049294310
MESH:D019465 Craniofacial Abnormalities Tretinoin 9.049142499 9224671 9211117 9125849 17551590 14991402 10589399 9664655 16925845 8800419
MESH:D019465 Craniofacial Abnormalities Valproic Acid 9.0416575769 17688650 8888407
MESH:D019465 Craniofacial Abnormalities Zinc 9.0419302082
MESH:D003643 Death Toluene 5.386431079
MESH:D003872 Dermatitis Benzene 4.4915902427
MESH:D017449 Dermatitis, Allergic Contact Nickel 6.9917244072 17100760 19470301
MESH:D017449 Dermatitis, Allergic Contact Thimerosal 6.9916958921 15932584
MESH:D003877 Dermatitis, Contact Nickel 4.382952479
MESH:D017453 Dermatitis, Irritant Xylenes 6.5517574719
MESH:D002658 Developmental Disabilities Thimerosal 4.6615764492
MESH:D003920 Diabetes Mellitus Zinc 3.9716479319
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.2716402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2717107852
MESH:D003930 Diabetic Retinopathy Sulindac 4.9112861449 17621415
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.2715331141
MESH:D056486 Drug-Induced Liver Injury 1,1,1-trichloroethane 6.064356632 6623471 2862719
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.0620420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.061733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5611462148
MESH:D050171 Dyslipidemias Clozapine 3.9916402076
MESH:D004417 Dyspnea Diazinon 4.5216487989
MESH:D004421 Dystonia Valproic Acid 3.791851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.1412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.0016714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.0018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9212538720
MESH:D016889 Endometrial Neoplasms Tretinoin 2.9316569247
MESH:D004715 Endometriosis Sulindac 8.3915652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.399294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.883659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.6316628512 3922381
MESH:D004827 Epilepsy Pilocarpine 6.8419439326 11162239 19700373
MESH:D004827 Epilepsy Valproic Acid 6.8418234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.367562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.027750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.793659116
MESH:D004938 Esophageal Neoplasms Sulindac 4.8012235107
MESH:D004938 Esophageal Neoplasms Zinc 4.8016543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.1511564622
MESH:D005124 Eye Abnormalities Tretinoin 8.159664655 16938888
MESH:D005221 Fatigue Amphetamine 5.3219890266
MESH:D005234 Fatty Liver Ethinyl Estradiol 6.9215345470
MESH:D005234 Fatty Liver Valproic Acid 6.9214986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.8618558336 8888407
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.2014745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 4.8519069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.7120067830
MESH:D005355 Fibrosis Tretinoin 7.7117994277
MESH:D005756 Gastritis Zinc 4.5117241300
MESH:D005764 Gastroesophageal Reflux Sulindac 4.7411910360
MESH:D005909 Glioblastoma Tretinoin 2.8317312396
MESH:D005911 Gliosis Paraquat 4.8811124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006130 Growth Disorders Zinc 3.7817217573
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8716084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.0511294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.0514991402 9664655
MESH:D006333 Heart Failure Zinc 3.4417162251
MESH:D006335 Heart Injuries Zinc 5.4917074742
MESH:D016481 Helicobacter Infections Zinc 4.2817241300
MESH:D006402 Hematologic Diseases Benzene 4.4016183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006505 Hepatitis Diazinon 4.3116487989
MESH:D006521 Hepatitis, Chronic 1,1,1-trichloroethane 6.5412594376
MESH:D006527 Hepatolenticular Degeneration Zinc 4.4217276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6216120746 15340226 12621046
MESH:D015658 HIV Infections Nickel 3.6717263646
MESH:D006849 Hydrocephalus Valproic Acid 4.5917688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.768697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Tretinoin 3.0016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2916778211
MESH:D006948 Hyperkinesis Amphetamine 17.691977408 14960337
MESH:D006948 Hyperkinesis Clozapine 17.6916046005
MESH:D006948 Hyperkinesis Methamphetamine 17.6917658665
MESH:D006973 Hypertension Benzene 4.9517940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9518670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5416569931 16945680
MESH:D007022 Hypotension marker/mechanism 18639534
MESH:D007247 Infertility, Female Dieldrin 9.4310630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 9.4312013081
MESH:D007248 Infertility, Male Diazinon 10.2812948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.2817937319
MESH:D007248 Infertility, Male Paraquat 10.284850670
MESH:D007249 Inflammation Nickel 7.6916166738
MESH:D007249 Inflammation Sulindac 7.693291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.6912878042 12200463
MESH:D007410 Intestinal Diseases Tretinoin 3.4917994277
MESH:D007414 Intestinal Neoplasms Sulindac 4.3912584176 12351151 12628509 10213222 12663524 10223192
MESH:D007417 Intestinal Polyps Sulindac 4.7311245490 12394442
MESH:D007511 Ischemia Zinc 4.3616584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.1016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.1015992940 17551590
MESH:D007674 Kidney Diseases Zinc 3.1716960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.1716518626
MESH:D007680 Kidney Neoplasms pyridine 4.9110696769
MESH:D007938 Leukemia Azacitidine 9.8519148494
MESH:D007938 Leukemia Benzene 9.8515935818 14694614 17119257 18335105
MESH:D007938 Leukemia Tretinoin 9.8517143497
MESH:D007951 Leukemia, Myeloid Azacitidine 14.7119077051
MESH:D007951 Leukemia, Myeloid Benzene 14.7117506065
MESH:D007951 Leukemia, Myeloid Tretinoin 14.7116482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 8.3617596541 18720364
MESH:D015470 Leukemia, Myeloid, Acute Benzene 8.3619478238
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 8.3616294345 19850784 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 8.3616294345 17596541
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.9319299654
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9716935935 17361223 16140955 17339181 17368321 19035177 17506722 16891316 12679006 17107899 19225113 17294898 19029980 16788101 17301526 19642359 16766008 19075265 17217047 17712046 15748426 16823087 16331271 17649720 9834237
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.119224671
MESH:D008064 Lipidoses Clozapine 3.7617567588
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.0512468960
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.2116248980 18397230
MESH:D008107 Liver Diseases Chlorpyrifos 4.5315991261
MESH:D008107 Liver Diseases Sulindac 4.5314986274 16867024
MESH:D008113 Liver Neoplasms Dieldrin 4.459539021 8742319
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4516984957
MESH:D008114 Liver Neoplasms, Experimental Benzene 5.4412562636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.4412151625
MESH:D017563 Lung Diseases, Interstitial Benzene 10.4414698565
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 10.4417228818
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.7517365036
MESH:D008175 Lung Neoplasms Azacitidine 4.6621224363
MESH:D008175 Lung Neoplasms Benzene 4.6612562636
MESH:D008175 Lung Neoplasms Sulindac 4.6619359593 15713900
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6619555203 11884234
MESH:D008223 Lymphoma Benzene 3.5417119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.1612562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 5.9011921183
MESH:D008325 Mammary Neoplasms, Experimental Zinc 5.9012773700
MESH:D008527 Medulloblastoma Tretinoin 2.6717453147
MESH:D008545 Melanoma Sulindac 3.4716642371
MESH:D008545 Melanoma Tretinoin 3.4716752155
MESH:D008591 Meningomyelocele Tretinoin 4.1516940565
MESH:D001523 Mental Disorders Clozapine 3.6716856516
MESH:D008607 Mental Retardation marker/mechanism 20890276
MESH:D008607 Mental Retardation Toluene 3.569294310
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.0716966607 18303189 16166281
MESH:D024821 Metabolic Syndrome X Clozapine 4.1819142101
MESH:D008881 Migraine Disorders Valproic Acid 2.9918803445 18765137
MESH:D009006 Monosomy Azacitidine 5.8019299654
MESH:D019957 Motor Skills Disorders Toluene 4.989294310
MESH:D009101 Multiple Myeloma Azacitidine 7.1619549372 18443271
MESH:D009101 Multiple Myeloma Benzene 7.1617119195
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.788888407
MESH:D009190 Myelodysplastic Syndromes Azacitidine 11.5017611569 19805378 17596541 18720364
MESH:D009190 Myelodysplastic Syndromes Tretinoin 11.5017596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 11.5017596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8012213967
MESH:D009369 Neoplasms Dieldrin 5.018820588
MESH:D009369 Neoplasms Tretinoin 5.0116946489 16594593
MESH:D009410 Nerve Degeneration Paraquat 3.5116893418
MESH:D009421 Nervous System Malformations Pilocarpine 15.0515987249
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.0514600291
MESH:D009421 Nervous System Malformations Tretinoin 15.059125849
MESH:D009436 Neural Tube Defects Benzene 11.1815643154
MESH:D009436 Neural Tube Defects Tretinoin 11.189142499
MESH:D009436 Neural Tube Defects Valproic Acid 11.188888407 16359493
MESH:D019636 Neurodegenerative Diseases Amphetamine 8.4315183010
MESH:D019636 Neurodegenerative Diseases Sulindac 8.4316850258 17266991
MESH:D020078 Neurogenic Inflammation Xylenes 5.7419159661
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.9815081274
MESH:D009765 Obesity Clozapine 2.9519142110 18515891
MESH:D009784 Occupational Diseases Benzene 3.9415913788 17119257 15935809 17178637 15612468 15576619 15727169 17479406 16737584
MESH:D010051 Ovarian Neoplasms Benzene 4.7812562636
MESH:D010051 Ovarian Neoplasms Tretinoin 4.7816936753
MESH:D010146 Pain Sulindac 10.373291741
MESH:D010146 Pain Tretinoin 10.3716870215
MESH:D010146 Pain Xylenes 10.373412491 19159661
MESH:D010190 Pancreatic Neoplasms Sulindac 5.2516820089 11504793
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2515976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4311578682
MESH:D010300 Parkinson Disease Dieldrin 5.4311445065 11181820 16809432 17291500 16112328
MESH:D010300 Parkinson Disease Paraquat 5.4311124998 12911755 16510128 11445065 11181820 15451049 16140633 15824117
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.1616190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.6210923243
MESH:D011014 Pneumonia Paraquat 4.1712504350
MESH:D011041 Poisoning Diazinon 4.1017603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011225 Pre-Eclampsia Zinc 3.9617114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.5311896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.5320603192
MESH:D011471 Prostatic Neoplasms Azacitidine 3.9118324645
MESH:D011471 Prostatic Neoplasms Zinc 3.9116517595 16700911 12429649 16606632
MESH:D011507 Proteinuria Tretinoin 3.3516636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0315861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.2612752131 11422049
MESH:D011618 Psychotic Disorders Clozapine 3.9915331141
MESH:D011625 Pterygium Tretinoin 4.5116723453
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.5415814490 17365031 17322281 17975199
MESH:D011658 Pulmonary Fibrosis Paraquat 5.5417997886 16324872
MESH:D012021 Reflex, Abnormal Pentobarbital 5.7410930210
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.6511700416
MESH:D012135 Respiratory Sounds Chlorpyrifos 9.0316611668 11874814 17119214
MESH:D012135 Respiratory Sounds Paraquat 9.0311874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.6116611668 17119214
MESH:D012162 Retinal Degeneration Paraquat 8.5116458197
MESH:D012162 Retinal Degeneration Zinc 8.5116584753
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.0016283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.0019155313
MESH:D012559 Schizophrenia marker/mechanism 18583979
MESH:D012559 Schizophrenia Clozapine 3.6820452607 18806925 20580759 17667964 11763009 20168265 18855531 16141801 20107430 20521320 17726453 19369910 20521326 17123785 11151749
MESH:D012559 Schizophrenia Valproic Acid 3.6819110320 15737665
MESH:D012640 Seizures Dizocilpine Maleate 16.6917157343 11218047 12660363
MESH:D012640 Seizures Pentobarbital 16.6910087439 9754883
MESH:D012640 Seizures Pilocarpine 16.6919660546 7750514
MESH:D012640 Seizures Toluene 16.699294310 6431079
MESH:D012640 Seizures Valproic Acid 16.6917978042 1511512 16876388 3137016 11044598 14763951 11738929 15475178
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.816418539
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.1216192470
MESH:D012878 Skin Neoplasms Tretinoin 5.1216467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6616709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5719490988
MESH:D013226 Status Epilepticus Pilocarpine 11.8919055492 19951488 19430551 11259499 15857427 15987249 19570321
MESH:D013226 Status Epilepticus Valproic Acid 11.8912833885
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.141977408
MESH:D013274 Stomach Neoplasms Benzene 2.5912562636
MESH:D013274 Stomach Neoplasms Tretinoin 2.5917261132
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 4.749754883 11529278
MESH:D013733 Testicular Diseases Toluene 10.3310048760 10514026
MESH:D013733 Testicular Diseases Xylenes 10.3310048760 10514026
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9215669648
MESH:D013953 Thymus Neoplasms Benzene 4.6810850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6212697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.8216026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 9.1816051514
MESH:D014062 Tongue Neoplasms Zinc 9.1816543248
MESH:D014178 Translocation, Genetic Valproic Acid 4.9517262798
MESH:D014202 Tremor Pilocarpine 5.5217594079
MESH:D014376 Tuberculosis Tretinoin 3.0616040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.243119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.378888407
MESH:D014570 Urologic Diseases Diazinon 4.9916487989
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4416129372
MESH:D014594 Uterine Neoplasms Benzene 14.6312562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 14.6314692618
MESH:D014594 Uterine Neoplasms Sulindac 14.6318645019
MESH:D014604 Uveal Neoplasms Tretinoin 4.3316752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2914671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.7916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
MESH:D015430 Weight Gain Clozapine 4.2316141801 20107430 16402076 17502770 20564506 20521320
MESH:D015431 Weight Loss Clozapine 4.8017933447
MESH:D009396 Wilms Tumor Tretinoin 3.7316287080
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
KEGG:04724 Glutamatergic synapse
KEGG:05016 Huntington's disease
KEGG:04720 Long-term potentiation
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
KEGG:05322 Systemic lupus erythematosus
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28980
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    Releated drug ID Related drug Name
    PA152241909PP2
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    PA450626nicotine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00454 blocker Meperidine Narcotics;Analgesics;Adjuvants, Anesthesia;Opiate Agonists;Analgesics, Opioid;Adjuvants
    DB00502 antagonist Haloperidol Antiemetics;Antidyskinetics;Antipsychotics;Dopamine Antagonists;Antipsychotic Agents;Butyrophenones;Anti-Dyskinesia Agents
    DB00949 antagonist Felbamate Anticonvulsants;Neuroprotective Agents;Antiepileptic Agents
    DB01043 antagonist Memantine Dopamine Agents;Central Nervous System Agents;Antiparkinson Agents;Antidyskinetics;Excitatory Amino Acid Antagonists
    DB01520 antagonist Tenocyclidine Neuroprotective Agents;Anesthetics, Dissociative
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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