Annotation Detail for CTNNA3
Basic Information Top
| Gene Symbol: | CTNNA3 ( MGC26194,MGC75041,VR22 ) |
|---|---|
| Gene Full Name: | catenin (cadherin-associated protein), alpha 3 |
| Band: | 10q21.3 |
| Quick Links | Entrez ID:29119; OMIM: 607667; Uniprot ID:CTNA3_HUMAN; ENSEMBL ID: ENSG00000183230; HGNC ID: 2511 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| hsa04670 | Leukocyte transendothelial migration |
| hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| hsa04530 | Tight junction |
| hsa05100 | Bacterial invasion of epithelial cells |
| hsa04520 | Adherens junction |
| hsa05213 | Endometrial cancer |
| hsa05200 | Pathways in cancer |
| No data |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| P00012 | Cadherin signaling pathway |
| P00057 | Wnt signaling pathway |
| No data |
| No data |
| Desease ID | Desease Name |
|---|---|
| 1740 | Alzheimer's disease |
| Desease Name |
|---|
| Asthma (toluene diisocyanate-induced) |
| CHEMDEPENDENCY |
| nicotine dependence |
| Alzheimer's disease |
| IMMUNE |
| NEUROLOGICAL |
| smoking cessation |
| Desease Name |
|---|
| Asthma (toluene diisocyanate-induced) |
| Nicotine dependence |
| Longevity |
| No data |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D009151 | Mustard Gas | Mustard Gas results in decreased expression of CTNNA3 mRNA | decreases expression | 18988085 |
| C006253 | pirinixic acid | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CTNNA3 mRNA | affects binding|decreases expression|increases activity | 19710929 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D055371 | Acute Lung Injury | pirinixic acid | 3.72 | 18653653 | |
| MESH:D018248 | Adenoma, Liver Cell | pirinixic acid | 4.37 | 16434500 | |
| MESH:D001249 | Asthma | marker/mechanism | 19187332 | ||
| MESH:D001249 | Asthma | Mustard Gas | 2.82 | 10378619 | |
| MESH:D001768 | Blister | Mustard Gas | 6.05 | 19167455 | |
| MESH:D001778 | Blood Coagulation Disorders | pirinixic acid | 3.70 | 19483382 | |
| MESH:D001989 | Bronchiolitis Obliterans | Mustard Gas | 6.05 | 15286001 | |
| MESH:D029481 | Bronchitis, Chronic | Mustard Gas | 6.05 | 17687719 10378619 | |
| MESH:D002779 | Cholestasis | pirinixic acid | 3.19 | 19176532 | |
| MESH:D003876 | Dermatitis, Atopic | pirinixic acid | 2.61 | 18249437 | |
| MESH:D004487 | Edema | Mustard Gas | 8.75 | 9260866 11428647 11428631 11402378 | |
| MESH:D004487 | Edema | pirinixic acid | 8.75 | 12083418 | |
| MESH:D004890 | Erythema | Mustard Gas | 6.05 | 9357497 | |
| MESH:D005234 | Fatty Liver | pirinixic acid | 3.31 | 20131406 19236843 | |
| MESH:D006333 | Heart Failure | pirinixic acid | 2.81 | 20558911 | |
| MESH:D006529 | Hepatomegaly | pirinixic acid | 3.76 | 19772884 18467677 16221962 19176532 | |
| MESH:D006943 | Hyperglycemia | pirinixic acid | 3.69 | 20558911 | |
| MESH:D007249 | Inflammation | Mustard Gas | 2.99 | 11428620 11402378 17524151 11428631 9260866 11428647 8975870 16001271 9357497 | |
| MESH:D007333 | Insulin Resistance | pirinixic acid | 2.93 | 16306350 | |
| MESH:D008106 | Liver Cirrhosis, Experimental | pirinixic acid | 1.35 | 15474484 | |
| MESH:D008113 | Liver Neoplasms | pirinixic acid | 1.95 | 20007298 16377806 15890375 | |
| MESH:D008171 | Lung Diseases | Mustard Gas | 3.76 | 18161513 18702808 | |
| MESH:D008175 | Lung Neoplasms | Mustard Gas | 2.18 | 8781369 3148597 | |
| MESH:D009135 | Muscular Diseases | pirinixic acid | 4.27 | 16239165 | |
| MESH:D009203 | Myocardial Infarction | pirinixic acid | 2.30 | 19151258 | |
| MESH:D015428 | Myocardial Reperfusion Injury | pirinixic acid | 3.33 | 16411023 | |
| MESH:D009369 | Neoplasms | pirinixic acid | 2.14 | 17405874 | |
| MESH:D009503 | Neutropenia | Mustard Gas | 4.58 | 16761898 7688884 | |
| MESH:D009765 | Obesity | pirinixic acid | 1.90 | 20558911 | |
| MESH:D011041 | Poisoning | Mustard Gas | 4.40 | 15727166 | |
| MESH:D011537 | Pruritus | Mustard Gas | 4.98 | 18058305 | |
| MESH:D011658 | Pulmonary Fibrosis | Mustard Gas | 3.07 | 17620002 17894541 10334151 17266442 17720292 | |
| MESH:D015427 | Reperfusion Injury | pirinixic acid | 2.58 | 19058328 | |
| MESH:D012871 | Skin Diseases | Mustard Gas | 2.80 | 15451306 12880345 16961503 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:04520 | Adherens junction |
| KEGG:05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| KEGG:05100 | Bacterial invasion of epithelial cells |
| KEGG:05213 | Endometrial cancer |
| KEGG:04670 | Leukocyte transendothelial migration |
| KEGG:05200 | Pathways in cancer |
| KEGG:04530 | Tight junction |
Drug Bank