AutismKB 2.0

Annotation Detail for GRM4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GRM4 ( GPRC1D,MGC177594,MGLUR4,mGlu4 )
Gene Full Name: glutamate receptor, metabotropic 4
Band: 6p21.31
Quick LinksEntrez ID:2914; OMIM: 604100; Uniprot ID:GRM4_HUMAN; ENSEMBL ID: ENSG00000124493; HGNC ID: 4596
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04742Taste transduction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C012729 2-amino-4-phosphonobutyric acid 2-amino-4-phosphonobutyric acid binds to and results in increased activity of GRM4 proteinaffects binding|increases activity 16806298
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRM4 mRNAaffects expression 16483693
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of GRM4 mRNAincreases expression 19440498
D003976 Diazinon Diazinon affects the expression of GRM4 mRNAaffects expression 19440498
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1918287403
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 11.3616611668 11874814 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 11.3616487989
MESH:D004417 Dyspnea Diazinon 5.5216487989
MESH:D006505 Hepatitis Diazinon 5.0816487989
MESH:D007248 Infertility, Male Diazinon 4.0716466525 12948887
MESH:D008107 Liver Diseases Chlorpyrifos 3.1415991261
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.4215081274
MESH:D011041 Poisoning Diazinon 4.8117603234
MESH:D012135 Respiratory Sounds Chlorpyrifos 5.1916611668 11874814 17119214
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.6117119214 16611668
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.816418539
MESH:D014570 Urologic Diseases Diazinon 6.0016487989
Pathway ID Pathway Name
KEGG:04724 Glutamatergic synapse
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
KEGG:04742 Taste transduction
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved