AutismKB 2.0

Annotation Detail for PYCARD


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PYCARD ( ASC,CARD5,MGC10332,TMS,TMS-1,TMS1 )
Gene Full Name: PYD and CARD domain containing
Band: 16p11.2
Quick LinksEntrez ID:29108; OMIM: 606838; Uniprot ID:ASC_HUMAN; ENSEMBL ID: ENSG00000103490; HGNC ID: 16608
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04621NOD-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
No data
Pathway IDPathway Name
200101Direct p53 effectors
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of PYCARD mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PYCARD mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PYCARD mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PYCARD mRNAdecreases expression 19730151
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PYCARD mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PYCARD mRNAincreases expression 20106945
D002784 Cholesterol Cholesterol analog results in increased expression of PYCARD mRNAincreases expression 19477266
C014347 decitabine decitabine affects the methylation of PYCARD promoteraffects methylation 17471463
C014347 decitabine [decitabine affects the methylation of PYCARD promoter] which affects the expression of PYCARD mRNAaffects expression|affects methylation 17986858
17471463
C014347 decitabine decitabine results in increased expression of PYCARD mRNAincreases expression 16367923
C014347 decitabine trichostatin A promotes the reaction [[decitabine affects the methylation of PYCARD promoter] which affects the expression of PYCARD mRNA]affects expression|affects methylation|increases reaction 17471463
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PYCARD mRNAincreases expression 17606305
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PYCARD mRNAincreases expression 16174780
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of PYCARD mRNAaffects cotreatment|increases expression 17183730
D007530 Isoflurane Isoflurane results in decreased expression of PYCARD mRNAdecreases expression 16978161
D009020 Morphine Morphine results in decreased expression of PYCARD mRNAdecreases expression 20144693
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of PYCARD mRNAdecreases expression 17616710
D010656 Phenylephrine Phenylephrine results in decreased expression of PYCARD mRNAdecreases expression 18158353
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PYCARD mRNAaffects binding|decreases expression|increases activity 19710929
D012643 Selenium Selenium results in increased expression of PYCARD mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PYCARD mRNAincreases expression 20106945
C012589 trichostatin A trichostatin A affects the methylation of PYCARD promoteraffects methylation 17471463
C012589 trichostatin A [trichostatin A affects the methylation of PYCARD promoter] which affects the expression of PYCARD mRNAaffects expression|affects methylation 17471463
C012589 trichostatin A trichostatin A promotes the reaction [[decitabine affects the methylation of PYCARD promoter] which affects the expression of PYCARD mRNA]affects expression|affects methylation|increases reaction 17471463
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of PYCARD mRNAaffects cotreatment|increases expression 17183730
C025643 vinclozolin vinclozolin affects the expression of PYCARD mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 13.927525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.9214514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 13.928875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8619490988
MESH:D000138 Acidosis Ammonium Chloride 3.5018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8917505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0518653653
MESH:D000230 Adenocarcinoma marker/mechanism 16778195
MESH:D000230 Adenocarcinoma arsenic trioxide 6.9319825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.9320127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.9314692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.616695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7016835633
MESH:D000550 Amblyopia Valproic Acid 5.1817688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D001008 Anxiety Disorders Valproic Acid 8.6717497229
MESH:D001008 Anxiety Disorders vinclozolin 8.6719015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0119183758
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.0517460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6215885639
MESH:D050197 Atherosclerosis Cholesterol 4.2016632123
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8520603192 18396377 18558336 19460635 17507914 19232924 15238991 18177632 18316065 17157402 18985861 18940202 18775368 17688650 16609825
MESH:D001714 Bipolar Disorder Valproic Acid 3.0417594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.9216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.9219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.9212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.8815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.888888407
MESH:D001919 Bradycardia Phenylephrine 4.4815306635
MESH:D002545 Brain Ischemia Morphine 5.0819211983
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8517474063 20146248
MESH:D001943 Breast Neoplasms decitabine 1.8519208741 18320071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8520435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2711589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism 17471463
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.863084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 2.8615073043 16217749 15553829 14691202 11135700
MESH:D018287 Carcinoma, Large Cell marker/mechanism 16778195
MESH:D002289 Carcinoma, Non-Small-Cell Lung marker/mechanism 16778195
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8219014326
MESH:D018288 Carcinoma, Small Cell marker/mechanism 16778195
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0612490120
MESH:D002294 Carcinoma, Squamous Cell marker/mechanism 16778195
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6120419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.6119215824
MESH:D006332 Cardiomegaly Phenylephrine 6.7617124262 16170337 15728586 17287366 11179087 11754973
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.7618850075 18670907 16120746
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.2914694615
MESH:D002386 Cataract Acetaminophen 7.2910977129
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1016835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.5817110522 17681005 17333356 15861022 16919318 16105132 11677210
MESH:D002779 Cholestasis pirinixic acid 7.5819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0816354765 15668235 12621046 8697196 15340226
MESH:D003092 Colitis Selenium 3.7217936198
MESH:D003110 Colonic Neoplasms decitabine 2.3217616700
MESH:D015179 Colorectal Neoplasms marker/mechanism 17986858
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5720501625
MESH:D015179 Colorectal Neoplasms decitabine 2.5718981723
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.9915095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.9917141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7320055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.7316575769 17688650 8888407
MESH:D003456 Cryptorchidism vinclozolin 4.2814966744
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0315213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6517107852
MESH:D003967 Diarrhea Morphine 4.462540324
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 11.8121346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.8110915739 15619225 16485898 2444490 17562736 17906064 11529661 11421492 12153990 16781746 11287661 11461765 19370779 17522070 11743745 14986274 16393943 19416960 18071297 19420014 10663392 16177239 18713872 19739265 12705907 15968718 11739529 16227642 12540782 14725611 14550746 16081117 12392966 19164858 10774834 19923254 19085960 12958197 16109766 12594235 11834606
MESH:D056486 Drug-Induced Liver Injury Selenium 11.8115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.8120420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 11.8119641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D004421 Dystonia Valproic Acid 3.991851702
MESH:D004487 Edema pirinixic acid 6.3312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.3311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8515322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1212538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 13.8419294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 13.8419294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.969294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.0917275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.863922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9020417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.536426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.237750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.003659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.2112903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.2116530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 7.2116805852 16510608 15547733 15264214 15623463 15878914 15150132 15547721 16704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver arsenic trioxide 18.2515073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.2515345470
MESH:D005234 Fatty Liver pirinixic acid 18.2520131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 18.2519224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.078888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8920067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2016904648
MESH:D005756 Gastritis Acetaminophen 3.6216983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.2416417039
MESH:D005909 Glioblastoma trichostatin A 3.7918801729
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.4419215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.3320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3311294989 10048152
MESH:D006333 Heart Failure pirinixic acid 6.8120558911
MESH:D006333 Heart Failure Selenium 6.8117162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006529 Hepatomegaly pirinixic acid 8.0519772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.0515340226 16120746 12621046
MESH:D006849 Hydrocephalus Valproic Acid 4.8117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.998697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.6516870215
MESH:D006937 Hypercholesterolemia Cholesterol 4.9116933029
MESH:D006943 Hyperglycemia pirinixic acid 3.1220558911
MESH:D006973 Hypertension Phenylephrine 5.228949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2218670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.5616612254
MESH:D006984 Hypertrophy Phenylephrine 4.4912791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7516569931 16945680
MESH:D007022 Hypotension Isoflurane 4.8812967683
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4012013081
MESH:D007248 Infertility, Male decitabine 10.9817581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.9817937319
MESH:D007248 Infertility, Male vinclozolin 10.9816467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8212200463 12878042
MESH:D007251 Influenza, Human Selenium 4.1416624496
MESH:D007333 Insulin Resistance pirinixic acid 2.5916306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007674 Kidney Diseases Acetaminophen 2.1615629191 12587719
MESH:D007676 Kidney Failure, Chronic Selenium 3.8216518626
MESH:D007859 Learning Disorders Cholesterol 5.0317134702
MESH:D007938 Leukemia arsenic trioxide 6.3415070760
MESH:D007938 Leukemia decitabine 6.3418980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7312560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.3819077051
MESH:D007951 Leukemia, Myeloid decitabine 9.3817236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 8.7117050201 19850784 20471514 16467208 16968895
MESH:D015470 Leukemia, Myeloid, Acute decitabine 8.7119387464 18460780 18704418 17679729 18206229 19010910
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 8.7118206229
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 8.7116294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4118055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1712712474 16823087 16112521 17649720 17107899 15336539 19035177 12679006 17217047 15622746 19075265 19225113 15213294 11161223 16891316 16330433 12018890 15748426 17712046 17869043 19642359 16966277 9834237 16331271 11468182
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2916882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6716417039
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1112878042
MESH:D008107 Liver Diseases Acetaminophen 1.6111587558 19784758 16610002 12969438 12587719 19460945 16611625 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1816871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 10.4614682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.4620195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 10.4620007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.4616984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.6620377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.6612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3015213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2117228818
MESH:D008175 Lung Neoplasms marker/mechanism 16778195
MESH:D008175 Lung Neoplasms arsenic trioxide 3.3219825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3220064080 20464547 18569708 17053015 20869020 18520028 6695378 18816296 20135361
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3211884234 19555203
MESH:D008223 Lymphoma decitabine 3.3719470736
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.7215318939
MESH:D008545 Melanoma decitabine 3.6916505122 17785578
MESH:D008545 Melanoma trichostatin A 3.6916505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008654 Mesothelioma Selenium 2.7715107826
MESH:D008881 Migraine Disorders Valproic Acid 3.1418803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1416381670
MESH:D009101 Multiple Myeloma arsenic trioxide 11.9614977855 19549372 19417148 11468182 15949261
MESH:D009101 Multiple Myeloma decitabine 11.9618172295
MESH:D009101 Multiple Myeloma trichostatin A 11.9618172295
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.968888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6218349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 12.1316105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 12.1319157545 19010910 16882708 18608210
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 12.1317596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8916411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9016624393
MESH:D009369 Neoplasms Benzo(a)pyrene 8.0411141357
MESH:D009369 Neoplasms decitabine 8.0419470736 17925555 19116145
MESH:D009369 Neoplasms pirinixic acid 8.0417405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1514600291
MESH:D009436 Neural Tube Defects arsenic trioxide 7.1810525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.1816359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8118514411
MESH:D052556 Niemann-Pick Disease, Type C Cholesterol 5.649802331 20557099
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 4.0414694615
MESH:D010051 Ovarian Neoplasms arsenic trioxide 7.9219769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms decitabine 7.9219331143 19259094
MESH:D010051 Ovarian Neoplasms trichostatin A 7.9219331143
MESH:D010146 Pain Acetaminophen 6.8716870215
MESH:D010146 Pain Morphine 6.8715215642 20225289 6776300 15275824 16273134 18699797
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.6315580305
MESH:D010190 Pancreatic Neoplasms decitabine 8.6319294695
MESH:D010190 Pancreatic Neoplasms trichostatin A 8.6319294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6211578682
MESH:D010235 Paraganglioma arsenic trioxide 4.1019927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010538 Peritonitis Isoflurane 5.1617414419
MESH:D010954 Plasmacytoma Selenium 4.8315087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.8911222880 11896295 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 15.8920603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 15.8918042343 18220299 19015723
MESH:D055728 Primary Myelofibrosis decitabine 12.2117616702
MESH:D055728 Primary Myelofibrosis trichostatin A 12.2117616702
MESH:D011469 Prostatic Diseases vinclozolin 4.8718220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6719131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6717292933
MESH:D011471 Prostatic Neoplasms trichostatin A 2.6718798265 19789329
MESH:D011472 Prostatitis vinclozolin 4.8718629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.2516919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.4911422049 12752131
MESH:D015427 Reperfusion Injury Morphine 6.7819211983
MESH:D015427 Reperfusion Injury pirinixic acid 6.7819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012208 Rhabdomyosarcoma decitabine 10.7619155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.7619155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9016646077
MESH:D012559 Schizophrenia Valproic Acid 2.0615737665 19110320
MESH:D012640 Seizures Valproic Acid 2.6915475178 3137016 17978042 1511512 16876388 14763951 11738929 11044598
MESH:D018805 Sepsis Isoflurane 4.9317414419
MESH:D012852 Sinusitis Phenylephrine 4.647327846
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.3719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8916709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7319490988
MESH:D013226 Status Epilepticus Valproic Acid 4.4912833885
MESH:D013274 Stomach Neoplasms marker/mechanism 16367923
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.7017007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.702093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 4.7019037991
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.7012958204 17575124
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.1519014326
MESH:D013964 Thyroid Neoplasms decitabine 7.1517967635
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9015213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.1817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.463119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.2020435036 11780464 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.2017053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.2017616700 19087683
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.588888407
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2314692618
MESH:D014604 Uveal Neoplasms decitabine 4.8617785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
Pathway ID Pathway Name
KEGG:04623 Cytosolic DNA-sensing pathway
KEGG:04621 NOD-like receptor signaling pathway
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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