AutismKB 2.0

Annotation Detail for CNIH4


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Basic Information Top
Gene Symbol:CNIH4 ( - )
Gene Full Name: cornichon homolog 4 (Drosophila)
Band: 1q42.11
Quick LinksEntrez ID:29097; OMIM: NA; Uniprot ID:CNIH4_HUMAN; ENSEMBL ID: ENSG00000143771; HGNC ID: 25013
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of CNIH4 mRNAincreases expression 20406850
C075773 4-phenylbutyric acid 4-phenylbutyric acid results in decreased expression of CNIH4 mRNAdecreases expression 14583596
D000082 Acetaminophen Acetaminophen affects the expression of CNIH4 mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in increased expression of CNIH4 mRNAincreases expression 20106945
C006253 pirinixic acid pirinixic acid results in increased expression of CNIH4 mRNAincreases expression 18301758
C010327 salinomycin salinomycin results in decreased expression of CNIH4 mRNAdecreases expression 19682730
D012643 Selenium Selenium results in decreased expression of CNIH4 mRNAdecreases expression 19244175
D014635 Valproic Acid Valproic Acid results in increased expression of CNIH4 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.828875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8620603192 18985861 18316065 18558336 17507914 16609825 15238991 18940202 17688650 18775368 17157402 18177632 19232924 19460635 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.548888407
MESH:D001943 Breast Neoplasms salinomycin 3.3319682730
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 2.9116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.913084413
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.116135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1112371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D002779 Cholestasis Cyclosporine 8.3519486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D003092 Colitis Selenium 4.0917936198
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 8888407 16575769
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.4918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4910663392 15968718 18071297 19085960 18713872 14986274 11461765 11834606 14725611 17906064 12153990 11287661 12705907 19923254 16781746 12958197 19416960 16081117 16393943 17522070 11743745 19739265 12540782 10915739 10774834 12594235 14550746 11421492 17562736 16227642 19370779 19164858 11529661 15619225 16485898 16109766 12392966 16177239 11739529 19420014 2444490
MESH:D056486 Drug-Induced Liver Injury Selenium 9.4915131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.491733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.463659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.2916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0418234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.807562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D005234 Fatty Liver Cyclosporine 14.5219224547
MESH:D005234 Fatty Liver pirinixic acid 14.5219236843 20131406
MESH:D005234 Fatty Liver Valproic Acid 14.5214986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.418888407 18558336
MESH:D005355 Fibrosis Cyclosporine 3.4512168785 12639820
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006333 Heart Failure pirinixic acid 7.4120558911
MESH:D006333 Heart Failure Selenium 7.4117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006529 Hepatomegaly pirinixic acid 3.3019176532 16221962 19772884 18467677
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007251 Influenza, Human Selenium 4.5716624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.228314463 10903974 18776723
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.9516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1816294345 17596541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6716610002 12969438 11587558 16611625 19460945 19784758 12587719 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.677678174
MESH:D008113 Liver Neoplasms pirinixic acid 4.6720007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.682876786 2876784 6135515
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 6.9519682730
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.9515318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D008881 Migraine Disorders Valproic Acid 3.3618765137 18803445
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2817596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2018551238 7678174
MESH:D009369 Neoplasms 4-phenylbutyric acid 5.7419116145
MESH:D009369 Neoplasms pirinixic acid 5.7417405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009436 Neural Tube Defects Valproic Acid 3.2716359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6616049721
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1720603192
MESH:D019310 Pseudolymphoma Valproic Acid 4.9212752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D012640 Seizures Valproic Acid 6.471511512 16876388 14763951 11738929 11044598 3137016 17978042 15475178
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3716049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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