AutismKB 2.0

Annotation Detail for GRM2


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Basic Information Top
Gene Symbol:GRM2 ( GLUR2,GPRC1B,MGLUR2,mGlu2 )
Gene Full Name: glutamate receptor, metabotropic 2
Band: 3p21.2
Quick LinksEntrez ID:2912; OMIM: 604099; Uniprot ID:GRM2_HUMAN; ENSEMBL ID: ENSG00000164082; HGNC ID: 4594
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00037Ionotropic glutamate receptor pathway
P00040Metabotropic glutamate receptor group II pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of GRM2 mRNAaffects expression 21346803
D000638 Amiodarone Amiodarone results in increased expression of GRM2 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRM2 mRNAaffects expression 16483693
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of GRM2 mRNAincreases expression 17452286
D003976 Diazinon Diazinon results in increased expression of GRM2 mRNAincreases expression 17452286
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of GRM2 mRNAdecreases expression 15620428
D004958 Estradiol Estradiol results in increased activity of GRM2 proteinincreases activity 15901789
D006220 Haloperidol Haloperidol results in increased expression of GRM2 mRNAincreases expression 18923069
C025256 nonylphenol nonylphenol results in decreased expression of GRM2 mRNAdecreases expression 15620428
D010269 Paraquat Paraquat affects the expression of GRM2 mRNAaffects expression 15206577
D014415 Tunicamycin Tunicamycin results in increased expression of GRM2 mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.777525203
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 9.776734493
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000230 Adenocarcinoma Estradiol 2.1311473722
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 15.7416611668 11874814 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 15.7416487989
MESH:D000382 Agricultural Workers' Diseases Paraquat 15.7411874814
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9318218290 18057881 20041841
MESH:D001281 Atrial Fibrillation Amiodarone 4.0119698954 18651412
MESH:D001321 Autistic Disorder Haloperidol 2.7319368416 18080171
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.0419483382
MESH:D001943 Breast Neoplasms Estradiol 2.1317289903 19861407 12948864 16675129 18497071 17018787 17261762 14630087
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7716924424
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9319225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2818974383
MESH:D002375 Catalepsy Haloperidol 5.101977408 15215559
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.7114694615
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8618566989
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.2815095906
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.9920210726
MESH:D003704 Dementia Haloperidol 4.7211575062
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 4.1016882537
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 4.3821346803
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.3815265979 18218290
MESH:D004417 Dyspnea Diazinon 5.0216487989
MESH:D016889 Endometrial Neoplasms Estradiol 3.0718566989 11473722 19148513
MESH:D005234 Fatty Liver Amiodarone 3.6614986274
MESH:D005911 Gliosis Paraquat 5.3811124998
MESH:D006505 Hepatitis Diazinon 4.7316487989
MESH:D006529 Hepatomegaly Amiodarone 3.9215265979
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006937 Hypercholesterolemia Amiodarone 4.019751232 8137927
MESH:D007037 Hypothyroidism Amiodarone 4.6917991464 18020914
MESH:D007248 Infertility, Male Diazinon 7.5312948887 16466525
MESH:D007248 Infertility, Male Paraquat 7.534850670
MESH:D007333 Insulin Resistance Estradiol 3.0516627594 16393666
MESH:D007674 Kidney Diseases Estradiol 2.6615618244
MESH:D007680 Kidney Neoplasms Estradiol 3.0915610895
MESH:D008064 Lipidoses Amiodarone 3.6115342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 1.6814659978 14716833
MESH:D008107 Liver Diseases Chlorpyrifos 3.1015991261
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 3.4811940454
MESH:D008133 Long QT Syndrome Amiodarone 3.6917391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 3.4612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.7018516814
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6416891317 11807958 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D001523 Mental Disorders Haloperidol 4.2016856516
MESH:D009181 Mycoses Amiodarone 5.1217974566 12754197
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3916810080
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009410 Nerve Degeneration Paraquat 3.8216893418
MESH:D009421 Nervous System Malformations Estradiol 3.8111399458 16427766
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.2615081274
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 4.2314694615
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D010300 Parkinson Disease Paraquat 2.8616510128 12911755 16140633 15451049 11124998 11181820 15824117 11445065
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.6116190885
MESH:D011014 Pneumonia Paraquat 4.6512504350
MESH:D011041 Poisoning Diazinon 4.5017603234
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0616740699
MESH:D011595 Psychomotor Agitation Haloperidol 5.1311575062
MESH:D011618 Psychotic Disorders Haloperidol 4.3511575062
MESH:D011658 Pulmonary Fibrosis Amiodarone 6.0012832656 12490602 11597910
MESH:D011658 Pulmonary Fibrosis Paraquat 6.0016324872 17997886
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 4.0511700416
MESH:D012135 Respiratory Sounds Chlorpyrifos 10.5311874814 16611668 17119214
MESH:D012135 Respiratory Sounds Paraquat 10.5311874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.1116611668 17119214
MESH:D012162 Retinal Degeneration Paraquat 3.9716458197
MESH:D012559 Schizophrenia marker/mechanism 18923069
MESH:D012559 Schizophrenia Haloperidol 2.8219369910 20107430 1830565 18513383
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.316418539
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2818724381
MESH:D013276 Stomach Ulcer Amiodarone 3.4518087811
MESH:D013610 Tachycardia Amiodarone 4.4511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 11.0819225199
MESH:D017180 Tachycardia, Ventricular Haloperidol 11.0820210726
MESH:D013959 Thyroid Diseases Amiodarone 4.9819731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.0418020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D016171 Torsades de Pointes Amiodarone 4.3817467628 11989578
MESH:D014570 Urologic Diseases Diazinon 5.4916487989
Pathway ID Pathway Name
KEGG:04724 Glutamatergic synapse
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00659 antagonist Acamprosate Alcohol Deterrents
No data
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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