AutismKB 2.0

Annotation Detail for MYLIP


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Basic Information Top
Gene Symbol:MYLIP ( IDOL,MIR )
Gene Full Name: myosin regulatory light chain interacting protein
Band: 6p22.3
Quick LinksEntrez ID:29116; OMIM: 610082; Uniprot ID:MYLIP_HUMAN; ENSEMBL ID: ENSG00000007944; HGNC ID: 21155
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic MYLIP mRNA results in decreased susceptibility to Arsenicdecreases response to substance 17976673
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of MYLIP mRNAincreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MYLIP mRNAdecreases expression 20018196
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MYLIP mRNAincreases expression 20382639
D004041 Dietary Fats Dietary Fats results in decreased expression of MYLIP mRNAdecreases expression 18042831
D002117 Calcitriol Calcitriol results in decreased expression of MYLIP mRNAdecreases expression 16002434
D005472 Fluorouracil Fluorouracil affects the expression of MYLIP mRNAaffects expression 16584549
D019833 Genistein Genistein results in increased expression of MYLIP mRNAincreases expression 18847459
C475919 hydroxytamoxifen hydroxytamoxifen results in decreased expression of MYLIP mRNAdecreases expression 16849584
D016685 Mitomycin MYLIP protein affects the susceptibility to Mitomycinaffects response to substance 16217747
C041786 palm oil palm oil results in decreased expression of MYLIP mRNAdecreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of MYLIP mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of MYLIP mRNAdecreases expression 19482888
D011374 Progesterone Progesterone results in increased expression of MYLIP mRNAincreases expression 18037150
D001335 Vehicle Emissions Vehicle Emissions results in increased expression of MYLIP mRNAincreases expression 19465080
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.566195326
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2520127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 7.2517638652
MESH:D000230 Adenocarcinoma Genistein 7.2511473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.706695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.0917620307
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3517306315
MESH:D000740 Anemia Fluorouracil 3.7917963324 16511603 15504547
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1819183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8918414634 16251483 16835338 12569548
MESH:D001161 Arteriosclerosis Dietary Fats 3.9915238619
MESH:D050197 Atherosclerosis Arsenic 3.2912928151 19371607
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4717868700
MESH:D001930 Brain Injuries Progesterone 4.3615665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.0020146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 3.0011237771
MESH:D001943 Breast Neoplasms Dietary Fats 3.0020435547
MESH:D001943 Breast Neoplasms Fluorouracil 3.0015136595 18357371 16595493 19217205 16557594 16110121 18608205
MESH:D001943 Breast Neoplasms Genistein 3.0016873071 17200150 16541309
MESH:D001943 Breast Neoplasms Progesterone 3.0015562024 17614352 16175315
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8016051944
MESH:D002277 Carcinoma Fluorouracil 3.6317121937
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6315504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Arsenic 6.7316507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.7318930000 17045692 16332177 17088986 17971768 16799960
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.7316924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.7320007298 1701930 20935162 6705139 17173139
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0518695887
MESH:D002294 Carcinoma, Squamous Cell Arsenic 11.0215504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 11.0220419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 11.0211237771
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 11.0218986760 16757204 16280240 17066447
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1518640142
MESH:D002318 Cardiovascular Diseases Arsenic 7.6915738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases Genistein 7.6916332659
MESH:D002340 Carotid Artery Diseases Arsenic 4.3818022660 16973168
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.7820889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.364080065
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9015001691 17172411 16510598 18772588 17725105 17169374 17018589 17016597 16340194 17287894
MESH:D003110 Colonic Neoplasms Genistein 3.9017182828
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018383874 18288408 16303861 18949393 20501625 17016601 17695437 15289873 16282729 17094418 15148649 16331619 18509181 17594712 17454858 17401013 18802399 17255274 16524972 14970324 16391804 18448328
MESH:D007644 Darier Disease Fluorouracil 4.9116733453
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5016647724
MESH:D003929 Diabetic Neuropathies Progesterone 4.6017187935
MESH:D050171 Dyslipidemias Dietary Fats 3.5118367378
MESH:D004421 Dystonia Phenobarbital 4.091851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.6315138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.6317692515
MESH:D004714 Endometrial Hyperplasia Genistein 4.7116402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4111473722
MESH:D004715 Endometriosis Progesterone 3.8416134523
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.213659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.0011558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.616401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.367750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.143659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.3416530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.3415173087 17638652 16337965 16785472 16481741
MESH:D005234 Fatty Liver Dietary Fats 3.3219004024 17967931 19551842 18296743
MESH:D005355 Fibrosis Dietary Fats 3.6318296743
MESH:D005534 Foot Diseases Arsenic 5.696392382
MESH:D005909 Glioblastoma Genistein 3.3116598420
MESH:D005910 Glioma Fluorouracil 2.9016145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4418337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6920471113
MESH:D006529 Hepatomegaly Phenobarbital 3.5916109766
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6721332399
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5317050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.7021332399
MESH:D006973 Hypertension Arsenic 2.9016076760 11953799 9931084
MESH:D006987 Hypesthesia Arsenic 5.6916093927
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5115869954
MESH:D007249 Inflammation Dietary Fats 5.3220412841
MESH:D007249 Inflammation Progesterone 5.3215869954
MESH:D007333 Insulin Resistance Dietary Fats 3.1511836018 18457598
MESH:D007642 Keratosis Arsenic 5.1112749816 16930632
MESH:D007680 Kidney Neoplasms Fluorouracil 3.3716985049
MESH:D007938 Leukemia Genistein 3.0618980019 17468513
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6017339181
MESH:D008103 Liver Cirrhosis Dietary Fats 6.8018296743
MESH:D008103 Liver Cirrhosis Phenobarbital 6.8021047994
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.0617823541
MESH:D008107 Liver Diseases Arsenic 4.3311134558
MESH:D008107 Liver Diseases Phenobarbital 4.3319363144
MESH:D008113 Liver Neoplasms Arsenic 14.5916368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.5921137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 14.5918383874 15113037 17045692 16603448
MESH:D008113 Liver Neoplasms Mitomycin 14.5915113037
MESH:D008113 Liver Neoplasms Phenobarbital 14.598742319 15975961 19812893 19073162 21047994 19482888
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.756150874 17172636 2563599 18308698 1399818
MESH:D008175 Lung Neoplasms Arsenic 5.0319168569 17306315 17976673
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0318569708 20064080 20464547 18816296 18520028 6695378 20135361 17053015 20869020
MESH:D008175 Lung Neoplasms Fluorouracil 5.0315246190
MESH:D008175 Lung Neoplasms Vehicle Emissions 5.039255578
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9115086387
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.3712929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.3717203775 11408345
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.7416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.7418986760 16757204
MESH:D009203 Myocardial Infarction Genistein 2.8917141266
MESH:D017202 Myocardial Ischemia Arsenic 4.0515371236
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7217141266
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5917484760
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1911141357
MESH:D009369 Neoplasms Fluorouracil 5.1918239605 18600527 16928823
MESH:D009421 Nervous System Malformations Genistein 4.1316427766
MESH:D009436 Neural Tube Defects Arsenic 3.5016620997
MESH:D020078 Neurogenic Inflammation Arsenic 4.4617056641
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4916436463
MESH:D009765 Obesity Dietary Fats 2.3016723640 19632207 18457598 18674790 17217161 11836018 21332399 20518802 20132043
MESH:D010018 Osteomalacia Phenobarbital 4.4817016548
MESH:D010024 Osteoporosis Genistein 3.3019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1716169203
MESH:D010051 Ovarian Neoplasms Arsenic 8.1317306315
MESH:D010051 Ovarian Neoplasms Genistein 8.1319005980
MESH:D010051 Ovarian Neoplasms Progesterone 8.1317393432 16525653
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.9316929163 19003803 15113037 16500647
MESH:D010190 Pancreatic Neoplasms Mitomycin 8.9315113037
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.9316965848
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.2716093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1115371236 6392382 16905509
MESH:D011230 Precancerous Conditions Phenobarbital 3.692563599
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9015572423
MESH:D011471 Prostatic Neoplasms Arsenic 1.8716140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8717292933
MESH:D011471 Prostatic Neoplasms Calcitriol 1.8716289102 18247401 12479363 15754350 16644109
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8719082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 1.8715378649 15256057 16925846
MESH:D011507 Proteinuria Arsenic 4.0921343184
MESH:D019310 Pseudolymphoma Phenobarbital 4.6312752131
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0815538739 16160472 18722050 18286688
MESH:D012135 Respiratory Sounds Vehicle Emissions 5.3218950799
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8818045962
MESH:D012640 Seizures Phenobarbital 2.743137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.946407741
MESH:D012871 Skin Diseases Arsenic 2.7619834688 18709164 17050553 17453740 16702368 16759981 17548696 16353154 6392382 17938729 15952646
MESH:D012878 Skin Neoplasms Arsenic 5.9517976673 15504454 17029826 19538983 17050553 16251483
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9519755658 10029692
MESH:D013119 Spinal Cord Injuries Progesterone 4.4016503802 15862959
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.442093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4418396642 19084572 17522103 16951190 18567086 15786421 16424979 19015929 17498489 17172411
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.111399818
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0616280240
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.7317306315 17976673 15987713 19322015 18640142 11144890 19429237
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7317053015
MESH:D001749 Urinary Bladder Neoplasms Vehicle Emissions 8.7311144890
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9516803524
MESH:D014652 Vascular Diseases Arsenic 4.8517056641
MESH:D015430 Weight Gain Dietary Fats 3.8116723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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