AutismKB 2.0

Annotation Detail for UBE2T


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:UBE2T ( PIG50 )
Gene Full Name: ubiquitin-conjugating enzyme E2T (putative)
Band: 1q32.1
Quick LinksEntrez ID:29089; OMIM: 610538; Uniprot ID:UBE2T_HUMAN; ENSEMBL ID: ENSG00000077152; HGNC ID: 25009
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
DNA Repair
No data
Pathway IDPathway Name
P00060Ubiquitin proteasome pathway
Pathway IDPathway Name
500068Fanconi Anemia pathway
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1720Fanconi's anemia
2066Lung cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of UBE2T mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of UBE2T proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of UBE2T mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of UBE2T mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of UBE2T mRNAdecreases expression 20382639
C006780 bisphenol A bisphenol A results in increased expression of UBE2T mRNAincreases expression 16474171
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of UBE2T mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of UBE2T mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of UBE2T mRNAincreases expression 18042831
D004958 Estradiol Estradiol results in increased expression of UBE2T mRNAincreases expression 16474171
D005472 Fluorouracil Fluorouracil affects the expression of UBE2T mRNAaffects expression 16557594
D019833 Genistein Genistein results in increased expression of UBE2T mRNAincreases expression 16474171
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of UBE2T mRNAincreases expression 20713471
C041786 palm oil palm oil results in increased expression of UBE2T mRNAincreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of UBE2T mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of UBE2T mRNAincreases expression 19482888
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of UBE2T mRNAincreases expression 16474171
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.496195326
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.2620464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 10.2611473722
MESH:D000230 Adenocarcinoma Fluorouracil 10.2617638652
MESH:D000230 Adenocarcinoma Genistein 10.2611473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.926695378
MESH:D000236 Adenoma Methylcholanthrene 6.9210545420 6695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.0217620307
MESH:D000740 Anemia Fluorouracil 3.7417963324 15504547 16511603
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1219183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.9315238619
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4711922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001862 Bone Resorption bisphenol A 3.8911985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.7917474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 3.7917123778
MESH:D001943 Breast Neoplasms Dietary Fats 3.7920435547
MESH:D001943 Breast Neoplasms Estradiol 3.7914630087 12948864 17261762 18497071 17289903 16675129 19861407 17018787
MESH:D001943 Breast Neoplasms Fluorouracil 3.7915136595 16557594 19217205 18357371 16595493 16110121 18608205
MESH:D001943 Breast Neoplasms Genistein 3.7916541309 17200150 16873071
MESH:D001943 Breast Neoplasms Methylcholanthrene 3.7917474063
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.823786805 16097048 10355542 18705752 16192424 15721981 16050911 16227642 16124888 16011737 15700767 15673190
MESH:D002276 Carcinoid Tumor Fluorouracil 4.7316051944
MESH:D002277 Carcinoma Fluorouracil 8.6917121937
MESH:D002277 Carcinoma Methylcholanthrene 8.6910545420
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 14.183084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 14.1812907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 14.1818788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 14.1816924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 14.1816799960 16332177 18930000 17045692 17971768 17088986
MESH:D006528 Carcinoma, Hepatocellular Genistein 14.1816924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 14.1817173139 1701930 6705139 20935162 20007298
MESH:D002278 Carcinoma in Situ bisphenol A 5.0417123778
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0318695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6720419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.6718986760 16757204 16280240 17066447
MESH:D002318 Cardiovascular Diseases Genistein 3.3216332659
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.2020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.2012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.2018566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 16.2016192471
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.294080065
MESH:D002779 Cholestasis Cyclosporine 2.9419486331
MESH:D003110 Colonic Neoplasms Fluorouracil 3.8717725105 17016597 16510598 17287894 18772588 16340194 15001691 17018589 17172411 17169374
MESH:D003110 Colonic Neoplasms Genistein 3.8717182828
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.8716524972 15148649 18802399 17255274 16282729 14970324 17695437 16331619 18448328 15289873 20501625 16303861 17594712 18949393 17454858 17401013 17016601 18509181 18288408 18383874 17094418 16391804
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.8715531428
MESH:D007644 Darier Disease Fluorouracil 4.8416733453
MESH:D003704 Dementia Polychlorinated Biphenyls 4.7316140633
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.4916647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.4419279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7711739529 17562736 12705907 19164858 17906064 16227642 12153990 11834606 11287661 15968718 10663392 19420014 10915739 10774834 18713872 16109766 14550746 19923254 11529661 12594235 11743745 19085960 12540782 16485898 14986274 19370779 12958197 16393943 19739265 16177239 16781746 16081117 14725611 12392966 11421492 19416960 17522070 2444490 18071297 11461765 15619225
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.7711566570 6884620 7120509 15027814 6623471 10915739 16227642 21278145 3732212 4309450 19085960 10092053 16177239 17522070 15998439 15968718 3786805 9327722 7179309 19336974 2869522 7440962
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D050171 Dyslipidemias Dietary Fats 3.4718367378
MESH:D004421 Dystonia Phenobarbital 4.041851702
MESH:D004714 Endometrial Hyperplasia Genistein 4.6416402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.5718566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 7.5711473722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.153659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.9311558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.576401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.297750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.073659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.2716530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.2716337965 16481741 15173087 16785472 17638652
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.2916239168 61145 17595544 12795759 19224547 12631006 16045604 15959796
MESH:D005234 Fatty Liver Cyclosporine 13.2919224547
MESH:D005234 Fatty Liver Dietary Fats 13.2917967931 18296743 19004024 19551842
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9910962813 14633661
MESH:D005355 Fibrosis Carbon Tetrachloride 15.0518705752
MESH:D005355 Fibrosis Cyclosporine 15.0512168785 12639820
MESH:D005355 Fibrosis Dietary Fats 15.0518296743
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D005909 Glioblastoma Genistein 3.2816598420
MESH:D005910 Glioma Fluorouracil 2.8816145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4015102660 18337622 15162350
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6720471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6319110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 3.5316109766
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D019584 Hot Flashes Estradiol 3.8117088409
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5816899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6521332399
MESH:D006973 Hypertension Cyclosporine 2.1110903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1315338365
MESH:D007249 Inflammation Dietary Fats 2.4420412841
MESH:D007333 Insulin Resistance bisphenol A 12.4916393666
MESH:D007333 Insulin Resistance Dietary Fats 12.4918457598 11836018
MESH:D007333 Insulin Resistance Estradiol 12.4916627594 16393666
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Acetaminophen 10.0712587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.078314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 10.0715618244
MESH:D007680 Kidney Neoplasms Cyclosporine 12.5512371664
MESH:D007680 Kidney Neoplasms Estradiol 12.5515610895
MESH:D007680 Kidney Neoplasms Fluorouracil 12.5516985049
MESH:D007938 Leukemia Genistein 3.0417468513 18980019
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.1216239168 17157831 16221502 16943688 11408273 11903743 17174718 21278145 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 11.1218296743
MESH:D008103 Liver Cirrhosis Phenobarbital 11.1221047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5615673190 16136751 12741479 17631135 12546737 12649538 17714472 15876570 15730626 20821823 18210741 16192424 18376398 16097048 17557913 12632512 17708605 15650968 16248980 16015684 15996030 18395095 15818738 18705752 15362042 12609069 18412020 18420326 12586293 12666154 18279442 18418968 18251166 12667390 18339082 18481824 18395914 15057751 15123356 17698563 18205269 14748882 17805973 16011737 17721639 18187930 10355542 18156304 15338365 17525996 17761835 17976157 12445418 18263696 15959796 12632514 12898905 12389079 18317297 18054572 16638106 11481614 16027843 17944888 18472332 18006644 18429990 15925388 14716496 17565644 14724832 14620537 17823541 14716833 17481882 18277467 14512876 17922224 15370692 15052691 13678700 17766677 17869086 16033810 18472094 12958196 12445421 17640975 18166357 16116963 15893842 15931870 17900296
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.5617823541
MESH:D008107 Liver Diseases Acetaminophen 6.5216611625 12587719 19460945 19784758 19014921 16610002 12969438 11587558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.5215830285 16246199 15720792 17285989 16964402
MESH:D008107 Liver Diseases Phenobarbital 6.5219363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.5017185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.5016899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.3618177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.3620195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.3619294768
MESH:D008113 Liver Neoplasms Fluorouracil 14.3615113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms Phenobarbital 14.3619073162 19812893 19482888 21047994 15975961 8742319
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 18.888603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 18.8812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 18.88598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 18.8818308698 2563599 17172636 6150874 1399818
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 18.881423854
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9214755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9220064080 18816296 20869020 17053015 6695378 20135361 20464547 18520028 18569708
MESH:D008175 Lung Neoplasms Fluorouracil 4.9215246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 4.929230183 16271038 10545420 20970405 21163286 1399818 20512841 15390079 16337739 6695378 11893704 7750092 17909032
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8415086387
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.1411807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.1414578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.5519453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.6016381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.6016757204 18986760
MESH:D009203 Myocardial Infarction Genistein 2.8717141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.5816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.5817141266
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5317484760
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1111141357
MESH:D009369 Neoplasms Fluorouracil 5.1118239605 16928823 18600527
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3119348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 16.6911399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 16.6911399458 16427766
MESH:D009421 Nervous System Malformations Genistein 16.6916427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4516436463
MESH:D009765 Obesity Dietary Fats 2.2917217161 19632207 20518802 18457598 20132043 16723640 21332399 18674790 11836018
MESH:D010018 Osteomalacia Phenobarbital 4.4117016548
MESH:D010024 Osteoporosis Genistein 3.2719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1216169203
MESH:D010049 Ovarian Diseases bisphenol A 5.0411985600
MESH:D010051 Ovarian Neoplasms Estradiol 4.9319401270
MESH:D010051 Ovarian Neoplasms Genistein 4.9319005980
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.3816500647 16929163 15113037 19003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.3816965848
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.4016702228
MESH:D011230 Precancerous Conditions Cyclosporine 9.0512371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.052563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.0010548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.6520887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.6520887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8916740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8918626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 1.8915256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 1.8915721890
MESH:D019310 Pseudolymphoma Phenobarbital 4.5612752131
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011629 Puberty, Precocious bisphenol A 4.8410548101
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0418286688 15538739 16160472 18722050
MESH:D012640 Seizures Phenobarbital 2.7116876388 3137016 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.876407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3819755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.432093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4316951190 15786421 18396642 17498489 19015929 16424979 17172411 19084572 18567086 17522103
MESH:D019966 Substance-Related Disorders bisphenol A 4.0316045194 16684133
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.071399818
MESH:D013978 Tibial Fractures Estradiol 4.7519048282
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0216280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1917053015
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9016803524
MESH:D014591 Uterine Diseases bisphenol A 5.0714652134
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D015430 Weight Gain Dietary Fats 3.7616723640
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
REACT:216 DNA Repair
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved