AutismKB 2.0

Annotation Detail for TBK1


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Basic Information Top
Gene Symbol:TBK1 ( FLJ11330,NAK,T2K )
Gene Full Name: TANK-binding kinase 1
Band: 12q14.2
Quick LinksEntrez ID:29110; OMIM: 604834; Uniprot ID:TBK1_HUMAN; ENSEMBL ID: ENSG00000183735; HGNC ID: 11584
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa04620Toll-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04623Cytosolic DNA-sensing pathway
Pathway IDPathway Name
Signaling in Immune system
No data
Pathway IDPathway Name
P00054Toll receptor signaling pathway
Pathway IDPathway Name
500465TRAM Cascade
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1872Chronic simple glaucoma
1970Virus disease
2052Infection
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of TBK1 mRNAaffects expression 17562736
D001310 Auranofin Auranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]decreases reaction|increases activity 17034761
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TBK1 mRNAdecreases expression 19150397
C043561 chrysin chrysin results in decreased activity of TBK1 proteindecreases activity 19426678
C007619 eriodictyol eriodictyol results in decreased activity of TBK1 proteindecreases activity 19426678
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of TBK1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of TBK1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TBK1 mRNAaffects cotreatment|increases expression 17942748
D047311 Luteolin Luteolin results in decreased activity of TBK1 proteindecreases activity 19426678
D047311 Luteolin Luteolin inhibits the reaction [TBK1 protein results in increased expression of IRF3 mRNA]decreases reaction|increases expression 19426678
C013592 mangiferin mangiferin results in decreased expression of TBK1 mRNAdecreases expression 15135318
D011794 Quercetin Quercetin results in decreased activity of TBK1 proteindecreases activity 19426678
C059514 resveratrol resveratrol inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]decreases reaction|increases activity 16678799
C059514 resveratrol resveratrol inhibits the reaction [TBK1 protein results in increased phosphorylation of IRF3 protein]decreases reaction|increases phosphorylation 16116226
C017947 sodium arsenite sodium arsenite results in increased expression of TBK1 mRNAincreases expression 19822182
D018038 Sodium Selenite Sodium Selenite inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]decreases reaction|increases activity 18279804
D013467 Sulindac Sulindac results in increased expression of TBK1 mRNAincreases expression 11093808
D013629 Tamoxifen Tamoxifen affects the expression of TBK1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TBK1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TBK1 mRNAincreases expression 17942748
D014415 Tunicamycin Tunicamycin results in decreased expression of TBK1 mRNAdecreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 13.1214745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 13.1214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8715322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D058186 Acute Kidney Injury resveratrol 9.0316538975
MESH:D058186 Acute Kidney Injury Sulindac 9.037897758
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5914692618
MESH:D000230 Adenocarcinoma Sulindac 4.5911910360
MESH:D000236 Adenoma resveratrol 7.2215688382
MESH:D000236 Adenoma Sulindac 7.2210223192
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4016835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.6011535846 12394442 19003578 11874996 16460482 17611924 15623613
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7315276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9317306315 16712894
MESH:D000544 Alzheimer Disease resveratrol 2.5716183991 16162502
MESH:D000707 Anaphylaxis mangiferin 5.4814669257 16536907
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.2417084956
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3715885639
MESH:D001169 Arthritis, Experimental resveratrol 7.3717115116
MESH:D001172 Arthritis, Rheumatoid Auranofin 4.5316510263
MESH:D001260 Ataxia Telangiectasia Quercetin 5.0015336622
MESH:D050197 Atherosclerosis mangiferin 7.2118450471
MESH:D050197 Atherosclerosis resveratrol 7.2116873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001327 Autoimmune Diseases Quercetin 4.4219761891
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001862 Bone Resorption mangiferin 4.929881647
MESH:D001913 Bowen's Disease Sulindac 5.3811207687
MESH:D002545 Brain Ischemia resveratrol 4.3017600658
MESH:D001943 Breast Neoplasms Quercetin 2.3618628248
MESH:D001943 Breast Neoplasms resveratrol 2.3617534123 16393696 17651959
MESH:D001943 Breast Neoplasms Sulindac 2.3616642371
MESH:D001943 Breast Neoplasms Tamoxifen 2.3619221464 20065188 15668708 18351453 16273361 20005174 21138602 19066611 19084267 18997820 19289846 20135344 19288272 17242785 17440819 19189212 16873071 19155303 20859285 11161223 19487384 18855134 18425577 16818667 15565566 19142967 20544844 18984771 19115204 18821012 19410462 19189210 19244106 18629630 19011961 16202921 20390343 18815881 19059307 19103187 19200415 17049068 17261762 21152245 17893378
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3620435547
MESH:D002105 Cadmium Poisoning Quercetin 5.5816962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5219066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.893084413
MESH:D006528 Carcinoma, Hepatocellular Quercetin 8.8912508355 19519916
MESH:D006528 Carcinoma, Hepatocellular resveratrol 8.8916227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.8917306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.8916924424
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.6116675471
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.9717234771
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.8516227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.8518572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6217572228
MESH:D006332 Cardiomegaly Quercetin 6.8119794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.8116120746 18850075 18670907
MESH:D002318 Cardiovascular Diseases resveratrol 3.4715458977
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7320889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.7320056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.8816105132 15861022 16919318 17110522 17333356 17681005 11677210
MESH:D019457 Chromosome Breakage Sodium Selenite 4.7615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1016354765 15340226 12621046 15668235 8697196
MESH:D003092 Colitis resveratrol 4.1416474422
MESH:D003110 Colonic Neoplasms Quercetin 6.0219056647 19440933 17148506 11134977 17191121 16640504 15741050
MESH:D003110 Colonic Neoplasms resveratrol 6.0216338953
MESH:D003110 Colonic Neoplasms Sulindac 6.0212902858 12458338
MESH:D015179 Colorectal Neoplasms Quercetin 3.6318852136 18095365
MESH:D015179 Colorectal Neoplasms resveratrol 3.6316550006
MESH:D015179 Colorectal Neoplasms Sulindac 3.6310666051 11197048 11076880 18059344
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0614669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.7516507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 10048152 20055451
MESH:D003457 Cryptosporidiosis mangiferin 5.8916547730
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3819031437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7816285004
MESH:D003921 Diabetes Mellitus, Experimental mangiferin 14.1512093613 19028559
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 14.1519496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 14.1516873680
MESH:D003924 Diabetes Mellitus, Type 2 mangiferin 4.709881663 11315760
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.7017107852
MESH:D003928 Diabetic Nephropathies mangiferin 15.2319706694 19960420
MESH:D003928 Diabetic Nephropathies resveratrol 15.2316286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 15.2319279558
MESH:D003930 Diabetic Retinopathy Sulindac 5.1917621415 12861449
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.1619416960 16109766 19164858 11834606 10915739 19085960 17906064 12392966 12153990 15619225 10774834 12958197 14550746 15968718 11287661 19420014 19923254 14986274 12594235 16081117 12705907 16177239 11739529 17522070 16781746 11421492 2444490 16227642 18071297 14725611 11461765 12540782 19739265 11529661 16393943 17562736 19370779 16485898 11743745 10663392 18713872
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.1615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D004487 Edema resveratrol 6.888985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9315322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.4212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 15.4217872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.4219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0520544844 16202921 17893378 19155303
MESH:D004715 Endometriosis Sulindac 9.2015652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.209294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.8617923197
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.7720426865
MESH:D004938 Esophageal Neoplasms Sulindac 4.7712235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.3015345470
MESH:D005234 Fatty Liver mangiferin 13.3015975614
MESH:D005234 Fatty Liver Tamoxifen 13.3019224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 13.0214745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 13.0214745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 11.7119069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 11.7119069698
MESH:D005355 Fibrosis Quercetin 8.8119474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8120067830
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005764 Gastroesophageal Reflux Sulindac 5.0211910360
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.7016452187
MESH:D005909 Glioblastoma Quercetin 3.3919804834
MESH:D005910 Glioma Quercetin 3.0517643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3311294989 10048152
MESH:D006331 Heart Diseases mangiferin 4.3912093613
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9112621046 15340226 16120746
MESH:D006561 Herpes Simplex mangiferin 10.3310715843
MESH:D006561 Herpes Simplex resveratrol 10.3316876885
MESH:D006689 Hodgkin Disease sodium arsenite 3.1612676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0816959395 8697196 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006937 Hypercholesterolemia resveratrol 4.0117188708
MESH:D006943 Hyperglycemia Quercetin 4.0311834736 18262572
MESH:D006946 Hyperinsulinism mangiferin 5.009881663 11315760
MESH:D006949 Hyperlipidemias mangiferin 9.7715975614
MESH:D006949 Hyperlipidemias resveratrol 9.7716873680
MESH:D006967 Hypersensitivity mangiferin 4.7016536907
MESH:D006973 Hypertension Quercetin 5.2318356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2318670907 18850075
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.3117488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216569931 16945680
MESH:D007154 Immune System Diseases mangiferin 5.8916076520
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.6617600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.6517937319
MESH:D007248 Infertility, Male sodium arsenite 6.6515346721 12646999
MESH:D007249 Inflammation mangiferin 15.9315222974
MESH:D007249 Inflammation resveratrol 15.9316366677
MESH:D007249 Inflammation Sulindac 15.933291741
MESH:D007249 Inflammation Tamoxifen 15.9319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.9312200463 12878042
MESH:D007251 Influenza, Human Quercetin 11.3016624496
MESH:D007251 Influenza, Human resveratrol 11.3016624496
MESH:D007333 Insulin Resistance mangiferin 7.9411315760
MESH:D007333 Insulin Resistance Sodium Selenite 7.9414714311
MESH:D007414 Intestinal Neoplasms Sulindac 4.6412351151 10223192 12584176 12663524 10213222 12628509
MESH:D007417 Intestinal Polyps Sulindac 4.9912394442 11245490
MESH:D007511 Ischemia mangiferin 5.2816806951
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3416580747
MESH:D007627 Keloid Quercetin 4.9717086741
MESH:D007674 Kidney Diseases Acetaminophen 14.5415629191 12587719
MESH:D007674 Kidney Diseases mangiferin 14.5412093613
MESH:D007674 Kidney Diseases Quercetin 14.5416962696
MESH:D007674 Kidney Diseases sodium arsenite 14.5420008137
MESH:D007680 Kidney Neoplasms Tamoxifen 3.0418625569
MESH:D007859 Learning Disorders mangiferin 4.9719182383
MESH:D007938 Leukemia Quercetin 3.1617468513
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive mangiferin 4.6215498116
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.5816087638
MESH:D008064 Lipidoses Tamoxifen 3.1617567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.2212468960
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.5012741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5012878042
MESH:D008107 Liver Diseases Acetaminophen 4.2512587719 12969438 19014921 19784758 11587558 16611625 19460945 16610002
MESH:D008107 Liver Diseases Sulindac 4.2514986274 16867024
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2417185352 16871587
MESH:D008113 Liver Neoplasms Quercetin 14.2718980244
MESH:D008113 Liver Neoplasms resveratrol 14.2720405173 19812893 19073162 19321006
MESH:D008113 Liver Neoplasms sodium arsenite 14.2715276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 14.2716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.2716984957
MESH:D008114 Liver Neoplasms, Experimental Quercetin 5.9319519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9312151625
MESH:D008171 Lung Diseases sodium arsenite 3.1719095001
MESH:D008175 Lung Neoplasms mangiferin 8.5818520028 18816296 18569708
MESH:D008175 Lung Neoplasms Quercetin 8.5816280456
MESH:D008175 Lung Neoplasms sodium arsenite 8.5816712894 17077188 17306315 19931552 15276417
MESH:D008175 Lung Neoplasms Sulindac 8.5819359593 15713900
MESH:D008175 Lung Neoplasms Tamoxifen 8.5818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.5819555203 11884234
MESH:D016393 Lymphoma, B-Cell resveratrol 10.3017088997
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 10.3014737004
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.8714749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 10.0715688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 10.0719428831
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.1811606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.1819196723 19196722 11731420 14580682 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.5819453300
MESH:D008545 Melanoma resveratrol 7.3617992120
MESH:D008545 Melanoma sodium arsenite 7.3619082730 16487513
MESH:D008545 Melanoma Sulindac 7.3616642371
MESH:D008545 Melanoma Tamoxifen 7.3612393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008569 Memory Disorders mangiferin 4.9419182383
MESH:D008659 Metabolic Diseases resveratrol 4.3817112576
MESH:D009101 Multiple Myeloma resveratrol 3.4717164350 16267019 14749477 17935668 16490592 17049120
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.8917962980
MESH:D009203 Myocardial Infarction mangiferin 9.7519172585 17052832 16584858 16697266 16538859
MESH:D009203 Myocardial Infarction Quercetin 9.7519595682
MESH:D009203 Myocardial Infarction resveratrol 9.7517125593 17188708 17015251 16525036 16456233 16317513
MESH:D017202 Myocardial Ischemia resveratrol 9.0217015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.0212213967
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.7919207477
MESH:D009205 Myocarditis resveratrol 4.7817322642
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009369 Neoplasms Quercetin 5.2615185748
MESH:D009369 Neoplasms sodium arsenite 5.2611559025
MESH:D009374 Neoplasms, Experimental resveratrol 9.278985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 9.2720056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0319196722 19200415 19189210
MESH:D009410 Nerve Degeneration mangiferin 4.6117433543
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2214600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1412854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 14.2018514411
MESH:D019636 Neurodegenerative Diseases resveratrol 14.2017652729
MESH:D019636 Neurodegenerative Diseases Sulindac 14.2016850258 17266991
MESH:D020078 Neurogenic Inflammation Quercetin 10.7217929310
MESH:D020078 Neurogenic Inflammation resveratrol 10.7217929310
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 10.2219495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 10.2217513867
MESH:D010051 Ovarian Neoplasms Luteolin 8.1419005980
MESH:D010051 Ovarian Neoplasms Quercetin 8.1419005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 8.1415276417 17306315
MESH:D010146 Pain Acetaminophen 6.9216870215
MESH:D010146 Pain Sulindac 6.923291741
MESH:D010190 Pancreatic Neoplasms Quercetin 5.7416965848
MESH:D010190 Pancreatic Neoplasms Sulindac 5.7411504793 16820089
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010300 Parkinson Disease mangiferin 3.7117433543
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D010518 Periodontitis mangiferin 5.6319026997
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Quercetin 3.9819056647
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.6616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.6611118676 11399792 11896295 11222880
MESH:D011471 Prostatic Neoplasms Quercetin 1.8717292933 14715546
MESH:D011471 Prostatic Neoplasms resveratrol 1.8717636462 17718901 15767336 17675339 17804756 16731767
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8716039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.8718760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8715067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.3315861022 16919318
MESH:D011833 Radiation Injuries, Experimental mangiferin 6.4415830843
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.6116325855
MESH:D015427 Reperfusion Injury resveratrol 3.2715827377 17520802 17058453 16314181 16317513
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012216 Rheumatic Diseases Auranofin 7.4617034761
MESH:D012554 Schistosomiasis japonica Quercetin 5.5816862918
MESH:D012772 Shock, Septic mangiferin 5.2615177305
MESH:D012878 Skin Neoplasms resveratrol 9.5015837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 9.5019524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.5016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.6616709447
MESH:D013088 Spermatocele Tamoxifen 11.6616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0619457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8012854658
MESH:D013276 Stomach Ulcer mangiferin 4.2817918041
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.4816321402
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D014062 Tongue Neoplasms resveratrol 4.2116227395
MESH:D014235 Trichinellosis mangiferin 6.0914669257
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.4016720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.4016712894 16452187 11723127 17306315
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.4017572228 16712894 8653321
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.5817473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.5811813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 16.2114692618
MESH:D014594 Uterine Neoplasms resveratrol 16.2117044934
MESH:D014594 Uterine Neoplasms Sulindac 16.2118645019
MESH:D014652 Vascular Diseases sodium arsenite 4.4417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5414671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.3117488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
Pathway ID Pathway Name
KEGG:04623 Cytosolic DNA-sensing pathway
KEGG:05160 Hepatitis C
KEGG:05162 Measles
KEGG:04622 RIG-I-like receptor signaling pathway
REACT:6900 Signaling in Immune system
KEGG:04620 Toll-like receptor signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36348
    • Releated gene ID Related gene Name
    PA76BCL2L1
    PA30196KRAS
    PA34321REL
    No data
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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