AutismKB 2.0

Annotation Detail for MRPL18


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Basic Information Top
Gene Symbol:MRPL18 ( L18mt,MRP-L18 )
Gene Full Name: mitochondrial ribosomal protein L18
Band: 6q25.3
Quick LinksEntrez ID:29074; OMIM: 611831; Uniprot ID:RM18_HUMAN; ENSEMBL ID: ENSG00000112110; HGNC ID: 14477
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MRPL18 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of MRPL18 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of MRPL18 mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of MRPL18 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of MRPL18 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MRPL18 mRNAaffects expression 17555576
C106014 gedunin gedunin results in increased expression of MRPL18 mRNAincreases expression 17010675
D008094 Lithium Lithium inhibits the reaction [Methamphetamine results in increased expression of MRPL18 mRNA]decreases reaction|increases expression 19149911
D008694 Methamphetamine Lithium inhibits the reaction [Methamphetamine results in increased expression of MRPL18 mRNA]decreases reaction|increases expression 19149911
C006253 pirinixic acid pirinixic acid results in decreased expression of MRPL18 mRNAdecreases expression 18445702
D018038 Sodium Selenite Sodium Selenite results in increased expression of MRPL18 mRNAincreases expression 18175754
C050414 tripterine tripterine results in increased expression of MRPL18 mRNAincreases expression 17010675
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.1511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1514692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.803712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.806695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D000544 Alzheimer Disease Lithium 3.4819621015
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1911289319 1440618
MESH:D001714 Bipolar Disorder Lithium 4.3719153942 20338123 17594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0520146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.0517289903 14630087 12948864 17261762 18497071 19861407 17018787 16675129
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.597296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.593084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5916924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.727296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.587505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.5812371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.5818566989
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 19.9019486331 9022650
MESH:D002779 Cholestasis Cyclosporine 19.9019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 19.9017681005 16919318 16105132 17110522 17333356 15861022 11677210
MESH:D002779 Cholestasis pirinixic acid 19.9019176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8915894690
MESH:D007644 Darier Disease Lithium 6.0620338123
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.948970840 8156756 2524372 12868966 11298694 18759878 14531868 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.612952479 3621924
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.8819244398
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8716285004
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.3918692083 16192314 9328219 7440962 9022650 6679447 1440618 11289319 6482804 9653073 18648102 18289764 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3910915739 19416960 10774834 12705907 19739265 16227642 19420014 15968718 2444490 12958197 14550746 14986274 11529661 16177239 12153990 17906064 12392966 19085960 19923254 16781746 11743745 16393943 11739529 11834606 18713872 11461765 11287661 17562736 12540782 14725611 15619225 16081117 10663392 19370779 19164858 18071297 12594235 16109766 11421492 17522070 16485898
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.3915131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.0511473722 19148513 18566989
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.453581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4516530937
MESH:D005234 Fatty Liver Cyclosporine 13.6519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.6515345470
MESH:D005234 Fatty Liver pirinixic acid 13.6520131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D005355 Fibrosis Cyclosporine 3.2812168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.3220471113
MESH:D006330 Heart Defects, Congenital Lithium 7.3219638421
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.646705139
MESH:D006529 Hepatomegaly pirinixic acid 3.1319176532 16221962 19772884 18467677
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006948 Hyperkinesis Methamphetamine 5.6617658665
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D006973 Hypertension Cyclosporine 2.1310903974
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007333 Insulin Resistance Estradiol 12.7216627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 12.7216306350
MESH:D007333 Insulin Resistance Sodium Selenite 12.7214714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.198074119 9022650
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 10.3312587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.3318776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 10.3315618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.916582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.9112371664
MESH:D007680 Kidney Neoplasms Estradiol 12.9115610895
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3315474484
MESH:D008107 Liver Diseases Acetaminophen 1.6516611625 19460945 11587558 19784758 12587719 19014921 16610002 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.4921137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 4.4920007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.591399818 598648 3712494 6587162
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5618816296 20869020 20464547 17053015 18569708 20064080 18520028 20135361 6695378
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1814737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6211807958 16891317 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction Lithium 6.2116288908
MESH:D009203 Myocardial Infarction pirinixic acid 6.2119151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.5316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.5316411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.513581430
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9911141357
MESH:D009369 Neoplasms pirinixic acid 4.9917405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 3.7811399458 16427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.986679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.524026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5217292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.5216740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5218760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.4716919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012640 Seizures Lithium 4.0519660546
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4110029692 19755658
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D013226 Status Epilepticus Lithium 5.9619570321 19951488 19430551
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.976582329 6587162 7505956 1399818 3712494
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.108074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1017053015
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6515869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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