AutismKB 2.0

Annotation Detail for GRM1


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Basic Information Top
Gene Symbol:GRM1 ( GPRC1A,GRM1A,MGLUR1,MGLUR1A,mGlu1 )
Gene Full Name: glutamate receptor, metabotropic 1
Band: 6q24.3
Quick LinksEntrez ID:2911; OMIM: 604473; Uniprot ID:GRM1_HUMAN; ENSEMBL ID: ENSG00000152822; HGNC ID: 4593
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04720Long-term potentiation
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
hsa04540Gap junction
hsa04730Long-term depression
hsa05016Huntington's disease
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
P00041Metabotropic glutamate receptor group I pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of GRM1 mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRM1 mRNAaffects expression 16483693
D003913 Dextroamphetamine GRM1 protein affects the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]affects reaction|increases expression 11566502
D003913 Dextroamphetamine GRM1 protein affects the susceptibility to Dextroamphetamineaffects response to substance 11566502
D000661 Amphetamine Amphetamine results in increased expression of GRM1 mRNAincreases expression 11418936
D020001 1-Butanol 1-Butanol affects the localization of GRM1 proteinaffects localization 15470141
D020001 1-Butanol PLD2 protein affects the reaction [1-Butanol affects the localization of GRM1 protein]affects localization|affects reaction 15470141
D003976 Diazinon Diazinon results in increased expression of GRM1 mRNAincreases expression 19440498
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of GRM1 mRNAdecreases expression 15620428
D004958 Estradiol Estradiol results in increased activity of GRM1 proteinincreases activity 15901789
D006220 Haloperidol Haloperidol results in increased expression of GRM1 mRNAincreases expression 15860345
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GRM1 mRNAdecreases expression 19285098
D009020 Morphine Morphine results in increased expression of GRM1 mRNAincreases expression 15183518
C025256 nonylphenol nonylphenol results in decreased expression of GRM1 mRNAdecreases expression 15620428
C037219 quinoline quinoline analog results in decreased activity of GRM1 proteindecreases activity 18005334
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000230 Adenocarcinoma Estradiol 2.1111473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.803712494
MESH:D000382 Agricultural Workers' Diseases Diazinon 4.4516487989
MESH:D019969 Amphetamine-Related Disorders Amphetamine 6.1716459022 16916582 18475255 15010207
MESH:D000855 Anorexia Amphetamine 10.9216084549 12183048 16101753 12005258
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 10.9215146954
MESH:D001259 Ataxia 1-Butanol 5.677820390
MESH:D001321 Autistic Disorder Haloperidol 2.7318080171 19368416
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.151440618 11289319
MESH:D002545 Brain Ischemia Morphine 5.2619211983
MESH:D001943 Breast Neoplasms Estradiol 2.1414630087 17289903 17261762 12948864 19861407 16675129 17018787 18497071
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.843581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.8416924424
MESH:D006528 Carcinoma, Hepatocellular quinoline 4.84598648
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D002375 Catalepsy Haloperidol 5.031977408 15215559
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.847505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8418566989
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.2119486331 9022650
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.5416037377
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.9320210726
MESH:D003704 Dementia Haloperidol 4.6611575062
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9018759878 8970840 12868966 14531868 8156756 11906362 2524372 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.583621924 2952479
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D003967 Diarrhea Morphine 4.612540324
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 1.9818648102 1440618 11289319 18692083 16192314 18289764 6482804 9328219 7440962 8291058 6679447 9653073 9022650
MESH:D004417 Dyspnea Diazinon 4.9316487989
MESH:D016889 Endometrial Neoplasms Estradiol 3.0318566989 11473722 19148513
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005221 Fatigue Amphetamine 5.7219890266
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006390 Hemangioendothelioma quinoline 6.04598648
MESH:D006394 Hemangiosarcoma quinoline 5.07598648
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.906705139
MESH:D006505 Hepatitis Diazinon 9.9016487989
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006948 Hyperkinesis Amphetamine 5.551977408 14960337
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D007248 Infertility, Male Diazinon 3.8712948887 16466525
MESH:D007333 Insulin Resistance Estradiol 3.0216393666 16627594
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.159022650 8074119
MESH:D007674 Kidney Diseases Estradiol 2.6315618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.596582329
MESH:D007680 Kidney Neoplasms Estradiol 7.5915610895
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814659978 14716833
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.58598648 1399818 6587162 3712494
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6111408345 11807958 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D001523 Mental Disorders Haloperidol 4.1316856516
MESH:D009041 Motion Sickness Dextroamphetamine 5.651613127
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3416810080
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.353581430
MESH:D009362 Neoplasm Metastasis quinoline 6.35598648
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009421 Nervous System Malformations Estradiol 3.7516427766 11399458
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.966679447
MESH:D019636 Neurodegenerative Diseases Amphetamine 4.7115183010
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.504026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010051 Ovarian Neoplasms Estradiol 2.2419401270
MESH:D010146 Pain Morphine 4.2520225289 16273134 15275824 15215642 18699797 6776300
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D011041 Poisoning Diazinon 4.4417603234
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0716740699
MESH:D011595 Psychomotor Agitation Haloperidol 5.0611575062
MESH:D011618 Psychotic Disorders Haloperidol 4.3111575062
MESH:D015427 Reperfusion Injury Morphine 4.1719211983
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012559 Schizophrenia Haloperidol 2.8118513383 19369910 1830565 20107430
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.561977408
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.8020210726
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.956587162 6582329 3712494 7505956 1399818
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.308074119
MESH:D014570 Urologic Diseases Diazinon 5.4116487989
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04540 Gap junction
KEGG:04724 Glutamatergic synapse
KEGG:05016 Huntington's disease
KEGG:04730 Long-term depression
KEGG:04720 Long-term potentiation
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28990
    • No data
    Releated disease ID Related disease Name
    PA443309Alcoholism
    Releated drug ID Related drug Name
    PA164743471adenosine triphosphate
    PA449396dopamine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB00659 antagonist Acamprosate Alcohol Deterrents
    DB04256 - 4-(1-Amino-1-Carboxy-Ethyl)-Benzoic Acid Excitatory Amino Acid Antagonists
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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