AutismKB 2.0

Annotation Detail for GRIN2C


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Basic Information Top
Gene Symbol:GRIN2C ( NMDAR2C,NR2C )
Gene Full Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2C
Band: 17q25.1
Quick LinksEntrez ID:2905; OMIM: 138254; Uniprot ID:NMDE3_HUMAN; ENSEMBL ID: ENSG00000161509; HGNC ID: 4587
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04720Long-term potentiation
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05010Alzheimer's disease
Pathway IDPathway Name
Synaptic Transmission
No data
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00037Ionotropic glutamate receptor pathway
P00029Huntington disease
P00041Metabotropic glutamate receptor group I pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of GRIN2C mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRIN2C mRNAaffects expression 16483693
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of GRIN2C mRNAincreases expression 12414654
D003024 Clozapine Clozapine results in decreased expression of GRIN2C mRNAdecreases expression 18923069
D003976 Diazinon Diazinon results in increased expression of GRIN2C mRNAincreases expression 19440498
17452286
D004026 Dieldrin Dieldrin affects the expression of GRIN2C mRNAaffects expression 19440498
D016291 Dizocilpine Maleate Dizocilpine Maleate results in decreased expression of GRIN2C mRNAdecreases expression 11169168
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GRIN2C mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRIN2C mRNAaffects cotreatment|increases expression 17942748
D005839 Gentamicins Gentamicins results in increased expression of GRIN2C proteinincreases expression 15200423
D006220 Haloperidol Haloperidol results in increased expression of GRIN2C mRNAincreases expression 15860345
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of GRIN2C mRNAincreases expression 12414654
D008911 Minocycline Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2C mRNA]decreases reaction|increases expression 19660546
D009020 Morphine Morphine results in increased expression of GRIN2C mRNAincreases expression 15183518
D009532 Nickel Nickel results in decreased expression of GRIN2C mRNAdecreases expression 19440498
D010424 Pentobarbital Pentobarbital affects the expression of GRIN2C mRNAaffects expression 9814547
D011066 Poly C Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2C mRNA]decreases reaction|increases expression 19660546
D011066 Poly C Poly C results in increased expression of GRIN2C mRNAincreases expression 19660546
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GRIN2C mRNAaffects cotreatment|increases expression 17942748
D024483 Vitamin K 3 Vitamin K 3 results in increased expression of GRIN2C mRNAincreases expression 12414654
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.367525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.3611752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D058186 Acute Kidney Injury Gentamicins 4.5011274264
MESH:D055371 Acute Lung Injury Nickel 4.5416166738
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8014692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3416835633
MESH:D000380 Agranulocytosis Clozapine 5.0212649775 16160616 14617031
MESH:D000382 Agricultural Workers' Diseases Diazinon 4.3016487989
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D001008 Anxiety Disorders Pentobarbital 4.6918313124 11141031
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6415885639
MESH:D001172 Arthritis, Rheumatoid Minocycline 4.2114528503
MESH:D001321 Autistic Disorder Haloperidol 2.7418080171 19368416
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D002545 Brain Ischemia Morphine 5.1119211983
MESH:D001943 Breast Neoplasms Dieldrin 2.1211859874 15770527
MESH:D001943 Breast Neoplasms Nickel 2.1215986119
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1220435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.4816936243
MESH:D002375 Catalepsy Haloperidol 4.871977408 15215559
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.6014694615
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8417110522 16105132 11677210 16919318 15861022 17681005 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.088697196 15340226 15668235 16354765 12621046
MESH:D003072 Cognition Disorders Clozapine 4.9217123785
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.0615095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.0614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.8020210726
MESH:D003704 Dementia Haloperidol 4.5411575062
MESH:D017449 Dermatitis, Allergic Contact Nickel 3.9117244072 17100760 19470301
MESH:D003877 Dermatitis, Contact Nickel 4.592952479
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.4716402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4717107852
MESH:D003967 Diarrhea Morphine 4.482540324
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.5315331141
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 3.9021346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9020420201
MESH:D004362 Drug Toxicity Gentamicins 8.2815033597 11033412
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.2811462148
MESH:D050171 Dyslipidemias Clozapine 4.1516402076
MESH:D004417 Dyspnea Diazinon 4.7716487989
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.5512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Minocycline 9.5511835378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.989294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.7715345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9120067830
MESH:D005600 Fragile X Syndrome Minocycline 6.7218835858
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D034381 Hearing Loss Gentamicins 4.8417868369 19130971 15968427 18024279
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3110048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006505 Hepatitis Diazinon 4.5316487989
MESH:D006521 Hepatitis, Chronic Minocycline 6.1214986274
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8515340226 12621046 16120746
MESH:D015658 HIV Infections Nickel 3.7917263646
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0216354765 8697196 18606429 15340226 16959395
MESH:D053565 Hypercalciuria Gentamicins 5.6717652376
MESH:D006948 Hyperkinesis Clozapine 4.8716046005
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716945680 16569931
MESH:D007247 Infertility, Female Dieldrin 10.1510630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 10.1512013081
MESH:D007248 Infertility, Male Diazinon 6.8512948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8517937319
MESH:D007249 Inflammation Nickel 5.2016166738
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2012878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007673 Kidney Cortex Necrosis Gentamicins 5.7018842672
MESH:D007674 Kidney Diseases Gentamicins 3.8018289764 17934191 19349640
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.2316518626
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 5.3511231351
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.4210219319
MESH:D008064 Lipidoses Clozapine 3.9317567588
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008113 Liver Neoplasms Dieldrin 4.758742319 9539021
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0812151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2311884234 19555203
MESH:D008545 Melanoma Vitamin K 3 3.1719082730
MESH:D001523 Mental Disorders Clozapine 8.2516856516
MESH:D001523 Mental Disorders Haloperidol 8.2516856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.3719142101
MESH:D020529 Multiple Sclerosis, Relapsing-Remitting Minocycline 6.7411835378
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 6.2518694830
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D009369 Neoplasms Dieldrin 3.458820588
MESH:D009395 Nephritis, Interstitial Minocycline 5.89435818 444868
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1714600291
MESH:D009765 Obesity Clozapine 3.0119142110 18515891
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 4.0614694615
MESH:D010146 Pain Morphine 4.1515215642 15275824 20225289 16273134 6776300 18699797
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010212 Papilloma Hydrogen Peroxide 4.0512065085
MESH:D010300 Parkinson Disease Dieldrin 3.5111181820 16809432 17291500 11445065 16112328
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D011041 Poisoning Diazinon 4.3117603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1611896295 11222880 11399792 11118676
MESH:D011507 Proteinuria Gentamicins 4.6815033597
MESH:D011537 Pruritus Ethinyl Estradiol 3.2816919318 15861022
MESH:D011595 Psychomotor Agitation Haloperidol 4.9211575062
MESH:D011618 Psychotic Disorders Clozapine 9.0515331141
MESH:D011618 Psychotic Disorders Haloperidol 9.0511575062
MESH:D012021 Reflex, Abnormal Pentobarbital 5.9910930210
MESH:D051437 Renal Insufficiency Gentamicins 4.9515728788 17132701
MESH:D015427 Reperfusion Injury Morphine 4.1119211983
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012173 Retinitis Gentamicins 6.2518644591
MESH:D012559 Schizophrenia Clozapine 4.0816141801 20168265 20580759 17667964 17726453 18806925 11763009 20521320 20521326 17123785 20107430 11151749 18855531 19369910 20452607
MESH:D012559 Schizophrenia Haloperidol 4.0819369910 18513383 1830565 20107430
MESH:D012640 Seizures Dizocilpine Maleate 6.9817157343 11218047 12660363
MESH:D012640 Seizures Pentobarbital 6.9810087439 9754883
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 9.3712065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.378532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.3716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9116709447
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 4.949754883 11529278
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.6720210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D014570 Urologic Diseases Diazinon 5.2516487989
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D015837 Vestibular Diseases Gentamicins 5.4818776599
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D015430 Weight Gain Clozapine 4.4317502770 20107430 20521320 20564506 16402076 16141801
MESH:D015431 Weight Loss Clozapine 5.0417933447
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:05014 Amyotrophic lateral sclerosis (ALS)
KEGG:04020 Calcium signaling pathway
KEGG:04724 Glutamatergic synapse
KEGG:04720 Long-term potentiation
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28981
    • No data
    Releated disease ID Related disease Name
    PA443309Alcoholism
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00145 - Glycine Dietary supplement;Micronutrient;Non-Essential Amino Acids;Glycine Agents
    DB00454 blocker Meperidine Narcotics;Analgesics;Adjuvants, Anesthesia;Opiate Agonists;Analgesics, Opioid;Adjuvants
    DB01520 antagonist Tenocyclidine Neuroprotective Agents;Anesthetics, Dissociative
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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